2,350 results match your criteria technetium-99m thyroid

Feasibility of lateral sentinel lymph node biopsy in medullary thyroid cancer: A surrogate tool for determining prophylactic lateral neck dissection-A pilot study.

Head Neck 2021 Jul 20. Epub 2021 Jul 20.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Backgrounds: This study aimed to evaluate usefulness of lateral sentinel lymph node biopsy (SLNB) in determining lateral neck dissection (LND) of patients with medullary thyroid cancer (MTC).

Methods: Sixteen patients with MTC were enrolled in the study from January 2013 to June 2019. Intratumoral injection of technetium (Tc)-99m phytate followed by lymphoscintigraphy was performed preoperatively. Read More

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Impact of multiple lymphatic basin drainage in truncal melanoma patients.

J Plast Reconstr Aesthet Surg 2021 Jun 18. Epub 2021 Jun 18.

Internal Medicine Clinic, University Clinical Centre of the Republic of Srpska, 12 Beba bb Street, Banja Luka, Republic of Srpska 78 000, Bosnia and Herzegovina.

Introduction: In many patients with cutaneous melanoma that affects the trunk area, there is lymphatic drainage to multiple basins (MLBD). This study aimed to examine whether MLBD is associated with disease outcomes.

Methods: Lymphatic mapping and sentinel lymph node (SLN) biopsy were performed in 161 patients with truncal melanoma. Read More

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Tzila Zwas

Harefuah 2021 Jul;160(7):468-473

Institute of Nuclear Medicine, The Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.

Introduction: Nuclear medicine (NM) in Israel started in 1952 with the use of isotopes in medicine, using I-131 for thyroid disorders, initiated by Prof. Czerniak, founder of the profession. The first institute opened in 1954. Read More

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Scintigraphic tracking of Technetium-labelled equine peripheral blood-derived mesenchymal stem cells after intravenous, intramuscular, and subcutaneous injection in healthy dogs.

Stem Cell Res Ther 2021 Jul 13;12(1):393. Epub 2021 Jul 13.

Global Stem cell Technology NV, Noorwegenstraat 4, 9940, Evergem, Belgium.

Background: Mesenchymal stem cell treatments in dogs have been investigated as a potential innovative alternative to current conventional therapies for a variety of conditions. So far, the precise mode of action of the MSCs has yet to be determined. The aim of this study was to gain more insights into the pharmacokinetics of MSCs by evaluating their biodistribution in healthy dogs after different injection routes. Read More

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Role of indocyanine green combined with radiotracer-Technetium 99 m in neck surgery for primary and recurrent head and neck cancer: preliminary results of a tertiary cancer center.

Eur Arch Otorhinolaryngol 2021 Jun 19. Epub 2021 Jun 19.

Department of Nuclear Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: Neck dissection (ND), whether therapeutic or elective, is an essential component of the treatment of head and neck squamous cell carcinoma (HNSCC). Due to altered anatomy and fibrosis caused by initial treatments, surgeons face challenges during salvage ND. A combination of Technetium-99 m and indocyanine green (ICG) previously used in the sentinel lymph node (SLN) biopsy for oral cavity cancers, may be useful in different types of neck surgeries. Read More

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Infants Diagnosed with Athyreosis on Scintigraphy May Have a Gland Present on Ultrasound and Have Transient Congenital Hypothyroidism.

Horm Res Paediatr 2021 27;94(1-2):36-43. Epub 2021 May 27.

Department of Paediatric Endocrinology, Children's Health Ireland at Temple St, Dublin, Ireland.

Scintigraphy using technetium-99m (99mTc) is the gold standard for imaging the thyroid gland in infants with congenital hypothyroidism (CHT) and is the most reliable method of diagnosing an ectopic thyroid gland. One of the limitations of scintigraphy is the possibility that no uptake is detected despite the presence of thyroid tissue, leading to the spurious diagnosis of athyreosis. Thyroid ultrasound is a useful adjunct to detect thyroid tissue in the absence of 99mTc uptake. Read More

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Effect of Ursodeoxycholic Acid on the Biodistribution and Excretion of Technetium-99m Radiopharmaceuticals in Rat: A Potential Image Quality Enhancer.

Yonsei Med J 2021 Jun;62(6):555-562

Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School and Hospital, Jeonju, Korea.

Purpose: This study aimed to investigate the effect of ursodeoxycholic acid (UDCA) on the biodistribution and excretion of technetium-99m (Tc-99m)-labeled radiopharmaceuticals.

Materials And Methods: Tc-99m hydroxy-methylene-diphosphonate (HDP), Tc-99m pertechnetate, and Tc-99m dimercaptosuccinic acid (DMSA) were injected via the tail vein of rats. After 30 min, the control group was administered saline, and the UDCA group was given UDCA orally. Read More

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Diagnosis and treatment of mediastinal ectopic thyroid tissue with normally located thyroid gland and primary hyperparathyroidism: a case report.

Gland Surg 2021 Apr;10(4):1532-1541

Department of Thoracic Surgery, Clinical Center of Montenegro, Podgorica, Montenegro.

Mediastinal ectopic thyroid tissue (ETT) is rare entity, accounting for 1% of all mediastinal tumours. A 53-year-old lady, presented with cough and atypical chest pain. A computed tomography (CT) scan of chest showed a 95 mm × 75 mm × 115 mm tumour mass; CT guided biopsy of mediastinal mass showed ETT. Read More

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In Vivo Imaging of Thyroid Cancer with Tc-TR1401 and Tc-TR1402: A Comparison Study in Dogs.

J Clin Med 2021 Apr 26;10(9). Epub 2021 Apr 26.

Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, 00161 Rome, Italy.

Differentiated thyroid cancer (DTC) cells may lose NIS expression and iodine uptake, but usually express TSH receptors (TSHR). Therefore, the aim of our study was to compare two radiolabeled superagonist TSH analogues for DTC imaging. These analogues (namely TR1401 and TR1402) have a higher TSHR binding affinity than recombinant human TSH (Thyrogen). Read More

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The EANM practice guidelines for parathyroid imaging.

Eur J Nucl Med Mol Imaging 2021 08 10;48(9):2801-2822. Epub 2021 Apr 10.

EANM Thyroid Committee, Vienna, Austria.

Introduction: Nuclear medicine parathyroid imaging is important in the identification of hyperfunctioning parathyroid glands in primary hyperparathyroidism (pHPT), but it may be also valuable before surgical treatment in secondary hyperparathyroidism (sHPT). Parathyroid radionuclide imaging with scintigraphy or positron emission tomography (PET) is a highly sensitive procedure for the assessment of the presence and number of hyperfunctioning parathyroid glands, located either at typical sites or ectopically. The treatment of pHPT is mostly directed toward minimally invasive parathyroidectomy, especially in cases with a single adenoma. Read More

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Endoscopic Left Central Lymph Node Dissection of Thyroid Cancer: Safe, Feasible, and Relatively Easy.

Surg Innov 2021 Apr 8:1553350620983640. Epub 2021 Apr 8.

Department of General Surgery, 162698Jinan University First Affiliated Hospital, Guangzhou, China.

. The purpose of this study was to explore the feasibility of left central lymph node dissection (CLND) in endoscopic thyroidectomy via chest-breast approach (ETCB). Retrospective analysis of 57 cases of left CLND (group A) via ETCB, 35 cases of open left CLND (group B), and 90 cases of right CLND via ETCB (Group C) were performed from October 2014 to October 2019. Read More

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Radioactive Parathyroid Adenomas on Sestamibi Scans: Low Parathyroid Hormone Secretory Potential and Large Volume.

Endocrinol Metab (Seoul) 2021 Apr 6;36(2):351-358. Epub 2021 Apr 6.

Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background: We investigated the clinical characteristics of parathyroid adenomas according to radioactivity on 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) in primary hyperparathyroidism (PHPT) patients.

Methods: The study included 217 patients diagnosed with PHPT from 2000 to 2019 at Seoul National University Hospital who underwent 99mTc-MIBI SPECT/CT scans. On SPECT/CT, the radioactivity of parathyroid adenomas was measured as the ratio of the mean radioactivity count of the parathyroid adenoma to that of the contralateral thyroid. Read More

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Assessment of normal reference values for thyroid uptake of technetium-99m pertechnetate in a Saudi population.

Ann Saudi Med 2021 Mar-Apr;41(2):86-90. Epub 2021 Apr 1.

From the Department of Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia.

Background: Thyrotoxicosis is a common medical problem. Thyroid nuclear imaging with either I or technetium-99m (Tc-99m) pertechnetate are used to determine the cause. Although I has been the standard technique, Tc-99m pertechnetate is now commonly used, acceptable and easier to perform. Read More

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A Pediatric Parathyroid Carcinoma: An Unusual Clinical Presentation and Mini-review.

Int J Endocrinol Metab 2021 Jan 25;19(1):e110234. Epub 2021 Jan 25.

Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Introduction: Primary hyperparathyroidism (PHPT) is a rare condition in the pediatric population. Parathyroid carcinoma (PC) is a very uncommon cause of PHPT, accounting for < 1% of pediatric PHPT cases. It is challenging to distinguish between parathyroid adenoma (PA), the most common cause of PHPT, and PC. Read More

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January 2021

Hyperparathyroidism-Jaw Tumor Syndrome.

Case Rep Oncol 2021 Jan-Apr;14(1):29-33. Epub 2021 Feb 18.

Division of Endocrinology, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Primary hyperparathyroidism is a relatively common endocrine disorder, affecting 7 out of 1,000 adults. The median age at onset is the 6th decade of life. Our objective was to present a young patient with primary hyperparathyroidism who has a positive mutation. Read More

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February 2021

Residual Pyramidal Lobe Increases Stimulated Thyroglobulin and Decreases Endogenous Thyroid Stimulating Hormone Stimulation in Differentiated Thyroid Cancer Patients.

Endocr Pract 2021 Mar 13;27(3):212-215. Epub 2020 Dec 13.

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Objective: To determine the frequency of pyramidal lobe remnants after total thyroidectomy (TT) and the effect on stimulated thyroglobulin (Tg).

Methods: The study included 1740 differentiated thyroid cancer (DTC) patients who were followed up by our center. The department database was searched to identify DTC patients with residual pyramidal lobe after TT. Read More

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Effect of Kinase Inhibitors on the Technetium-99m Uptake into Thyroid Carcinoma Cells .

In Vivo 2021 Mar-Apr;35(2):721-729

Department of Nuclear Medicine, University Hospital of Marburg, Marburg, Germany.

Background/aim: We evaluated the potential of the kinase inhibitors sorafenib, lenvatinib and selumetinib on increasing the uptake of technetium-99m into thyroid cancer cells.

Materials And Methods: Four established cell lines and three patient's cell cultures were treated with 0.1, 1 and 5 μM of sorafenib, lenvatinib and selumetinib for 72 hours. Read More

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Long-Term Outcomes of Radioiodine Therapy for Juvenile Graves Disease with Emphasis on Subsequently Detected Thyroid Nodules: A Single Institution Experience from Japan.

Endocr Pract 2020 Jul 24;26(7):729-737. Epub 2020 Nov 24.

From the Tajiri Thyroid Clinic, Kumamoto, Japan.

Objective: To investigate the long-term outcomes of radioiodine therapy (RIT) for juvenile Graves disease (GD) and the ultrasonographic changes of the thyroid gland.

Methods: All of 117 juvenile patients (25 males and 92 females, aged 10 to 18 [median 16] years) who had undergone RIT for GD at our clinic between 1999 and 2018 were retrospectively reviewed. Each RIT session was delivered on an outpatient basis. Read More

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Intra-operative parathyroid hormone evaluation is superior to frozen section analysis in parathyroid surgery.

Am J Otolaryngol 2021 May-Jun;42(3):102886. Epub 2021 Jan 12.

Dokuz Eylül University Faculty of Medicine, Department of General Surgery, Izmir, Turkey. Electronic address:

Background: Surgery is currently the only treatment option for patients with primary hyperparathyroidism (PHPT). Recently, minimally invasive parathyroidectomy (MIP) has begun to replace traditional bilateral neck exploration (BNE).

Objective: The aim of this study is to compare the results of parathyroidectomies performed in our hospital over the past decade that were guided by intra-operative parathyroid hormone (IOPTH) sampling or frozen section (FS) analysis. Read More

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January 2021


Probl Radiac Med Radiobiol 2020 Dec;25:579-591

National Cancer Institute of the Ministry of Health of Ukraine, 33/43 Lomonosova St., Kyiv, 03022, Ukraine.

Objective: Developing of algorithm for the post-surgical management of patients with iodine-negative metastasesof differentiated thyroid cancer (DTC).

Materials And Methods: The DTC patients with iodine-negative metastases (n = 115) were enrolled in the study.Of them the whole body scintigraphy (WBS) was performed with technetium-99m-hexakis-2-methoxyisobutylisonitrile(99mTc-MIBI) (n = 30), WBS with technetium-99m dimercaptosuccinic acid (99mTc-DMSA) (n = 30), 18FDG PET (n = 30), andcomputer tomography (CT-scan) (n = 25). Read More

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December 2020


AACE Clin Case Rep 2020 Nov-Dec;6(6):e326-e329. Epub 2020 Aug 6.

Objective: Acrodysostosis is a rare skeletal dysplasia with one gene mutation associated with pseudohypoparathyroidism. We describe a 15-year-old male patient with genetic acrodysostosis who presented with hyperparathyroidism.

Methods: Laboratory testing, including genetic testing for acrodysostosis and biochemical evaluation for hypercalcemia, were obtained. Read More

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Gender differences in estimating I-131 thyroid uptake from Tc-99m thyroid uptake for benign thyroid disease.

Br J Radiol 2021 Feb 11;94(1118):20200700. Epub 2020 Dec 11.

St James's Hospital, Dublin, Ireland.

Objective: For radioactive Iodine-131 (I) treatments of thyroid diseases, increased efficacy has been reported for personalized dosimetry treatments. The measurement of Iodine-131 thyroid uptake (IU) is required in these cases. This study aims to investigate whether Tc thyroid uptake (TcU) may be used in place of IU for implementing personalised treatments. Read More

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February 2021

Effectiveness of radioactive iodine (I) in the treatment of Graves' disease: single center experience in Assiut University hospital.

Am J Nucl Med Mol Imaging 2020 15;10(5):235-242. Epub 2020 Oct 15.

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University Egypt.

To evaluate the effectiveness of radioactive iodine (I) therapy in patients with Graves' disease (GD) in Assiut University Hospital. We retrospectively evaluated two hundred and seven patients with GD, after their therapy with I. Before therapy all the included patients underwent neck ultrasound, hormonal assay and Technetium-pertechntate (Tc) thyroid scintigraphy to evaluate percentage uptake of the thyroid gland, after therapy all patients followed up clinically and laboratory every 3 months for at least one year to detect outcome; where euthyroid or hypothyroid status denotes successful therapy. Read More

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October 2020

Utility of the New Indian Society of Paediatric and Adolescent Endocrinology (ISPAE) Guidelines for Congenital Hypothyroidism Screening in a High Risk Unit.

Indian J Pediatr 2020 Nov 20. Epub 2020 Nov 20.

Department of Neonatology, Mehta Multispeciality Hospitals India Pvt Ltd, Chennai, India.

Objective: To study the new ISPAE guidelines in neonates with congenital hypothyroidism and present authors' experience in managing these neonates.

Methods: A retrospective review of all babies who were screened for congenital hypothyroidism in the institution over a period of 5 y was conducted. Details pertaining to maternal risk factors, neonatal risk factors, screening TSH, venous TSH and details of etiological evaluation including: ultrasound thyroid, technetium 99m scintigraphy and anti thyroid peroxidase antibody estimation were retrieved. Read More

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November 2020

Efficacy and safety of Xiaochaihu decoction for subacute thyroiditis: A protocol of systematic review and meta-analysis.

Medicine (Baltimore) 2020 Nov;99(46):e23011

Hospital of Chengdu University of Traditional Chinese Medicine.

Background: Subacute thyroiditis (SAT) is a transient and self-limiting inflammatory thyroid disease. There is no clear evidence for specific etiology, but it is generally thought to occur after viral infection. Characteristics of SAT include severe pain of the anterior neck, enlarged firm thyroid, disordered thyroid function, elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), typical ultrasound findings (hypoechoic areas) and low thyroid uptake of radioactive iodine or technetium-99 m because of the destructive etiology of the hyperthyroidism. Read More

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November 2020

Factors associated with severity of orbitopathy in patients with Graves' disease.

Taiwan J Ophthalmol 2020 Jul-Sep;10(3):197-202. Epub 2020 May 4.

Department of Physiology, Government Medical College, Baramulla, Jammu and Kashmir, India.

Purpose: Graves' orbitopathy (GO) is one of the most frequent orbital disorders and is the most common cause of proptosis in adults. GO is described as chronic inflammation of orbital and periorbital tissues. This study aimed to evaluate the risk factors for severe GO in patients with Graves' disease (GD). Read More

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Persistent Hypercalcemia Crisis and Recurrent Acute Pancreatitis Due to Multiple Ectopic Parathyroid Carcinomas: Case Report and Literature Review of Mediastinal Parathyroid Carcinoma.

Front Endocrinol (Lausanne) 2020 10;11:647. Epub 2020 Sep 10.

Key Laboratory of Endocrinology, Department of Endocrinology, National Commission of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.

Mediastinal parathyroid carcinoma (PC) is a rare entity in primary hyperparathyroidism. The aim of this report is to demonstrate a case of mediastinal PC, and to provide a systemic literature review of this rare condition. A 34-year-old woman who had already undergone two cervical operations for hyperparathyroidism suffered from another recurrence, presenting with recurrent acute pancreatitis and persistent hypercalcemic crisis. Read More

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The diagnostic value of dual-phase SPECT/CT scintigraphy based on transport kinetics of 99mTc-sestamibi confirmed with histopathological findings in patients with secondary hyperparathyroidism - practical consideration.

Nucl Med Rev Cent East Eur 2020 ;23(2):71-77

Department of Nuclear Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Background: Dual phase 99mTc-sestamibi SPECT/CT preoperative parathyroid scintigraphy (PPS) is seldom discussed in terms of the transport kinetics of the tracer.

Objectives: To assess the relationship between the characteristic type of tracer transport in particular PPS and histopathological findings in patients with secondary hyperparathyroidism (sHPT).

Material And Methods: The study comprised 27 patients (13 females and 14 males) with sHPT. Read More

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A remarkable case of thyrotoxicosis initially caused by graves' disease followed by a probable TSHoma - a case report.

BMC Endocr Disord 2020 Aug 27;20(1):133. Epub 2020 Aug 27.

Department of Diabetes and Endocrinology, Beaumont Hospital and the RCSI, Dublin, Ireland.

Background: Graves' disease is the commonest cause of thyrotoxicosis whilst thyrotropin (TSH)-producing pituitary adenomas (thyrotropinomas, TSHomas) are very rare and account for just 1-2% of all pituitary adenomas. Coexistence of a TSHoma and Graves' disease has been very rarely reported. Here, we report a case of a patient whose initial presentation with primary thyrotoxicosis due to Graves' disease, was subsequently followed by a relapse of thyrotoxicosis due to a probable TSHoma. Read More

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Esophageal 99mTc-pertechnetate uptake mimicking an autonomous thyroid adenoma in a patient with subacute thyroiditis: a case report.

Avicenna J Med 2020 Jul-Sep;10(3):125-127. Epub 2020 Jul 3.

Department of Radiology and Nuclear Medicine, School of Medicine, The University of Jordan/Jordan University Hospital, Amman, Jordan.

Subacute thyroiditis (SAT) is one of the most common causes of thyrotoxicosis. Thyroid scans with radioiodine or technetium-99m pertechnetate (99mTc) are often performed in the workup of patients with thyrotoxicosis, particularly to differentiate between SAT and Graves's disease. Although very helpful, thyroid scans are prone to pitfalls that may occasionally lead to misdiagnosis. Read More

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