27,872 results match your criteria tbi


Persistent posttraumatic headaches and functioning in veterans: Injury type can matter.

Headache 2021 Sep 27. Epub 2021 Sep 27.

Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

Objective: To characterize the relationship between head trauma types (blast injury, blunt injury, combined blast+blunt injury) with subsequent headache presentations and functioning.

Background: Posttraumatic headaches (PTHs), the most common sequelae of traumatic brain injury (TBI), are painful and disabling. More than 400,000 veterans report having experienced a TBI, and understanding the predictors of PTHs may guide treatment developments. Read More

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September 2021

Depression associated with APOE status and hippocampal volume but not cognitive decline in older adults aging with traumatic brain injury.

Neuropsychology 2021 Sep 27. Epub 2021 Sep 27.

Department of Psychology.

Objective: To examine the relationship between depression and cognition, genetic risk, and hippocampal differences in a sample of older adults with a history of traumatic brain injury (TBI).

Method: Participants were 85 males and 35 females (91 Caucasian, 29 African-American) with a mean age of 65.04 (±8. Read More

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September 2021

EAST MCT: COMPARISON OF PRE-INJURY ANTITHROMBOTIC USE AND REVERSAL STRATEGIES AMONG SEVERE TBI PATIENTS.

J Trauma Acute Care Surg 2021 Sep 24. Epub 2021 Sep 24.

University of Florida College of Medicine- Jacksonville, 653 W 8th Street, Jacksonville, FL 32209, P: 904-244-3416, F: 904-244-4687, Our Lady of the Lake RMC, Tulane University Medical School, Department of Surgery, UC Health Memorial Hospital, Allegheny General Hospital, Allegheny Health Network, Tufts Medical Center, Division of Trauma/Acute Care Surgery, Loma Linda University Medical Center, Department of Surgery, Loma Linda University Medical Center, Department of Surgery, Reading Hospital- Tower Health, Crozer Keystone Health System, Tulane University Medical School, Medical City Plano, Via Christi Hospitals- Wichita, Via Christi Hospitals- Wichita, St. Mary's Medical Center, St. Mary's Medical Center, Maine Medical Center, Broward Health Medical Center, Broward Health Medical Center, Eskenazi Health, Indiana University School of Medicine, Center for Data Solutions, University of Florida College of Medicine- Jacksonville, University of Florida College of Medicine- Jacksonville, University of Florida College of Medicine- Jacksonville,

Background: Trauma teams are often faced with patients on antithrombotic drugs, which is challenging when bleeding occurs. We sought to compare the effects of different antithrombotic medications on head injury severity and hypothesized that antithrombotic reversal would not improve mortality in severe TBI patients.

Methods: An EAST-sponsored prospective, multi-centered, observational study of 15 trauma centers was performed. Read More

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September 2021

Carotid Arterial Compliance and Aerobic Exercise Training in Chronic Traumatic Brain Injury: A Pilot Study.

J Head Trauma Rehabil 2021 Sep 23. Epub 2021 Sep 23.

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (Drs Tomoto, Tarumi, and Zhang); Departments of Neurology (Drs Tomoto, Le, Tarumi, Dieppa, Zhang, and Ding), Physical Medicine and Rehabilitation (Dr Bell), Neurological Surgery (Dr Madden), and Internal Medicine (Dr Zhang), University of Texas Southwestern Medical Center, Dallas; and Human Informatics Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan (Dr Tarumi).

Objective: Decreased carotid arterial compliance (CAC) is associated with cerebral microvascular damage, cerebral blood flow (CBF) dysregulation, and increased risk for stroke and dementia, which are reported to be prevalent after traumatic brain injury (TBI). However, the effect of TBI on CAC has not been reported. The purposes of this pilot study were to (1) compare CAC between participants with chronic traumatic brain injury (cTBI) and age-matched healthy control (HC) subjects and (2) to examine whether CAC changed after 3 months of exercise training in those with cTBI. Read More

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September 2021

Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels.

Function (Oxf) 2021 6;2(3). Epub 2021 Apr 6.

Department of Surgery, University of Vermont Larner College of Medicine, Burlington, VT, USA.

Trauma can lead to widespread vascular dysfunction, but the underlying mechanisms remain largely unknown. Inward-rectifier potassium channels (Kir2.1) play a critical role in the dynamic regulation of regional perfusion and blood flow. Read More

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Influence of Antibiotic Management on Microbial Selection and Infectious Complications After Trauma.

Front Med (Lausanne) 2021 10;8:678382. Epub 2021 Sep 10.

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Frankfurt, Germany.

The inflammatory response and post-traumatic complications like infections play an important role in the pathophysiology of severe injuries. This study examines the microbiological aspects in anti-infective treatment of trauma patients and their inflammatory response in post-traumatic infections complications. A retrospective analysis of prospectively collected data in trauma patients (ISS ≥ 16) over a 1-year period (01/2018 to 12/2018) is provided. Read More

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September 2021

Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes.

Microsyst Nanoeng 2021 3;7:20. Epub 2021 Mar 3.

Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708 USA.

Traumatic brain injury (TBI) is a global cause of morbidity and mortality. Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available, noninvasive diagnostic biomarker. In particular, a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI (mTBI). Read More

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Age-at-Injury Determines the Extent of Long-Term Neuropathology and Microgliosis After a Diffuse Brain Injury in Male Rats.

Front Neurol 2021 8;12:722526. Epub 2021 Sep 8.

Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.

Traumatic brain injury (TBI) can occur at any age, from youth to the elderly, and its contribution to age-related neuropathology remains unknown. Few studies have investigated the relationship between age-at-injury and pathophysiology at a discrete biological age. In this study, we report the immunohistochemical analysis of naïve rat brains compared to those subjected to diffuse TBI by midline fluid percussion injury (mFPI) at post-natal day (PND) 17, PND35, 2-, 4-, or 6-months of age. Read More

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September 2021

P300 as a Potential Indicator in the Evaluation of Neurocognitive Disorders After Traumatic Brain Injury.

Front Neurol 2021 9;12:690792. Epub 2021 Sep 9.

Shanghai Key Laboratory of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai, China.

Few objective indices can be used when evaluating neurocognitive disorders after a traumatic brain injury (TBI). P300 has been widely studied in mental disorders, cognitive dysfunction, and brain injury. Daily life ability and social function are key indices in the assessment of neurocognitive disorders after a TBI. Read More

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September 2021

Systematic Review of Sex and Gender Effects in Traumatic Brain Injury: Equity in Clinical and Functional Outcomes.

Front Neurol 2021 10;12:678971. Epub 2021 Sep 10.

KITE Toronto Rehabilitation Institute University Health Network, Toronto, ON, Canada.

Although traumatic brain injury (TBI) is a leading cause of death and disability in male and female patients worldwide, little is known about the effect of sex and gender on TBI outcomes. This systematic review summarizes the evidence on the effect of sex and gender on core TBI outcomes. All English-language studies from six literature databases that addressed core outcomes in adults with TBI and included sex or gender, TBI severity, and age in their analyses were considered eligible. Read More

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September 2021

Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury.

J Neuroinflammation 2021 Sep 25;18(1):221. Epub 2021 Sep 25.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Background: Neuroinflammation following traumatic brain injury (TBI) has been shown to be associated with secondary injury development; however, how systemic inflammatory mediators affect this is not fully understood. The aim of this study was to see how systemic inflammation affects markers of neuroinflammation, if this inflammatory response had a temporal correlation between compartments and how different compartments differ in cytokine composition.

Methods: TBI patients recruited to a previous randomised controlled trial studying the effects of the drug anakinra (Kineret®), a human recombinant interleukin-1 receptor antagonist (rhIL1ra), were used (n = 10 treatment arm, n = 10 control arm). Read More

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September 2021

A Variable Height Microfluidic Device for Multiplexed Immunoassay Analysis of Traumatic Brain Injury Biomarkers.

Biosensors (Basel) 2021 Sep 7;11(9). Epub 2021 Sep 7.

Biomedical Engineering Department, University of Michigan, Ann Arbor, MI 48109, USA.

Traumatic brain injury (TBI) is a leading cause of global morbidity and mortality, partially due to the lack of sensitive diagnostic methods and efficacious therapies. Panels of protein biomarkers have been proposed as a way of diagnosing and monitoring TBI. To measure multiple TBI biomarkers simultaneously, we present a variable height microfluidic device consisting of a single channel that varies in height between the inlet and outlet and can passively multiplex bead-based immunoassays by trapping assay beads at the point where their diameter matches the channel height. Read More

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September 2021

The Current State of Traumatic Brain Injury Biomarker Measurement Methods.

Biosensors (Basel) 2021 Sep 7;11(9). Epub 2021 Sep 7.

Biomedical Engineering Department, University of Michigan, Ann Arbor, MI 48109, USA.

Traumatic brain injury (TBI) is associated with high rates of morbidity and mortality partially due to the limited tools available for diagnosis and classification. Measuring panels of protein biomarkers released into the bloodstream after injury has been proposed to diagnose TBI, inform treatment decisions, and monitor the progression of the injury. Being able to measure these protein biomarkers at the point-of-care would enable assessment of TBIs from the point-of-injury to the patient's hospital bedside. Read More

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September 2021

Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury.

Curr Med Chem 2021 Sep 23. Epub 2021 Sep 23.

Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil.

Traumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI's long-term consequences being the search for novel therapeutic targets, a goal of highest scientific and clinical priority. Read More

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September 2021

Recurrence risk after a first remote symptomatic seizure in adults: epilepsy or not?

Authors:
Johan Zelano

Epilepsia Open 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurology, Sahlgrenska university hospital, Gothenburg, Sweden.

The ILAE practical definition of epilepsy has a one seizure-possibility to diagnose epilepsy after a first seizure if the recurrence risk is very high. The recurrence risk after a first seizure in brain disorders (first remote seizure) is often high, but varies with etiology, so more specific information is needed for clinical practice. This review describes etiology-specific recurrence risks in adults with a first remote seizure in stroke, traumatic brain injury, infections, dementia, multiple sclerosis, and tumors. Read More

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September 2021

Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders.

Biol Psychiatry 2021 Jul 31. Epub 2021 Jul 31.

Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin. Electronic address:

The psychological trauma associated with events resulting in traumatic brain injury (TBI) is an important and frequently overlooked factor that may impede brain recovery and worsen mental health following TBI. Indeed, individuals with comorbid posttraumatic stress disorder (PTSD) and TBI have significantly poorer clinical outcomes than individuals with a sole diagnosis. Emotion dysregulation is a common factor leading to poor cognitive and affective outcomes following TBI. Read More

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Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder?

Biol Psychiatry 2021 Jul 21. Epub 2021 Jul 21.

Department of Physical Medicine & Rehabilitation, Wexner Medical Center, The Ohio State University, Columbus, Ohio.

There is a high co-occurrence of risky substance use among adults with traumatic brain injury (TBI), although it is unknown if the neurologic sequelae of TBI can promote this behavior. We propose that to conclude that TBI can cause risky substance use, it must be determined that TBI precedes risky substance use, that confounders with the potential to increase the likelihood of both TBI and risky substance use must be ruled out, and that there must be a plausible mechanism of action. In this review, we address these factors by providing an overview of key clinical and preclinical studies and list plausible mechanisms by which TBI could increase risky substance use. Read More

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Alzheimer's disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and cerebrolysin with monoclonal antibodies to amyloid beta peptide.

Prog Brain Res 2021 12;265:1-97. Epub 2021 Aug 12.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Military personnel are prone to traumatic brain injury (TBI) that is one of the risk factors in developing Alzheimer's disease (AD) at a later stage. TBI induces breakdown of the blood-brain barrier (BBB) to serum proteins into the brain and leads to extravasation of plasma amyloid beta peptide (ΑβP) into the brain fluid compartments causing AD brain pathology. Thus, there is a need to expand our knowledge on the role of TBI in AD. Read More

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Effects of hypertonic saline on intracranial pressure and cerebral autoregulation in pediatric traumatic brain injury.

J Neurosurg Pediatr 2021 Sep 24:1-7. Epub 2021 Sep 24.

2Pediatric Intensive Care Unit, University Children's Hospital of Tuebingen, Tuebingen; and.

Objective: Hypertonic saline (HTS) is commonly used in children to lower intracranial pressure (ICP) after severe traumatic brain injury (sTBI). While ICP and cerebral perfusion pressure (CPP) correlate moderately to TBI outcome, indices of cerebrovascular autoregulation enhance the correlation of neuromonitoring data to neurological outcome. In this study, the authors sought to investigate the effect of HTS administration on ICP, CPP, and autoregulation in pediatric patients with sTBI. Read More

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September 2021

An Assessment of Global Neurotrauma Prevention and Care Delivery: The Provider Perspective.

World Neurosurg 2021 Sep 21. Epub 2021 Sep 21.

Program in Global Surgery and Social Change, Harvard University, Boston, MA, USA.

Introduction: Neurotrauma is one of the leading causes of morbidity and mortality around the world. Assessment of injury prevention and pre-hospital care for neurotrauma patients is necessary to improve care systems.

Methods: A 29-question electronic survey was developed based on the EQUATOR checklist to assess neurotrauma policies and laws related to safety precautions. Read More

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September 2021

Outcomes and Practice Patterns of Medical Management of Blunt Thoracic Aortic Injury from the Aortic Trauma Foundation Global Registry.

J Vasc Surg 2021 Sep 21. Epub 2021 Sep 21.

Division of Vascular Surgery, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address:

Objectives: Blunt Thoracic Aortic Injury (BTAI) is the second leading cause of death from blunt trauma. This study aims to determine the outcomes of medical management for BTAI. We hypothesized based on several previously published articles, that patients with minimal aortic injury (BTAI Grades 1 & 2) could safely be treated with definitive medical management (MM) alone. Read More

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September 2021

Rescuing mitochondria in traumatic brain injury and intracerebral hemorrhages - A potential therapeutic approach.

Neurochem Int 2021 Sep 22;150:105192. Epub 2021 Sep 22.

Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA. Electronic address:

Mitochondria are dynamic organelles responsible for cellular energy production. Besides, regulating energy homeostasis, mitochondria are responsible for calcium homeostasis, signal transmission, and the fate of cellular survival in case of injury and pathologies. Accumulating reports have suggested multiple roles of mitochondria in neuropathologies, neurodegeneration, and immune activation under physiological and pathological conditions. Read More

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September 2021

Mesenchymal Stem Cell-Induced Anti-Neuroinflammation Against Traumatic Brain Injury.

Cell Transplant 2021 Jan-Dec;30:9636897211035715

Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.

Traumatic brain injury (TBI) is a pervasive and damaging form of acquired brain injury (ABI). Acute, subacute, and chronic cell death processes, as a result of TBI, contribute to the disease progression and exacerbate outcomes. Extended neuroinflammation can worsen secondary degradation of brain function and structure. Read More

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September 2021

Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase.

J Am Chem Soc 2021 Sep 24. Epub 2021 Sep 24.

RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

The extant complex proteins must have evolved from ancient short and simple ancestors. The double-ψ β-barrel (DPBB) is one of the oldest protein folds and conserved in various fundamental enzymes, such as the core domain of RNA polymerase. Here, by reverse engineering a modern DPBB domain, we reconstructed its plausible evolutionary pathway started by "interlacing homodimerization" of a half-size peptide, followed by gene duplication and fusion. Read More

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September 2021

Analysis of changes in the volume of edema around brain contusions and the influencing factors: A single-center, retrospective, observational study.

Medicine (Baltimore) 2021 Sep;100(38):e27246

Department of Neurosurgery of the 900th Hospital, Fuzong Clinical Medical School of Fujian Medical University, Fuzhou, Fujian Province, China.

Abstract: Traumatic brain injury (TBI), a common neurosurgical condition, has well-known treatment guidelines. However, the mechanisms underlying the varying severity of brain edema secondary to TBI are largely unknown, leading to controversial treatments.This study seeks to measure edema volumes around brain contusions in different regions, analyze factors related to differences in edema volume and provide a theoretical basis for brain edema treatment. Read More

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September 2021

Diffusion tensor tractography characteristics of axonal injury in concussion/mild traumatic brain injury.

Neural Regen Res 2022 May;17(5):978-982

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

The main advantage of diffusion tensor tractography is that it allows the entire neural tract to be evaluated. In addition, configurational analysis of reconstructed neural tracts can indicate abnormalities such as tearing, narrowing, or discontinuations, which have been used to identify axonal injury of neural tracts in concussion patients. This review focuses on the characteristic features of axonal injury in concussion or mild traumatic brain injury (mTBI) patients through the use of diffusion tensor tractography. Read More

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Pediatric traumatic brain injury prehospital guidelines: a systematic review and appraisal.

Childs Nerv Syst 2021 Sep 23. Epub 2021 Sep 23.

Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Traumatic brain injury (TBI) disproportionately affects children within low- and middle-income countries (LMICs). Prehospital emergency care can mitigate secondary brain injury and improve outcomes. Here, we systematically review clinical practice guidelines (CPGs) for pediatric TBI with the goal to inform LMICs prehospital care. Read More

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September 2021

Compounding Effects of Traumatic Brain Injury, Military Status, and Other Factors on Pittsburgh Sleep Quality Index: A Meta-analysis.

Mil Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Veterans Affairs, War Related Illness and Injury Study Center (WRIISC), Washington, DC 20422, USA.

Introduction: Traumatic brain injury (TBI) or concussion is a known risk factor for multiple adverse health outcomes, including disturbed sleep. Although prior studies show adverse effects of TBI on sleep quality, its compounding effect with other factors on sleep is unknown. This meta-analysis aimed to quantify the effects of TBI on subjective sleep quality in the context of military status and other demographic factors. Read More

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September 2021

Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury.

Front Neurol 2021 7;12:729184. Epub 2021 Sep 7.

Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Winnipeg, MB, Canada.

Despite changes in guideline-based management of moderate/severe traumatic brain injury (TBI) over the preceding decades, little impact on mortality and morbidity have been seen. This argues against the "one-treatment fits all" approach to such management strategies. With this, some preliminary advances in the area of personalized medicine in TBI care have displayed promising results. Read More

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September 2021

Antimicrobial immunity impedes CNS vascular repair following brain injury.

Nat Immunol 2021 Sep 23. Epub 2021 Sep 23.

Viral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Traumatic brain injury (TBI) and cerebrovascular injury are leading causes of disability and mortality worldwide. Systemic infections often accompany these disorders and can worsen outcomes. Recovery after brain injury depends on innate immunity, but the effect of infections on this process is not well understood. Read More

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September 2021