25,405 results match your criteria target antibacterials

Enzyme-based treatment of skin and soft tissue infections.

Epidemiol Mikrobiol Imunol 2021 ;70(1):52-61

Inflammatory diseases of the skin and soft tissues are an important group of human infections. The most common causes are the bacteria Staphylococcus aureus and Streptococcus pyogenes. Given the growing resistance of these pathogens to antimicrobials, the current research focuses on the search for novel therapeutic options that would be effective against infections refractory to conventional antimicrobials. Read More

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An antipathogenic compound that targets the OxyR peroxide sensor in .

J Med Microbiol 2021 Apr;70(4)

Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Gyeonggi-do 13488, Republic of Korea.

Antipathogenic or antivirulence strategy is to target a virulence pathway that is dispensable for growth, in the hope to mitigate the selection for drug resistance. Peroxide stress responses are one of the conserved virulence pathways in bacterial pathogens and thus good targets for antipathogenic strategy. This study aims to identify a new chemical compound that targets OxyR, the peroxide sensor required for the full virulence of the opportunistic human pathogen, . Read More

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Development of Inhalable Nanostructured Lipid Carriers for Ciprofloxacin for Noncystic Fibrosis Bronchiectasis Treatment.

Int J Nanomedicine 2021 25;16:2405-2417. Epub 2021 Mar 25.

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Purpose: Ciprofloxacin (CIP) has poor lung targeting after oral inhalation. This study developed optimized inhalable nanostructured lipid carriers (NLCs) for CIP to enhance deposition and accumulation in deeper parts of the lungs for treatment of noncystic fibrosis bronchiectasis (NCFB).

Methods: NLC formulations based on stearic acid and oleic acid were successfully prepared by hot homogenization and in vitro-characterized. Read More

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Effective Small Molecule Antibacterials from a Novel Anti-Protein Secretion Screen.

Microorganisms 2021 Mar 13;9(3). Epub 2021 Mar 13.

Laboratory of Molecular Bacteriology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.

The increasing problem of bacterial resistance to antibiotics underscores the urgent need for new antibacterials. Protein export pathways are attractive potential targets. The Sec pathway is essential for bacterial viability and includes components that are absent from eukaryotes. Read More

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Molecular characterization of mutations associated with resistance to second line drugs in Mycobacterium tuberculosis patients from Casablanca, Morocco.

Rev Inst Med Trop Sao Paulo 2021 24;63:e19. Epub 2021 Mar 24.

Centre National de l'Energie, des Sciences et Techniques Nucléaires, Département des Sciences du Vivant, Unité de Recherches Médicales et Biologiques, Rabat, Morocco.

The emergence and spread of extensively drug-resistant tuberculosis (XDR-TB) is a serious threat to global health. Therefore, its rapid diagnosis is crucial. The present study aimed to characterize mutations conferring resistance to second line drugs (SLDs) within multidrug Mycobacterium tuberculosis (MDR-MTB) isolates and to estimate the occurrence of XDR-TB in Casablanca, Morocco. Read More

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Optimal empiric treatment for KPC-2-producing Klebsiella pneumoniae infections in critically ill patients with normal or decreased renal function using Monte Carlo simulation.

BMC Infect Dis 2021 Mar 26;21(1):307. Epub 2021 Mar 26.

State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.

Background: Limited clinical studies describe the pharmacodynamics of fosfomycin (FOS), tigecycline (TGC) and colistin methanesulfonate (CMS) in combination against KPC-producing Klebsiella pneumoniae (KPC-Kp). Population pharmacokinetic models were used in our study. Monte Carlo simulation was conducted to calculate probability of target attainment (PTA) and cumulative fraction of response (CFR) of each agent alone and in combination against KPC-Kp in patients with normal or decreased renal function. Read More

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WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity.

Science 2021 03;371(6536)

Mount Sinai Hospital, Toronto, Ontario, Canada.

Cytoskeletal regulatory protein dysfunction has been etiologically linked to inherited diseases associated with immunodeficiency and autoimmunity, but the mechanisms involved are incompletely understood. Here, we show that conditional ablation in T cells causes severe autoimmunity associated with increased mammalian target of rapamycin (mTOR) activation and metabolic reprogramming that engender spontaneous activation and accelerated differentiation of peripheral T cells. These mice also manifest diminished antigen-specific T cell responses associated with increased inhibitory receptor expression, dysregulated mitochondrial function, and reduced cell survival upon activation. Read More

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Translation error clusters induced by aminoglycoside antibiotics.

Nat Commun 2021 03 23;12(1):1830. Epub 2021 Mar 23.

Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany.

Aminoglycoside antibiotics target the ribosome and induce mistranslation, yet which translation errors induce bacterial cell death is unclear. The analysis of cellular proteins by quantitative mass spectrometry shows that bactericidal aminoglycosides induce not only single translation errors, but also clusters of errors in full-length proteins in vivo with as many as four amino acid substitutions in a row. The downstream errors in a cluster are up to 10,000-fold more frequent than the first error and independent of the intracellular aminoglycoside concentration. Read More

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COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies.

CNS Drugs 2021 03 20;35(3):317-330. Epub 2021 Mar 20.

Biogen, Cambridge, MA, USA.

Background: Disease-modifying therapies (DMTs) for multiple sclerosis (MS) target immunity and have the potential to increase the risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and alter its clinical course. We assessed these risks in patients with MS (PwMS).

Objective: The objective of this study was to describe the overall risk of coronavirus disease 2019 (COVID-19) infection, severe disease course, and potential population-level predictors of COVID-19 infection in PwMS, and to provide a context using a cohort of patients with systemic lupus erythematosus (SLE). Read More

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[Removal of Antibiotics and Antibiotic Resistance Genes from Urban Rivers Using Artificial Ecosystems].

Huan Jing Ke Xue 2021 Feb;42(2):850-859

School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, China.

Four antibiotics[azithromycin (AZM), sulfamethoxazole (SMZ), ciprofloxacin (CIP), and tetracycline (TCY)], and the antibiotic resistance genes (ARGs)[sulfonamides ( and ), tetracyclines ( and ), quinolones ( and ), macrolides (), and 16S rDNA] were selected as target compounds. Artificial ecosystems were constructed with combinations of two emergent plants and (+, algae+, algae+, and algae++) in an indoor-simulated river system. Throughout the artificial ecosystems, changes in antibiotic concentrations and other pollution indicators (i. Read More

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February 2021

[Occurrence of Antibiotics and Antibiotic Resistance Genes in Representative Drinking Water Resources in Jiangsu Province].

Huan Jing Ke Xue 2021 Feb;42(2):749-760

Key Laboratory for Integrated Regulation and Resources Development on Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China.

Emerging contaminants including antibiotics and antibiotic resistance genes (ARGs) have been frequently detected in drinking water resources. In this study, the occurrence of antibiotics and ARGs in various environmental matrices in representative drinking water sources in Jiangsu Province and their influencing factors were explored. Five representative drinking water sources in northern, central, and southern Jiangsu were selected. Read More

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February 2021

[Spatiotemporal Distributions and Ecological Risk Assessments of Typical Antibiotics in Surface Water of Taihu Lake].

Huan Jing Ke Xue 2021 Apr;42(4):1811-1819

State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.

Using solid phase extraction-high performance liquid chromatography tandem mass spectrometry, antibiotics belonging to four classes (i.e. sulfonamides, quinolones, tetracycline, and macrolides) in the surface water of Taihu Lake were monitored monthly for a year. Read More

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Correlation between the sulfamethoxazole-trimethoprim resistance of Shigella flexneri and the sul genes.

Medicine (Baltimore) 2021 Mar;100(10):e24970

Department of Clinical Laboratory, The Fourth People's Hospital of Jinan.

Abstract: The aim of this study was to discuss the correlation between the sulfamethoxazole-trimethoprim resistance of Shigella flexneri (S. flexneri) and the antibiotic resistance genes sul1, sul2, and sul3 and SXT element.From May 2013 to October 2018, 102 isolates of S. Read More

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Low-dose amikacin in the treatment of Multidrug-resistant Tuberculosis (MDR-TB).

BMC Infect Dis 2021 Mar 10;21(1):254. Epub 2021 Mar 10.

Department of Respirology, Toronto Western Hospital, West Park Healthcare Centre, and University of Toronto, Toronto, Canada.

Background: The World Health Organization recommends intravenous amikacin for the treatment of MDR-TB at a dose of 15 mg/kg. However, higher doses are associated with significant toxicity.

Methods: Patients with MDR-TB treated at our institution receive amikacin at 8-10 mg/kg, with dose adjustment based on therapeutic drug monitoring. Read More

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Target Product Profile and Development Path for Shigellosis Treatment with Antibacterials.

ACS Infect Dis 2021 Mar 10. Epub 2021 Mar 10.

Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases, University of Washington School of Medicine, Seattle, Washington 98109, United States.

Enteric infection with spp. can lead to symptoms ranging from acute watery diarrhea to sudden, severe dysentery. Approximately 212 000 diarrheal deaths annually are attributed to with a disproportionate impact in low-resource countries. Read More

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Chlortetracycline, a Novel Arf Inhibitor That Decreases the Arf6-Dependent Invasive Properties of Breast Cancer Cells.

Molecules 2021 Feb 12;26(4). Epub 2021 Feb 12.

Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), UMR 7275 CNRS-Université Côte d'Azur, 660, Route des Lucioles, 06560 Valbonne, France.

Breast cancer is a major disease for women worldwide, where mortality is associated with tumour cell dissemination to distant organs. While the number of efficient anticancer therapies increased in the past 20 years, treatments targeting the invasive properties of metastatic tumour cells are still awaited. Various studies analysing invasive breast cancer cell lines have demonstrated that Arf6 is an important player of the migratory and invasive processes. Read More

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February 2021

Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock.

Int J Mol Sci 2021 Feb 23;22(4). Epub 2021 Feb 23.

Division of Infectious Diseases, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI 02905, USA.

Endotoxin removal therapy with polymyxin B immobilized fiber column (PMX) has been clinically applied for sepsis and septic shock patients since 1994. The effectiveness and usefulness of this therapy have been demonstrated for more than a quarter of a century. However, a documented survival benefit has not yet been demonstrable in a large, multicenter, randomized and controlled trial. Read More

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February 2021

Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components.

Biomolecules 2021 Feb 19;11(2). Epub 2021 Feb 19.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23219, USA.

The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for millions of infections yearly. Since many T3SS knockout strains are incapable of causing systemic infection, the T3SS has emerged as an attractive anti-virulence target for therapeutic design. Read More

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February 2021

Dysfunctional Inflammation in Cystic Fibrosis Airways: From Mechanisms to Novel Therapeutic Approaches.

Int J Mol Sci 2021 Feb 16;22(4). Epub 2021 Feb 16.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.

Cystic fibrosis (CF) is an inherited disorder caused by mutations in the gene encoding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an ATP-gated chloride channel expressed on the apical surface of airway epithelial cells. CFTR absence/dysfunction results in defective ion transport and subsequent airway surface liquid dehydration that severely compromise the airway microenvironment. Noxious agents and pathogens are entrapped inside the abnormally thick mucus layer and establish a highly inflammatory environment, ultimately leading to lung damage. Read More

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February 2021

Aromadendrin Protects Neuronal Cells from Methamphetamine-Induced Neurotoxicity by Regulating Endoplasmic Reticulum Stress and PI3K/Akt/mTOR Signaling Pathway.

Int J Mol Sci 2021 Feb 25;22(5). Epub 2021 Feb 25.

College of Pharmacy, Keimyung University, Daegu 42601, Korea.

Methamphetamine (METH) is a highly addictive drug that induces irreversible damage to neuronal cells and pathological malfunction in the brain. Aromadendrin, isolated from the flowers of , has been shown to have anti-inflammatory or anti-tumor activity. Nevertheless, it has been reported that METH exacerbates neurotoxicity by inducing endoplasmic reticulum (ER) stress via the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway in neuronal cells. Read More

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February 2021

Ultrasound-Assisted Synthesis of 4-Alkoxy-2-methylquinolines: An Efficient Method toward Antitubercular Drug Candidates.

Molecules 2021 Feb 24;26(5). Epub 2021 Feb 24.

Centro de Pesquisas em Biologia Molecular e Funcional, Instituto Nacional de Ciência e Tecnologia em Tuberculose, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900 Porto Alegre, Rio Grande do Sul, Brazil.

Tuberculosis (TB) has been described as a global health crisis since the second half of the 1990s. (Mtb), the etiologic agent of TB in humans, is a very successful pathogen, being the main cause of death in the population among infectious agents. In 2019, it was estimated that around 10 million individuals were contaminated by this bacillus and about 1. Read More

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February 2021

[The new target of Rapamycin: lysosomal calcium channel TRPML1].

Sheng Li Xue Bao 2021 Feb;73(1):137-142

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Rapamycin (Rap) is an immunosuppressant, which is mainly used in the anti-rejection of organ transplantation. Meanwhile, it also shows great potential in the fields of anticancer, neuroprotection and anti-aging. Rap can inhibit the activity of mammalian target of Rap (mTOR). Read More

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February 2021

Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19.

Front Immunol 2021 12;12:574425. Epub 2021 Feb 12.

Department of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington, KY, United States.

The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to identify effective therapeutics. Stages of the disease course have been defined by viral burden, lung pathology, and progression through phases of the immune response. Immunological factors including inflammatory cell infiltration and cytokine storm have been associated with severe disease and death. Read More

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High-throughput planar solid-phase extraction coupled to orbitrap high-resolution mass spectrometry via the autoTLC-MS interface for screening of 66 multi-class antibiotic residues in food of animal origin.

Food Chem 2021 Jul 1;351:129211. Epub 2021 Feb 1.

Chair of Food Science, Institute of Nutritional Science, and Interdisciplinary Research Center, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany. Electronic address:

Antibiotic residues in food pose a major threat to the health of humans and animals worldwide. Their trace-level analysis is still too time- and cost-intensive to be adequately covered in routine analysis. Thus, a new high-throughput planar solid-phase extraction method has been developed for rapid screening of 66 antibiotics. Read More

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Combinational Antibacterial Activity of Nisin and 3-Phenyllactic Acid and Their Co-production by Engineered .

Front Bioeng Biotechnol 2021 5;9:612105. Epub 2021 Feb 5.

Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.

Nisin produced by certain strains is commercially used in meat and dairy industries because of its effective antibacterial activity and food safety characteristics. It has been proved that the antibacterial activity could be enhanced when combined with other antimicrobial agents. In this study, we demonstrated that nisin and 3-phenyllactic acid (PLA) in combination displayed excellent combinational antibacterial activity against foodborne pathogens including and . Read More

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February 2021

Drug susceptibility patterns of Mycobacterium tuberculosis from adults with multidrug-resistant tuberculosis and implications for a household contact preventive therapy trial.

BMC Infect Dis 2021 Feb 24;21(1):205. Epub 2021 Feb 24.

Department of Internal Medicine, Section of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, 68198-8106, USA.

Background: Drug susceptibility testing (DST) patterns of Mycobacterium tuberculosis (MTB) from patients with rifampicin-resistant tuberculosis (RR-TB) or multidrug-resistant TB (MDR-TB; or resistant to rifampicin and isoniazid (INH)), are important to guide preventive therapy for their household contacts (HHCs).

Methods: As part of a feasibility study done in preparation for an MDR-TB preventive therapy trial in HHCs, smear, Xpert MTB/RIF, Hain MTBDRplus, culture and DST results of index MDR-TB patients were obtained from routine TB programs. A sputum sample was collected at study entry and evaluated by the same tests. Read More

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February 2021

Reprograming of sRNA target specificity by the leader peptide peTrpL in response to antibiotic exposure.

Nucleic Acids Res 2021 03;49(5):2894-2915

Institute of Microbiology and Molecular Biology, University of Giessen, 35392 Giessen, Germany.

Trans-acting regulatory RNAs have the capacity to base pair with more mRNAs than generally detected under defined conditions, raising the possibility that sRNA target specificities vary depending on the specific metabolic or environmental conditions. In Sinorhizobium meliloti, the sRNA rnTrpL is derived from a tryptophan (Trp) transcription attenuator located upstream of the Trp biosynthesis gene trpE(G). The sRNA rnTrpL contains a small ORF, trpL, encoding the 14-aa leader peptide peTrpL. Read More

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Single and competitive sorption of sulfadiazine and chlortetracycline on loess soil from Northwest China.

Environ Pollut 2020 Aug 27;263(Pt A):114650. Epub 2020 Apr 27.

Key Laboratory of Petroleum Resources Research, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, 730000, China.

The fate of veterinary antibiotics (VAs) in soil environment is determined by the hydrophilic performance and solubility of VAs and the type of soil. In this study, sulfadiazine (SDZ) and chlortetracycline (CTC) were selected as target pollutants, and a batch sorption method was used to find out the single and sorption competitive behavior and mechanism of the target pollutants on loess soil. Kinetic studies showed the apparent sorption equilibrium was reached 0-6 h for CTC and 0-12 h for SDZ. Read More

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Solar photon-Fenton process eliminates free plasmid DNA harboring antimicrobial resistance genes from wastewater.

J Environ Manage 2021 May 19;285:112204. Epub 2021 Feb 19.

Research Group on the Environmental Application of Advanced Oxidation Processes (GruPOA), Universidade Federal de Minas Gerais, Engineering School - Sanitary and Environmental Engineering Department, Av. Antônio Carlos 6627, 31270-901, Pampulha, Belo Horizonte, Brazil. Electronic address:

This work aimed to assess the elimination and inactivation of resistance-conferring plasmids (RCPs) present in suspension in secondary wastewater by solar photo-Fenton as these are important vectors for the dissemination of antimicrobial resistance. Experiments were performed in synthetic secondary wastewater (SWW) and municipal wastewater treatment plant effluent (MWWTPE). Solar photo-Fenton (50 mg L of HO and 30 mg L of Fe) was carried out for 60 min at neutral pH by applying the intermittent iron addition strategy. Read More

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[The safety and efficacy of Firesorb bioresorbable scaffold in first-in-man study for coronary artery disease: the four-year outcomes].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Feb;49(2):128-135

Department of Cardiology, Fuwai Hospital, National Cardiovascular Center, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037, China.

To evaluate the 4-year clinical outcomes of patients following Firesorb bioresorbable scaffold (BRS) implantation. The study reported the 4-year follow-up results of the FUTURE I study. FUTURE I was a prospective, single-center, open-label, first-in-man study which evaluated the feasibility, preliminary safety, and efficacy of Firesorb stent in the treatment of coronary artery stenosis. Read More

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February 2021