30,479 results match your criteria tamoxifen

Altering the microbiome inhibits tumorigenesis in a mouse model of oviductal high-grade serous carcinoma.

Cancer Res 2021 Apr 16. Epub 2021 Apr 16.

Pathology, Internal Medicine, University of Michigan Medical School

Studies have shown bacteria influence the initiation and progression of cancers arising in sites that harbor rich microbial communities, such as the colon. Little is known about the potential for the microbiome to influence tumorigenesis at sites considered sterile, including the upper female genital tract. The recent identification of distinct bacterial signatures associated with ovarian carcinomas suggests microbiota in the gut, vagina, or elsewhere might contribute to ovarian cancer pathogenesis. Read More

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Cyanocobalamin and/or calcitriol mitigate renal damage-mediated by tamoxifen in rats: Implication of caspase-3/NF-κB signaling pathways.

Life Sci 2021 Apr 15;277:119512. Epub 2021 Apr 15.

Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Aim: Tamoxifen (TAMO) is a chemotherapeutic drug used for the treatment of breast cancer. Nevertheless, there is a lack of information available in regarding its nephrotoxicity. The purpose of this work was to investigate the impact of cyanocobalamin (COB) and/or calcitriol (CAL) injections on TAMO-induced nephrotoxicity. Read More

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CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.

PLoS One 2021 16;16(4):e0246264. Epub 2021 Apr 16.

Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Jeollabuk-do, Republic of Korea.

Tamoxifen (TAM) is a selective estrogen receptor modulator used for breast cancer patients. Prolonged use of tamoxifen is not recommended for some patients. In this study, we aimed to identify molecular targets sensitive to TAM using a genome-wide gene deletion library screening of fission yeast heterozygous mutants. Read More

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ANETT: PhAse II trial of NEoadjuvant TAK-228 plus Tamoxifen in patients with hormone receptor-positive breast cancer.

Breast Cancer Res Treat 2021 Apr 15. Epub 2021 Apr 15.

Houston Methodist Cancer Center, Houston, TX, USA.

Introduction: Neoadjuvant endocrine therapy is often utilized to downstage Estrogen Receptor-positive (ER+) breast cancer prior to surgery. However, this approach is sometimes met with endocrine resistance mechanisms within the tumor. This trial examines the safety and efficacy of tamoxifen in combination with an mTORC1/2 inhibitor, TAK-228, in the neoadjuvant treatment of ER+ breast cancer. Read More

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Activation of creER recombinase in the mouse calvaria induces local recombination without effects on distant skeletal segments.

Sci Rep 2021 Apr 15;11(1):8214. Epub 2021 Apr 15.

Department of Periodontics and Preventive Dentistry, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA.

Conditional creER-mediated gene inactivation or gene induction has emerged as a robust tool for studying gene functions in mouse models of tissue development, homeostasis, and regeneration. Here, we present a method to conditionally induce cre recombination in the mouse calvarial bone while avoiding systemic recombination in distal bones. To test our method, we utilized Prx1creER-egfp;td-Tomato mice and delivered 4-hydroxytamoxifen (4-OHT) to the mouse calvaria, subperiosteally. Read More

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Interferon regulatory factor 4 controls effector functions of CD8 memory T cells.

Proc Natl Acad Sci U S A 2021 Apr;118(16)

Institute of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany

The transcription factor IRF4 is required for CD8 T cell activation, proliferation, and differentiation to effector cells and thus is essential for robust CD8 T cell responses. The function of IRF4 in memory CD8 T cells yet needs to be explored. To investigate the role of IRF4 for maintaining differentiation state and survival of CD8 memory T cells, we used a mouse model with tamoxifen-inducible knockout to preclude effects due to inefficient memory cell differentiation in absence of IRF4. Read More

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Efficacy and safety of endocrine therapy for breast-cancer prevention in high-risk premenopausal or postmenopausal women: a Bayesian network meta-analysis of nine randomized controlled trials.

Menopause 2021 Apr 12. Epub 2021 Apr 12.

Department of Surgical Oncology, Affiliated Hospital of Qinghai University, Xining, China Department of Oncology, Affiliated Hospital of Jining Medical University, Zaozhuang Municipal Hospital, Zaozhuang, China Zaozhuang Vocational College Gucheng Campus, Shandong, China Department of Cardiology, Heart Center Leipzig at University Leipzig, Leipzig, Germany.

Importance: Findings in this work might provide certain guidance for current clinical work.

Objective: This study aimed to evaluate the efficacy and safety of these drugs based on the Bayesian network meta-analysis.

Evidence Review: Two researchers systematically and comprehensively searched PubMed, Embase, and the central databases of the Cochrane Library from inception to September 15, 2020. Read More

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Novel transgenic mice with Cre-dependent co-expression of GFP and human ACE2: a safe tool for study of COVID-19 pathogenesis.

Transgenic Res 2021 Apr 14. Epub 2021 Apr 14.

Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Vavilova st. 34/5, Moscow, Russian Federation, 119334.

The current coronavirus disease (COVID-19) pandemic remains one of the most serious public health problems. Increasing evidence shows that infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a very complex and multifaceted disease that requires detailed study. Nevertheless, experimental research on COVID-19 remains challenging due to the lack of appropriate animal models. Read More

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miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence.

PLoS One 2021 14;16(4):e0249424. Epub 2021 Apr 14.

Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.

Analysis of regulatory networks is a powerful framework for identification and quantification of intracellular interactions. We introduce miRGTF-net, a novel tool for construction of miRNA-gene-TF networks. We consider multiple transcriptional and post-transcriptional interaction types, including regulation of gene and miRNA expression by transcription factors, gene silencing by miRNAs, and co-expression of host genes with their intronic miRNAs. Read More

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Sex and Tamoxifen confound murine experimental studies in cardiovascular tissue engineering.

Sci Rep 2021 Apr 13;11(1):8037. Epub 2021 Apr 13.

Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, USA.

Tissue engineered vascular grafts hold promise for the creation of functional blood vessels from biodegradable scaffolds. Because the precise mechanisms regulating this process are still under investigation, inducible genetic mouse models are an important and widely used research tool. However, here we describe the importance of challenging the baseline assumption that tamoxifen is inert when used as a small molecule inducer in the context of cardiovascular tissue engineering. Read More

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Cardiac-Specific Deletion of Orai3 Leads to Severe Dilated Cardiomyopathy and Heart Failure in Mice.

J Am Heart Assoc 2021 Apr 14:e019486. Epub 2021 Apr 14.

Department of Physiology University of Tennessee Health Science Center Memphis TN.

Background Orai3 is a mammalian-specific member of the Orai family (Orai1‒3) and a component of the store-operated Ca entry channels. There is little understanding of the role of Orai channels in cardiomyocytes, and its role in cardiac function remains unexplored. Thus, we developed mice lacking Orai1 and Orai3 to address their role in cardiac homeostasis. Read More

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Precocious pseudo-puberty in a 2-year-old girl, presenting with bilateral ovarian enlargement and progressing to unilateral juvenile granulosa cell tumour.

J Clin Res Pediatr Endocrinol 2021 Apr 14. Epub 2021 Apr 14.

Glasgow University School of Medicine, Glasgow, United Kingdom.

Ovarian causes of precocious pseudo-puberty (PPP) include McCune-Albright syndrome (MAS) and juvenile granulosa cell tumour (JGCT). We describe a case of PPP in which bilateral ovarian enlargement with multiple cysts progressed to unilateral JGCT. A girl aged 2. Read More

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Effects of tamoxifen therapy on sciatic nerve crush injury: An experimental study in rats.

Acta Orthop Traumatol Turc 2021 Mar;55(2):87-93

Department of Pathology, Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey.

Objective: This study aimed to determine the effects of tamoxifen on sciatic nerve crush injury in a rat model using histopathological, histomorphometric, and immunohistochemical approaches.

Methods: In this study, 24 male Sprague-Dawley rats aged of 5 to 7 weeks and weighing between 300 g and 400 g were used. The rats were randomly divided into 3 groups: control (group C), sciatic nerve injury (group SNI), and sciatic nerve injury with tamoxifen (group SNT). Read More

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Traditional Korean medicine treatment for tamoxifen associated adverse events of breast cancer patient: A CARE - Compliant case report.

Complement Ther Clin Pract 2021 Apr 2;43:101378. Epub 2021 Apr 2.

Chung-Yeon Central Institute, 64, Sangmujungang-ro, Seo-gu, Gwangju, 61949, Republic of Korea. Electronic address:

Background: Adverse events of endocrine therapy reduce the breast cancer patient's quality of life and adversely affect treatment compliance.

Method: A 50-year-old breast cancer patient complained of several symptoms such as hot flush, hyperhidrosis, urinary frequency, and depression. These symptoms occurred after taking tamoxifen. Read More

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The prognostic value of cyclin D1 in breast cancer patients treated with hormonal therapy: A pilot study.

Pathol Res Pract 2021 Apr 5;222:153430. Epub 2021 Apr 5.

Department of Experimental Oncology, Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia. Electronic address:

The Aim: of the study was to determine the clinical relevance of cyclin D1 (cD1) and its association with clinicopathological parameters in breast cancer patients treated with hormonal therapy.

Material And Methods: The study included 96 primary breast cancer patients with known clinicopathological parameters. In adjuvant setting, 44 patients were tamoxifen-treated and 52 were treated with ovarian irradiation/ablation. Read More

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Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells.

Proc Natl Acad Sci U S A 2021 Mar;118(11)

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104;

Thrombomodulin (TM) is a thrombin receptor on endothelial cells that is involved in promoting activation of the anticoagulant protein C pathway during blood coagulation. TM also exerts protective anti-inflammatory properties through a poorly understood mechanism. In this study, we investigated the importance of TM signaling to cellular functions by deleting it from endothelial cells by CRISPR-Cas9 technology and analyzed the resultant phenotype of TM-deficient ( ) cells. Read More

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Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.

Neuron 2021 Mar 31. Epub 2021 Mar 31.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease, Research Center, Washington University, St. Louis, MO 63110, USA. Electronic address:

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease and directly influences tauopathy and tau-mediated neurodegeneration. ApoE4 has strong deleterious effects on both parameters. In the brain, apoE is produced and secreted primarily by astrocytes and by activated microglia. Read More

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Evaluation of the Effects of Tamoxifen on Adipose-Derived Stem Cells: A Pilot Study.

Front Cell Dev Biol 2021 22;9:555248. Epub 2021 Mar 22.

Laboratory of Cellular and Molecular Endocrinology, Humanitas Clinical and Research Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, Italy.

Autologous fat grafting (AFG) is a safe and minimally invasive procedure to correct soft tissue defects. The benefit of AFG is attributed to adipose-derived stem cells (ASCs) in fat tissue graft. This technique is useful also in patients undergoing reconstructive surgery following quadrantectomy for breast cancer. Read More

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Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism.

BMC Cancer 2021 Apr 6;21(1):356. Epub 2021 Apr 6.

Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.

Background: Evidence bearing on the role of statins in the prevention and treatment of cancer is confounded by the diversity of statins, chemotherapeutic agents and cancer types included in the numerous published studies; consequently, the adjunctive value of statins with chemotherapy remains uncertain.

Methods: We assayed lovastatin in combination with each of ten commonly prescribed chemotherapy drugs in highly reproducible in vitro assays, using a neutral cellular substrate, Saccharomyces cerevisiae. Cell density (OD) data were analyzed for synergism and antagonism using the Loewe additivity model implemented with the Combenefit software. Read More

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Photolytic fate of (E)- and (Z)-endoxifen in water and treated wastewater exposed to sunlight.

Environ Res 2021 Apr 3;197:111121. Epub 2021 Apr 3.

Department of Civil and Environmental Engineering and Construction, University of Nevada, Las Vegas, Las Vegas, NV, 89154, USA. Electronic address:

Endoxifen is the main active metabolite of a common cytostatic drug, tamoxifen. Endoxifen has been recently detected in the final effluent of municipal wastewater treatment plants. The antiestrogenic activity of endoxifen could bring negative effects to aquatic life if released to the water environment. Read More

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Water extract of Er-xian decoction selectively exerts estrogenic activities and interacts with SERMs in estrogen-sensitive tissues.

J Ethnopharmacol 2021 Apr 3;275:114096. Epub 2021 Apr 3.

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, PR China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, 518057, PR China. Electronic address:

Ethnopharmacological Relevance: The increasing use of "kidney"-nourishing Traditional Chinese Medicine (TCM) like Er-xian decoction (EXD) for management of menopausal symptoms and osteoporosis has aroused concerns about their safety, and whether they interact with prescription drugs as both of them act via estrogen receptors (ERs) and regulate serum estradiol.

Aim Of The Study: The present study aimed to evaluate whether EXD selectively exerted estrogenic activities and interacted with Selective Estrogen Receptor Modulators (SERMs).

Materials And Methods: In vivo, mature ovariectomized (OVX) rats were administrated with EXD or combined treatment of EXD and SERMs for 12 weeks. Read More

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Spontaneous seizures and elevated seizure susceptibility in response to somatic mutation of sodium channel Scn8a in the mouse.

Hum Mol Genet 2021 Apr 3. Epub 2021 Apr 3.

Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 USA.

De novo mutations of neuronal sodium channels are responsible for approximately 5% of developmental and epileptic encephalopathies, but the role of somatic mutation of these genes in adult-onset epilepsy is not known. We evaluated the role of post-zygotic somatic mutation by adult activation of a conditional allele of the pathogenic variant Scn8aR1872W in the mouse. After activation of CAG-CRE-ER by tamoxifen, the mutant transcript was expressed throughout the brain at a level proportional to tamoxifen dose. Read More

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Molecular Mechanism of Secondary Endocrine Resistance in Luminal Breast Cancer.

Biomed Res Int 2021 16;2021:6618519. Epub 2021 Mar 16.

Li Huili Hospital, Ningbo Medical Center, Ningbo 315040, China.

Objective: The molecular mechanism of secondary resistance in Luminal breast cancer was studied to provide new ideas for the treatment of breast cancer.

Methods: The sensitivity of the downregulation of myeloid leukemia factor 1-interacting proteins (MLF1IP) to Tamoxifen (TAM) was tested by the Cell Counting Kit-8 (CCK-8). The apoptosis of MLF1IP-mediated resistance was analyzed by flow cytometry (FCM) with/without TAM. Read More

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SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development.

Front Immunol 2021 18;12:642173. Epub 2021 Mar 18.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

The suppressor of cytokine signaling 3 (SOCS3) is a major regulator of immune responses and inflammation as it negatively regulates cytokine signaling. Here, the role of SOCS3 in thymic T cell formation was studied in mice (Δ with a tamoxifen inducible and ubiquitous deficiency. Δ thymi showed a 90% loss of cellularity and altered cortico-medullary organization. Read More

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Preventing Breast Cancer Through Identification and Pharmacologic Management of High-Risk Patients.

Mayo Clin Proc 2021 04;96(4):1033-1040

Department of Internal Medicine, Jacoby Center for Breast Health, Mayo Clinic, Jacksonville, FL.

Breast cancer remains the most common cancer in women in the United States. For certain women at high risk for breast cancer, endocrine therapy (ET) can greatly decrease the risk. Tools such as the Breast Cancer Risk Assessment Tool (or Gail Model) and the International Breast Cancer Intervention Study risk calculator are available to help identify women at increased risk for breast cancer. Read More

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Anticancer drugs in the aquatic ecosystem: Environmental occurrence, ecotoxicological effect and risk assessment.

Environ Int 2021 Apr 2;153:106543. Epub 2021 Apr 2.

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China. Electronic address:

Anticancer drugs are a group of therapeutic agents used to enhance cell death in targeted cell types of neoplasia. Because of frequent use and eventual discharge, they have been often detected in wastewater from pharmaceutical factories and hospitals, domestic wastewater, and surface waters. The occurrence of these drugs in aquatic ecosystems and their effects on aquatic organisms have been poorly characterized. Read More

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Replacing the -phenyl Ring in Tamoxifen with a -Connected NCN Pincer-Pt-Cl Grouping by Post-Modification †.

Molecules 2021 Mar 26;26(7). Epub 2021 Mar 26.

Organic Chemistry and Catalysis, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.

Post-modification of a series of NCN-pincer platinum(II) complexes [PtX(NCN-R-4)] (NCN = [CH(CHNMe)-2,6], R = C(O)H, C(O)Me and C(O)Et), X = Cl or Br) at the -position using the McMurry reaction was studied. The synthetic route towards two new [PtCl(NCN-R-4)] (R = C(O)Me and C(O)Et) complexes used above is likewise described. The utility and limitations of the McMurry reaction involving these pincer complexes was systematically evaluated. Read More

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Repurposing of the Tamoxifen Metabolites to Combat Infections by Multidrug-Resistant Gram-Negative Bacilli.

Antibiotics (Basel) 2021 Mar 22;10(3). Epub 2021 Mar 22.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, University Hospital Virgen del Rocío, 41013 Seville, Spain.

The development of new strategic antimicrobial therapeutic approaches, such as drug repurposing, has become an urgent need. Previously, we reported that tamoxifen presents therapeutic efficacy against multidrug-resistant (MDR) , , and in experimental infection models by modulating innate immune system cell traffic. The main objective of this study was to analyze the activity of N-desmethyltamoxifen, 4-hydroxytamoxifen, and endoxifen, three major metabolites of tamoxifen, against these pathogens. Read More

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Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments.

Cells 2021 Mar 16;10(3). Epub 2021 Mar 16.

Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia.

Molecular alterations in cancer genes and associated signaling pathways are used to inform new treatments for precision medicine in cancer. Small molecule inhibitors and monoclonal antibodies directed at relevant cancer-related proteins have been instrumental in delivering successful treatments of some blood malignancies (e.g. Read More

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