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Hot-melt extruded copper sulfate affects the growth performance, meat quality, and copper bioavailability of broiler chickens.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

College of Animal Life Sciences, Kangwon National University, Chuncheon 24341, Korea.

Objective: This study was conducted to evaluate the effects of the supplementation of diets of broiler chickens with hot-melt extruded CuSO4 (HME-Cu) on their growth performance, nutrient digestibility, gut microbiota, small intestinal morphology, meat quality, and copper (Cu) bioavailability.

Methods: A total of 225 broilers (Ross 308), one-day old and initial weight 39.14 g, were weighed and distributed between 15 cages (15 birds per cage) in a completely randomized experimental design with 3 treatments (diets) and 5 replicates per treatment. Read More

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Assessment of technological characteristics and microbiological quality of marinated turkey meat with the use of dairy products and lemon juice.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

Department of Fruit Science, Viticulture and Enology, Faculty of Horticulture and Landscape Engineering, Slovak University of Agriculture, 949 76 Nitra, Slovakia.

Objective: The aim of this study was to evaluate the effect of marinating turkey meat with buttermilk and acid whey on the technological traits and microbiological quality of the product.

Methods: Slices of turkey meat muscles were marinated for 12 hours in buttermilk (n=30), acid whey (n=30) and comparatively, in lemon juice (n=30). The control group (n=30) consisted of unmarinated slices of turkey breast muscles. Read More

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Comparison of transcriptome between high- and low-marbling fineness in longissimus thoracis muscle of Korean cattle.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea.

Objective: This study compared differentially expressed genes (DEGs) between groups with high and low numbers of fine marbling particles (NFMP) in the longissimus thoracis muscle (LT) of Korean cattle to understand the molecular events associated with fine marbling particle formation.

Methods: The size and distribution of marbling particles in the LT were assessed with a computer image analysis method. Based on the NFMP, 10 LT samples were selected and assigned to either high- (n = 5) or low- (n = 5) NFMP groups. Read More

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Moderate dietary boron supplementation improved growth performance, crude protein digestibility and diarrhea index in weaner pigs regardless to the sanitary condition.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

Department of Animal Science and Biotechnology, Chungnam National University, Daejeon 34134, Korea.

Objective: The study was conducted to investigate the impact of boron supplementation on nutrient digestibility, inflammatory responses, blood metabolites and diarrhea index, and their relevance to growth performance in weaned pigs housed in good and poor sanitary environments for 14 days after weaning.

Methods: A total of 108 male pigs [Duroc × (Yorkshire × Landrace)] weaned at 21 days of age were used in a randomized complete block design with 2 × 3 factorial arrangement. Pigs were assigned to three boron treatments (0, 5, and 10 mg/kg) under two environments (good and poor sanitary) to give six replicates per treatment (3 pigs per replicate). Read More

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Additivity of digestible energy and nutrient concentrations in hatchery byproducts fed to nursery pigs.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

Department of Animal Science and Technology, Konkuk University, Seoul 05029, Korea.

Objective: The objective was to test additivity of digestible energy and nutrient concentrations in the hatchery byproduct mixture fed to nursery pigs.

Methods: In the previous studies, energy, phosphorus, calcium, and amino acid digestibility of infertile eggs, unhatched eggs, culled chicks, and a mixture of 3 hatchery byproduct ingredients was determined in nursery pigs (initial body weight = 9.4 to 14. Read More

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Blood biochemical parameters and organs development of brown layers fed reduced dietary protein levels in two rearing systems.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

Department of Animal Science, Federal University of Goiás, GO, 74690-900, Brazil.

Objective: An experiment was conducted to evaluate the effect of different levels of crude protein (CP) and two rearing systems (cage and floor), on blood parameters and digestive and reproductive organ development of brown laying hens.

Methods: A total of 400 Hisex Brown laying hens between 30 and 45 weeks of age were distributed in a completely randomized design and a 2×4 factorial arrangement, with main effects including two rearing systems (cage and floor) and levels of CP (140, 150, 160, and 180 g/kg), in a total of eight treatments and five replicates of 10 birds each with initial body weight of 1,877 g (laying hen in cage) and 1,866 g (laying hens in floor). The parameters evaluated were plasma total protein, albumin, uric acid, total cholesterol, relative weights of oviduct, abdominal fat, liver, gizzard, crest and dewlap, length of small intestine and oviduct. Read More

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Effect of social order, perch and dust-bath allocation on behavior in laying hens.

Anim Biosci 2021 Jun 24. Epub 2021 Jun 24.

College of Animal Science and Technology, Northeast Agricultural University, 150030 Harbin, China.

Objective: The objective of this study was to determine the effects of different social ranking order (SRO) and the enrichments (perch and dust-bath) allocation (EA) on behavior of laying hens in furnished cages.

Methods: A total of 4 weeks in experiment period. 216 Hy-line brown layers beak-trimmed at 1 d of age were selected randomly at 14 weeks of age from a commercial farm, and randomly divided into 36 cages with 6 hens in each cage. Read More

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Effects of aerobic exercise on obese children with metabolic syndrome: a systematic review and meta-analysis.

J Pediatr Endocrinol Metab 2021 Jul 21. Epub 2021 Jul 21.

Research Center for Physical Fitness and Health Promotion of Adolescent, Guangzhou Sport University, Guangzhou, China.

Objectives: Metabolic syndrome (MetS) is systemic metabolic disease that results from insulin resistance or obesity. Numerous meta-analyses have investigated the effect of exercise on different populations, but none were aimed at the effect of aerobic exercise alone on obese children. This review systematically assessed and performed a meta-analysis on the effect of aerobic exercise on obese children with MetS. Read More

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Extracellular vesicles: Regenerative medicine prospect in hematological malignancies.

Cell Biol Int 2021 Jul 22. Epub 2021 Jul 22.

Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Extracellular vesicles (EVs) either as endocytic or plasma membrane-emerged vesicles play pivotal role in cell-to-cell communication. Due to the bioactive molecules transformation, lymphoma cell-derived vesicles can alter a recipient cell's function and contribute to signal transduction and drug resistance. These vesicles by acting not only in tumor cells but also in tumor-associated cells have important roles in tumor growth and invasion. Read More

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Continuous monitoring of colonoscopy performance in the Netherlands: first results of a nationwide registry.

Endoscopy 2021 Jul 22. Epub 2021 Jul 22.

Gastroenterology & Hepatology, Amsterdam University Medical Centres, Amsterdam, Netherlands.

Background: To optimize colonoscopy quality, several performance measures have been developed. These are usually assessed without distinction between the indications for colonoscopy. This study aims to assess the feasibility of linkage between two registries: a national colonoscopy registry and a national registry for adverse events of gastrointestinal endoscopies in the Netherlands, and to describe the results of colonoscopy quality per indication. Read More

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[Translation, Adaptation, Reliability and Validity of the German Version of the Prosthesis Mobility Questionnaire 2.0 (PMQ) on Patients with Major Lower Limb Amputation].

Rehabilitation (Stuttg) 2021 Jul 22. Epub 2021 Jul 22.

Klinik für Rehabilitationsmedizin, Medizinische Hochschule Hannover.

Purpose: The aim of this prospective validation study was to translate the Prosthesis Mobility Questionnaire 2.0 (PMQ) into German based on a guideline, following by psychometric testing for its validity and reliability using classical test theory.

Methods: The PMQ was translated into German according to ISPOR guidelines using double forward and double backward translations, finalized by pilot testing (N=10). Read More

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Genome-wide survey of the F-box/Kelch (FBK) members and molecular identification of a novel FBK gene TaAFR in wheat.

PLoS One 2021 22;16(7):e0250479. Epub 2021 Jul 22.

College of Life Sciences/Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Hebei Agricultural University, Baoding, Hebei, China.

F-box proteins play critical roles in plant responses to biotic/abiotic stresses. In the present study, a total of 68 wheat F-box/Kelch (TaFBK) genes, unevenly distributed across 21 chromosomes and encoding 74 proteins, were identified in EnsemblPlants. Protein sequences were compared with those of Arabidopsis and three cereal species by phylogenetic and domain analyses, where the wheat sequences were resolved into 6 clades. Read More

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Highly accurate protein structure prediction for the human proteome.

Nature 2021 Jul 22. Epub 2021 Jul 22.

European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.

Protein structures can provide invaluable information, both for reasoning about biological processes and for enabling interventions such as structure-based drug development or targeted mutagenesis. After decades of effort, 17% of the total residues in human protein sequences are covered by an experimentally-determined structure. Here we dramatically expand structural coverage by applying the state-of-the-art machine learning method, AlphaFold, at scale to almost the entire human proteome (98. Read More

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Relatively Low Rate of Heterotopic Ossification Following Primary Total Knee Arthroplasty: A Systematic Review and Meta-analysis.

J Am Acad Orthop Surg Glob Res Rev 2021 07 22;5(7). Epub 2021 Jul 22.

From the Stavros Niarchos Foundation Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY (Dr. Gkiatas, Mr. Xiang, Mr. Windsor, Dr. Malahias, Dr. Tarity, and Dr. Sculco), and the School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece (Mr. Karasavvidis).

Background: Heterotopic ossification (HO) is abnormal growth of ectopic bone and negatively affects the outcomes after total knee arthroplasty (TKA). This systematic review and meta-analysis were performed to characterize the prevalence and severity of HO after primary TKA.

Methods: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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Long-Term Quality of Life in Patients Following Minimally Invasive Conjunctivodacryocystorhinostomy With StopLoss Jones Tube.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Ophthalmology, Jozef Strus City Hospital, Poznan, Poland Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Hyderabad, India.

Purpose: To assess the long-term quality of life outcomes of minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes.

Methods: A retrospective interventional case series was performed on all patients diagnosed with proximal bicanalicular obstruction who underwent a minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes over a period of 5 years from October 2014 to September 2019. The procedure was performed as per standard published protocols of minimally invasive conjunctivodacryocystorhinostomy and StopLoss Jones tubes. Read More

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Retrobulbar Hyaluronidase Injection: Does It Reach the Eye?

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Jhaveri Microbiology Centre, Brien Holden Eye Research Centre Ophthalmic Plastic Surgery Service, L.V. Prasad Eye Institute, Hyderabad, India.

Purpose: To determine if retrobulbar injection of hyaluronidase reaches the vitreous cavity, and to determine its concentration in the vitreous.

Methods: Prospective case-control study. Patients undergoing evisceration with implant for noninfective blind eyes were enrolled in the study. Read More

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Gender Authorship Trends in the Ophthalmic Plastic and Reconstructive Surgery Literature.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Wills Eye Hospital, Philadelphia, Pennsylvania, U.S.A. Faculty of Medicine, McGill University, Montreal, Quebec, Canada Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, U.S.A.

Purpose: Despite increasing numbers of women oculoplastic surgeons, they remain underrepresented within the subspecialty. The purpose of this study was to analyze trends in gender authorship within the field of ophthalmic plastic and reconstructive surgery.

Methods: This retrospective observational study sampled articles published in Ophthalmic Plastic and Reconstructive Surgery (OPRS) and Orbit during the years 1985, 1995, 2005, 2015, and 2020. Read More

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Retinal Toxicity Following Presumed Inadvertent Intraocular Injection of Mitomycin C during Trabeculectomy.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Northwestern Lake Forest Hospital, Lake Forest, Illinois, United States of America Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

Purpose: To describe a case of post-operative retinal toxicity following the use of mitomycin C during a routine trabeculectomy.

Methods: Case report of a single patient who underwent complete ophthalmic examination and multimodal imaging, including color fundus photos, optical coherence tomography (OCT), fundus autofluorescence (FAF), and fluorescein angiography (FA). The study was declared exempt by the Institutional Review Board of Northwestern University. Read More

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Anatomic Distribution of Cherry Angiomas in the General Population.

Dermatology 2021 Jul 22:1-9. Epub 2021 Jul 22.

The University of Queensland Diamantina Institute, The University of Queensland, Dermatology Research Centre, Brisbane, Queensland, Australia.

Background: Cherry angiomas are common benign vascular skin lesions of unknown aetiology, found largely on the trunk. However, their exact anatomic distribution besides their truncal predisposition, and how they manifest in the general population, has not been characterised.

Methods: Three-dimensional (3D) total body imaging was obtained from 163 adult participants of a general population cohort study in Brisbane, Australia. Read More

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An Analysis of Frequency of Continuous Blood Pressure Variation and Haemodynamic Responses during Haemodialysis.

Blood Purif 2021 Jul 22:1-15. Epub 2021 Jul 22.

Centre for Kidney Research and Innovation, Academic unit for Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom.

Background: Higher beat-to-beat blood pressure (BP) variation during haemodialysis (HD) has been shown to be associated with elevated cardiac damage markers and white matter ischaemic changes in the brain suggesting relevance to end-organ perfusion. We aimed to characterize individual patterns of BP variation and associated haemodynamic responses to HD.

Methods: Fifty participants underwent continuous non-invasive haemodynamic monitoring during HD and BP variation were assessed using extrema point (EP) frequency analysis. Read More

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Validation of the Mini-Addenbrooke's Cognitive Examination in Mild Cognitive Impairment in Arabic Speakers.

Dement Geriatr Cogn Disord 2021 Jul 22:1-5. Epub 2021 Jul 22.

Geriatrics and Gerontology Department, Ain Shams University, Cairo, Egypt.

Introduction: Mild cognitive impairment (MCI) represents a target for early detection and intervention in dementia, yet there is a shortage of validated screening tools in Arabic to diagnose MCI. The mini-Addenbrooke's Cognitive Examination (m-ACE) is a brief cognitive battery that is scored out of 30 and can be administered in under 5 min providing a quick screening tool for assessment of cognition.

Objective: We aimed to validate the m-ACE in Arabic speakers in Egypt with MCI to provide cut-off scores. Read More

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Simulation study of potential time-of-flight capabilities for a multilayer DOI-PET detector with an independent readout structure.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, JAPAN.

A multilayer depth-of-interaction positron emission tomography (DOI-PET) detector with an independent readout structure has a potential advantage as a time-of-flight (TOF)-PET detector. To evaluate the potential TOF capabilities of a multilayer DOI-PET detector, which consists of thin layers of a cerium-doped lutetium-yttrium oxyorthosilicate (LYSO:Ce) scintillator coupled to a multi-pixel photon counter (MPPC) array, we examined the detector's CTR performance via Monte Carlo simulations. We used several types of scintillator structures: a monolithic plate, laser-processing array with 3. Read More

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Improvement of exhausted cerebral autoregulation in patients with idiopathic intracranial hypertension benefit of venous sinus stenting.

Physiol Meas 2021 Jul 22. Epub 2021 Jul 22.

Neurology, Beijing Tiantan Hospital, Beijing, CHINA.

Objective: Utilizing transfer function analysis to assess the cerebral autoregulation in patients with idiopathic intracranial hypertension (IIH), and to explore its improvement after venous sinus stenting.

Approach: In total, 15 consecutive IIH patients with venous sinus stenosis and 15 controls were recruited. All the patients underwent digital subtraction angiography and venous manometry. Read More

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Enhancing robustness of activated sludge with Aspergillus tubingensis as a protective backbone structure under high-salinity stress.

J Environ Manage 2021 Jul 19;297:113302. Epub 2021 Jul 19.

State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Bioprocess, Beijing, 100029, People's Republic of China; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing, 100029, People's Republic of China; Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China. Electronic address:

High salt seriously destroys the stable interactions among key functional species of activated sludge, which in turn limits the performance of high-salinity wastewater biological treatment. In this study, pelletized Aspergillus tubingensis (AT) was used as a protective backbone structure for activated sludge under high-salinity stress, and a superior salt-tolerant AT-based aerobic granular sludge (AT-AGS) was developed. Results showed that the COD and NH-N removal efficiencies of salt-domesticated AT-AGS were 11. Read More

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Identifying optimal virtual water management strategy for Kazakhstan: A factorial ecologically-extended input-output model.

J Environ Manage 2021 Jul 20;297:113303. Epub 2021 Jul 20.

School of Environmental Science and Engineering, Xiamen University of Technology, Xiamen, 361024, China. Electronic address:

Virtual water is an important indicator measuring the amount of water needed from the perspective of consumption, which can help decision makers to identify desired system design and optimal management strategy against water resources shortage. In this study, a novel model named as factorial ecologically-extended input-output model (abbreviated as FEIOM) is developed for virtual water management. FEIOM integrates techniques of input-output model (IOM), ecological network analysis (ENA) and factorial analysis (FA) into a general framework. Read More

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Prognostic value of tumour-infiltrating lymphocytes based on the evaluation of frequency in patients with oestrogen receptor-positive breast cancer.

Eur J Cancer 2021 Jul 19;154:217-226. Epub 2021 Jul 19.

Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, 350007, China. Electronic address:

Purpose: We investigate the prognostic value of tumour-infiltrating lymphocytes (TILs) based on the evaluation of the present frequency in patients with breast cancer rather than that of the density proposed in previous research.

Methods: Multiphoton microscopy (MPM) was introduced to label-freely obtain TIL images from a total of 564 patients, and then TILs were redefined as TILs-1 to TILs-3 from MPM images according to the relative positions between TILs, tumour cells and collagen fibres. More seminally, a new method, which was based on the present frequency of TILs-1 to TILs-3, was presented for assessing the predictive ability of TILs, and then a tumour-infiltrating lymphocytes score (TILs-score) for each patient was obtained by ridge regression analysis. Read More

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Systemic therapy and prognosis of older patients with stage II/III breast cancer: A large-scale analysis of the Japanese Breast Cancer Registry.

Eur J Cancer 2021 Jul 19;154:157-166. Epub 2021 Jul 19.

Department of Breast Oncology, Aichi Cancer Center, Nagoya, Japan. Electronic address:

Aim: This study aimed at investigating the real-world prognostic impact of systemic treatment in older patients with stage II/III breast cancer (BC).

Methods: This retrospective cohort study included patients with stage II/III primary BC, aged ≥55 years, and registered in the Japanese Breast Cancer Registry from 2004 to 2011. The clinicopathological characteristics, treatments, and prognosis of patients aged ≥75 years (older) were compared to those of younger patients. Read More

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Long term follow up in 183 high grade meningioma: A single institutional experience.

Clin Neurol Neurosurg 2021 Jul 10;207:106808. Epub 2021 Jul 10.

Neuro-oncology Unit, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria, 11, 20133 Milan, Italy.

Introduction: Meningiomas are usually considered benign lesions, however a proportion of them shows a more aggressive behavior, defined high-grade meningiomas (HGM). Effective medical treatments are lacking, especially at the time of recurrence.

Methods: Through a retrospective analysis, we examined epidemiological, diagnostic, therapeutic, recurrence information and survival data of HGM treated at our institution between 2010 and 2018. Read More

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Chondrosarcoma arising in monostotic fibrous dysplasia treated with total femur resection and megaprothesis: A case report.

Int J Surg Case Rep 2021 Jul 9;85:106194. Epub 2021 Jul 9.

Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Indonesia. Electronic address:

Introduction: Fibrous dysplasia is tumor like lesions of bone which develop as substitution of bone by an expansion of fibrous connective tissue mixed with hard trabeculae. Chondrosarcomas is one of common malignant primary bone tumor derived from heterogenous group of neoplasm producing chondroid matrix. Chondrosarcoma arising in fibrous dysplasia, especially in monostotic fibrous dysplasia is a very rare case. Read More

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Salivary parameters alterations after early exposure to environmental methylmercury: A preclinical study in offspring rats.

J Trace Elem Med Biol 2021 Jul 16;68:126820. Epub 2021 Jul 16.

Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Belém, PA, Brazil. Electronic address:

Background: Methylmercury (MeHg) is still considered a global pollutant of major concern; thus, it becomes relevant to investigate and validate alternative diagnostic methods to track early-life human exposure. This study aimed to evaluate the salivary parameters and to characterize potential mechanisms of oxidative damage on the salivary glands (SG) of offspring rats after pre- and postnatal environmental-experimental MeHg exposure.

Methods: Pregnant Wistar rats were daily exposed to 40 μg/kg MeHg during both gestational and lactation periods. Read More

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