DNA Repair (Amst) 2021 Jun 19;105:103162. Epub 2021 Jun 19.
Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA. Electronic address:
The proper spatial organization of DNA, RNA, and proteins is critical for a variety of cellular processes. The genome is organized into numerous functional units, such as topologically associating domains (TADs), the formation of which is regulated by both proteins and RNA. In addition, a group of chromatin-bound proteins with the ability to undergo liquid-liquid phase separation (LLPS) can affect the spatial organization and compartmentalization of chromatin, RNA, and proteins by forming condensates, conferring unique properties to specific chromosomal regions. Read More