14 results match your criteria tac peroxynitrite

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Comparison of Three Different Cord Clamping Techniques Regarding Oxidative-antioxidative Capacity in Term Newborns.

Am J Perinatol 2022 Jan 13. Epub 2022 Jan 13.

Biochemistry, Gaziantep University, Gaziantep, Turkey.

Objective As newborns are exposed to oxidative stress during delivery, cord clamping techniques play significant role on antioxidant status. In this study, we aimed to show the relationship between early cord clamping (ECC), delayed cord clamping (DCC) and cut umblical cord milking (C-UCM) techniques with total oxidant capacity (TOC), total antioxidant capacity (TAC) and peroxynitrite levels. Study Design Sixty-nine term infants were selected with APGAR score of 7 and above in the first and fifth minutes. Read More

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January 2022

Melatonin and alcohol-related disorders.

Chronobiol Int 2020 06 18;37(6):781-803. Epub 2020 May 18.

Department of Zoology and Animal Physiology, Institute of Biology and Earth Sciences, Pomeranian University in Słupsk , Słupsk, Poland.

This review concerns the current knowledge of melatonin and alcohol-related disorders. Chronobiological effects of ethanol are related to melatonin suppression and in relation to inflammation, stress, free radical scavenging, autophagy and cancer risk. It is postulated that both alcohol- and inflammation-induced production of reactive oxygen species (ROS) alters cell membrane properties leading to tissue dysfunction and, subsequent further ROS production. Read More

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Mammalian target of rapamycin inhibition attenuates myocardial ischaemia-reperfusion injury in hypertrophic heart.

J Cell Mol Med 2018 03 4;22(3):1708-1719. Epub 2018 Jan 4.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institute of Biomedical Science, Fudan University, Shanghai, China.

Pathological cardiac hypertrophy aggravated myocardial infarction and is causally related to autophagy dysfunction and increased oxidative stress. Rapamycin is an inhibitor of serine/threonine kinase mammalian target of rapamycin (mTOR) involved in the regulation of autophagy as well as oxidative/nitrative stress. Here, we demonstrated that rapamycin ameliorates myocardial ischaemia reperfusion injury by rescuing the defective cytoprotective mechanisms in hypertrophic heart. Read More

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Eclipta yellow vein virus enhances chlorophyll destruction, singlet oxygen production and alters endogenous redox status in Andrographis paniculata.

Plant Physiol Biochem 2016 Jul 23;104:165-73. Epub 2016 Mar 23.

Plant Pathology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India. Electronic address:

The infection of Eclipta yellow vein virus [EcYVV-IN, Accession No. KC476655], recently reported for the first time, on Andrographis paniculata was studied for redox-mediated alteration mechanism in infected plants. A. Read More

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Sepiapterin prevents left ventricular hypertrophy and dilatory remodeling induced by pressure overload in rats.

Am J Physiol Heart Circ Physiol 2015 Nov 25;309(10):H1782-91. Epub 2015 Sep 25.

Department of Internal Medicine II, Kansai Medical University, Moriguchi City, Japan.

Uncoupling of nitric oxide (NO) synthase (NOS) has been implicated in left ventricular (LV) hypertrophy (LVH) and dilatory remodeling induced by pressure overload. We investigated whether administration of sepiapterin, a substrate of the salvage pathway of tetrahydrobiopterin synthesis, prevents LVH and dilatory LV remodeling by inhibiting NOS uncoupling and increasing bioavailable NO. Pressure overload was induced in rats by transverse aortic constriction (TAC). Read More

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November 2015

Free radical scavenging actions of three Trifolium species in the protection of blood plasma antioxidant capacity in vitro.

Pharm Biol 2015 9;53(9):1277-84. Epub 2015 Apr 9.

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz , Lodz , Poland and.

Context: Three clover [Trifolium L. (Leguminosae)] species were selected on the basis of data from traditional medicine, phytochemical profiles, and agricultural significance.

Objective: The in vitro evaluations of free radical scavenging properties, ferric reducing abilities, and antioxidant effects of extracts from T. Read More

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Reverse myocardial effects of intermedin in pressure-overloaded hearts: role of endothelial nitric oxide synthase activity.

J Physiol 2013 Feb 19;591(3):677-87. Epub 2012 Nov 19.

Department of Physiology and Cardiothoracic Surgery, Cardiovascular R&D Unit, Faculty of Medicine, University of Porto, Portugal.

Intermedin (IMD) is a cardiac peptide synthesized in a prepro form, which undergoes a series of proteolytic cleavages and amidations to yield the active forms of 47 (IMD(1-47)) and 40 amino acids (IMD(8-47)). There are several lines of evidence of increased IMD expression in rat models of cardiac pathologies, including congestive heart failure and ischaemia; however, its myocardial effects upon cardiac disease remain unexplored. With this in mind, we investigated the direct effects of increasing concentrations of IMD(1-47) (10(-10) to10(-6) m) on contraction and relaxation of left ventricular (LV) papillary muscles from two rat models of chronic pressure overload, one induced by transverse aortic constriction (TAC), the other by nitric oxide (NO) deficiency due to chronic NO synthase inhibition (NG-nitro-l-arginine, l-NAME), and respective controls (Sham and Ctrl). Read More

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February 2013

Relationship of seminal reactive nitrogen and oxygen species and total antioxidant capacity with sperm DNA fragmentation in infertile couples with normal and abnormal sperm parameters.

Andrologia 2014 Feb 5;46(1):17-23. Epub 2012 Nov 5.

Department of Anatomy, Medical School, Tehran University of Medical Sciences, Tehran, Iran.

The objective of this study was to investigate the association between the amount of superoxide anion, peroxynitrite as oxidative stress (OS) markers and total antioxidant capacity (TAC) with sperm DNA fragmentation in infertile men with abnormal semen parameters. Semen samples were obtained from 102 infertile couples and divided into groups with normal and abnormal semen parameters according to the World Health Organization (WHO). Peroxynitrite and superoxide anions were detected using spectrofluorometric assays combined with 2,7 dicholorofluorescein (DCF)-DA and 4-chloro-7-nitrobenzo-2-oxa -1, 3-diazole (NBD-CL). Read More

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February 2014

Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice.

J Pharmacol Exp Ther 2010 Feb 4;332(2):421-8. Epub 2009 Nov 4.

Institute of Pharmacology, Toxicology, and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, China.

Using a heart ischemia/reperfusion model in rats, we recently demonstrated that 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a calmodulin inhibitor, is a cardioprotective drug. Here, we examined cardioprotective mechanisms of DY-9760e in hypertrophy and heart failure using a mouse transverse aortic constriction (TAC) model. Read More

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February 2010

Sex-specific effects of prenatal testosterone on nestling plasma antioxidant capacity in the zebra finch.

J Exp Biol 2009 Jan;212(Pt 1):89-94

Department of Animal Ecology, Lund University, Ecology Building, SE-223 62 Lund, Sweden.

Trans-generational transfer of non-genetic, maternal resources such as hormones can have a substantial influence on offspring phenotype in many vertebrate species. In birds, maternal androgens enhance both growth and competitive behaviour, but also suppress the immune system. It has been hypothesised that high levels of egg androgens could also influence the prooxidant-antioxidant balance through their positive effect on growth and metabolism. Read More

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January 2009

Comparison of total antioxidant capacity of salivary, capillary and venous samplings: interest of the salivary total antioxidant capacity on triathletes during training season.

J Sports Med Phys Fitness 2008 Dec;48(4):522-9

Laboratory of Mouvement, Sport, Santé (M2S), UFRAPS Rennes 2, France.

Aim: Total antioxidant capacity (TAC) is an essential parameter to watch over defense system of athletes exposed to an oxidant stress during intensive periods of training. To control this parameter throughout the training period, repetitive biological samples are required. The TAC is usually investigated in venous blood which needs invasive withdrawings. Read More

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December 2008

Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure.

Circ Res 2007 Apr 15;100(7):1089-98. Epub 2007 Mar 15.

Center of Vascular Biology and Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Inducible nitric oxide synthase (iNOS) protein is expressed in cardiac myocytes of patients and experimental animals with congestive heart failure (CHF). Here we show that iNOS expression plays a role in pressure overload-induced myocardial chamber dilation and hypertrophy. In wild-type mice, chronic transverse aortic constriction (TAC) resulted in myocardial iNOS expression, cardiac hypertrophy, ventricular dilation and dysfunction, and fibrosis, whereas iNOS-deficient mice displayed much less hypertrophy, dilation, fibrosis, and dysfunction. Read More

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The use of pholasin as a probe for the determination of plasma total antioxidant capacity.

Clin Biochem 2006 Jan 2;39(1):55-61. Epub 2005 Dec 2.

Department of Medicine, Royal Free and University College London School of Medicine, London, The Middlesex Hospital, Mortimer Street, W1N 8AA London, UK.

Background And Objectives: Total antioxidant capacity (TAC) reflects the capacity of plasma, or other body fluid, to resist oxidation. The aim of the present study was to assess the prognostic value of Pholasin as a probe for the determination of plasma TAC.

Design And Methods: Plasma samples either oxidised using the free radical generator 2'-azobis-(2-amidinopropane) hydrochloride (AAPH) at 60 degrees C for 180 min or obtained from diabetic (type 1 and type 2) patients (n = 61 and 124, respectively) with or without polyneuropathy (PN) and/or cardiovascular autonomic neuropathy (CAN) and control subjects (n = 70) were analysed for TAC status. Read More

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January 2006

[Tuberculous infection and biological response in man].

Kaoru Shimokata

Kekkaku 2004 Sep;79(9):541-5

Division of Respiratory Medicine, Department of Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.

The characteristics and function of human lymphocytes in tuberculous morbid site were studied. Exudative-sensitized lymphocytes in tuberculous pleural fluid reacted to the specific antigen more effectively and produced higher titers of cytokines including interferon gamma (IFN-gamma) than circulating lymphocytes. CD4+/CD8- T-cell subset is responsible for the antigen-specific IFN-gamma production in pleural T lymphocytes of patients with tuberculous pleurisy. Read More

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September 2004
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