24,055 results match your criteria t2dm


Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets.

Cell Chem Biol 2021 Jun 2. Epub 2021 Jun 2.

Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany; Institute of Metabolic Physiology, Heinrich Heine University, 40225 Düsseldorf, Germany; Center of Competence for Innovative Diabetes Therapy (KomIT), German Diabetes Center (DDZ), 40225 Düsseldorf, Germany; German Center for Diabetes Research (DZD e.V.), Helmholtz Zentrum München, 85764 Neuherberg, Germany. Electronic address:

Dextromethorphan (DXM) acts as cough suppressant via its central action. Cell-protective effects of this drug have been reported in peripheral tissues, making DXM potentially useful for treatment of several common human diseases, such as type 2 diabetes mellitus (T2DM). Pancreatic islets are among the peripheral tissues that positively respond to DXM, and anti-diabetic effects of DXM were observed in two placebo-controlled, randomized clinical trials in humans with T2DM. Read More

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Safety of Dapagliflozin in Patients with Type 2 Diabetes Mellitus in Saudi Arabia: A Post Authorization Safety Study.

Diabetes Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Introduction: Sodium-glucose co-transporter-2 (SGLT2) inhibitors moderately reduce glucose levels in type-2 diabetes mellitus (T2DM). Some cases of diabetic ketoacidosis (DKA) were reported with SGLT2 inhibitors. However, data on the long-term safety of dapagliflozin in Saudi Arabia are lacking. Read More

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Treatment Patterns, Effectiveness, and Satisfaction Among Patients with Type 2 Diabetes Treated with Insulin in Saudi Arabia: Results of the RIMODIS Study.

Diabetes Ther 2021 Jun 11. Epub 2021 Jun 11.

Sanofi Medical Department, Jeddah, Saudi Arabia.

Introduction: The alarming increase in type 2 diabetes mellitus (T2DM) in Saudi Arabia is aggravated by increasing obesity, sedentary lifestyle, and population aging. The RIMODIS study aimed at describing the practices in the therapeutic management of patients with T2DM treated with different insulin regimens.

Methods: This national, multicenter, non-interventional, cross-sectional disease registry on the real-life therapeutic management of insulin-treated patients with T2DM in Saudi Arabia enrolled 3010 patients. Read More

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The Incessant increase Curve during the Oral Glucose Tolerance Test and its association with gut hormone level in Chinese T2DM Adults: A preliminary study.

Peptides 2021 Jun 8:170595. Epub 2021 Jun 8.

Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

Purpose: To investigate glucose curve shape during an oral glucose tolerance test (OGTT) and its association with β-cell function or gut hormone.

Materials And Methods: Glucose curves during 180 min OGTTs (n = 89) were classified as incessant increase and monophasic. Data on demographics, β-cell function, and insulin sensitivity were collected. Read More

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Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function.

Handb Exp Pharmacol 2021 Jun 11. Epub 2021 Jun 11.

Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany.

Beta-cell dysfunction and beta-cell death are critical events in the development of type 2 diabetes mellitus (T2DM). Therefore, the goals of modern T2DM management have shifted from merely restoring normoglycemia to maintaining or regenerating beta-cell mass and function. In this review we summarize current and novel approaches to achieve these goals, ranging from lifestyle interventions to N-methyl-D-aspartate receptor (NMDAR) antagonism, and discuss the mechanisms underlying their effects on beta-cell physiology and glycemic control. Read More

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Prediction of Type II Diabetes Onset with Computed Tomography and Electronic Medical Records.

Multimodal Learn Clin Decis Support Clin Image Based Proc (2020) 2020 Oct 1;12445:13-23. Epub 2020 Oct 1.

Vanderbilt University, , Nashville, USA.

Type II diabetes mellitus (T2DM) is a significant public health concern with multiple known risk factors (, body mass index (BMI), body fat distribution, glucose levels). Improved prediction or prognosis would enable earlier intervention before possibly irreversible damage has occurred. Meanwhile, abdominal computed tomography (CT) is a relatively common imaging technique. Read More

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October 2020

Analogous telomeres shortening and different metabolic profile: hypertension versus hypertension/type 2 diabetes mellitus comorbidity.

Cardiovasc Endocrinol Metab 2021 Jun 3;10(2):106-112. Epub 2020 Sep 3.

Department of Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University.

Background: Eukaryotes chromosomal ends are capped and protected by telomeres, which are noncoding DNA repeats synthesized by telomerase enzyme. The telomerase enzyme is a nucleoprotein encoded by and genes. Naturally, the length of the telomeres shortens with each cell cycle but the shortening is fastened in certain age-related diseases like hypertension (HTN) and type 2 diabetes mellitus (T2DM). Read More

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Effect of pericarp extract on glial NF-κB levels and expression of serum inflammation markers in an obese-type 2 diabetes mellitus animal model.

Biomed Rep 2021 Jul 3;15(1):63. Epub 2021 Jun 3.

Department of Physics, Faculty of Science and Mathematics Diponegoro University, Semarang, Java 50275, Indonesia.

Type 2 diabetes mellitus (T2DM) is an age-related disease associated with cerebral inflammation and Alzheimer's disease. pericarp (GMP) possesses antihyperglycemic, antidiabetic and anti-inflammatory effects. The aim of the present study was to evaluate the effect of GMP extract on cerebral inflammation in Wistar rats with T2DM by examining the expression levels of glial nuclear factor-κB (NF-κB), interleukin (IL)-6, tumor necrosis factor-α (TNF-α) and superoxide dismutase (SOD). Read More

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Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder.

Front Psychiatry 2021 25;12:636174. Epub 2021 May 25.

Department of Medical Neuroscience, Dalhousie University, Halifax, NS, Canada.

Bipolar disorder (BD) often progresses to a more chronic and treatment resistant (neuroprogressive) course. Identifying which patients are at risk could allow for early intervention and prevention. Bipolar disorder is highly comorbid with metabolic disorders including type II diabetes mellitus (T2DM), hypertension, obesity, and dyslipidemia. Read More

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Impact of a personalized mHealth program for type 2 diabetes mellitus during the COVID-19 pandemic: single-group pre-post retrospective analysis.

JMIR Diabetes 2021 Jun 6. Epub 2021 Jun 6.

NOVI Health, Singapore, SG.

Background: With increasing type 2 diabetes mellitus (T2DM) prevalence, there is a need for effective programs that support diabetes management and improve T2DM outcomes. Mobile health (mHealth) interventions have shown promising results. With advances in wearable sensors and improved integration, mHealth programs could become more accessible and personalized. Read More

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Evaluation of salusin-α and salusin-β levels in patients with type 2 diabetes mellitus and determination of the impact of severity of hyperglycemia on salusin levels.

Ir J Med Sci 2021 Jun 9. Epub 2021 Jun 9.

Department of Internal Medicine, Biruni University Medical Faculty, Istanbul, Turkey.

Aims: To investigate the usefulness of salusin-α and salusin-β as biomarkers in patients with type 2 diabetes mellitus (T2DM) and to determine whether diabetes severity and obesity have an effect on the salusin levels in diabetic patients.

Methods: The study included a total of 90 patients, comprising 55 diagnosed with T2DM and 35 healthy volunteers with similar demographic characteristics. Salusins were assayed by a commercially available ELISA kit. Read More

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Revisional large gastric pouch with Roux-en-Y gastric bypass for patients with type 2 diabetes and a body mass index less than 35 kg/m: a cause and effect analysis.

Surg Today 2021 Jun 9. Epub 2021 Jun 9.

Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha, 410013, China.

Purpose: To evaluate the long-term efficacy of large gastric pouch surgery and revisional surgery in patients with a body mass index (BMI) < 35 kg/m and type 2 diabetes mellitus (T2DM).

Methods: We conducted a retrospective review of patients who underwent laparoscopic Roux-en-Y gastrojejunostomy with a large gastric pouch in our hospital. The clinical pre- and post-surgery data, including BMI, waist circumference, fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), lipid metabolism-related indicators, homoeostatic model assessment of insulin resistance (HOMA-IR), and major complications, were recorded and analyzed. Read More

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Hyperglycemia at 1h-OGTT in Pregnancy: A Reliable Predictor of Metabolic Outcomes?

Front Endocrinol (Lausanne) 2021 24;12:612829. Epub 2021 May 24.

Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy.

Gestational diabetes mellitus (GDM) is associated with a high risk of developing type 2 diabetes (T2DM) and cardiovascular disease (CVD). Identifying among GDM women those who are at high risk may help prevent T2DM and, possibly CVD. Several studies have shown that in women with GDM, hyperglycemia at 1 h during an oral glucose tolerance test (OGTT) (1-h PG) is not only associated with an increase in adverse maternal and perinatal outcomes but is also an independent predictor of T2DM. Read More

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Repurposing of Anti-Diabetic Agents as a New Opportunity to Alleviate Cognitive Impairment in Neurodegenerative and Neuropsychiatric Disorders.

Front Pharmacol 2021 24;12:667874. Epub 2021 May 24.

Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.

Cognitive impairment is a shared abnormality between type 2 diabetes mellitus (T2DM) and many neurodegenerative and neuropsychiatric disorders, such as Alzheimer's disease (AD) and schizophrenia. Emerging evidence suggests that brain insulin resistance plays a significant role in cognitive deficits, which provides the possibility of anti-diabetic agents repositioning to alleviate cognitive deficits. Both preclinical and clinical studies have evaluated the potential cognitive enhancement effects of anti-diabetic agents targeting the insulin pathway. Read More

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Evaluation of Candidate SNPs for Type 2 Diabetes Mellitus in Tohid Hospital of Sanandaj.

Clin Lab 2021 Jun;67(6)

Background: The allele frequency of 4 SNPs was evaluated in patients with type 2 diabetes mellitus (T2DM) and compared with healthy controls who had records in Tohid Hospital of Sanandaj.

Methods: This case-control study was performed on 100 T2DM patients and 100 healthy controls with matched gender and age. After DNA extraction, allele frequency of 4 variant genotypes was evaluated using Tetra-Arms technique. Read More

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Type 2 diabetes and the risk of colorectal polyps: A retrospective nationwide population-based study.

Medicine (Baltimore) 2021 May;100(19):e25933

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Abstract: The incidence rates of type 2 diabetes mellitus (T2DM) and colorectal polyps have been increasing over the last decades. However, direct associations between T2DM and colorectal polyps have not been extensively reported. We will explore the relationship between T2DM and colorectal polyps. Read More

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Cost-Utility Analysis of Dapagliflozin as an Add-On to Standard Treatment for Patients with Type 2 Diabetes and High Risk of Cardiovascular Disease in Thailand.

Diabetes Ther 2021 Jun 9. Epub 2021 Jun 9.

Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.

Introduction: Diabetes treatment has incurred financial burden. We examined the cost-utility of adding dapagliflozin to the standard treatment for treating type 2 diabetes (T2DM) with cardiovascular risk in a Thai context.

Methods: A two-part model, decision tree and Markov models, was developed to capture the benefits in terms of heart failure (HF) and chronic kidney disease. Read More

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Gender characteristics of lipid profile parameters and markers of vascular inflammation in patients with stable angina pectoris in groups with presence and absence of type 2 diabetes.

Klin Lab Diagn 2021 Jun;66(6):325-332

Tyumen Cardiology Research Center, Tomsk National Research Medical Center RAS.

The study of the parameters of the lipid profile and markers of the inflammatory reaction of the vascular wall in patients with stable angina pectoris in the presence or absence of type 2 diabetes mellitus (T2DM) is of great importance for revealing the gender characteristics of the pathophysiological mechanisms of the development and course of diseases, developing secondary prevention of complications and determining the prognosis. 194 patients with stable angina pectoris (SA), single-vessel coronary artery disease, mean age 60.3 ± 7. Read More

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Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years.

Int J Clin Pract 2021 Jun 9:e14447. Epub 2021 Jun 9.

Department of Clinical Biochemistry, University Hospitals of the North Midlands NHS Trust, Stoke-on-Trent, UK.

Introduction: Women with gestational diabetes (GDM) are at greatly increased risk of type 2 diabetes (T2DM). The UK guidance recommends screening for T2DM at around 6 weeks post-partum and annually thereafter. We evaluated conformity to this guidance in two separate time periods. Read More

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Association between dental visits at primary care and glycated hemoglobin level in patients with type 2 diabetes: a cohort study.

Rev Bras Epidemiol 2021 7;24:e210032. Epub 2021 Jun 7.

Department of Preventive and Social Dentistry, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brazil.

Objective: To evaluate the association between dental visits and variation in the glycated hemoglobin index (A1C) of patients with type 2 diabetes (T2DM) with well or not well glycemic control over time.

Methods: Patients with T2DM, A1C ≥ 7% (not well-controlled) and < 7% (well-controlled), who attended a primary care service and were followed up from January 2010 to May 2018. The outcome was the variation of A1C obtained from reference laboratories. Read More

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HAC01 ameliorates type 2 diabetes in high-fat diet and streptozotocin-induced diabetic mice in association with modulating the gut microbiota.

Food Funct 2021 Jun 9. Epub 2021 Jun 9.

AtoGen Co., Ltd, Daejeon, 34015, Korea.

Type 2 diabetes mellitus (T2DM) is a serious metabolic disorder that occurs worldwide; however, this condition can be managed with probiotics. We assessed the potential therapeutic effects of Lactobacillus plantarum HAC01 on hyperglycemia and T2DM and determined their potential mechanisms using mice with high-fat diet (HFD) and streptozotocin (STZ)-induced diabetes. The diabetic model was established with an HFD and 50 mg kg-1 STZ. Read More

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First trimester fasting glucose and glycated haemoglobin cut-offs associated with abnormal glucose homeostasis in the post-partum reclassification in women with hyperglycaemia in pregnancy.

Arch Gynecol Obstet 2021 Jun 9. Epub 2021 Jun 9.

Serviço de Endocrinologia do Centro Hospitalar do Tâmega e Sousa, Avenida do Hospital Padre Américo 210, Guilhufe, 4564-007, Penafiel, Portugal.

Hyperglycaemia first detected during pregnancy is either gestational diabetes mellitus (GDM) or previous undiagnosed diabetes. We aimed to study if there were a first trimester fasting glycaemia (FTG) and a glycated haemoglobin (HbA1c) cut-off values associated with type 2 diabetes mellitus (T2DM) or abnormal glucose homeostasis (AGH) at the post-partum oral glucose tolerance test (OGTT) reclassification. We retrospectively studied a group of pregnant women from the Portuguese National Registry of GDM. Read More

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Cost-Effectiveness of Saxagliptin Compared With Glibenclamide as a Second-Line Therapy Added to Metformin for Type 2 Diabetes Mellitus in Ethiopia.

MDM Policy Pract 2021 Jan-Jun;6(1):23814683211005771. Epub 2021 Apr 27.

Bergen Center for Ethics and Priority Setting, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Metformin is a widely accepted first-line pharmacotherapy for patients with type 2 diabetes mellitus (T2DM). Treatment of T2DM with glibenclamide, saxagliptin, or one of the other second-line treatment agents is recommended when the first-line treatment (metformin) cannot control the disease. However, there is little evidence on the additional cost and cost-effectiveness of adding second-line drugs. Read More

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Mulberroside A from Cortex Mori Enhanced Gut Integrity in Diabetes.

Evid Based Complement Alternat Med 2021 20;2021:6655555. Epub 2021 May 20.

Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macao SAR 999078, China.

Background: Diabetic endotoxemia has been recognized as one of the hallmarks of type 2 diabetes mellitus (T2DM). Recent findings suggest that gut leak plays a pivotal role in diabetic endotoxemia. Cortex Mori (CM) has been widely applied in China to ameliorate development of T2DM, but its effect on endotoxemia is unknown. Read More

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Association analysis of 374T/A (rs1800624) receptor for advanced glycation end-products (RAGE) gene polymorphism with diabetic retinopathy in Pakistani patients.

Pak J Med Sci 2021 May-Jun;37(3):733-739

Prof. Dr. Abdul Khaliq Naveed, FCPS, PhD. Department of Biochemistry, Riphah International University, Islamabad, Pakistan.

Objectives: to determine the relationship of 374T/A (rs1800624) polymorphism in the gene encoding RAGE with Type-2 diabetes mellitus (T2DM), diabetic retinopathy (DR) and serum soluble RAGE (sRAGE) level in Pakistani patients.

Methods: A case-control study, conducted from January 2017 to December 2018, involving 150 healthy controls (HC), 150 T2DM patients with no retinopathy (DNR) and 150 DR patients diagnosed by coloured fundus photography. Tetra-primer amplification refractory mutation system - polymerase chain reaction (T-ARMS-PCR) was used for genotyping. Read More

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Circulating IRAPe, Irisin, and IL-34 in Relation to Insulin Resistance in Patients With Type 2 Diabetes.

Clin Ther 2021 Jun 5. Epub 2021 Jun 5.

Department of Clinical Pharmacy and Pharmacy Practice, Damanhour University, Damanhour, Egypt. Electronic address:

Purpose: This study aimed to evaluate the role of the extracellular part of insulin-regulated aminopeptidase (IRAPe), interleukin (IL)-34, irisin, and visfatin in the development of insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).

Methods: This observational parallel-group study was conducted in 60 subjects without T2DM who served as a control group and 60 patients with newly diagnosed T2DM. The 2 groups were matched for age, sex ratio, and body mass index. Read More

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Effects of omega-3 fatty acids and metformin combination on diabetic cardiomyopathy in rats through autophagic pathway: Effects of omega-3 fatty acids and metformin combination on diabetic cardiomyopathy: Role of autophagy.

J Nutr Biochem 2021 Jun 5:108798. Epub 2021 Jun 5.

Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.

Diabetic cardiomyopathy (DCM) is a primary cause of increased morbidity and mortality in diabetics. Evidence has suggested a pivotal role for interrupted mitochondrial dynamics and quality control machinery in the onset and development of DCM. Sequestosome 1 (SQSTM1) is a major reporter of selective autophagic activity. Read More

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A case of T2DM with edema result in subcutaneous insulin resistance syndrome.

J Diabetes Investig 2021 Jun 8. Epub 2021 Jun 8.

Clinical Pharmacy Center, Zhejiang Provincial People's Hospital, Hangzhou, China.

Subcutaneous insulin resistance syndrome caused by obesity, induration at the injection site, skin temperature and other factors are common clinically, while resistance events caused by edema are relatively rare. This paper introduced a case of female type 2 diabetes mellitus adult with heart failure edema, her blood-glucose control is significantly associated with edema level. Excluded other factors, it can be concluded that edema may lead to subcutaneous insulin resistance syndrome, even if the edema at the injection site is not obvious. Read More

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Body weight and metabolic risk factors in patients with type 2 diabetes on a self-selected high-protein low-carbohydrate diet.

Eur J Nutr 2021 Jun 8. Epub 2021 Jun 8.

Department of Nutrition, Exercise and Sports, Københavns Universitet, Copenhagen, Denmark.

Purpose: We previously reported beneficial glucoregulatory effects of a fully provided carbohydrate-reduced, high-protein (CRHP) diet in patients with type 2 diabetes mellitus (T2DM) in a crossover 2 × 6-week trial, in which patients maintained their body weight. Here, we investigated physiological changes during an additional 6-month period on a self-selected and self-prepared CRHP diet.

Methods: Twenty-eight patients with T2DM were instructed to consume a CRHP diet (30% of energy from carbohydrate and 30% from protein) for 24 weeks, after an initial 2 × 6-week trial when all food was prepared and provided to them. Read More

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Hepatoprotective effect of gallic acid against type 2-induced diabetic liver injury in male rats through modulation of fetuin-A and GLP-1 with involvement of ERK1/2/NF-κB and Wnt1/β-catenin signaling pathways.

Gen Physiol Biophys 2021 May;40(3):221-234

Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Gallic acid is a phenolic compound with biological and pharmacological activities. Therefore, our study aimed to examine whether gallic acid has a beneficial effect against type 2-induced diabetic hepatic injury in rats and attempt to discover its possible intracellular pathways. Adult male rats were subdivided into six groups: Control, DM (diabetes mellitus), GA (gallic acid)+DM, DM+GA, DM+MET (metformin) and DM+GA+MET. Read More

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