Transplantation 2021 Jan 19. Epub 2021 Jan 19.
1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy 2Division of General and Transplant Surgery, Cisanello University Hospital, Pisa, Italy 3Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy 4Diabetes Unit, Versilia Hospital, Azienda ASL Area Vasta Nord-Ovest, Lido di Camaiore, Lucca, Italy 5Departmental Section of Endocrinology and Metabolism of Organ and Cellular Transplantation, Cisanello University Hospital, Pisa, Italy 6Division of Nephrology, Cisanello University Hospital, Pisa, Italy 7Department of Surgical, Medical, Molecular Pathology and Critical Area, Division of Surgical Pathology, Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy.
Background: Physiologically regulated insulin secretion and euglycemia are achievable in type 1 diabetes (T1D) by islet or pancreas transplantation. However, pancreas transplant alone (PTA) remains a debated approach, with uncertainties on its relative benefits and risks. We determined the actual long-term (10 years) efficacy and safety of PTA in carefully characterized T1D subjects. Read More