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Atomic-engineering Au-Ag nanoalloys for screening antimicrobial agents with low toxicity towards mammalian cells.

Colloids Surf B Biointerfaces 2021 May 11;204:111831. Epub 2021 May 11.

School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China. Electronic address:

Silver nanoparticles (AgNPs) have shown potent antibacterial activity against numerous bacteria strains. However, their toxicity against mammalian cells is still a big challenge, limiting their in vivo applications. Here, we found that alloying Ag and Au in an atomic level to form Au-Ag nanoalloys (NAs) could effectively reduce the cytotoxicity of AgNPs, and the antimicrobial activity of NAs could be well maintained by tuning the composition of Ag. Read More

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Stigma and its influencing factors among breast cancer survivors in China: A cross-sectional study.

Eur J Oncol Nurs 2021 May 4;52:101972. Epub 2021 May 4.

School of Nursing, Sun Yat-sen University, Zhongshan 2 Rd 74#, Guangzhou, Guangdong, PR China. Electronic address:

Purpose: Although stigma has attracted considerable scholarly attention, few studies have focused on its influencing factors among discharged breast cancer survivors, especially in a Chinese cultural context. The present study therefore explores stigma and its influencing factors among breast cancer survivors in China.

Method: Between December 2017 and May 2018, 103 breast cancer survivors at the outpatient clinic of a tertiary cancer center in southern China were enrolled in a cross-sectional study. Read More

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Integrating multi-omics data through deep learning for accurate cancer prognosis prediction.

Comput Biol Med 2021 May 9;134:104481. Epub 2021 May 9.

School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, 510000, China; Key Laboratory of Machine Intelligence and Advanced Computing (MOE), Sun Yat-sen University, Guangzhou, 510000, China. Electronic address:

Background: Genomic information is nowadays widely used for precise cancer treatments. Since the individual type of omics data only represents a single view that suffers from data noise and bias, multiple types of omics data are required for accurate cancer prognosis prediction. However, it is challenging to effectively integrate multi-omics data due to the large number of redundant variables but relatively small sample size. Read More

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Sediment microbiota in polyculture of shrimp and fish pattern is distinctive from those in monoculture intensive shrimp or fish ponds.

Sci Total Environ 2021 May 7;787:147594. Epub 2021 May 7.

State Key Laboratory of Biocontrol, Southern Marine Sciences and Engineering Guangdong Laboratory (Zhuhai), School of Marine Sciences, Sun Yat-sen University, Guangzhou, China; Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. Electronic address:

Sediment microbial community plays a crucial role in aquaculture ecosystem. In aquaculture practice, rather than monoculture intensive shrimp (IS) or intensive fish (IF) patterns, polyculture of shrimp and fish (PolySF) pattern leads to a more reliable production. However, knowledge is still limited about the characteristics of sediment microbiota and its potential functions in the PolySF ponds compared to monoculture patterns (IS and IF). Read More

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Both viable and inactivated amoeba spores protect their intracellular bacteria from drinking water disinfection.

J Hazard Mater 2021 May 11;417:126006. Epub 2021 May 11.

School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou 510006, China; Environmental Microbiomics Research Center, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou 510006, China. Electronic address:

In drinking water systems, waterborne pathogens constitute a significant threat. While most studies focus on a single infectious agent, such as bacteria, fungi, viruses, and protists, the effect of interactions among these infectious agents on disinfection treatment has largely been ignored. In this study, we find that dormant amoeba spores, a frequently found protist in drinking water systems, can protect their intracellular bacteria from drinking water disinfection. Read More

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Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis.

Cell Death Dis 2021 May 12;12(5):474. Epub 2021 May 12.

Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, 510630, China.

Fas/Fas ligand (FasL)-mediated cell apoptosis involves a variety of physiological and pathological processes including chronic hepatic diseases, and hepatocytes apoptosis contributes to the development of liver fibrosis following various causes. However, the mechanism of the Fas/FasL signaling and hepatocytes apoptosis in liver fibrogenesis remains unclear. The Fas/FasL signaling and hepatocytes apoptosis in liver samples from both human sections and mouse models were investigated. Read More

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The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry.

Signal Transduct Target Ther 2021 05 12;6(1):189. Epub 2021 May 12.

Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.

Since the outbreak of coronavirus disease 2019 (COVID-19), it has become a global pandemic. The spike (S) protein of etiologic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specifically recognizes human angiotensin-converting enzyme 2 (hACE2) as its receptor, which is recently identified as an interferon (IFN)-stimulated gene. Here, we find that hACE2 exists on the surface of exosomes released by different cell types, and the expression of exosomal hACE2 is increased by IFNα/β treatment. Read More

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To what extent can Ulva and Sargassum be detected and separated in satellite imagery?

Authors:
Lin Qi Chuanmin Hu

Harmful Algae 2021 Mar 8;103:102001. Epub 2021 Mar 8.

College of Marine Science, University of South Florida, St. Petersburg, FL, USA. Electronic address:

Blooms of floating macroalgae have been reported around the world, among which are recurrent blooms of Ulva prolifera and Sargassum horneri in the Yellow Sea and East China Sea. While satellite remote sensing has often been used to estimate their distributions and abundance as well as to trace their origins, because the algae mats are often much smaller than the size of an image pixel, it is unclear to what extent they can be detected and discriminated from each other in satellite imagery. Using data collected from laboratory experiments and by the Sentinel-3 OLCI (Ocean and Land Colour Instrument) and Sentinel-2 MSI (Multi Spectral Instrument) satellite instruments, we conduct simulated experiments to determine the lower detection limit and discrimination limit for these two macroalgae in different water environments and under different atmospheric conditions. Read More

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Insights into the endophytic bacterial community comparison and their potential role in the dimorphic seeds of halophyte Suaeda glauca.

BMC Microbiol 2021 May 12;21(1):143. Epub 2021 May 12.

State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Science, Sun Yat-Sen University, Guangzhou, 510275, China.

Background: Seed dimorphism has been thought to be a bet-hedging strategy that helps plants survive in the disturbed environment and has been widely studied for its ecological adaptation mechanism. Many studies showed that seed-associated microorganisms play an important role in enhancing plant fitness, but information regarding endophytic bacteria associated with dimorphic seeds is limited. This study explores the influence of seed coat structure and seed phytochemical properties on the community composition and diversity of endophytic bacteria of dimorphic seeds of Suaeda glauca. Read More

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Kinetics, pathways and toxicity of hexabromocyclododecane biodegradation: Isolation of the novel bacterium Citrobacter sp. Y3.

Chemosphere 2021 Jul 15;274:129929. Epub 2021 Feb 15.

School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou, 510275, China.

This research investigated the biodegradation kinetics, pathways and ecological risk of hexabromocyclododecane (HBCD) by a novel bacterium Citrobacter sp. Y3. Results showed the biodegradation followed a first-order model. Read More

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Combined healthy lifestyle and depressive symptoms: a meta-analysis of observational studies.

J Affect Disord 2021 Apr 26;289:144-150. Epub 2021 Apr 26.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan. Electronic address:

Background: To systematically summarize the association between combined lifestyle (at least three factors, including but not limited to smoking, drinking, physical activity, body mass index, diet) and depressive symptoms by a meta-analysis in general populations.

Methods: Multiple electronic databases were searched for observational studies investigating combined lifestyle factors and depressive symptoms published before September 2020. Pooled risk estimates were calculated using random-effects models. Read More

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Thermoelectric transports in pristine and functionalized boron phosphide monolayers.

Sci Rep 2021 May 11;11(1):10030. Epub 2021 May 11.

School of Materials, Sun Yat-Sen University, Guangzhou, 510275, People's Republic of China.

Recently, a new monolayer Group III-V material, two-dimensional boron phosphide (BP), has shown great potential for energy storage and energy conversion applications. We study the thermoelectric properties of BP monolayer as well as the effect of functionalization by first-principles calculation and Boltzmann transport theory. Combined with a moderate bandgap of 0. Read More

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A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation.

Nat Commun 2021 05 11;12(1):2697. Epub 2021 May 11.

Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.

Although human antibodies elicited by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is known about the function of N-reactive antibodies. Herein, we isolate and profile a panel of 32 N protein-specific monoclonal antibodies (mAbs) from a quick recovery coronavirus disease-19 (COVID-19) convalescent patient who has dominant antibody responses to the SARS-CoV-2 N protein rather than to the SARS-CoV-2 spike (S) protein. The complex structure of the N protein RNA binding domain with the highest binding affinity mAb (nCoV396) reveals changes in the epitopes and antigen's allosteric regulation. Read More

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An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness.

Nat Commun 2021 May 11;12(1):2693. Epub 2021 May 11.

Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.

Notch signaling represents a key mechanism mediating cancer metastasis and stemness. To understand how Notch signaling is overactivated to couple tumor metastasis and self-renewal in NSCLC cells, we performed the current study and showed that RFC4, a DNA replication factor amplified in more than 40% of NSCLC tissues, directly binds to the Notch1 intracellular domain (NICD1) to competitively abrogate CDK8/FBXW7-mediated degradation of NICD1. Moreover, RFC4 is a functional transcriptional target gene of Notch1 signaling, forming a positive feedback loop between high RFC4 and NICD1 levels and sustained overactivation of Notch signaling, which not only leads to NSCLC tumorigenicity and metastasis but also confers NSCLC cell resistance to treatment with the clinically tested drug DAPT against NICD1 synthesis. Read More

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FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer.

Nat Commun 2021 May 11;12(1):2672. Epub 2021 May 11.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1 immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a highly glycosylated protein. However, the mechanisms of B7H3 glycosylation regulation and whether the sugar moiety contributes to immunosuppression are unclear. Read More

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CircRNA_2646 functions as a ceRNA to promote progression of esophageal squamous cell carcinoma via inhibiting miR-124/PLP2 signaling pathway.

Cell Death Discov 2021 May 11;7(1):99. Epub 2021 May 11.

Department of Thoracic Surgery, the First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, China.

MicroRNA-124 (miR-124) has been predicted as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). However, factors contributing to miR-124 reduction remain unclear. Circular RNAs (circRNAs) are a new family of non-coding RNAs with gene regulatory potential via interacting with miRNAs. Read More

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Activation of transmembrane receptor tyrosine kinase DDR1-STAT3 cascade by extracellular matrix remodeling promotes liver metastatic colonization in uveal melanoma.

Signal Transduct Target Ther 2021 May 12;6(1):176. Epub 2021 May 12.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Colonization is believed a rate-limiting step of metastasis cascade. However, its underlying mechanism is not well understood. Uveal melanoma (UM), which is featured with single organ liver metastasis, may provide a simplified model for realizing the complicated colonization process. Read More

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Retro-orbital injection of FITC-dextran combined with isolectin B4 in assessing the retinal neovascularization defect.

BMC Ophthalmol 2021 May 11;21(1):208. Epub 2021 May 11.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Jinsui Road 7, Tianhe District, 510000, Guangzhou, China.

Background: A reliable and effective method is required to deliver agent that can aid the in vivo imaging of retinal vessels. The aim of the present study was to evaluate retro-orbital (RO) injection of fluorescein-labeled isothiocyanate dextran (FITC-dextran) as a method of demonstrating retinal neovascularization (NV) and avascular areas in oxygen-induced retinopathy (OIR) mice.

Methods: Different concentrations of FITC-dextran were used to compare the efficacy of this agent in perfusing the retinal vessels. Read More

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Pollution level and health risk assessment of polycyclic aromatic hydrocarbons in marine fish from two coastal regions, the South China Sea.

Mar Pollut Bull 2021 May 8;168:112376. Epub 2021 May 8.

School of Marine Sciences, Sun Yat-sen University, Zhuhai 519082, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519080, China; Pearl River Estuary Marine Ecosystem Research Station, Ministry of Education, Zhuhai 519082, China. Electronic address:

Marine fishes are consumed in large quantities by humans as nutritious food. However, the intake of fish polluted by chemicals may pose a severe threat to human health. This study measured the concentrations of 16 priority polycyclic aromatic hydrocarbons (PAHs) in the muscles of 22 species of marine fish from two coastal regions, i. Read More

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Qualitative screening and quantitative determination of multiclass water-soluble synthetic dyes in foodstuffs by liquid chromatography coupled to quadrupole Orbitrap mass spectrometry.

Food Chem 2021 Apr 24;360:129948. Epub 2021 Apr 24.

Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China. Electronic address:

A LC-Q-Orbitrap HRMS analytical method for both qualitative screening and quantitative determination of 90 synthetic dyes including ten groups of isomers in foods has been established. An in-house synthetic dyes database and characteristic ions were also developed. Based on Q-Orbitrap HRMS, mass spectrum and fragmentation patterns of synthetic dyes were studied, which indicated that double charged ions were usually the main precursor ions. Read More

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Tuning luminescence of didysprosium single-molecule magnets with a π-conjugated/non-conjugated bridging ligand.

Dalton Trans 2021 May 11. Epub 2021 May 11.

Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University, 510275 Guangzhou, Guangdong, P. R. China.

Herein, we reported two didysprosium single-molecule magnets constructed with {Dy(bbpen)(MeOH)} subunits and a π-conjugated tpb or non-conjugated tpcb bridging ligand. The former exhibits extremely weak luminescence that makes it difficult to simulate its emission spectra. However, the later shows obviously enhanced and well-resolved luminescence, which helps us to gain knowledge about the magneto-optical correlation and the relevant magnetic energy levels. Read More

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N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.

Oncogene 2021 May 10. Epub 2021 May 10.

Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

N6-methyladenosine (mA) is the most abundant internal mRNA modification in eukaryotes and plays an important role in tumorigenesis. However, the underlying mechanism remains largely unclear. Here, we established a cell model of rapamycin-induced autophagy to screen mA-modifying enzymes. Read More

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Normalization of γ-glutamyl transferase levels is associated with better metabolic control in individuals with nonalcoholic fatty liver disease.

BMC Gastroenterol 2021 May 10;21(1):215. Epub 2021 May 10.

Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China.

Background: The normalization of liver biochemical parameters usually reflects the histological response to treatment for nonalcoholic fatty liver disease (NAFLD). Researchers have not clearly determined whether different liver enzymes exhibit various metabolic changes during the follow-up period in patients with NAFLD.

Methods: We performed a retrospective analysis of patients with NAFLD who were receiving therapy from January 2011 to December 2019. Read More

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Health tourism destinations as therapeutic landscapes: Understanding the health perceptions of senior seasonal migrants.

Soc Sci Med 2021 Apr 21;279:113951. Epub 2021 Apr 21.

School of Tourism Management, Sun Yat-sen University, Building 329, 135 Xingangxi Road, Guangzhou, 510275, PR China; Key Laboratory of the Sustainable Development of Xinjiang's Historical and Cultural Tourism, Xinjiang University, Urumqi, Xinjiang, 830046, PR China. Electronic address:

Health-driven seasonal tourism has become a new way of providing for the aged, which demonstrates a profound relationship between place and health. Therapeutic landscapes strongly suggest a causal relationship between health tourism destination and individual health. However, the quantitative validation of such relationship remains neglected and possible mechanisms underlying the relationship lack a strong theoretical basis. Read More

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Intracardiac, pulmonary cement embolism in a 67-year-old female after cement-augmented pedicle screw instrumentation: A case report and review of literature.

World J Clin Cases 2021 May;9(13):3120-3129

Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510289, Guangdong Province, China.

Background: We report a case of Intracardiac, pulmonary, and intravenous cement embolism after cement-augmented pedicle screw instrumentation in treating spondylolisthesis underlying osteoporotic bone, which was successfully managed by conservative treatment. We describe the treatment and outcome of the patient, hoping to shed light on the management of bone cement embolism.

Case Summary: A 67-year-old female suffered from progressive low back pain and numbness in lower extremities for 30 years. Read More

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Clinical value of minimal residual disease assessed by multiparameter flow cytometry in amyloid light chain amyloidosis.

J Cancer Res Clin Oncol 2021 May 8. Epub 2021 May 8.

Department of Haematology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Purpose: To assess the feasibility and prognostic value of minimal residual disease (MRD) evaluated by multiparameter flow cytometry (MFC) in newly diagnosed amyloid light chain (AL) amyloidosis.

Methods: Clinical data from 25 consecutive newly diagnosed AL amyloidosis patients with MRD data tested at 3 months after first-line therapy completion were retrospectively analysed in a single centre from 2012 to 2019. First-line therapy included 8 courses of VD or 4 courses of VD plus sequential autologous stem cell transplantation (ASCT), both without maintenance therapy. Read More

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Recent advances in artificial intelligence for cardiac imaging.

Comput Med Imaging Graph 2021 May 3;90:101928. Epub 2021 May 3.

Department of Medical Imaging, Western University, London, ON, Canada; Digital Imaging Group, London, ON, Canada.

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Procyanidine resists the fibril formation of human islet amyloid polypeptide.

Int J Biol Macromol 2021 May 7;183:1067-1078. Epub 2021 May 7.

Department of Chemistry, Renmin University of China, Beijing 100872, China. Electronic address:

Human islet amyloid polypeptide (hIAPP) is widely studied due to its close correlation with the pathogenic mechanism of type II diabetes mellitus (T2DM). Bioflavonoids have been used in the neurodegeneration and diabetes studies. However, the structure-activity relationship remains unclear in many of these compounds. Read More

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Mapping the distribution of perfluoroalkyl substances in zebrafishes by liquid extraction surface analysis mass spectrometry.

Talanta 2021 Aug 6;231:122377. Epub 2021 Apr 6.

State Key Laboratory of Biocontrol, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, School of Life Sciences, Sun Yat-Sen University, 135 Xingangxi Road, Guangzhou, 510275, China; Institute of Environmental and Ecological Engineering, Guangdong University of Technology, 100 Waihuanxi Road, Guangzhou, 510006, China. Electronic address:

Investigation on the distribution of persistent organic pollutants (POPs) in aquatic organisms is of great importance for exploring the biological toxicity and health risks of environmental pollutants. In this study, a liquid extraction surface analysis mass spectrometry (LESA-MS) method was developed for rapid and in situ analysis of the spatial distribution of perfluoroalkyl substances (PFASs) in zebrafish. By combining the high-precision automated moving platform of LESA device and the high-resolution MS, quantitative analysis of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in zebrafish tissue section were easily achieved. Read More

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The combination of conventional ultrasound and shear-wave elastography in evaluating the segmental heterogeneity of liver fibrosis in biliary atresia patients after Kasai portoenterostomy.

Pediatr Surg Int 2021 May 9. Epub 2021 May 9.

Department of Medical Ultrasonics, Institute for Diagnostic and Interventional Ultrasound, The First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan Er Road, Guangzhou, 510080, People's Republic of China.

Objective: To retrospectively assess the value of the combination of conventional ultrasound and shear-wave elastography (SWE) in evaluating the segmental heterogeneity of liver fibrosis in biliary atresia (BA) patients after Kasai portoenterostomy.

Methods: A total of 35 BA patients with liver segmental deformation were enrolled. The segmental deformation was assessed by conventional ultrasound followed with SWE examinations for evaluating the liver stiffness. Read More

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