3,908 results match your criteria systemic necrotizing


Blood transcriptomic markers of necrotizing enterocolitis in preterm pigs.

Pediatr Res 2021 Jun 10. Epub 2021 Jun 10.

Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Necrotizing enterocolitis (NEC), a severe gut disorder in preterm infants, is difficult to predict due to poor specificity and sensitivity of clinical signs and biomarkers. Using preterm piglets as a model, we hypothesized that early development of NEC affects blood gene expression, potentially related to early systemic immune responses.

Methods: A retrospective analysis of clinical, tissue, and blood data was performed on 129 formula-fed piglets with NEC diagnosis at necropsy on day 5. Read More

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ANCA-associated vasculitis after COVID-19.

Rheumatol Int 2021 Jun 7. Epub 2021 Jun 7.

Division of Nephrology, Department of Internal Medicine, Ondokuz Mayıs University Medical Faculty, Korfez Mahallesi, 55270, Atakum/Samsun, Turkey.

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are systemic autoimmune diseases that may lead to renal failure due to the infiltration of mononuclear cells and the destruction of small- and medium-sized blood vessels. It has been shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger the presentation or exacerbation of autoimmune diseases. Crescentic glomerulonephritis (GN) has rarely been reported in patients with Coronavirus disease-2019 (COVID-19). Read More

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The Long Pentraxin PTX3 Controls Severe Infection.

Front Immunol 2021 20;12:666198. Epub 2021 May 20.

Department of Inflammation and Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.

is a common pathogen in human sepsis. The emergence of multidrug-resistant strains represents a major clinical challenge in nosocomial and community acquired infections. The long pentraxin PTX3, a key component of humoral innate immunity, is involved in resistance to selected pathogens by promoting opsonophagocytosis. Read More

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Legionnaires' disease arising with hirsutism: case report of an extremely confusing event.

BMC Infect Dis 2021 Jun 6;21(1):532. Epub 2021 Jun 6.

Department of Interdisciplinary Medicine, Occupational Health Division, University of Bari, Bari, Italy.

Background: Legionella bacteria is a common cause of pneumonia, but the infection may affect several organs in the most serious cases. A systemic involvement ab initio could be non-specific, leading to a diagnostic misinterpretation.

Case Presentation: A 33-year-old woman had been complaining of mental confusion, restlessness, aggressiveness, and, subsequently, hirsutism. Read More

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Myopathy associated with anti-signal recognition particle antibodies with pulmonary involvement and response to rituximab.

Rheumatol Int 2021 Jun 4. Epub 2021 Jun 4.

Rheumatology Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal.

The authors present the case of a 76-year-old female patient with progressive decrease in proximal muscle strength, fatigue, dyspnea, diffuse hand edema and painful triphasic Raynaud's phenomenon. Anti-SRP and anti-SSA antibodies were detected, muscle biopsy revealed changes consistent with necrotizing myopathy and capillaroscopy had findings compatible with systemic sclerosis. High-resolution chest computed tomography revealed interstitial lung disease with a non-specific interstitial pneumonia pattern. Read More

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Successful Spinal Cord Stimulation for Necrotizing Raynaud's Phenomenon in COVID-19 Affected Patient: The Nightmare Comes Back.

Cureus 2021 Apr 19;13(4):e14569. Epub 2021 Apr 19.

Department of Intedisciplinary Medicine, University of Bari Aldo Moro, Bari, ITA.

Necrotizing Raynaud's phenomenon is a vascular clinical syndrome characterized by vasospasm of distal resistance vessels, usually triggered by cold temperatures or by psychological conditions such as anxiety and stress. Pain is the first reported symptom, related to insufficient oxygen delivery to the extremities that leads to ischemia of the peripheral tissues. The initial treatment is conservative, but if the symptoms persist, necrosis and distal amputation can occur. Read More

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Case of vaso-occlusive retinopathy in Kikuchi-Fujimoto and lupus overlap syndrome.

BMJ Case Rep 2021 May 31;14(5). Epub 2021 May 31.

Department of Ophthalmology, Medical Eye Unit, Guy's and St Thomas' Hospitals NHS Trust, London, UK.

A 35-year-old woman presented with a constellation of systemic symptoms: rashes, weight loss, arthralgia and mouth ulcers. Six months afterwards, she experienced bilateral and sequential reduction in vision, and was found to have bilateral vaso-occlusive retinopathy, with critical macular ischaemia in the left eye. Her serological markers were consistent with a diagnosis of lupus. Read More

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Prevasculitic Eosinophilic Granulomatosis With Polyangiitis.

Cureus 2021 Apr 23;13(4):e14649. Epub 2021 Apr 23.

Critical Care Medicine, University of Pittsburgh Medical Center Mercy, Pittsburgh, USA.

Eosinophilic granulomatosis with polyangiitis (EGPA) is an exceptionally rare systemic necrotizing vasculitis. The disease is clinically characterized by asthma with concomitant blood and tissue eosinophilia, often progressing to eosinophilic vasculitis. From the onset of asthma, there is usually a three to nine year delay of EGPA diagnosis. Read More

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Upper Eyelid Necrosis Secondary to Hordeolum: A Case Report.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):270-276. Epub 2021 Apr 19.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

We reported a case of upper eyelid necrosis initially misdiagnosed as a preseptal cellulitis following a hordeolum externum resulting in great damage to the upper eyelid (anterior lamella). The infection was successfully treated with surgical cleansing, drainage, and endovenous antibiotics. Early treatment may avoid severe complications such as eyelid deformity, systemic involvement, and blindness. Read More

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Primary Chemotherapy in a 47-Year-Old Patient with Giant Ulcerative and Necrotizing Nonseminomatous Testicular Germ Cell Tumor.

Case Rep Oncol 2021 Jan-Apr;14(1):681-689. Epub 2021 Apr 15.

Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.

Testicular cancer is a rare disease; however, cure rates are high for all tumor stages. Mostly, the disease is diagnosed in an early (local) stage. We report the case of a 47-year-old male patient with a giant nonseminomatous germ cell tumor. Read More

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[Analysis on the diagnosis and treatment of necrotizing fasciitis complicated with sepsis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Apr;33(4):483-486

Department of Burn and Wound Repair Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, Guangdong, China. Corresponding author: Lai Wen, Email:

Objective: To recognize the characteristics of necrotizing fasciitis patients complicated with sepsis and summarize the experience the treatment.

Methods: A retrospective study was conducted. The clinical data of 57 patients with necrotizing fasciitis complicated with sepsis admitted to Guangdong Provincial People's Hospital from July 2009 to December 2019 was analyzed by collecting such factors as gender, age, complications, infection sites, pathogens, surgery information, treatment options and outcome. Read More

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[NEUROLOGIC COMPLICATIONS AROUND THE DIAGNOSIS OF KIKUCHI-FUJIMOTO DISEASE: A RARE PRESENTATION OF THE DISEASE OR A HINT OF AN ADDITIONAL DIAGNOSIS?]

Harefuah 2021 May;160(5):307-310

Department of Medicine E, Rabin Medical Center- Beilinson, Petah Tikva, Israel.

Introduction: Neurologic symptoms are an extremely rare presentation of Kikuchi-Fujimoto disease. We report a case of a young female patient diagnosed with Kikuchi-Fujimoto disease, presenting with neurologic symptoms compatible with aseptic meningitis, along with radiographic findings which improved with steroidal treatment. Despite the rarity of these findings, they were reported as part of the disease manifestation, however, since Kikuchi-Fujimoto disease is associated with other diseases, such as systemic lupus erythematosus (SLE), other diagnoses cannot be ruled out. Read More

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Case report of recurrent haemoptysis in an older patient with repaired tetralogy of Fallot.

Eur Heart J Case Rep 2021 May 17;5(5):ytab155. Epub 2021 May 17.

Department of Cardiovascular Diseases, Division of Congenital and Structural Cardiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.

Background: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect. Although most infants nowadays undergo surgical repair approximately at the age of 6 months with excellent outcomes, older patients typically underwent a staged approach with an initial systemic-to-pulmonary Blalock-Taussig-Thomas (BTT) shunt reducing hypoxaemia, followed by surgical TOF repair at an older age (with takedown of the BTT shunt). Late complications related to the BTT shunt are rare. Read More

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Sub-clinical necrotizing enterocolitis-induced systemic immune suppression in neonatal preterm pigs.

Am J Physiol Gastrointest Liver Physiol 2021 05 19. Epub 2021 May 19.

Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark.

Preterm infants are at high risks of sepsis and necrotizing enterocolitis (NEC). Some develop sepsis shortly after suspected or confirmed NEC, implying that NEC may predispose to sepsis but the underlying mechanisms are unknown. Using NEC-sensitive preterm pigs as models, we investigated the immune status in animals following development of sub-clinical NEC-like lesions with variable severities. Read More

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A Pediatric Case of Granulomatous Myositis and Response to Treatment.

Cureus 2021 Apr 15;13(4):e14507. Epub 2021 Apr 15.

Neurology, Strong Memorial Hospital, Rochester, USA.

Idiopathic inflammatory myopathy encompasses a group of acquired, heterogeneous, systemic diseases of the skeletal muscle, including adult polymyositis, adult dermatomyositis, juvenile dermatomyositis, juvenile polymyositis, inclusion body myositis, and necrotizing myopathy, all resulting in muscle weakness. Granulomatous myositis (GM) is a rare myopathy disorder histologically characterized by the development of endomyseal and/or perimyseal granulomas in striated muscle. GM is often associated with sarcoidosis. Read More

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Simultaneous Onset of Mycobacterium kansasii Pulmonary Infection and Systemic Lupus Erythematosus: A Case Report.

Am J Case Rep 2021 May 19;22:e929866. Epub 2021 May 19.

Division of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy.

BACKGROUND Systemic lupus erythematosus (SLE) is a systemic autoimmune disease resulting from dysregulation of the immune response. In genetically predisposed subjects, infections reputedly trigger an immune activation leading to autoimmunity and overt autoimmune diseases such as SLE. CASE REPORT We report the case of a 19-year-old woman who presented to our hospital reporting high-grade fever, dry cough, and polyarthralgia despite a course of empiric antibiotic and steroid therapy administered by her general practitioner (GP). Read More

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Increased Urinary CD163 Levels in Systemic Vasculitis with Renal Involvement.

Biomed Res Int 2021 30;2021:6637235. Epub 2021 Apr 30.

Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, Xinjiang 830001, China.

Objectives: Systemic vasculitis includes a group of disorders characterized by inflammation of the vessel wall, involving multiple systems, and can cause malignant hypertension. CD163 is a specific marker of anti-inflammatory macrophages. This study is aimed at evaluating the CD163 levels in relation to systemic vasculitis and renal involvements. Read More

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Necrotizing lymphadenitis may be induced by overexpression of Toll-like receptor7 (TLR7) caused by reduced TLR9 transport in plasmacytoid dendritic cells (PDCs).

J Clin Exp Hematop 2021 Jun 14;61(2):85-92. Epub 2021 May 14.

Department of Pediatrics, Iwaki City Medical Center, Iwaki, Japan.

Necrotizing lymphadenitis (NEL) is a self-limited systemic disease exhibiting characteristic clinical features. The pathogenesis of the disease remains unclear, but it may be associated with viral infection. In lymph nodes affected by this disease, innumerable plasmacytoid dendritic cells produce interferon-α when triggered by certain viral stimuli. Read More

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Necrotizing Fasciitis of the Breast Underlying an Autoimmune Disease.

Eur J Case Rep Intern Med 2021 15;8(4):002434. Epub 2021 Apr 15.

Department of Internal Medicine, University Hospital of Mohammed VI, Marrakesh, Morocco.

Necrotizing fasciitis is a serious soft tissue infection that causes necrosis of the subcutaneous tissues and the muscle fascia. It is associated with a high mortality rate of around 25%. Necrotizing fasciitis of the breast is a rare entity. Read More

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The Effects of Early Oropharyngeal Administration of Microdosed Colostrum on Feeding Status in Ventilated Extremely Low-Birth-Weight Infants.

Breastfeed Med 2021 May 13. Epub 2021 May 13.

Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

For extremely low-birth-weight infants (ELBWIs), mechanical ventilation and total parenteral nutrition are generally required in the early stages and lose the protective effect of early gastrointestinal nutrition of colostrum. We conducted a prospective randomized controlled trial to explore the effectiveness of early colostrum oropharyngeal administration on the feeding status of ELBWIs on mechanical ventilation. We randomly divided mechanically ventilated ELBWIs into an intervention group and a control group. Read More

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The role of imaging in acute pancreatitis.

Radiol Med 2021 May 12. Epub 2021 May 12.

Dipartimento di diagnostica per immagini, Radioterapia, Oncologia ed Ematologia, Fondazione Universitaria "A. Gemelli", IRCCS - Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168, Rome, Italy.

Acute pancreatitis is one of the most commonly encountered etiologies in the emergency setting, with a broad spectrum of findings that varies in severity from mild interstitial pancreas to severe forms with significant local and systemic complications that are associated with a substantial degree of morbidity and mortality. In this article the radiological aspect of the terminology and classification of acute pancreatitis are reviewed. The roles of ultrasound, computed tomography, and magnetic resonance imaging in the diagnosis and evaluation of acute pancreatitis and its complications are discussed. Read More

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Granulomatosis with Polyangiitis with Ocular Manifestations.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):98-104. Epub 2021 Apr 6.

Postgraduate Education Department, Kazakh Eye Research Institute, Almaty, Kazakhstan.

Granulomatosis with polyangiitis (GPA) is a granulomatous-necrotic systemic vasculitis with a lesion of predominantly the upper and lower respiratory tracts at the onset of the disease (vasculitis, accompanied by granulomatous inflammation), and subsequently renal (glomerulonephritis). In addition, GPA may manifest as inflammation of small arteries and veins. Despite many years of study of this disease, the etiology of GPA remains unknown. Read More

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Histopathological features of systemic sclerosis-associated myopathy: A scoping review.

Autoimmun Rev 2021 Jul 7;20(7):102851. Epub 2021 May 7.

Division of Rheumatology, Centre hospitalier de l'Université de Montréal (CHUM), CHUM Research Center, Department of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Background: Scleromyositis (SM) is an emerging subset of myositis associated with features of systemic sclerosis (SSc) but it is currently not recognized as a distinct histopathological subset by the European NeuroMuscular Center (ENMC). Our aim was to review studies reporting muscle biopsies from SSc patients with myositis and to identify unique histopathological features of SM.

Methods: A scoping review was conducted and included all studies reporting histopathological findings in SSc patients with myositis searching the following databases: PubMed, MEDLINE, EMBASE, CINAHL and EBM-Reviews. Read More

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Successful endoscopic surgery for emphysematous pyelonephritis in a non-diabetic patient with autosomal dominant polycystic kidney disease: A case report.

World J Clin Cases 2021 Apr;9(12):2862-2867

Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, Guangdong Province, China.

Background: Emphysema pyelonephritis (EPN) is a very dangerous type of urinary tract infection. It is a lethal disease that develops rapidly and causes the patient to deteriorate rapidly, and it can easily lead to systemic infections and even sepsis. The incidence is extremely low, and it is prevalent in patients with diabetes. Read More

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Rhabdomyolysis Following Recovery from Severe COVID-19: A Case Report.

Am J Case Rep 2021 May 8;22:e931616. Epub 2021 May 8.

Oregon Health & Science University, Portland, OR, USA.

BACKGROUND Rhabdomyolysis occurs when muscle injury leads to the release of muscle cell constituents into circulation, often leading to significant systemic complications. There are many causes of rhabdomyolysis, and the etiology is often multifactorial or unclear. Current data suggest that acute COVID-19 may cause muscle injury that can lead to rhabdomyolysis, particularly in cases of severe illness requiring prolonged hospitalization; however, data on the long-term effects of COVID-19 on the musculoskeletal system are lacking. Read More

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COVID-19 Related Acute Hemorrhagic Necrotizing Encephalitis: A Report of Two Cases and Literature Review.

Cureus 2021 Apr 1;13(4):e14236. Epub 2021 Apr 1.

Medicine/Neurological Intensive Care, Prisma Health Greenville Memorial Hospital, Greenville, USA.

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, has proven neurotropism and causes a multitude of neurologic manifestations. Acute hemorrhagic necrotizing encephalitis (AHNE), though rare, can be seen in patients with severe infection and is associated with devastating neurologic outcomes. The true prevalence of this syndrome is unknown due to underrecognition, difficulty in timely acquisition of neuroimaging, and high mortality in this subset of patients escaping detection. Read More

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Therapeutic options for cutaneous polyarteritis nodosa: a systematic review.

Rheumatology (Oxford) 2021 May 3. Epub 2021 May 3.

Department of Internal Medicine, Division of Rheumatology, University of Cyprus Medical School, Nicosia, Cyprus.

Objective: Cutaneous polyarteritis nodosa (CPAN) is a necrotizing vasculitis of the middle-size vessels, confined to the skin. We conducted a systematic review in order to identify studies evaluating the different treatment modalities used in CPAN.

Methods: This systematic review was conducted according to PRISMA guidelines, registered in PROSPERO: CRD42020222195. Read More

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Emergency amputation necessitated within 24 hours by a human bite: a case report.

J Int Med Res 2021 May;49(5):3000605211012201

Department of Foot and Ankle Surgery, Center for Orthopaedic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou 510610, China.

We herein review and analyze the diagnosis, treatment, and outcome of a severe infection caused by a human bite. A 68-year-old man was bitten on the forearm by a 3-year-old child. Rapid progression of infection, severe local and systemic poisoning, and diverse clinical manifestations were observed at presentation. Read More

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Delayed genital necrosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with Mitomycin-C.

Eur J Surg Oncol 2021 Apr 20. Epub 2021 Apr 20.

Department of Surgical Oncology, The Institute for Cancer Care, Mercy Medical Center 227 St. Paul Place, 4th Floor Weinberg, Baltimore, MD, 21202-2001, USA. Electronic address:

Introduction: Genital necrosis (GN) is a rare complication of cytoreductive surgery with hyperthermic intraoperative chemotherapy (CRS/HIPEC) which can be confused with necrotizing fasciitis. We present an analysis of GN after CRS/HIPEC to define its natural history.

Methods: We identified patients with GN after CRS/HIPEC at two peritoneal surface malignancy institutions. Read More

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Disseminated coccidioidomycosis in a patient with juvenile idiopathic arthritis receiving infliximab.

Pediatr Rheumatol Online J 2021 May 1;19(1):63. Epub 2021 May 1.

Presbyterian Healthcare Services, New Mexico, Albuquerque, USA.

Background: Coccidioides immitis is a dimorphic fungus endemic to the arid climates of the Southwest United States, Mexico and parts of Central and South America. Human infection occurs through inhalation of spores with less than half of exposures progressing to a symptomatic state that primarily consists of pulmonary manifestations. Disseminated coccidioidomycosis is exceedingly rare, occurring in fewer than 1 % of symptomatic infections. Read More

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