9,410 results match your criteria systemic manifestation

[Retinal tumors in adults: Part 2 nonvascular tumors of retina and retinal pigment epithelium].

Ophthalmologe 2021 Jul 29. Epub 2021 Jul 29.

Klinik für Augenheilkunde, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Retinal tumors are a heterogeneous group of congenital and acquired lesions. In the second part of the article retinocytic and glial cell tumors of the retina, tumors of the retinal pigment epithelium, malignant tumors, such as lymphomas and metastases are presented. In benign and malignant tumors visual symptoms, such as exudative retinal detachment occur, which often lead to irreversible visual impairments. Read More

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Isolated Lupus-Associated Protein-Losing Enteropathy in a Resource-Limited Centre.

Cureus 2021 Jun 22;13(6):e15826. Epub 2021 Jun 22.

Medicine, Teaching Hospital, Batticaloa, LKA.

Systemic lupus erythematosus (SLE) is a relatively common autoimmune disease with recently reported cases of lupus-associated protein-losing enteropathy (LUPLE) as an unusual manifestation. It is a well-recognized clinical entity predominantly affecting middle-aged Asian females. LUPLE is diagnosed by exclusion of possible causes for hypoalbuminemia in a patient with positive anti-nuclear antibody (ANA). Read More

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Hyperviscosity Retinopathy and Immunogammopathy Maculopahy as New Onset of Multiple Myeloma.

Case Rep Ophthalmol 2021 May-Aug;12(2):578-584. Epub 2021 Jul 1.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

The purpose is to report a case of immunogammopathy maculopathy and hyperviscosity retinopathy as the presenting feature of new-onset multiple myeloma (MM) in an otherwise healthy man. A 50-years-old man presented with painless visual changes in both eyes for 2 months. Ocular examination revealed bilateral CRVO-like associated with macular edema (ME) and an inferior serous detachment. Read More

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Charcot-Bouchard aneurysms revisited: clinicopathologic correlations.

Mod Pathol 2021 Jun 14. Epub 2021 Jun 14.

Section of Neuropathology, Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center and David Geffen School of Medicine, Los Angeles, CA, USA.

Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide. Hypertension and cerebral amyloid angiopathy (CAA) are the most common causes of primary ICH, but the mechanism of hemorrhage in both conditions is unclear. Although fibrinoid necrosis and Charcot-Bouchard aneurysms (CBAs) have been postulated to underlie vessel rupture in ICH, the role and significance of CBAs in ICH has been controversial. Read More

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Presentation, Diagnosis and Management of Subglottic and Tracheal Stenosis During Systemic Inflammatory Diseases.

Chest 2021 Jul 26. Epub 2021 Jul 26.

Department of Internal Medicine, National Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (APHP)-Centre Université Paris (CUP), Paris, France. Electronic address:

Background: Subglottic (SGS) and tracheal stenoses (TS) are characterized by a narrowing of the airways. We aimed to describe characteristics and prognosis of nontraumatic and nontumoral SGS or TS.

Research Question: What are the inflammatory etiologies of subglottic and tracheal stenosis and what are their characteristics and prognosis?

Study Design And Methods: We conducted a multicenter observational retrospective study of patients with neither traumatic nor tumoral SGS or TS. Read More

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Comparative evaluation of clinical findings and prognostic outcome parameters in hospitalized, critically ill neonatal foals and crias.

J Vet Emerg Crit Care (San Antonio) 2021 Jul 29. Epub 2021 Jul 29.

Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts.

Objective: Species-related differences in the prevalence, manifestation, and outcome of neonatal illness may impact management practices of neonatal intensive care. The study aimed to elucidate similarities between disease manifestations and mortality risks of critically ill (CI) neonatal crias and foals admitted to the same referral center.

Design: A comparative, retrospective cohort evaluation of two species (camelid and equine). Read More

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Systemic Inflammation and Microbial Translocation Are Characteristic Features of SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children.

Open Forum Infect Dis 2021 Jul 6;8(7):ofab279. Epub 2021 Jul 6.

National Institutes of Health-National Institute for Research in Tuberculosis - International Center for Excellence in Research, Chennai, India.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children that can result in increased morbidity and mortality. The inflammatory underpinnings of MIS-C have not been examined in detail.

Methods: We examined the plasma levels of acute phase proteins and microbial translocation markers in children with MIS-C, children with acute coronavirus disease 2019 (COVID-19) infection, SARS-CoV-2-seropositive children, and controls. Read More

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Carcinoid Crisis-Induced Acute Systolic Heart Failure.

JACC Case Rep 2020 Nov 28;2(13):2068-2071. Epub 2020 Oct 28.

Department of Medicine, Division of Cardiology, University of California-San Francisco, San Francisco, California.

Carcinoid crisis is a life-threatening manifestation of carcinoid syndrome characterized by profound autonomic instability in the setting of catecholamine release from stress, tumor manipulation, or anesthesia. Here, we present an unusual case of carcinoid crisis leading to acute systolic heart failure requiring mechanical circulatory support. (). Read More

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November 2020

β-Caryophyllene attenuates lipopolysaccharide-induced acute lung injury via inhibition of the MAPK signalling pathway.

J Pharm Pharmacol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, China.

Objectives: Acute lung injury (ALI) is a pulmonary manifestation of an acute systemic inflammatory response, which is associated with high morbidity and mortality. Accordingly, from the perspective of treating ALI, it is important to identify effective agents and elucidate the underlying modulatory mechanisms. β-Caryophyllene (BCP) is a naturally occurring bicyclic sesquiterpene that has anti-cancer and anti-inflammatory activities. Read More

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[Retinal tumors in adults - Part 1: vascular tumors of the retina].

Ophthalmologe 2021 Jul 26. Epub 2021 Jul 26.

Klink für Augenheilkunde, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Retinal tumors are a heterogeneous group of congenital and acquired lesions. In this review series the important retinal tumors are discussed and presented in two articles. In the first part of the article the most important vascular tumors of the retina are presented. Read More

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How 'eye' helped in von Hippel-Lindau syndrome.

Eur J Ophthalmol 2021 Jul 24:11206721211035632. Epub 2021 Jul 24.

Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.

Background: Von Hippel-Lindau syndrome is a rare autosomal dominantly inherited multisystemic oncologic syndrome, presenting predominantly with angiomatosis in embryologically similar neurologic tissue such as retina, cerebellum and adrenals. Retinal hemangioblastomas are the hallmark ophthalmic finding. In this case report, we describe the importance of timely diagnosis, thorough systemic examination and treatment of bilaterally asymmetrical retinal hemangioblastomas in a young adult male. Read More

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Esophageal manifestation in patients with scleroderma.

World J Clin Cases 2021 Jul;9(20):5408-5419

Department of Gastroenterology and Hepatology, Laiko General Hospital, National and Kapodistian University of Athens, Athens 11527, Greece.

The esophagus is the most commonly affected part of the gastrointestinal system in patients with systemic sclerosis (SSc). Esophageal involvement may lead to a significant reduction in patient quality of life. The exact pathophysiology is complex and not yet fully elucidated. Read More

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Retinal Hemangioblastoma with Extraocular Extension: Report of Three Cases.

Ocul Oncol Pathol 2021 Jun 7;7(3):177-181. Epub 2021 Jan 7.

Laboratory Services, Dr Shroff's Charity Eye Hospital, New Delhi, India.

Retinal hemangioblastoma (RH) is the earliest and most common clinical manifestation in Von Hippel-Lindau (VHL) disease. RH can also present in isolation without any evidence of VHL. Clinical course of RH can be stationary or progress to exudation and chronic retinal detachment requiring surgical intervention. Read More

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Review of oral ulcerative lesions in COVID-19 patients: a comprehensive study of 51 cases.

J Dent Sci 2021 Jul 15. Epub 2021 Jul 15.

Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Numerous oral manifestations of COVID-19 have been reported in the literatures. Common oral lesions in COVID-19 patients included ulcerations, xerostomia, dysgeusia, gingival inflammation, and erythema. Among them, oral ulceration is the most frequent finding and is present as various but distinct patterns. Read More

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Associated genetic polymorphisms and clinical manifestations in systemic lupus erythematosus in Asian populations - A systematic literature review.

Med J Malaysia 2021 Jul;76(4):541-550

Universiti Kebangsaan Malaysia (UKM), UKM Medical Molecular Biology Institute (UMBI), Cheras, Kuala Lumpur, Malaysia.

Introduction: Systemic lupus erythematosus (SLE) is a chronic and life-threatening autoimmune disease. Its prevalence and clinical manifestations are known to be particularly severe in the Asian populations. Although genetics is known to play an important role in SLE susceptibility and clinical manifestations, the specific polymorphisms associated with these phenotypes in Asia are unclear. Read More

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Kawasaki-like multisystem inflammatory syndrome associated with SARS-CoV-2 infection in an adult.

BMJ Case Rep 2021 Jul 23;14(7). Epub 2021 Jul 23.

Department of Infectious Diseases, Cork University Hospital Group, Cork, Ireland

Kawasaki-like hyperinflammatory syndrome has been widely described as a manifestation of SARS-CoV-2 infection in paediatric patients. We report a compatible presentation and suggest that physicians consider the potential for this multisystem inflammatory syndrome to occur in adults. A 23-year-old man presented to hospital with a 4-day history of vomiting, diarrhoea, dry cough, fever and a blanching erythematous rash on hands, feet and buttocks. Read More

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Visual Hallucinations After a Russell's Viper Bite.

Wilderness Environ Med 2021 Jul 20. Epub 2021 Jul 20.

Department of Internal Medicine, Chennai Medical College Hospital & Research Center, Irungalur, Trichy, India.

Visual hallucinations (VHs) are extremely rare in snakebites. We report a case of Russell's viper bite in an otherwise healthy 55-y-old woman who presented to a hospital in south India with established clinical features of systemic and local envenomation, including coagulation failure, without any neurologic manifestations on admission. She reported simple VH on the third day, which abruptly stopped on the fifth day without any specific medications. Read More

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Mandibular Brown Tumor as a Result of Secondary Hyperparathyroidism: A Case Report with 5 Years Follow-Up and Review of the Literature.

Int J Environ Res Public Health 2021 Jul 9;18(14). Epub 2021 Jul 9.

Department of Oral and Cranio-Maxillofacial Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany.

Background: Brown tumor is a rare skeletal manifestation of secondary hyperparathyroidism. Although diagnosis of the disease is increasingly seen in early stages due to improved screening techniques, some patients still present in a progressed disease stage. The treatment depends on tumor mass and varies from a conservative approach with supportive parathyroidectomy to extensive surgical resection with subsequent reconstruction. Read More

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Lysine demethylase KDM6B regulates HIF-1α mediated systemic and cellular responses to intermittent hypoxia.

Physiol Genomics 2021 07 23. Epub 2021 Jul 23.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, IL, United States.

Intermittent hypoxia (IH) is a hallmark manifestation of Obstructive Sleep Apnea (OSA). Rodents treated with IH exhibit hypertension. Hypoxia-inducible factor (HIF)-1-dependent transcriptional activation of NADPH oxidases (Nox) and the resulting increase in reactive oxygen species (ROS) levels is a major molecular mechanism underlying IH/OSA-induced hypertension. Read More

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Chronic rhinosinusitis in cystic fibrosis: a review of therapeutic options.

Eur Arch Otorhinolaryngol 2021 Jul 22. Epub 2021 Jul 22.

Department of Otolaryngology Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland.

Purpose: Chronic rhinosinusitis (CRS) is observed in almost 100% of patients with cystic fibrosis (CF). CF-related CRS treatment is extremely challenging because of the underlying genetic defect leading to its development. CRS in CF is often refractory to standard therapy, while recurrences after surgical treatment are inevitable in the majority of patients. Read More

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Characteristic manifestation of ocular and cervical vestibular evoked myogenic potentials findings in severe obstructive sleep apnea patients.

Acta Otolaryngol 2021 Jul 21:1-8. Epub 2021 Jul 21.

ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Background: Studies of saccular and utricular function in patients with obstructive sleep apnea (OSA) are rare. We noticed that some OSA patients also had positive results in vestibular function tests, and this inspired our interest in exploring the vestibular function patterns of OSA patients.

Objectives: To investigate otolithic organ function in severe OSA patients who lack vestibular symptoms and systemic disease. Read More

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Multi-targeted therapy for refractory eosinophilic granulomatosis with polyangiitis characterized by intracerebral hemorrhage and cardiomyopathy: a case-based review.

Rheumatol Int 2021 Jul 21. Epub 2021 Jul 21.

Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic autoimmune disorder classified under anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, predominantly affecting small- to medium-sized vessels, characterized by asthma, eosinophilia, and necrotizing granulomatous inflammation. Most patients with EGPA experience peripheral neuropathy, whereas intracerebral hemorrhage is rare as EGPA-related presentation in central nervous system involvement, causing severe morbidity and mortality. Here, we present a 45-year-old man with refractory EGPA who developed intracerebral hemorrhage as the first manifestation, followed by cardiac involvement. Read More

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Lupus retinopathy: epidemiology and risk factors.

Arq Bras Oftalmol 2021 Jul-Aug;84(4):395-401

Ophthalmology Department, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Lupus retinopathy is a clinical manifestation of systemic lupus erythematosus in the visual system. It is generally asymptomatic; however, it can become a threatening condition. It is closely associated with the inflammatory activity and higher mortality of systemic lupus erythematosus. Read More

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December 2019

Ophthalmologic manifestations in patients with antiphospholipid antibodies: Beware of iatrogenic complications.

Lupus 2021 Jul 20:9612033211033988. Epub 2021 Jul 20.

Université de Lorraine, Inserm UMR_S 1116 DCAC and CHRU de Nancy, Vascular Medicine Division And Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases, F-54000 Nancy, France.

Background: Antiphospholipid syndrome (APS) is characterized by several clinical manifestations such as venous and arterial thrombosis associated with persistent antiphospholipid antibodies (aPL). Several studies confirmed that retinal vein occlusion was the most common APS ocular manifestation. The purpose of this study was to identify ophthalmologic manifestations in a homogeneous cohort of well-defined persistently aPL-positive patients and to determine variables associated with these manifestations. Read More

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Hyperacute reversible encephalopathy related to cytokine storm following COVID-19 vaccine.

J Neuroimmunol 2021 Jul 13;358:577661. Epub 2021 Jul 13.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

We describe the first case of hyperacute reversible encephalopathy following COVID-19 vaccination. A patient presented with acute onset encephalopathy, mainly characterized by agitation and confusion, rapidly responsive to high dosage steroid therapy and complete remission within 3 days from onset. The clinical manifestation was related with systemic and CSF cytokine hyperproduction, responsive to steroid therapy. Read More

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Pancytopenia as the main manifestation of human immunodeficiency virus infection in the AIDS stage The authors present a case.

Vnitr Lek 2021 ;67(E-4):26-28

The authors present a case report of 59-years-old woman examined for pancytopenia recently diagnosed during hospitalization for bilateral interstitial pneumonia without any confirmed etiological agents. Concomitantly, some systemic symptoms like lack of appetite and weight loss were present. Primary hematological disease was ruled out. Read More

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Pediatric morphea state-of-the-art literature review: Reframing morphea as a systemic disease.

Pediatr Dermatol 2021 Jul 17. Epub 2021 Jul 17.

Departments of Dermatology (Section of Pediatric Dermatology) and Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.

Pediatric morphea is an inflammatory, fibrosing dermatologic disorder. Although morphea may be localized to the skin and subcutaneous tissues, differentiating it from systemic sclerosis, there is increasing evidence that morphea is a manifestation of a systemic inflammatory process, with the potential to involve many organ systems. Given the potential risk for irreversible sequelae, pediatric morphea should be treated early and aggressively. Read More

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Lupus mastitis: A rare breast cancer differential diagnosis.

Clin Case Rep 2021 Jul 9;9(7):e04416. Epub 2021 Jul 9.

General Surgery Department Centro Hospitalar do Baixo Vouga Aveiro Portugal.

Lupus mastitis is an uncommon SLE breast manifestation. Clinically, it can present itself as a malignant-like mass. Therefore, a tissue biopsy is warranted to confirm the diagnosis. Read More

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Gender Differences in Atherosclerotic Vascular Disease: From Lipids to Clinical Outcomes.

Front Cardiovasc Med 2021 28;8:707889. Epub 2021 Jun 28.

Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia.

Cardiovascular diseases (CVDs) are one of the main reasons of death and morbidity in the world. Both women and men have high rates of cardiovascular morbidity and mortality, although gender-related differences in mortality and morbidity rates are observed in different age groups of the population. In the large cohort of cardiovascular disease, ischemic heart disease (IHD), heart failure (HF), systemic hypertension, and valvular heart disease are particularly common in the population. Read More

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Case Report: Systemic Sclerosis After Covid-19 Infection.

Serena Fineschi

Front Immunol 2021;12:686699. Epub 2021 Jun 28.

Department of Public Health and Caring Sciences, Unit of General Practice, Uppsala University, Uppsala, Sweden.

The coronavirus disease (COVID-19) is a respiratory tract infection caused by the new virus SARS-CoV-2. The acute phase of the infection may in certain individuals be followed by another longer phase of disease (long COVID) of unknown etiology probably associated in certain cases with autoimmune activation. It has been shown that COVID-19 can trigger autoantibody production and in genetically predisposed patients may cause the onset or exacerbation of autoimmune diseases. Read More

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