Clin Exp Rheumatol 2021 Sep 13. Epub 2021 Sep 13.
College of Medicine, China Medical University, Taichung; Translational Medicine Laboratory, Rheumatology and Immunology Centre, China Medical University Hospital, Taichung; Rheumatology and Immunology Centre, China Medical University Hospital, Taichung, and Ph.D. Program in Translational Medicine and Rong Hsing Research Centre for Translational Medicine, National Chung Hsing University, Taichung, Taiwan.
Objectives: Adult-onset Still's disease (AOSD) is a rare and complex inflammatory disease with unclear immunopathogenesis. This study aims to investigate the expression signature of inflammation-associated long non-coding RNAs (lncRNAs) in AOSD and to evaluate its utility for disease diagnosis and prognostication.
Methods: Expression levels of lncRNAs MIAT, THRIL, NTT, RMRP, PACERR and NEAT1 in peripheral blood mononuclear cells (PBMCs) from treatment-naïve AOSD patients and healthy donors were assessed by quantitative real-time PCR and logistic regression analysis. Read More