20,919 results match your criteria systemic corticosteroid


Postoperative Infection Rate and Associated Factors Following Endoscopic Sinus Surgery.

Ann Otol Rhinol Laryngol 2021 Apr 9:34894211007240. Epub 2021 Apr 9.

Division of Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle WA, USA.

Objectives: There is a paucity of data on postoperative infections after endoscopic sinus surgery and associated risk factors. Our objective was to evaluate a cohort of patients undergoing endoscopic sinus surgery (ESS) for chronic rhinosinusitis to determine which perioperative factors may be associated with infection in the 30-day postoperative period.

Methods: A retrospective cohort study of adults who underwent ESS at a tertiary academic medical center from 2015 to 2018 was performed. Read More

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In Vitro-Administered Dexamethasone Suppresses T Cell Function With Reversal by Interleukin-7 in Coronavirus Disease 2019.

Crit Care Explor 2021 Apr 2;3(4):e0378. Epub 2021 Apr 2.

Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO.

Objectives: Corticosteroid therapy has become standard of care therapy for hospitalized patients infected with the severe acute respiratory syndrome coronavirus-2 global pandemic-causing virus. Whereas systemic inflammation is a notably important feature in coronavirus disease 2019 pathogenesis, adaptive immune suppression and the inability to eradicate effectively the virus remain significant factors as well. We sought to evaluate the in vitro effects of dexamethasone phosphate on T cell function in peripheral blood mononuclear cells derived from patients with acute, severe, and moderate coronavirus disease 2019. Read More

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Pityriasis rosea Gibert triggered by SARS-CoV-2 infection: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25352

Lucian Blaga University of Sibiu, Faculty of Medicine Sibiu, Academic Emergency Hospital Sibiu - Dermatology Clinic, Sibiu, Romania.

Rationale: Pityriasis rosea Gibert is an erythematous-papulosquamous dermatosis that frequently occurs in young adults. The etiopathogenesis of PR is still unknown, but is frequently associated with episodes of upper respiratory tract infections. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

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Occult Adrenal Insufficiency in Renal Amyloidosis Patients.

Medeni Med J 2021 26;36(1):52-57. Epub 2021 Mar 26.

University of Health Sciences, Ankara Bilkent City Hospital, Division of Nephrology, Ankara, Turkey.

Objective: Systemic amyloidosis may affect many organs, and may cause endocrinologic problems which may result in adrenal insufficiency. However, assessment of adrenocortical reserve is challenging in amyloidosis patients with renal involvement. We aimed to evaluate adrenocortical reserve with various methods of cortisol measurement to determine any occult clinical condition. Read More

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Parallel disease activity of Behçet's disease with renal and entero involvements: a case report.

BMC Nephrol 2021 Apr 7;22(1):122. Epub 2021 Apr 7.

Department of Internal Medicine, Kushiro Red Cross Hospital, 21-14, Shinei-cho, Kushiro, 085-8512, Japan.

Background: Behçet's disease (BD) is a systemic inflammatory vasculitis with both autoimmune and autoinflammatory properties. Renal involvement in BD and its spontaneous remission have been rare. We herein describe a case of parallel disease activity of BD with entero and renal involvements, followed by a spontaneous remission without corticosteroid treatment. Read More

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Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results.

Blood 2021 Apr 7. Epub 2021 Apr 7.

City of Hope National Medical Center, Duarte, California, United States.

This phase 1-2 study evaluated brentuximab vedotin (BV) combined with nivolumab (Nivo) as first salvage therapy in patients with relapsed or refractory classical Hodgkin lymphoma. In parts 1 and 2, patients received staggered dosing of BV and Nivo in cycle 1, followed by same-day dosing in cycles 2-4. In part 3, both study drugs were dosed same day for all 4 cycles. Read More

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Treatment of Inflammatory Macular Hole: Case Series and Review of Literature.

Ocul Immunol Inflamm 2021 Apr 7:1-7. Epub 2021 Apr 7.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

: To present the success rate of nonsurgical management of full-thickness inflammatory macular hole (IMH): Retrospective case series of five patients with IMH.: Five eyes from five patients with IMH enrolled in the current case series. All five eyes had successful closure with corticosteroid in the form of topical, periocular, or intravitreal injections. Read More

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Pain Management in Painful Psoriasis and Psoriatic Arthropathy: Challenging and Intricately Intertwined Issues Involving Several Systems.

Curr Pain Headache Rep 2021 Apr 6;25(6):36. Epub 2021 Apr 6.

Yale University School of Medicine, 333 Cedar St, TMP3, CT, 06510, New Haven, USA.

Purpose Of Review: Psoriasis and psoriatic arthropathy are inflammatory autoimmune conditions that can lead to profound emotional distress, social stigmatization, isolation, disfigurement, pain, disability, unemployment, and decreased quality of life. Thus, this disease has immense psychological, social, and economic implications as the pain experienced is closely associated with the primary disease burden. This review focuses on discussing the primary disease burden of psoriasis and psoriatic arthropathy, as well as management of different types of pain in these patients. Read More

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Cervical duplex ultrasound for the diagnosis of giant cell arteritis with vertebral artery involvement.

J Neuroimaging 2021 Apr 5. Epub 2021 Apr 5.

Second Department of Neurology, National & Kapodistiran University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.

Giant cell arteritis (GCA) is a systemic inflammatory arteriopathy of medium and large-sized arteries, predominantly affecting branches of the external carotid artery. Ischemic stroke has been reported in 2.8-7% of patients diagnosed with GCA. Read More

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Behcet disease - A nonvenereal cause of genital ulceration.

Indian J Sex Transm Dis AIDS 2020 Jul-Dec;41(2):198-201. Epub 2020 Jul 31.

Department of SKIN and VD, S.B.K.S. Medical Institute and Research Center, Dhiraj Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.

Behcet's disease (BD) is a chronic, relapsing, inflammatory vascular disease with no diagnostic or pathognomonic test. Here, we present a case of 26-year-old male with a complaint of recurrent oral, genital, and cutaneous lesions. The diagnosis of BD was confirmed on the basis of revised the International Criteria for BD. Read More

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PECULIARITIES OF BONE MINERAL DENSITY IN WOMEN OF DIFFERENT REPRODUCTIVE AGE WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

Wiad Lek 2021 ;74(2):303-309

NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.

Objective: The aim: To study the peculiarities of bone mineral density in the Ukrainian population of women of different reproductive age with systemic lupus erythematosus and to evaluate its connection with traditional and specific (typical for systemic lupus erythematosus) risk factors.

Patients And Methods: Materials and methods: A total of 91 women with systemic lupus erythematosus and 29 healthy individuals were examined. Along with the clinical study of the activity and severity of the disease, the serum levels of interleukin-6 were determined by the enzyme immunoassay. Read More

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Autologous Blood Injection for Treatment of Steroid Atrophy: A Case Report.

J Cosmet Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Nazilli State Hospital, Aydın, Turkey.

Background: Intramuscular corticosteroid injections are frequently used for a variety of conditions in dermatology practice. Unfortunately, many complications are associated with systemic and local administration of corticosteroids. Localized subcutaneous lipoatrophy is among the most common adverse effects that can lead to permanent disfigurement. Read More

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Cost-efficacy and pharmacoeconomics of scalp lesions of psoriatic patients in current Japanese health-care insurance system.

J Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Research Institute of Psoriasis, Housui General Medical Clinic, Sapporo, Japan.

Psoriatic scalp lesion is occasionally recalcitrant to topical or systemic treatments including biologic agents. The combined active vitamin D /corticosteroids are more expensive despite their marked efficacy. The aim of the present study is to evaluate total costs as well as costs versus efficacy of topical scalp psoriasis treatments under the current Japanese health-care insurance system. Read More

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Treatment with tofacitinib in refractory psoriatic arthritis. National multicenter study of the first 87 patients of clinical practice.

J Rheumatol 2021 Apr 1. Epub 2021 Apr 1.

Rheumatology Department, Hospital Universitario de Basurto, Bilbao, Spain; Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Santander, Spain; Rheumatology Department, Hospital de Sierrallana, Torrelavega, Spain; Rheumatology Department, Hospital Universitario 12 de octubre, Madrid, Spain; Rheumatology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain; Rheumatology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain; Rheumatology Department, Hospital Universitario Politécnico La Fé, Valencia, Spain; Rheumatology Department, Fundación Alcorcón, Madrid, Spain. Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain; Rheumatology Department, Hospital Universitari Arnau de Vilanova-Lleida, Spain; Rheumatology Department, Hospital Virgen del Rocío, Sevilla, Spain; Rheumatology Department, Hospital de la Princesa, IIS-Princesa, Cátedra UAMRoche (EPID-Future), Universidad Autónoma de Madrid, Madrid, Spain; Research Group, Hospital Universitario de Basurto, Bilbao, Spain. University of Cantabria, School of Medicine, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. This study was presented in part at the European e-Congress of Rheumatology 2020 (EULAR 2020). Disclosures that might be interpreted as constituting of possible conflict(s) of interest for the study: Dra. Galíndez-Agirregoikoa has received research support from Roche, AbbVie, Lilly, Pfizer, MSD, Amgen, Bristol-Myers, Janssen and UCB Pharma. Dra. Prieto-Peña has received research support from Roche, AbbVie, Lilly, Pfizer, Sanofi and UCB Pharma.Dr. Martín-Varillas received grants/research supports from AbbVie, Pfizer, Janssen and Celgene. Dr. Melero-González has received research support from Roche, Astrazeneca, Sanofi Aventis, BMS, Abbvie, Lilly, Faes, Italfarmaco, Gebro, Abbvie, Esteve, UCB, Novartis, Janssen Cilag. Dra. Almodóvar has received research support from abbvie, celgene, Gebro, Janssen, Lilly, MSD, Novartis, Pfizer, UCB. Dra. García-Vicuña reports grants, personal fees and non-financial support from Abbvie, BMS, Lilly, Novartis, MSD and Pfizer; personal fees from Biogen, Celltrion and Mylan; grants from Roche, grants, personal fees and non-financial support from Sanofi, grants, personal fees and non-financial support from Sandoz, grants and personal fees from Janssen, outside the submitted work. Dr. Atienza-Mateo is a recipient of a 'López-Albo' Post- Residency Programme funded by Servicio Cantabro de Salud and she received grants/research supports from Kern Pharma, AbbVie, Pfizer, Celgene and GSK.Dr. MA Gonzalez-Gay received grants/research supports from Abbott, MSD and Roche, and had consultation fees/participation in company sponsored speaker´s bureau from Pfizer, Roche, Sanofi and Jansen. Dr. R Blanco received grants/research supports from Abbvie, MSD and Roche, and had consultation fees/participation in company sponsored speaker´s bureau from Abbvie, Lilly, Pfizer, Roche, Bristol-Myers, Janssen, UCB Pharma and MSD. No financial disclosures declared for the other coauthors. Dr. Eva Galíndez-Agirregoikoa and Dr. Diana Prieto-Peña share first authorship. Correspondence to: Joint corresponding authors: Ricardo Blanco or Prof. Miguel A. González-Gay, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, Avda. Valdecilla s/n., ES-39008, Santander. SPAIN.

Objective: Tofacitinib (TOFA) is the first Janus kinase (JAK) inhibitor approved for Psoriatic Arthritis (PsA). It has shown efficacy in patients refractory to anti-TNFα in Randomized Clinical Trials (RCT). Our aim was to assess efficacy and safety of TOFA in clinical practice. Read More

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Intratympanic Triamcinolone Acetonide as a Salvage Treatment for Idiopathic Sudden Sensorineural Hearing Loss.

Audiol Neurootol 2021 Mar 31:1-10. Epub 2021 Mar 31.

Department of Otorhinolaryngology, Medical University of Graz, Graz, Austria.

Introduction: Intratympanic steroid (ITS) injections represent an increasingly used salvage treatment option for patients with idiopathic sudden sensorineural hearing loss -(ISSHL) after systemic treatment. The most effective corticosteroid for this treatment modality still remains unclear. Triamcinolone acetonide has been used for ITS treatment in various clinical settings. Read More

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Potential Role of Mast Cells in Regulating Corticosteroid Insensitivity in Severe Asthma.

Adv Exp Med Biol 2021 ;1303:1-12

Department of Respiratory Sciences, University of Leicester, Leicester, UK.

The mechanisms driving corticosteroid insensitivity in asthma are still unclear although evidence points toward a potential role of lung mast cells. Indeed, a number of in vitro studies using various cell types showed that different mediators produced by activated mast cells, including cytokines, have the capacity to interfere with the therapeutic action of corticosteroids. In patients with severe allergic refractory asthma, the anti-IgE monoclonal antibody (mAb), Omalizumab, has been shown to be associated with a marked reduction in inhaled and systemic use of corticosteroids, further suggesting a key role of mast cells in the poor response of patients to these drugs. Read More

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Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.

Mol Metab 2021 Mar 27:101225. Epub 2021 Mar 27.

British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom. Electronic address:

Objective: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may contribute to the cardiometabolic complications of obesity. This study tested the hypothesis that Cbr1-mediated glucocorticoid metabolism influences glucocorticoid and mineralocorticoid receptor activation in adipose tissue, and impacts glucose homeostasis in the lean and obese state.

Methods: The actions of 20β-DHB on corticosteroid receptors in adipose tissue were investigated first using a combination of in silico, in vitro and transcriptomic techniques and then in vivo administration in combination with receptor antagonists. Read More

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Effect of Intranasal corticosteroid treatment on allergen-induced changes in group 2 innate lymphoid cells in allergic rhinitics with mild asthma.

Allergy 2021 Mar 30. Epub 2021 Mar 30.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Background: Allergic rhinitis is characterized by rhinorrhea, nasal congestion, sneezing and nasal pruritis. Group 2 innate lymphoid cells (ILC2s), CD4 T cells and eosinophils in nasal mucosa are increased significantly after nasal allergen challenge (NAC). Effects of intranasal corticosteroids (INCS) on ILC2s remains to be investigated. Read More

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Performance of Eosinophil Cationic Protein as a Biomarker in Asthmatic Children.

J Allergy Clin Immunol Pract 2021 Mar 26. Epub 2021 Mar 26.

Department of Pediatrics, Emory University, Atlanta, Ga; Center for Cystic Fibrosis and Airways Disease Research, Children's Healthcare of Atlanta, Atlanta, Ga. Electronic address:

Background: Although blood eosinophils are a frequently used marker of type 2 inflammation in children with asthma, their sensitivity is relatively poor. Additional markers of type 2 inflammation are needed.

Objective: We hypothesized that plasma concentrations of eosinophil cationic protein (ECP), a marker of eosinophil activation, would be useful for detection of type 2 inflammation and would predict poorer asthma outcomes over 1 year. Read More

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Recombinant human hyaluronidase PH20-mediated dermal spreading activity in mice is not altered by steroids, antihistamines, or salicylic acid.

Drug Metab Pers Ther 2020 Dec 25. Epub 2020 Dec 25.

Halozyme Therapeutics Inc., San Diego, CA, USA.

Objectives: Drug-drug interaction studies for hyaluronidase safety assessments have evaluated only animal-derived enzyme preparations. We therefore set out to evaluate whether high-dose administration of two antihistamines, a potent corticosteroid, steroid hormone, adrenocorticotropic hormone (ACTH), or salicylic acid would alter the dispersive activity of recombinant human hyaluronidase PH20 (rHuPH20).

Methods: NCr nu/nu mice were pretreated with diphenhydramine, cetirizine, dexamethasone, estrogen, ACTH, salicylic acid, and/or neutral-buffered saline (NBS). Read More

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December 2020

Validation and verification of the Japanese version of the systemic lupus erythematosus symptom checklist for patient quality of life.

Lupus 2021 Mar 28:9612033211005026. Epub 2021 Mar 28.

Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objective: The systemic lupus erythematosus (SLE) symptom checklist (SSC) is a patient-reported outcome measure consisting of 38 queries. We translated SSC into Japanese and attempted to validate its usefulness for evaluating the quality of life (QOL) of SLE patients and identify factors that affect QOL.

Methods: Data from the Medical Outcomes Study Short-form 36 questionnaire (SF-36), Japanese LupusPRO, the Japanese version of the SSC (SSC-J) questionnaire, SLEDAI-2k, and the physician global assessment (PGA) were obtained on the same day from 226 SLE outpatients of the Kyoto Lupus cohort at Kyoto University Hospital. Read More

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Judicious use of low-dosage corticosteroids for non-severe COVID-19: A case report.

Open Med (Wars) 2021 19;16(1):440-445. Epub 2021 Mar 19.

Changchun Infectious Diseases Hospital, Changchun, Jilin, China 130123.

Inflammation-mediated lung injury in severe cases of infection with SARS-CoV-2, the aetiological agent of Coronavirus disease 2019 (COVID-19), can lead to respiratory failure and death, and therapies that block or ameliorate lung injury-associated inflammatory "cytokine storms" and progression to acute respiratory distress syndrome (ARDS) are urgently needed. Therapeutic use of corticosteroids for this purpose has been controversial because of conflicting reports on their efficacy and immunosuppressive behaviour. The WHO has strongly recommended treating critical COVID-19 patients with systemic corticosteroid therapy, but recommends against corticosteroid therapy in non-severe COVID-19 disease because of a lack of strong evidence on its efficacy. Read More

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Pharmacokinetics of mometasone furoate delivered via two dry powder inhalers.

Pulm Pharmacol Ther 2021 Mar 23:102019. Epub 2021 Mar 23.

Novartis Pharma AG, Basel, Switzerland. Electronic address:

Background: QMF149 is an inhaled fixed-dose combination of indacaterol acetate and mometasone furoate (MF) delivered via Breezhaler®, under development for once-daily treatment of asthma. MF delivered via Twisthaler® is approved as Asmanex® Twisthaler® for the treatment of asthma. Bridging of MF delivered via Twisthaler® to MF delivered via Breezhaler® was undertaken as part of QMF149 development to enable dose comparisons between the devices. Read More

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Intestinal pseudo-obstruction: Unusual presentation of systemic lupus erythematous.

Clin Case Rep 2021 Mar 8;9(3):1759-1762. Epub 2021 Feb 8.

Gastroenterology Unit Internal Medicine Department La Marsa Internal Security Forces Hospital Tunis Tunisia.

Systemic diseases should be always considered when managing unexplained intestinal pseudo-obstruction. Intestinal pseudo-obstruction related to systemic lupus erythematosus is often responsive to corticosteroid therapy when promptly treated. Read More

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Efficacy and safety of i.v. methylprednisolone pulse therapy for vitiligo: A retrospective study of 58 therapy experiences for 33 vitiligo patients.

J Dermatol 2021 Mar 25. Epub 2021 Mar 25.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Systemic corticosteroid is indicated for vitiligo, especially for generalized and progressive vitiligo. However, no consensus exists yet for the dosages and modalities of systemic corticosteroid treatments for vitiligo. The purpose of this study is to validate the efficacy and safety of i. Read More

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Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock.

Front Immunol 2021 9;12:607217. Epub 2021 Mar 9.

Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.

Large clinical trials testing hydrocortisone therapy in septic shock have produced conflicting results. Subgroups may benefit of hydrocortisone treatment depending on their individual immune response. We performed an exploratory analysis of the database from the international randomized controlled clinical trial Corticosteroid Therapy of Septic Shock (CORTICUS) employing machine learning to a panel of 137 variables collected from the Berlin subcohort comprising 83 patients including demographic and clinical measures, organ failure scores, leukocyte counts and levels of circulating cytokines. Read More

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Integrated Chinese and western medicine for SLE: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Mar;100(12):e23597

Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau.

Background: The efficacy and safety of integrated Chinese and western medicine in the treatment of Systemic Lupus Erythematosus (SLE) have not been systematically evaluated.

Methods: This systematic review and meta-analysis will be performed and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We will search PubMed, Embase, Cochrane Library, Chinese Biomedical Database WangFang, VIP, and China National Knowledge Infrastructure (CNKI) for potentially eligible studies from their inception to Dec. Read More

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Characteristics of patients with frequent systemic corticosteroid bursts for asthma in real clinical practice: are there frequent "short bursts?"

J Asthma 2021 Apr 1:1-8. Epub 2021 Apr 1.

Department of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.

Objective: The data on intermittent systemic corticosteroid therapy for asthma exacerbation, clinically called a "short burst," is limited. This study aimed to investigate the characteristics of patients with frequent systemic corticosteroid bursts for asthma in real clinical practice.

Methods: Consecutive patients who regularly visited our hospital for asthma treatment between January 2019 and December 2020 were reviewed. Read More

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Glucocorticoids in Spondyloarthritis-Systematic Review and Real-world Analysis.

Rheumatology (Oxford) 2021 Mar 20. Epub 2021 Mar 20.

Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India 160012.

Objective: To identify and summarise the efficacy and safety of systemic glucocorticoids (GC) and local injections of GC in spondyloarthritis (SpA).

Methods: PubMed (Medline) and EMBASE were searched with predefined keywords and relevant articles in English reporting RCTs, non-randomized and observational studies on efficacy of GC in SpA, with 5 or more patients, were included in the systematic literature review (SLR). Local injections of GC included intra-articular (IA) and entheseal injections, but excluded sacroiliac joint injections. Read More

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