542,167 results match your criteria systemic

Cytomorphological spectrum of cysticercosis: a study of 26 cases.

Cytopathology 2021 Jul 31. Epub 2021 Jul 31.

Department Of Pathology, Atal Bihari Vajpayi Institute Of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Background: Cysticercosis is a systemic parasitic disease caused by the larval stage of Taenia solium. It is the most common parasitic disease worldwide. Fine needle aspiration cytology plays an important role in prompt recognition of this disease. Read More

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Management of nasal myiasis and type 2 diabetes mellitus: A rare case and review article.

Int J Surg Case Rep 2021 Jul 26;85:106244. Epub 2021 Jul 26.

Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Electronic address:

Background: Nasal myiasis is a nasal infestation caused by house fly larvae (maggot). It's a rare condition with only a few reported cases and no treatment consensus.

Case Presentation: A 54-year-old woman was admitted to the emergency unit with a complaint of larvae found in the left nasal cavity and bloody nasal discharge for 2 days. Read More

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The protective effect of isoflurane pretreatment on liver IRI by suppressing noncanonical pyroptosis of liver macrophages.

Int Immunopharmacol 2021 Jul 29;99:107977. Epub 2021 Jul 29.

Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 40010, China. Electronic address:

Background: Liver ischaemia-reperfusion injury (IRI) is a major complication in the perioperative period and often leads to liver failure and even systemic inflammation. Sufficient evidence has demonstrated that isoflurane has anti-inflammatory effects. We aimed to determine whether isoflurane pretreatment protects against liver IRI and to investigate the mechanisms involved in this protection. Read More

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Local and systemic gene expression levels of IL-10, IL-17 and TGF-β in active ocular toxoplasmosis in humans.

Cytokine 2021 Jul 28;146:155643. Epub 2021 Jul 28.

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: To compare mRNA expression of interleukin 10 (IL-10), interleukin 17 (IL-17) and Transforming Growth Factor-β (TGF-β) in aqueous humor (AH) and peripheral blood mononuclear cells (PBMCs) in human ocular toxoplasmosis (OT) and controls.

Method: RNA isolation, cDNA synthesis and real-time polymerase chain reaction were performed on AH sediments and PBMCs of 16 patients with active OT and 21 controls at the Khatam-al-Anbia Eye Hospital, Iran. For comparison, Mann Whitney U test was used at a discrimination level of p < 0. Read More

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Endocytosis of peroxiredoxin 1 links sterile inflammation to immunoparalysis in pediatric patients following cardiopulmonary bypass.

Redox Biol 2021 Jul 28;46:102086. Epub 2021 Jul 28.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taiwan; Center of Precision Medicine, College of Medicine, National Taiwan University, Taiwan. Electronic address:

After cardiopulmonary bypass (CPB), the occurrence of systemic inflammatory response is often accompanied by a persistent compensatory anti-inflammatory response syndrome that can lead to a compromised immune competence termed immunoparalysis, rendering the patients susceptible to infections which is a leading complication following cardiac surgery. However, the underlying mechanisms of CPB-elicited immunoparalysis remain obscure. In this study we showed that peroxiredoxin 1 (Prdx1), a putative cytosolic antioxidant, was released immediately after CPB in a cohort of pediatric patients receiving congenital cardiac surgery. Read More

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Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) : Series of 49 French pediatric cases.

J Allergy Clin Immunol Pract 2021 Jul 28. Epub 2021 Jul 28.

Service de Dermatologie, Hôtel Dieu, Centre Hospitalier Universitaire de Nantes, Nantes, France. Electronic address:

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal adverse drug reaction. It can be difficult to diagnose, even more so among children, since symptoms may mimic other commonly encountered pediatric conditions.

Objective: To describe clinical and laboratory features of DRESS syndrome in the pediatric population (≤ 18 years of age), establish causative agents and treatment modalities. Read More

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Frequent Eczematous Dermatitis in Unrelated Cord Blood Hematopoietic Cell Transplant Recipients Compared to Other Donor Types.

Transplant Cell Ther 2021 Jul 28. Epub 2021 Jul 28.

Fred Hutchinson Cancer Research Center, Seattle, WA; University of Washington, Seattle, WA; Seattle Cancer Care Alliance. Electronic address:

Background: We have consistently noticed in our clinical practice eczematous dermatitis (EcD) without other pathologic findings of graft-versus-host disease (GVHD) in recipients of unrelated cord blood transplantation (CBT). We hypothesized that the incidence of EcD was higher in CBT compared to other donor types.

Objective: To compare the frequency, clinical course, and response to therapy of EcD among CBT and non-CBT recipients. Read More

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Clin Res Hepatol Gastroenterol 2021 Jul 28:101768. Epub 2021 Jul 28.

Service d'hépatologie, Hôpital Rangueil, CHU Toulouse, Toulouse.

Rare genetic liver diseases can result in multi-systemic damage, which may compromise the patient's prognosis. Wilson's disease, must be investigated in any patient with unexplained liver disease and/or unexplained neurological or neuropsychiatric disorders. The diagnosis is based on a combination of clinical, biological features, including copper balance. Read More

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Proteomics, lipidomics, metabolomics and 16S DNA sequencing of dental plaque from patients with diabetes and periodontal disease.

Mol Cell Proteomics 2021 Jul 28:100126. Epub 2021 Jul 28.

Morgridge Institute for Research, Madison, WI 53715, USA; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; National Center for Quantitative Biology of Complex Systems, Madison, WI 53706, USA. Electronic address:

Oral microbiome influences human health, specifically pre- and type 2 diabetes (Pre-DM/DM) and periodontal diseases (PD), through complex microbial interactions. To explore these relations, we performed 16S rDNA sequencing, metabolomics, lipidomics, and proteomics analyses on supragingival dental plaque collected from individuals with Pre-DM/DM (n=39), Pre-DM/DM and PD (n=37), PD alone (n=11), or neither (n=10). We identified on average 2,790 operational taxonomic units and 2,025 microbial and host proteins per sample and quantified 110 metabolites and 415 lipids. Read More

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Energy intake focused analysis of sexual dimorphism in biological aging and hypothesized sex-specificity in sirtuin dependency.

Mitochondrion 2021 Jul 28. Epub 2021 Jul 28.

Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna, Bangladesh.

The process of biological aging or senescence refers to the gradual loss of homeostasis and subsequently, loss of function leading to higher chances of mortality. Many mechanisms and driving forces have been suggested to facilitate the evolution of a molecular circuit acting as a tradeoff between survival and proliferation resulting in senescence. A major observation on biological aging and longevity in humans and model organisms is the prevalence of significant sexual divergence in the onset, mechanisms and effects of aging associated processes. Read More

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Epigenetic regulation of inflammatory factors in adipose tissue.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Jul 28:159019. Epub 2021 Jul 28.

Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA 94720. Electronic address:

Obesity is a strong risk factor for insulin resistance. Chronic low-grade tissue inflammation and systemic inflammation have been proposed as major mechanisms that promote insulin resistance in obesity. Adipose tissue has been recognized as a nexus between inflammation and metabolism, but how exactly inflammatory gene expression is orchestrated during the development of obesity is not well understood. Read More

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Cyclodextrin-based formulation of carbonic anhydrase inhibitors for ocular delivery - A review.

Int J Pharm 2021 Jul 28:120955. Epub 2021 Jul 28.

Department of Ophthalmology, Faculty of Medicine, National University Hospital, University of Iceland, Landspitalinn, IS-101 Reykjavik, Iceland.

Carbonic anhydrase inhibitors (CAIs) are used as systemic and topical agents for lowering intraocular pressure (IOP) in patients with glaucoma. Owing to the wide distribution of CAs and their physiological functions in various tissues, systemic administration of CAIs may lead to unwanted side effects. Thus, exploration of drugs targeting the specific CA isoenzyme in ocular tissues and application of the same as topical eye drops would be desirable. Read More

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Thermo-Responsive Hydrogels for Cancer Local Therapy: Challenges and State-of-Art.

Int J Pharm 2021 Jul 28:120954. Epub 2021 Jul 28.

Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain; Networking Research Centre for Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, Madrid, Spain; Functional Validation and Preclinical Research (FVPR), CIBBIM-Nanomedicine, Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, Barcelona, Spain.

Despite the enormous efforts done by the scientific community in the last decades, advanced cancer is still considered an incurable disease. New formulations are continuously under investigation to improve drugs therapeutic index, i.e. Read More

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Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study.

J Steroid Biochem Mol Biol 2021 Jul 28:105958. Epub 2021 Jul 28.

Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France.

Background: The objective of this extension phase of the quasi-experimental GERIA-COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19.

Methods: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000IU per month, or 80,000IU or 100,000IU or 200,000IU every 2-3 months), or daily supplementation with 800IU. Read More

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The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity.

Metabolism 2021 Jul 28:154839. Epub 2021 Jul 28.

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands. Electronic address:

Background And Aims: Serotonergic and dopaminergic systems in the brain are essential for homeostatic and reward-associated regulation of food intake and systemic energy metabolism. It is largely unknown how fasting influences these systems or if such effects are altered in humans with obesity. We therefore aimed to evaluate the effects of fasting on hypothalamic/thalamic serotonin transporter (SERT) and striatal dopamine transporter (DAT) availability in lean subjects and subjects with obesity. Read More

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Oral vaccination with attenuated Salmonella encoding the Trichinella spiralis 43-kDa protein elicits protective immunity in BALB/c mice.

Acta Trop 2021 Jul 28:106071. Epub 2021 Jul 28.

College of Veterinary Medicine, Jilin Agricultural University, Changchun, China; Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Agricultural University, Changchun, China; Key Laboratory of animal production and product quality safety of Ministry of Education, Jilin Agricultural University, Changchun, China. Electronic address:

A vaccine against Trichinella spiralis infection is urgently needed to interrupt its transmission from domestic animals to humans. However, no vaccine against T. spiralis is currently available. Read More

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Hepatic mitochondrial SAB deletion or knockdown alleviates diet induced metabolic syndrome, steatohepatitis and hepatic fibrosis.

Hepatology 2021 Jul 31. Epub 2021 Jul 31.

USC Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

The hepatic MAPK cascade leading to JNK activation has been implicated in the pathogenesis of nonalcoholic fatty liver /non-alcoholic steatohepatitis (NAFL/NASH). In acute hepatotoxicity we previously identified a pivotal role for mitochondrial SH3BP5 (SAB) as a target of JNK which sustains its activation through promotion of reactive oxygen species (ROS) production.

Aim: Assess the role of hepatic SAB in experimental NASH and metabolic syndrome. Read More

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Dynamics of Decision-Making in Medical Pluralism: A Systematic Review of Conceptual Models.

Altern Ther Health Med 2021 Jul 31. Epub 2021 Jul 31.

Purpose: Plurality of treatment choice is often observed, as in many instances people choose to use both conventional and complementary and alternative medicine (CAM). The existing models of healthcare utilization or healthcare behavior do not specifically address this medical pluralism. Hence, to understand an individual's pluralistic choice of treatment, major studies describing this have been systematically reviewed in this study in order to extract the principal factors driving such choice. Read More

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Relationship Between Acanthosis Nigricans, Acrochordon and Metabolic Syndrome in Patients with Lichen Planus.

Int J Clin Pract 2021 Jul 31:e14687. Epub 2021 Jul 31.

Necmettin Erbakan University Meram Medical Faculty, Department of Public Health, Turkey.

Aim: In the literature, there are no data examining the association with lichen planus with acanthosis nigricans and acrochordon, which are skin findings of metabolic syndrome (MS).

Materials: 108 lichen planus (LP) cases, age and sex-matched 109 controls, 217 cases in total were prospectively included in the study.

Results: Metabolic Syndrome was found in 55 (50. Read More

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Multiple Inducers of endothelial NOS (eNOS) Dysfunction in Sickle Cell Disease.

Am J Hematol 2021 Jul 31. Epub 2021 Jul 31.

Division of Hematology-Oncology-Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.

A characteristic aspect of the robust, systemic inflammatory state in sickle cell disease is dysfunction of endothelial nitric oxide synthase (eNOS). We identify ten aberrant endothelial cell inputs, present in the specific sickle context, that are known to have the ability to cause eNOS dysfunction. These are: endothelial arginase depletion, asymmetric dimethylarginine, complement activation, endothelial glycocalyx degradation, free fatty acids, inflammatory mediators, microparticles, oxidized low density lipoproteins, reactive oxygen species, and Toll-like receptor 4 signaling ligands. Read More

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Submicron particle docetaxel intratumoral injection in combination with anti-mCTLA-4 into 4T1-Luc orthotopic implants reduces primary tumor and metastatic pulmonary lesions.

Med Oncol 2021 Jul 31;38(9):106. Epub 2021 Jul 31.

US Biotest, Inc., 231 Bonetti Drive, Suite 240, San Luis Obispo, CA, USA.

We describe here characterization of the response of local and metastatic disease and immunomodulation following intratumoral (IT) injection of submicron particle docetaxel (SPD) administered alone or in combination with systemic antibody anti-mCTLA-4 (anti-mCTLA-4) in the metastatic 4T1-Luc2-1A4 (4T1) murine breast cancer model. In-life assessments of treatment tolerance, tumor volume (TV), and metastasis were performed (n = 10 animals/group). At study end, immune cell populations in tumor-site tissues and peripheral blood were analyzed using flow cytometry. Read More

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A systematic review of carbohydrate-based microneedles: current status and future prospects.

J Mater Sci Mater Med 2021 Jul 31;32(8):89. Epub 2021 Jul 31.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Vile Parle [W], Mumbai, 400056, Maharashtra, India.

Microneedles (MNs) are minimally invasive tridimensional biomedical devices that bypass the skin barrier resulting in systemic and localized pharmacological effects. Historically, biomaterials such as carbohydrates, due to their physicochemical properties, have been used widely to fabricate MNs. Owing to their broad spectrum of functional groups, carbohydrates permit designing and engineering with tunable properties and functionalities. Read More

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A Comparative Study of Invasive Modalities for Evaluation of Pulmonary Arteriovenous Fistula after Bidirectional Glenn Shunt.

Pediatr Cardiol 2021 Jul 31. Epub 2021 Jul 31.

Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, 695011, India.

Development of pulmonary AV fistula (PAVF) after bidirectional glenn shunt (BDG) results in significant cyanosis, impaired exercise performance, and increased morbidity and mortality. We attempted to detect and quantify PAVF in post-BDG patients by saline contrast transesophageal echocardiography (TEE) and compare with pulmonary angiography and pulmonary vein oximetry. This was a prospective study done between 2017 and 2018. Read More

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Microorganisms: crucial players of smokeless tobacco for several health attributes.

Appl Microbiol Biotechnol 2021 Jul 31. Epub 2021 Jul 31.

Department of Environmental Microbiology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, 226025, India.

Global consumption of smokeless tobacco (SLT) reached 300 million users worldwide majorly from middle-income countries. More than 4000 chemical compounds represent it as one of the noxious consumable products by humans. Besides toxicants/carcinogens, the heavy microbial load on smokeless tobacco further keeps human health at higher risk. Read More

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Correlation between Echocardiographic Left Ventricular Hypertrophy and various Electrocardiographic Criteria of Left Ventricular Hypertrophy among Black Hypertensives.

West Afr J Med 2021 Jul;38(7):695-700

Department of Medicine, Usmanu Danfodiyo University Teaching Hospital, Sokoto.

Background: Systemic hypertension remains an important risk factor for cardiovascular diseases and a major global public health problem. Left ventricular hypertrophy (LVH) is a recognized complication of systemic hypertension and strongly predicts cardiovascular morbidity and mortality. In Nigeria, few studies have evaluated the correlation of ECG criteria in the diagnosis of left ventricular hypertrophy among hypertensives and almost all the previous studies on ECG LVH used only one or two criteria. Read More

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Elevated urinary mutagenicity among those exposed to bituminous coal combustion emissions or diesel engine exhaust.

Environ Mol Mutagen 2021 Jul 31. Epub 2021 Jul 31.

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Urinary mutagenicity reflects systemic exposure to complex mixtures of genotoxic/carcinogenic agents and is linked to tumor development. Coal combustion emissions (CCE) and diesel engine exhaust (DEE) are associated with cancers of the lung and other sites, but their influence on urinary mutagenicity is unclear. We investigated associations between exposure to CCE or DEE and urinary mutagenicity. Read More

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Impurity Profiling and Stability-Indicating Method Development and Validation for the Estimation of Assay and Degradation Impurities of Midostaurin in Softgel Capsules by HPLC and LC-MS.

Biomed Chromatogr 2021 Jul 31:e5222. Epub 2021 Jul 31.

JMJ College for Women, Tenali, Guntur (Dist.), India.

Midostaurin (MDS) is used for treatment of acute myeloid leukemia, myelodysplastic syndrome and advanced systemic mastocytosis. Sample of MDS softgel capsules were subjected to stress testing as per ICH guidelines for the impurity profiling study. MDS had undergone extensively degradation under the stress-testing (acid, alkaline, oxidative, photolytic, thermolytic and hydrolysis conditions) and formed four degradation products (DPs). Read More

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Exogenous Intake of Fluorides in Caries Prevention: Benefits and Risks.

Acta Medica (Hradec Kralove) 2021 ;64(2):71-76

Department of Dentistry, Faculty of Medicine, Charles University and University Hospital, Pilsen, Czech Republic.

Caries incidence and prevalence have decreased significantly over the last few decades due to widespread use of fluoride. However, an increase in the prevalence of dental fluorosis has been reported in both fluoridated and non-fluoridated communities. Care must be taken to ensure that a balance between the optimal fluoride preventive effect at the individual and community level and minimal risk of dental fluorosis is maintained. Read More

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January 2021

A systematic review and gap analysis of frailty and oral health characteristics in older adults: A call for clinical translation.

Gerodontology 2021 Jul 30. Epub 2021 Jul 30.

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Objective: This systematic review updates the evidence for association between oral health characteristics and frailty status, identifying gaps in translational dental research and application of frailty assessment into clinical practice.

Background: Clinicians have little guidance on stage-appropriate dental treatment for medically complex older adults. Oral health characteristics have been associated with frailty status, determined through validated assessment tools representing a concise measure of health. Read More

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Nanomedicine-based combination of dexamethasone palmitate and MCL-1 siRNA for synergistic therapeutic efficacy against rheumatoid arthritis.

Drug Deliv Transl Res 2021 Jul 30. Epub 2021 Jul 30.

Department of Rheumatology and Immunology, Yantaishan Hospital, Yantai, 264000, Shandong, China.

The main aim of this research was to design a MCL-1 siRNA and dexamethasone (DEX)-loaded folate modified poly(lactide-co-glycolide) (PLGA)-based polymeric micelles with an eventual goal to improve the therapeutic outcome in the rheumatoid arthritis (RA). Polymeric micelles encapsulating the MCL-1 siRNA and DEX was successfully developed and observed to be stable. Physicochemical characteristics such as particle size and particle morphology were ideal for the systemic administration. Read More

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