7,436 results match your criteria systematically varied


Current progress and quality of radiomic studies for predicting EGFR mutation in patients with non-small cell lung cancer using PET/CT images: a systematic review.

Br J Radiol 2021 Apr 21:20201272. Epub 2021 Apr 21.

Department of Radiology, The First People's Hospital of Kashi Area, Kashi, Xinjiang, China.

Objectives: To assess the methodological quality of radiomic studies based on positron emission tomography/computed tomography (PET/CT) images predicting epidermal growth factor receptor (EGFR) mutation status in patients with non-small cell lung cancer (NSCLC).

Methods: We systematically searched for eligible studies in the PubMed and Web of Science datasets using the terms "radiomics", "PET/CT", "NSCLC", and "EGFR". The included studies were screened by two reviewers independently. Read More

View Article and Full-Text PDF

Adult female urinary incontinence guidelines: a systematic review of evaluation guidelines across clinical specialties.

Int Urogynecol J 2021 Apr 21. Epub 2021 Apr 21.

Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, USA.

Introduction And Hypothesis: To systematically review evaluation guidelines of uncomplicated urinary incontinence (UI) in community-dwelling adult women to assess guidance available to the full range of providers treating UI.

Methods: Systematic literature search of eight bibliographic databases. We included UI evaluation guidelines written for medical providers in English after January 1, 2008. Read More

View Article and Full-Text PDF

Reproducible Quantitative Stimulation Allows New Analysis of Crayfish Muscle Receptor Organ Responses.

J Undergrad Neurosci Educ 2020 31;19(1):A1-A20. Epub 2020 Dec 31.

Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544.

The crustacean muscle receptor organ (MRO) has provided a particularly accessible preparation for the study of sensory coding, which has been widely used in introductory laboratory courses incorporating extracellular recording from sensory nerves in living preparations. We describe three innovations to the standard laboratory exercise using the MRO: (1) a new form of suction electrode to facilitate extracellular recording; (2) a new, Arduino-driven actuator to allow reproducible and quantifiable mechanical stimulation of the MRO; and (3) a new approach to the crayfish abdomen preparation that allows linear extension of the MRO muscles. These novel approaches allow the collection of data sets comprised of sensory cell spike trains under software control as important mechanical stimulus parameters are varied systematically through software. Read More

View Article and Full-Text PDF
December 2020

Molecular genetic analysis of pollen irradiation mutagenesis in Arabidopsis.

New Phytol 2004 Nov;164(2):279-288

Plant Sciences Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK.

•  Pollen γ-irradiation mutagenesis was systematically investigated to generate targeted mutations in Arabidopsis. •  Irradiation effects on viability, germination and frequency of loci deletions were evaluated. •  Mutation frequency increased with irradiation dose and varied depending upon pollen developmental stage. Read More

View Article and Full-Text PDF
November 2004

Fermentation characteristics and bacterial dynamics during Chinese sauerkraut fermentation by Lactobacillus curvatus LC-20 under varied salt concentrations reveal its potential in low-salt suan cai production.

J Biosci Bioeng 2021 Apr 14. Epub 2021 Apr 14.

College of Life Sciences, Northeast Forestry University, Harbin, Heilongjiang 150036, China. Electronic address:

Salt profoundly affects the physicochemical properties and microbial abundance of fermented foods such as suan cai, a popular traditional fermented food in China. It is vital to systematically investigate the effects of salt concentrations on fermented suan cai for high fermentation quality and large-scale production. We elucidated the effects of salt concentrations on Lactobacillus curvatus (LC-20) and suan cai during fermentation, and found that salt (0-1%) favoured an increase in LC-20 growth and a decrease in pH (salt: 0-2%). Read More

View Article and Full-Text PDF

Sex Disparities in Cardiovascular Risk Factor Assessment and Screening for Diabetes-Related Complications in Individuals With Diabetes: A Systematic Review.

Front Endocrinol (Lausanne) 2021 30;12:617902. Epub 2021 Mar 30.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Background: Insight in sex disparities in the detection of cardiovascular risk factors and diabetes-related complications may improve diabetes care. The aim of this systematic review is to study whether sex disparities exist in the assessment of cardiovascular risk factors and screening for diabetes-related complications.

Methods: PubMed was systematically searched up to April 2020, followed by manual reference screening and citations checks (snowballing) using Google Scholar. Read More

View Article and Full-Text PDF

Consistency in Motion Event Encoding Across Languages.

Front Psychol 2021 30;12:625153. Epub 2021 Mar 30.

Department of Linguistics, Stockholm University, Stockholm, Sweden.

Syntactic templates serve as schemas, allowing speakers to describe complex events in a systematic fashion. Motion events have long served as a prime example of how different languages favor different syntactic frames, in turn biasing their speakers toward different event conceptualizations. However, there is also variability in how motion events are syntactically framed within languages. Read More

View Article and Full-Text PDF

Maternal pre- and postnatal substance use and attachment in young children: A systematic review and meta-analysis.

Dev Psychopathol 2021 Apr 16:1-18. Epub 2021 Apr 16.

Faculty of Social Sciences/Psychology, Tampere University, Tampere, Finland.

Maternal substance use has often been associated with insecure and disorganized child attachment. We evaluated this association with a meta-analysis of young children and, further, systematically reviewed mediating and moderating factors between maternal substance use and child attachment. We performed a systematic database search of quantitative English language studies on child attachment that included substance-using mothers and their children below 6 years of age. Read More

View Article and Full-Text PDF

Comparison of stereotactic body radiotherapy and radiofrequency ablation for hepatocellular carcinoma: systematic review and meta-analysis of propensity score studies.

Hepatol Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Pulmonology, Yokohama city university graduate school of medicine, Yokohama, Kanagawa, Japan.

Aim: Stereotactic body radiotherapy (SBRT) is emerging treatment for hepatocellular carcinoma (HCC) and has shown excellent local control (LC) as with radiofrequency ablation (RFA). Since no randomized controlled trial compared SBRT and RFA for HCC, data from propensity score matched study (PSMS) is valuable. However, the results greatly varied and depend on composing factors of Barcelona Clinic Liver Cancer staging (BCLC-factors) adjusted. Read More

View Article and Full-Text PDF

mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity.

Brief Bioinform 2021 Apr 14. Epub 2021 Apr 14.

Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.

MicroRNA (miRNA) is not a single sequence, but a series of multiple variants (also termed isomiRs) with sequence and expression heterogeneity. Whether and how these isoforms contribute to functional variation and complexity at the systems and network levels remain largely unknown. To explore this question systematically, we comprehensively analyzed the expression of small RNAs and their target sites to interrogate functional variations between novel isomiRs and their canonical miRNA sequences. Read More

View Article and Full-Text PDF

The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.

Immunity 2021 Apr;54(4):660-672.e9

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA. Electronic address:

Interleukin-22 (IL-22) acts on epithelial cells to promote tissue protection and regeneration, but can also elicit pro-inflammatory effects, contributing to disease pathology. Here, we engineered a high-affinity IL-22 super-agonist that enabled the structure determination of the IL-22-IL-22Rα-IL-10Rβ ternary complex to a resolution of 2.6 Å. Read More

View Article and Full-Text PDF

Coupling between the phase of a neural oscillation or bodily rhythm with behavior: evaluation of different statistical procedures.

Neuroimage 2021 Apr 10:118050. Epub 2021 Apr 10.

Laboratoire de Neurosciences Cognitives et Computationnelles, Ecole Normale Supérieure, Inserm u960, PSL University, Paris, France.

Growing experimental evidence points at relationships between the phase of a cortical or bodily oscillation and behavior, using various circular statistical tests. Here, we systematically compare the performance (sensitivity, False Positive rate) of four circular statistical tests (some commonly used, i.e. Read More

View Article and Full-Text PDF

Metformin, A Potential Role in Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.

Ophthalmol Ther 2021 Apr 12. Epub 2021 Apr 12.

Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK.

Background: Currently, no generally approved medical treatment can delay the onset of age-related macular degeneration (AMD) or slow the progression of degenerative changes. Repurposing drugs with beneficial effects on AMD pathophysiology offers a route to new treatments which is faster, cost-effective, and safer for patients. Recent studies indicate a potential role for metformin in delaying AMD development and progression. Read More

View Article and Full-Text PDF

The anatomical basis behind the neuromodulation effects associated with pulmonary vein isolation.

J Cardiovasc Electrophysiol 2021 Apr 12. Epub 2021 Apr 12.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, UK.

The anatomical basis underlying the neuromodulation effects seen with pulmonary vein (PV) isolation (PVI) is not fully understood. Left atrial (LA) electro-anatomical maps of 38 patients who underwent catheter cardioneuroablation for vagally mediated bradycarrhythmias (VMB) were studied. During the procedure, LA ganglionic plexi (GPs) were systematically identified and ablated. Read More

View Article and Full-Text PDF

Contemporary outcomes of continuous-flow left ventricular assist devices-a systematic review.

Ann Cardiothorac Surg 2021 Mar;10(2):186-208

Division of Cardiac Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Background: End stage heart failure is a major cause of morbidity and mortality, and its prevalence is expected to rise with the ageing population. For suitable patients, orthotopic heart transplantation remains the gold standard therapy, however, a paucity of donor organs has led to the development of left ventricular assist devices (LVAD). These devices can be utilized as either a bridge-to-transplant (BTT) or as an alternative to heart transplantation. Read More

View Article and Full-Text PDF

Knowledge and practice of diabetic foot care - A scoping review.

Diabetes Metab Syndr 2021 Mar 31;15(3):783-793. Epub 2021 Mar 31.

Gastrointestinal Cancer Research Group, Department of General Surgery, University of KwaZulu-Natal, Durban, South Africa.

Background And Aims: This review aims to systematically map global evidence on foot-care knowledge and practices in relation to diabetes mellitus (DM) and identify areas that need further research.

Methods: Database searches were undertaken using Google Scholar, Medline (PubMed), Academic Search Complete (EBSCOhost), and Medline (EBSCOhost). Studies were initially sought by title and focused on knowledge of diabetic foot ulcer burden. Read More

View Article and Full-Text PDF

Effect of the Molecular Conformation on Excitation Energy Transfer in Conformationally Constrained Boryl-BODIPY Dyads.

Inorg Chem 2021 Apr 8;60(8):5452-5462. Epub 2021 Apr 8.

Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.

We studied the dual emission characteristics of a series of boryl-BODIPYs (-) comprised of triarylborane (TAB) as an energy donor and BODIPY as an energy acceptor. The molecular conformations of dyads - were systematically tuned by judiciously changing the spacer that bridged the boryl and BODIPY moieties. Frontier molecular orbitals (FMOs) are localized in , , and with a twisted molecular conformation. Read More

View Article and Full-Text PDF

Shared decision making for children with chronic respiratory failure-It takes a village and a process.

Pediatr Pulmonol 2021 Apr 8. Epub 2021 Apr 8.

Department of Pediatrics, Stony Brook Children's Hospital, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.

Background And Objectives: Shared decision making (SDM) before nonurgent tracheostomy in a child with chronic respiratory failure (CRF) is often recommended, but has proven challenging to implement in practice. We hypothesize that utilization of the microsystem model for analysis of the complex ecosystem in which SDM occurs will yield insights that enable formation of a reproducible, measurable SDM process.

Methods: Retrospective chart review of a case series of children with CRF in whom a SDM process was pursued. Read More

View Article and Full-Text PDF

The impact of fracture liaison services on subsequent fractures and mortality: a systematic literature review and meta-analysis.

Osteoporos Int 2021 Apr 7. Epub 2021 Apr 7.

Department of Internal Medicine, VieCuri Medical Centre, Venlo, The Netherlands.

This systematic review and meta-analysis suggests that fracture liaison service (FLS) is associated with a significantly lower probability of subsequent fractures and mortality although the latter was only found in studies comparing outcomes before and after the introduction of an FLS.

Introduction: To systematically review and evaluate the impact of fracture liaison services (FLSs) on subsequent fractures and mortality using meta-analysis.

Methods: A literature search was performed within PubMed and Embase to identify original articles published between January 1, 2010, and April 30, 2020, reporting the effect of FLSs on subsequent fractures and/or mortality. Read More

View Article and Full-Text PDF

The effects of mobile health on emergency care in low- and middle-income countries: A systematic review and narrative synthesis.

J Glob Health 2021 Apr 3;11:04023. Epub 2021 Apr 3.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Background: In resource-constrained settings, mobile health (mHealth) has varied applications. While there is strong evidence for its use in chronic disease management, the applications of mHealth for management of acute illness in low- and middle-income countries (LMICs) are not as well described. This review systematically explores current available evidence on the effectiveness of mHealth interventions at improving health outcomes in emergency care settings in LMICs. Read More

View Article and Full-Text PDF

Toughening and polymerization stress control in composites using thiourethane-treated fillers.

Sci Rep 2021 Apr 7;11(1):7638. Epub 2021 Apr 7.

Division of Biomaterials and Biomechanics, Department of Restorative Dentistry, Oregon Health & Science University, Portland, OR, USA.

Filler particle functionalization with thiourethane oligomers has been shown to increase fracture toughness and decrease polymerization stress in dental composites, though the mechanism is poorly understood. The aim of this study was to systematically characterize the effect of the type of filler surface functionalization on the physicochemical properties of experimental resin composites containing fillers of different size and volume fraction. Barium glass fillers (1, 3 and 10 µm) were functionalized with 2 wt% thiourethane-silane (TU-Sil) synthesized de novo and characterized by thermogravimetric analysis. Read More

View Article and Full-Text PDF

Clinical features of parainfluenza infections among young children hospitalized for acute respiratory illness in Amman, Jordan.

BMC Infect Dis 2021 Apr 7;21(1):323. Epub 2021 Apr 7.

Department of Pediatrics, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.

Background: Parainfluenza virus (PIV) is a leading cause of acute respiratory illness (ARI) in children. However, few studies have characterized the clinical features and outcomes associated with PIV infections among young children in the Middle East.

Methods: We conducted hospital-based surveillance for ARI among children < 2 years of age in a large referral hospital in Amman, Jordan. Read More

View Article and Full-Text PDF

Synergistics of FeC and Fe on Mesoporous Fe-N-C Sulfur Host for Nearly Complete and Fast Lithium Polysulfide Conversion.

ACS Appl Mater Interfaces 2021 Apr 6;13(15):17791-17799. Epub 2021 Apr 6.

Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.

The practical deployment of advanced Li-S batteries is severely constrained by the uncontrollable lithium polysulfide conversion under realistic conditions. Although a plethora of advanced sulfur hosts and electrocatalysts have been examined, the fundamental mechanisms are still elusive and predictive design approaches have not yet been established. Here, we examined a series of well-defined Fe-N-C sulfur hosts with systematically varied and strongly coupled FeC and Fe electrocatalysts, prepared by one-step pyrolysis of a novel Fe[Fe(CN)]/polypyrrole composite at different temperatures. Read More

View Article and Full-Text PDF

Reduced Biofilm Formation at the Air-Liquid-Solid Interface via Introduction of Surfactants.

ACS Biomater Sci Eng 2021 Apr 6. Epub 2021 Apr 6.

Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.

Reduced biofilm formation is highly desirable in applications ranging from transportation to separations and healthcare. Biofilms often form at the three-phase interface where air, liquid, and solid coexist due to the close proximity to nutrients and oxygen. Reducing biofilm formation at the triple interface presents challenges because of the conflicting requirements for hydrophobicity at the air-solid interface (for self-cleaning properties) and for hydrophilicity at the liquid-solid interface (for reduced foulant adhesion). Read More

View Article and Full-Text PDF

Dysbiosis of the Human Oral Microbiome During the Menstrual Cycle and Vulnerability to the External Exposures of Smoking and Dietary Sugar.

Front Cell Infect Microbiol 2021 19;11:625229. Epub 2021 Mar 19.

Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Physiological hormonal fluctuations exert endogenous pressures on the structure and function of the human microbiome. As such, the menstrual cycle may selectively disrupt the homeostasis of the resident oral microbiome, thus compromising oral health. Hence, the aim of the present study was to structurally and functionally profile the salivary microbiome of 103 women in reproductive age with regular menstrual cycle, while evaluating the modifying influences of hormonal contraceptives, sex hormones, diet, and smoking. Read More

View Article and Full-Text PDF

Impact of differences in acute respiratory distress syndrome randomised controlled trial inclusion and exclusion criteria: systematic review and meta-analysis.

Br J Anaesth 2021 Apr 1. Epub 2021 Apr 1.

Critical Care, Guy's and St Thomas' NHS Foundation Trust, London, UK; School of Immunology & Microbial Sciences, King's College London, London, UK. Electronic address:

Background: Control-arm mortality varies between acute respiratory distress syndrome (ARDS) RCTs.

Methods: We systematically reviewed ARDS RCTs that commenced recruitment after publication of the American-European Consensus (AECC) definition (MEDLINE, Embase, and Cochrane central register of controlled trials; January 1994 to October 2020). We assessed concordance of RCT inclusion criteria to ARDS consensus definitions and whether exclusion criteria are strongly or poorly justified. Read More

View Article and Full-Text PDF

RNA sequence and structure determinants of Pol III transcriptional termination in human cells.

J Mol Biol 2021 Mar 31:166978. Epub 2021 Mar 31.

Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd, Evanston, IL, 60208, USA; Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd, Evanston, IL, 60208, USA.

The precise mechanism of transcription termination of the eukaryotic RNA polymerase III (Pol III) has been a subject of considerable debate. Although previous studies have clearly shown that multiple uracils at the end of RNA transcripts are required for Pol III termination, the effects of upstream RNA secondary structure in the nascent transcript on transcriptional termination is still unclear. To address this, we developed an in cellulo Pol III transcription termination assay using the recently developed Tornado-Corn RNA aptamer system to create a Pol III-transcribed RNA that produces a detectable fluorescent signal when transcribed in human cells. Read More

View Article and Full-Text PDF

Secondary Structure Libraries for Artificial Evolution Experiments.

Molecules 2021 Mar 17;26(6). Epub 2021 Mar 17.

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 166 10 Prague, Czech Republic.

Methods of artificial evolution such as SELEX and in vitro selection have made it possible to isolate RNA and DNA motifs with a wide range of functions from large random sequence libraries. Once the primary sequence of a functional motif is known, the sequence space around it can be comprehensively explored using a combination of random mutagenesis and selection. However, methods to explore the sequence space of a secondary structure are not as well characterized. Read More

View Article and Full-Text PDF

National Colorectal Cancer Screening Program in Lithuania: Description of the 5-Year Performance on Population Level.

Cancers (Basel) 2021 Mar 6;13(5). Epub 2021 Mar 6.

Laboratory of Cancer Epidemiology, National Cancer Institute, LT-08406 Vilnius, Lithuania.

We aimed to report the results of the implementation of the National Colorectal Cancer (CRC) Screening Program covering all the country. The National Health Insurance Fund (NHIF) reimburses the institutions for performing each service; each procedure within the program has its own administrative code. Information about services provided within the program was retrieved from the database of NHIF starting from the 1 January 2014 to the 31 December 2018. Read More

View Article and Full-Text PDF