80,641 results match your criteria system involvement

[Electroretinography in evaluation of neuroprotective effect in an experimental model of glaucoma].

Vestn Oftalmol 2021 ;137(3):86-92

Research Institute of Pharmacology of Living Systems of the Belgorod State University, Belgorod, Russia.

For drugs that have a therapeutic effect on glaucoma through mechanisms not associated with decreasing intraocular pressure (IOP), special attention is paid to the choice of effectiveness criteria. The article examines the possibility of using - and waves of electroretinography (ERG) in preclinical studies to predict the effectiveness of glaucoma drug candidates.

Purpose: To examine the possibility of reliably associating changes in the amplitude of - and ERG waves with functional changes in the retina of experimental glaucoma rats with morphological evidence of loss of functional integrity of the retina. Read More

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January 2021

ANCA-associated vasculitis with protein-losing enteropathy is characterized by hypocomplementemia.

Rheumatol Int 2021 Jun 22. Epub 2021 Jun 22.

Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Protein-losing enteropathy (PLE) has been reported to be associated with various systemic autoimmune diseases. However, reports regarding PLE in ANCA-associated vasculitis (AAV) patients are limited. We herein aimed to describe the clinical characteristics of AAV with PLE. Read More

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Polymorphism in miRNA target sites of and ring complex influences expression of CEP genes and favors tumorigenesis in glioma.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Cancer Genetics & Epigenetics Lab, Department of Biosciences, COMSATS University Islamabad, Park Road Tarlai Kalan, Islamabad, 44000, Pakistan.

The present study was designed to screen the genetic polymorphisms and expression profiling of and genes in brain tumor patients. The amplification refractory mutation system PCR technique (ARMS-PCR) was used for mutation analysis using 300 blood samples of brain tumor patients and 300 overtly healthy controls. For expression analysis, 150 brain tumor tissue samples along with adjacent uninvolved/normal tissues (controls) were collected. Read More

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Study protocol of a factorial trial ECHO: optimizing a group-based school intervention for children with emotional problems.

BMC Psychol 2021 Jun 21;9(1):97. Epub 2021 Jun 21.

The Center for Child and Adolescent Mental Health - Eastern and Southern Norway, Postboks 4623, 0405, Nydalen, Oslo, Norway.

Background: Youth mental health problems are a major public health concern. Anxiety and depression are among the most common psychological difficulties. The aim of this study is to evaluate an optimized version of a promising indicated group intervention for emotional problems. Read More

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Levels of lymphocyte-associated regulators of complement system CD55 and CD59 are changed in schizophrenia patients.

Int J Psychiatry Clin Pract 2021 Jun 21:1-6. Epub 2021 Jun 21.

Department of Medical Microbiology, School of Medicine, Akdeniz University, Antalya, Turkey.

Objective: Although pathological mechanisms of schizophrenia are unknown, evidence in the literature suggests that the immune system might be involved in the pathogenesis. Complement is an important part of the immune system and it has been suggested to play role in the pathogenesis of schizophrenia. We aimed to investigate the potential involvement of the complement system in schizophrenia by the determination of peripheral concentrations of certain complement proteins and their regulators in patients. Read More

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Capecitabine-induced hyperammonemic encephalopathy.

Rev Esp Enferm Dig 2021 Jun 22. Epub 2021 Jun 22.

Aparato Digestivo, Hospital Universitario San Agustín, España.

Central nervous system involvement is an uncommon side effect of fluoropyrimidine-based chemotherapy regimens. We report the case of a 79-yer-old male who presented with hyperammonemic encephalopathy shortly after treatment onset with capecitabine monotherapy for local progression of a a mucus-secreting pancreatic adenocarcinoma, with complete clinical resolution upon capecitabine discontinuation in association with supportive treatment. Read More

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Knockout of FosB gene changes drug sensitivity and invasion activity via the regulation of Bcl-2, E-cadherin, β-catenin, and vimentin expression.

Biochem Biophys Res Commun 2021 Jun 18;567:131-137. Epub 2021 Jun 18.

Department of Biological Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address:

Our previous research suggested the presence of a novel SETDB1-mediated FosB pathway that could be responsible for the regulation of cell proliferation and invasiveness during anticancer treatments. In this study, we prepared FosB knock-out (FosB-KO) A549 human lung cancer cells using the CRISPR/Cas9 system and examined the physiological and molecular changes that caused. Annexin V and TUNEL assays showed that FosB-KO clones were less sensitive to doxorubicin treatment compared to the control A549 cells. Read More

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Neurosci Biobehav Rev 2021 Jun 18. Epub 2021 Jun 18.

Department of Neurology and ALS Centre, University of Piemonte Orientale, Maggiore della Carità Hospital, Corso Mazzini 18, Novara, 28100, Italy. Electronic address:

Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative disease. Despite decades of research and many new insights into disease biology over the 150 years since the disease was first described, causative pathogenic mechanisms in ALS remain poorly understood, especially in sporadic cases. Our understanding of the role of the immune system in ALS pathophysiology, however, is rapidly expanding. Read More

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Kappa opioid receptor modulation of endometriosis pain in mice.

Neuropharmacology 2021 Jun 18:108677. Epub 2021 Jun 18.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra. Barcelona, Spain; IMIM (Hospital Del Mar Medical Research Institute), Barcelona, Spain. Electronic address:

The kappa opioid receptor is a constituent of the endogenous opioid analgesia system widely expressed in somatosensory nervous pathways and also in endometrial tissues. This work investigates the possible involvement of kappa opioid receptor on the nociceptive, behavioral and histopathological manifestations of endometriosis in a murine model. Female mice receiving endometrial implants develop a persistent mechanical hypersensitivity in the pelvic area that is stronger during the estrus phase of the estrous cycle. Read More

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Occupational and Personal Consequences of the COVID-19 Pandemic on US Oncologist Burnout and Well-Being: A Study From the ASCO Clinician Well-Being Task Force.

JCO Oncol Pract 2021 Jun 21:OP2100147. Epub 2021 Jun 21.

Northern California (NCAL), Kaiser Permanente, Oakland, CA.

Introduction: The COVID-19 pandemic is an unprecedented global crisis profoundly affecting oncology care delivery.

Purpose: This study will describe the occupational and personal consequences of the COVID-19 pandemic on oncologist well-being and patient care.

Materials And Methods: Four virtual focus groups were conducted with US ASCO member oncologists (September-November 2020). Read More

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Relationship of complement activation pathway to clinical and pathological characteristics and renal outcome in patients with lupus nephritis.

Z Rheumatol 2021 Jun 21. Epub 2021 Jun 21.

Department of Nephrology, First Affiliated Hospital of Soochow University, 215006, Suzhou, China.

Background: Involvement of the complement system in the pathogenesis of lupus nephritis (LN) is well accepted, but its exact role remains unclear. The aim of this study was to investigate the relationship of complement activation pathway to clinical and pathological characteristics and renal outcome in patients with LN.

Material And Methods: Patients with LN were divided into two groups: those in whom the complement system was mainly activated through the classical pathway (low serum C3 and C4 levels; CP group); and those in whom the complement system was solely activated through the alternative pathway (low serum C3 with normal C4 levels; AP group). Read More

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Functional Selectivity of a Biased Cannabinoid-1 Receptor (CBR) Antagonist.

ACS Pharmacol Transl Sci 2021 Jun 8;4(3):1175-1187. Epub 2021 Apr 8.

Laboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.

Seven-transmembrane receptors signal via G-protein- and β-arrestin-dependent pathways. We describe a peripheral CBR antagonist (MRI-1891) highly biased toward inhibiting CBR-induced β-arrestin-2 (βArr2) recruitment over G-protein activation. In obese wild-type and βArr2-knockout (KO) mice, MRI-1891 treatment reduces food intake and body weight without eliciting anxiety even at a high dose causing partial brain CBR occupancy. Read More

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Bilateral vision loss as the initial presentation for central nervous system involvement of mantle cell lymphoma: A case series.

Am J Ophthalmol Case Rep 2021 Sep 3;23:101131. Epub 2021 Jun 3.

Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.

Purpose: Mantle cell lymphoma is a rare aggressive subtype of non-Hodgkins B cell lymphoma. It typically presents with asymptomatic monoclonal lymphocytosis, lymphadenopathy or bulky extranodal disease. Mantle cell lymphoma rarely affects the central nervous system. Read More

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September 2021

Major Differences in Lymphocyte Subpopulations Between Cerebrospinal Fluid and Peripheral Blood in Non-Hodgkin Lymphoma Without Leptomeningeal Involvement: Flow Cytometry Evidence of a Cerebral Lymphatic System.

Front Oncol 2021 3;11:685786. Epub 2021 Jun 3.

Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Cerebrospinal fluid (CSF) flow cytometry has a crucial role in the diagnosis of leptomeningeal disease in onco-hematology. This report describes the flow cytometry characterization of 138 CSF samples from patients affected by non-Hodgkin lymphoma, negative for disease infiltration. The aim was to focus on the CSF non-neoplastic population, to compare the cellular composition of the CSF with paired peripheral blood samples and to document the feasibility of flow cytometry in hypocellular samples. Read More

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Oncological Outcomes of Patients With Different Pathological Features of pT3a Renal Tumor: A Systematic Review and Quantitative Synthesis.

Front Oncol 2021 3;11:678459. Epub 2021 Jun 3.

Department of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Purpose: To identify the differences in oncological outcomes for patients with different pT3a renal tumor invasion patterns and pathological features.

Methods: The protocol of this study was registered on PROSPERO (CRD42021234475). Relevant studies were identified by searching the PubMed, Cochrane library, Embase, and Web of Science databases. Read More

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Mental Health of High-Risk Urban Youth: The Housing Subsidies Paradox.

Race Soc Probl 2021 Mar 9;13(1):22-33. Epub 2021 Mar 9.

Global Psychiatric Epidemiology Group, Division of Child and Adolescent Psychiatry, Department of Psychiatry, Columbia University-New York State Psychiatric Institute, room 5217, 1051 Riverside Drive, New York, 10032, USA.

Housing subsidies, including public housing and Section 8 vouchers, are key components of the social safety net, intended to promote family and child welfare. Studies evaluating the impact of housing subsidies on child and adolescent mental health, however, are generally inconclusive. This may reflect variation in the influence by type of subsidies to income, improved physical environment, increased access to resources, and improved perception of neighborhood safety. Read More

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Transcriptome Profiling Reveals a Novel Mechanism of Antiviral Immunity Upon Sacbrood Virus Infection in Honey Bee Larvae ().

Front Microbiol 2021 2;12:615893. Epub 2021 Jun 2.

Key Laboratory of Pollinating Insect Biology of the Ministry of Agriculture, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China.

The honey bee is one of the most important pollinators in the agricultural system and is responsible for pollinating a third of all food we eat. Sacbrood virus (SBV) is a member of the virus family and affects honey bee larvae and causes particularly devastating disease in the Asian honey bees, . Chinese Sacbrood virus (CSBV) is a geographic strain of SBV identified in China and has resulted in mass death of honey bees in China in recent years. Read More

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Bereitschaftspotential in Multiple System Atrophy.

Front Neurol 2021 2;12:608322. Epub 2021 Jun 2.

Department of Neurology, China Medical University Hospital, Taichung, Taiwan.

Multiple system atrophy (MSA) is a neurodegenerative disorder manifesting as parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is categorized into MSA with predominant parkinsonism (MSA-P) and into MSA with predominant cerebellar ataxia (MSA-C). The pathophysiology of motor control circuitry involvement in MSA subtype is unclear. Read More

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Ocular Manifestations: Are They Significant in Hypertensive Disorders of Pregnancy?

J Obstet Gynaecol India 2021 Apr 17;71(2):118-123. Epub 2020 Nov 17.

Department of Obstetrics and Gynecology, Government Medical College, Chnadra Villa, PO: West Hill, Chungam, Kozhikode, Kerala India.

Background: Hypertensive disorders of pregnancy lead to pathological changes in various organ systems of mother and fetus which contributes to maternal and fetal morbidity and mortality. It is a multisystem disorder which can involve end organs like kidneys, liver, eyes, hemopoietic system and placenta. Retinal involvement, though quite common, is rarely investigated. Read More

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Serotonin involvement in okadaic acid-induced diarrhoea in vivo.

Arch Toxicol 2021 Jun 20. Epub 2021 Jun 20.

Departamento de Farmacología, Facultad de Veterinaria, Universidade de Santiago de Compostela, 27002, Lugo, Spain.

The consumption of contaminated shellfish with okadaic acid (OA) group of toxins leads to diarrhoeic shellfish poisoning (DSP) characterized by a set of symptoms including nausea, vomiting and diarrhoea. These phycotoxins are Ser/Thr phosphatase inhibitors, which produce hyperphosphorylation in cellular proteins. However, this inhibition does not fully explain the symptomatology reported and other targets could be relevant to the toxicity. Read More

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Follicular Dendritic Cell Sarcoma of the Chest.

Ann Thorac Surg 2021 Jun 17. Epub 2021 Jun 17.

Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Follicular dendritic cell sarcoma is a rare, low-grade cancer derived from follicular dendritic cells, which serve as accessory cells to the lymphoid system. Here, we describe the case of a 57-year-old man who had a mediastinal mass with aortic involvement incidentally identified during evaluation for indeterminate pulmonary nodules. The mass, later diagnosed as follicular dendritic cell sarcoma, was successfully treated with surgical resection aided by placement of endovascular aortic stent graft. Read More

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Double Trap Interface: A novel gas interface for high throughput analysis of biomedical samples by AMS.

Drug Metab Pharmacokinet 2021 May 7;39:100400. Epub 2021 May 7.

Laboratory of Ion Beam Physics, ETH Zurich, Otto-Stern-Weg 5, 8093, Zurich, Switzerland. Electronic address:

Although Accelerator Mass Spectrometry (AMS) offers unparalleled sensitivity by investigating the fate of C-labeled compounds within the organism, its widespread use in ADME (absorption, distribution, metabolism, excretion) studies is limited. Conventional approaches based on Liquid Scintillation Counting (LSC) are still preferred, in particular because of complexity and costs associated with AMS measurements. Progress made over the last decade towards more compact AMS systems increased the interest in a combustion-based AMS approach allowing the analysis of samples in gaseous form. Read More

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Silicon-induced mitigation of drought stress in peanut genotypes (Arachis hypogaea L.) through ion homeostasis, modulations of antioxidative defense system, and metabolic regulations.

Plant Physiol Biochem 2021 Jun 9;166:290-313. Epub 2021 Jun 9.

Plant Omics Division, CSIR- Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Gijubhai Badheka Marg, Bhavnagar, 364002, Gujarat, India; Academy of Scientific and Innovative Research, Ghaziabad, 201002, Uttar Pradesh, India. Electronic address:

Drought stress considered as a major environmental constraint that frequently limits crop production globally. In the current investigation, drought stress-induced alterations in growth, ion homeostasis, photosynthetic pigments, organic osmolytes, reactive oxygen species (ROS) generation, antioxidative components, and metabolic profile were examined in order to assess the role of silicon (Si) in mitigation of drought effects and to understand the drought adaptive mechanism in two contrasting peanut genotypes (GG7: fast growing and tall, TG26: slow growing and semi-dwarf). Si application significantly improved the leaf chlorophyll content, relative water content % (RWC %), growth and biomass in GG7 compared with TG26 genotype under water stress. Read More

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Additive Prognostic Impact of Gastrointestinal Involvement in Severe Multisystem Langerhans Cell Histiocytosis.

J Pediatr 2021 Jun 16. Epub 2021 Jun 16.

Department of Pediatrics, University of Toronto, Toronto, Canada.

Objective: To evaluate the prognostic impact of gastrointestinal involvement (GI-LCH) on the survival of children with Langerhans cell histiocytosis registered on the international clinical trials of the Histiocyte Society.

Study Design: Retrospective analysis of 2414 pediatric patients registered onto the consecutive trials DAL-HX 83, DAL-HX 90, LCH-I, LCH-II, and LCH-III.

Results: Among the 1289 patients with single-system LCH, there was no single case confined to the gastrointestinal tract; 114 of 1125 (10%) patients with multisystem-LCH (MS-LCH) had GI-LCH at initial presentation. Read More

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Evolutionary and functional analysis of Two-Component System in chickpea reveals CaRR13, a TypeB RR, as positive regulator of symbiosis.

Plant Biotechnol J 2021 Jun 19. Epub 2021 Jun 19.

National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi, 110067, India.

The critical role of cytokinin in early nodulation in legumes is well known. In our study, exogenous cytokinin application to roots of the important crop legume, chickpea (Cicer arietinum L.) led to the formation of pseudo nodules even in the absence of rhizobia. Read More

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EBI2 is expressed in glial cells in multiple sclerosis lesions and its knock-out modulates remyelination in the cuprizone model.

Eur J Neurosci 2021 Jun 19. Epub 2021 Jun 19.

Department of Laboratory Medicine, Medical University of Gdańsk, Gdańsk, Poland.

EBI2 receptor regulates the immune system and in multiple sclerosis is upregulated in the central nervous system infiltrating lymphocytes. In newborn EBI2-deficient mice, myelin development is delayed and its persistent antagonism inhibits remyelination in chemically-demyelinated organotypic cerebellar slices. We used the cuprizone model of multiple sclerosis to elucidate the role of central nervous system-expressed EBI2 in de- and remyelination. Read More

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Judicial interventions in health policy: Epistemic competence and the courts.

Leticia Morales

Bioethics 2021 Jun 18. Epub 2021 Jun 18.

School of Law, Universidad Austral de Chile (Puerto Montt), Los Lagos, Chile.

The judiciary is a key policy actor that is involved in deciding health rights and policy by intervening in the policy process through a variety of judicial mechanisms, yet the appropriate extent of its involvement remains contentious. Taking the competence objection seriously requires understanding it as an epistemic problem about how courts assess empirical and scientific evidence in order to competently adjudicate controversial health claims. This paper examines recent advances in social epistemology to develop insights for the epistemic competence of the judiciary from a system-oriented approach. Read More

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Methionine sulfoxide and the methionine sulfoxide reductase system as modulators of signal transduction pathways: a review.

Amino Acids 2021 Jun 18. Epub 2021 Jun 18.

Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, 66045, USA.

Methionine oxidation and reduction is a common phenomenon occurring in biological systems under both physiological and oxidative-stress conditions. The levels of methionine sulfoxide (MetO) are dependent on the redox status in the cell or organ, and they are usually elevated under oxidative-stress conditions, aging, inflammation, and oxidative-stress related diseases. MetO modification of proteins may alter their function or cause the accumulation of toxic proteins in the cell/organ. Read More

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Buprenorphine-Related Deaths in North Carolina from 2010-2018.

J Anal Toxicol 2021 Jun 19. Epub 2021 Jun 19.

Office of the Chief Medical Examiner, Raleigh, NC, USA.

Buprenorphine is a commonly prescribed medication for the treatment of opioid-use disorder. As prescriptions increase in North Carolina, buprenorphine is more frequently encountered statewide in routine postmortem casework. Between 2010 and 2018, there were 131 select cases investigated by the Office of the Chief Medical Examiner where buprenorphine was detected in peripheral blood and considered a primary cause of death, with no other opioids present and no other non-opioid substances found in the lethal range. Read More

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nCoV-2019 infection induced neurological outcome and manifestation, linking its historical ancestor SARS-CoV and MERS-CoV: a systematic review and meta-analysis.

Sci Rep 2021 Jun 18;11(1):12888. Epub 2021 Jun 18.

Department of Pharmacology, Research Block: B, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

The first systematic review and meta-analysis to help clinician to identify early signs and symptoms of neurological manifestation in COVID-19 positive patients which will further help in early management of patients. Present systematic review and meta-analysis aimed to discuss the prevalence of neurological involvement of the 2019-nCoV patients and assess the symptomatic trend of events as compared to the 2002 "SARS" and 2012 "MERS" pandemics. The articles were systematically screened through several search engine and databases. Read More

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