59,740 results match your criteria synthroid

Detecting Suspected Prescribing Cascades by Prescription Sequence Symmetry Analysis of Nationwide Real-World Data.

J Am Med Dir Assoc 2021 Jul 26. Epub 2021 Jul 26.

Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Aging and Health Research Center, National Yang-Ming University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan. Electronic address:

Objective: A prescription cascade is a subsequent event that occurs when an adverse drug event is misinterpreted as a new medical condition, resulting in the prescription of a potentially unnecessary medication to treat this new condition. This study was designed to test the hypothesis of whether prescribing cascades exist and their magnitude among older individuals by using prescription sequence symmetry analysis (PSSA).

Design: A retrospective population-based cohort study based on data from Taiwan's National Health Insurance Research Database (NHIRD), a nationwide claims-based database that covers 99% of the population in Taiwan. Read More

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Correction to: Relationship between the seasonal changes in plasma testosterone and thyroxine concentrations with sperm cryoresistance in Gabon bucks.

Trop Anim Health Prod 2021 Jul 29;53(4):419. Epub 2021 Jul 29.

Departamento de Reproducción Animal, Instituto de Investigación Y Tecnología Agraria Y Alimenticia (INIA), Madrid, Spain.

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Investigating the potential of clinical and biochemical markers to differentiate between functional hypothalamic amenorrhoea and polycystic ovarian syndrome: a retrospective observational study.

Clin Endocrinol (Oxf) 2021 Jul 29. Epub 2021 Jul 29.

Section of Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Hammersmith Hospital, London.

Objectives: Functional hypothalamic amenorrhoea (FHA) is a common cause of amenorrhoea, but diagnosis can be challenging. The aim of this study was to investigate the clinical and biochemical features of FHA, compared to that of polycystic ovarian syndrome (PCOS) and assess the diagnostic performance of the different parameters for differentiating the two conditions.

Design And Patients: This was a retrospective observational study. Read More

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Post-embryonic development and aging of the appendicular skeleton in Ambystoma mexicanum.

Dev Dyn 2021 Jul 28. Epub 2021 Jul 28.

Technische Universität Dresden, CRTD/ Center for Regenerative Therapies TU Dresden, Dresden, Germany.

Background: The axolotl is a key model to study appendicular regeneration. The limb complexity resembles that of humans in structure and tissue components; however, axolotl limbs develop post-embryonically. In this work, we evaluated the post-embryonic development of the appendicular skeleton and its changes with aging. Read More

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Old Bottle, New Wine: Diplopia Sans Proptosis as the Sole Presentation of Thyroid Orbitopathy.

Cureus 2021 Jun 23;13(6):e15850. Epub 2021 Jun 23.

Neurology, Lady Hardinge Medical College, New Delhi, IND.

Thyroid orbitopathy holds a dominant place in the list of causes for external ophthalmoplegia and is commonly accompanied by eye surface signs such as congestion, lacrimation, and proptosis. An elderly male presented to us with painless diplopia in the absence of proptosis, conjunctival congestion, tearing or irritative symptoms. He had bilateral complete external ophthalmoplegia. Read More

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Assessment of qualitative and quantitative parameters of healthy thyroid gland in adult horses by magnetic resonance imaging.

Anat Histol Embryol 2021 Jul 28. Epub 2021 Jul 28.

Department of Animal Reproduction and Veterinary Radiology, São Paulo State University (UNESP), Botucatu, Brazil.

In humans and pets, magnetic resonance imaging (MRI) provides important adjunctive anatomic information about the thyroid and its adjacent structures. To the best of our knowledge, however, no studies have been reported regarding the use of MRI for thyroid evaluation in horses. The aim of this study was to obtain qualitative and quantitative parameters of healthy thyroid gland in adult horses by MRI. Read More

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TSH, Hyperthyroidism, and Bone Mass.

J Clin Endocrinol Metab 2021 Jul 28. Epub 2021 Jul 28.

The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center of Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, USA.

Thyrotropin, traditionally seen as a pituitary hormone that regulates thyroid glands, has additional roles in physiology including skeletal remodeling. Population-based observations in subjects with euthyroidism or subclinical hyperthyroidism indicated a negative association between bone mass and low-normalTSH. The findings of correlative studies were supported by small intervention trials using recombinant human TSH (rhTSH) injection, and genetic and case-based evidence. Read More

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ABCD of thyroid hormone action: After and Before Cloning of Deiodinase Genes.

Endocrinology 2021 Jul 28. Epub 2021 Jul 28.

Maine Medical Center Research Institute, Maine Health, Scarborough, Maine.

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shell powder improves the metabolism, testosterone level, and sound frequency of Pelung chickens.

Vet World 2021 Jun 18;14(6):1564-1571. Epub 2021 Jun 18.

Department of Physiology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Background And Aim: Pelung chickens make unique, pleasant, and rhythmic sounds in addition to having strong muscle mass. Performance is controlled by testosterone. A natural aromatase blocker is an agent capable of blocking the aromatase enzyme, which consequently prevents testosterone from being changed into estradiol. Read More

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Maternal Perfluoroalkyl Substances, Thyroid Hormones, and Genes: A Spanish Cross-sectional Study.

Environ Sci Technol 2021 Jul 27. Epub 2021 Jul 27.

Epidemiology and Environmental Health Joint Research Unit, FISABIO-University Jaume I-University of Valencia, 46019 Valencia, Spain.

Results of studies on perfluoroalkyl substances (PFASs) and thyroid hormones (THs) are heterogeneous, and the mechanisms underlying the action of PFASs to target THs have not been fully characterized. We examined the relation between first-trimester maternal PFAS and TH levels and the role played by polymorphisms in the iodothyronine deiodinase 1 (1) and 2 (2) genes in this association. Our sample comprised 919 pregnant Spanish women (recruitment = 2003-2008) with measurements of perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), and free thyroxine (FT4), and we genotyped for single-nucleotide polymorphisms in the 1 (rs2235544) and 2 (rs12885300) genes. Read More

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Free thyroxine, brain frailty and clock drawing test performance in patients with acute minor stroke or transient ischaemic attack.

Clin Endocrinol (Oxf) 2021 Jul 26. Epub 2021 Jul 26.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Objective: Thyroid dysfunction is associated with an elevated risk of cognitive decline, but the mechanism underlying this relationship is elusive. In this study, we investigate the relationships between free thyroxine (FT4), brain frailty and clock drawing test (CDT) performance in patients with acute minor stroke or transient ischaemic attack (TIA).

Design, Patients And Measurements: A total of 204 consecutive patients admitted to our hospital within 72 h after the onset of acute minor stroke or TIA were prospectively enroled and categorized in terms of quartiles of FT4 between March 2018 and August 2019. Read More

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Atypical Thyroid Function Tests and Thyroid Hormone Resistance.

Cureus 2021 Jul 12;13(7):e16328. Epub 2021 Jul 12.

Critical Care Medicine, Mayo Clinic, Rochester, USA.

Clinical interpretation of thyroid labs is usually straightforward. However, there are rare instances when the atypical profile of thyroid labs warrants systematic investigation to determine the underlying cause. We report the case of a 90-year-old Caucasian male with a chronic history of atrial fibrillation with chronic pacemaker dependence who presented with significantly elevated free thyroxine level (>7. Read More

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Effect of comprehensive care on the negative emotions and life quality in parturients with postpartum depression and gestational hypertension.

Am J Transl Res 2021 15;13(6):7228-7234. Epub 2021 Jun 15.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu Province, China.

Objective: To investigate the efficacy of comprehensive care during the nursing process of parturients with gestational hypertension and postpartum depression.

Methods: This prospective study recruited 70 patients with gestational hypertension concurrent with postpartum depression, and the patients were randomly divided into a control group (35 patients received routine care) and an observation group (35 patients, treated by comprehensive care). Indicators including psychological condition, life quality, thyroid function, the incidence of eclampsia, and nursing satisfaction were recorded and compared before intervention (at the diagnosis of postpartum depression) and after intervention (three months after delivery) in the two groups. Read More

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A rare presentation of ectopic thyroid gland at right axilla.

Med J Malaysia 2021 Jul;76(4):600-602

Hospital Sultanah Nora Ismail, Batu Pahat, Johor, Malaysia.

The thyroid gland and its hormones play important roles in organ development and in the homeostatic control of physiological mechanisms in human beings. As a result of embryogenic descent of thyroid gland, it commonly resides along the midline - from tongue to mediastinum (90%). Ectopic thyroid gland is a rare occurrence, with extra-lingual ectopic thyroid gland being even rarer. Read More

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The effect of food groups and nutrients on thyroid hormone levels in healthy individuals.

Nutrition 2021 Jun 20;91-92:111394. Epub 2021 Jun 20.

Department of Nuclear Medicine, University Hospital Split, Split, Croatia; Department of Medical Biology, School of Medicine, University of Split, Split, Croatia. Electronic address:

Objectives: The aim of the study was to analyze the association of dietary groups (groups of food items) with thyroid hormone levels in healthy individuals.

Methods: This cross-sectional study enrolled 4585 healthy individuals from the Dalmatian region of south Croatia with measurements of plasma free triiodothyronine (fT3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) levels. Dietary intake was assessed according to data of the completed food frequency questionnaire, containing 58 food items. Read More

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Association between valproate treatment for acute phase schizophrenia and risk of new onset hypothyroidism.

Schizophr Res 2021 Jul 20;235:12-16. Epub 2021 Jul 20.

School of Public Health, Xinxiang Medical University, Xinxiang 453003, China; Henan International Joint Laboratory of non-Invasive Neuro-modulation, Xinxiang Medical University, Xinxiang 453003, China. Electronic address:

Aim: To assess the association between acute phase treatment by valproate as an adjunctive drug and risk of new onset hypothyroidism in a large cohort of patients affected by schizophrenia.

Methods: We conducted a retrospective cohort study in a psychiatric hospital in China between January 2016 and December 2018. We obtained approval from the Ethics Committee of the study hospital prior to the commencement of the study. Read More

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Acute suppurative thyroiditis seeded from infective endocarditis and intravenous drug use.

IDCases 2021 7;25:e01221. Epub 2021 Jul 7.

Saint Bernards Healthcare, 300 Carson Street, Jonesboro, AR, 72401, United States.

Acute suppurative thyroiditis (AST) is a rare infection of the thyroid gland, and most patients are euthyroid upon presentation. We present an interesting case of a 42-year-old man with a history of intravenous drug use (IVDU) and poorly controlled type 2 diabetes mellitus who was admitted for sepsis and thyrotoxicosis from infective endocarditis (IE), AST, prostate abscess, and pyelonephritis. He suffered from a cerebral vascular accident (CVA) from septic embolic showering. Read More

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Oral Levothyroxine Treatment in Lithium Intoxication- Induced Myxedema Coma: A Case Report.

Po-Hsuan Kao

J Acute Med 2021 Jun;11(2):68-71

National Taiwan University Hospital Department of Emergency Medicine Taipei Taiwan.

Lithium intoxication-induced myxedema coma, a rare but dangerous condition of severe hypothyroidism, can be easily misdiagnosed in patients without history of hypothyroidism. The objective of this case report is to describe a lithium-treated patient who presented to emergency department with obtundation and moderate hypothermia and was diagnosed with myxedema coma and lithium toxicity. A 64-year-old female presented to the emergency department with obtundation and hypothermia. Read More

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Thyroid-Stimulating Hormone and Free Thyroxine Alterations in Subjects with Occupational Hearing Loss.

Indian J Occup Environ Med 2021 Jan-Mar;25(1):4-10. Epub 2021 Apr 26.

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.

Context And Aim: Occupational hearing loss (OHL) is caused by exposure to industrial noise. Alterations in the thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels are related to hearing loss. The purpose of this study is to investigate the TSH and FT4 level alterations in OHL. Read More

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Vitamin D improves oxidative stress and histopathological damage in rat ovaries caused by hyperthyroidism.

J Obstet Gynaecol Res 2021 Jul 21. Epub 2021 Jul 21.

Department of Gynecology and Obstetrics, Adıyaman University School of Medicine, Adıyaman, Turkey.

Objective: The aim of this study is to investigate the histopathological and biochemical efficacy of vitamin D on oxidative damage and fibrosis in rat ovaries induced by experimental hyperthyroidism.

Methods: This study is a comparative, prospective experimental rat study. Sprague-Dawley female rats were divided into four groups. Read More

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Are serum cortisol measurements by immunoassays reliable?: A case series.

Med Res Arch 2020 May 25;8(5). Epub 2020 May 25.

Department of Laboratory Medicine. National Institutes of Health, Clinical Center. Bethesda, MD, United States of America.

Routinely used automated immunoassays have been found to give unrealiable measurements of thyroid hormones in the presence of either high or low levels of thyroxine-binding globulin. Thyroid hormones are not the only analytes bound to specific binding proteins that are measured by immunoassays. Preliminary data from a series of cases, comparing IA measurements to those obtained by liquid chromatography-tandem mass spectrometry, reveal for the first time that IA measurements report falsely low (by an average of 27%) serum cortisol concentrations. Read More

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Usefulness of FT3 to FT4 Ratio to Predict Mortality in Euthyroid Patients With Prior Cardiovascular Events Undergoing PCI: Five-Year Findings From a Large Single-Center Cohort Study.

Front Endocrinol (Lausanne) 2021 5;12:700349. Epub 2021 Jul 5.

Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Background: In euthyroid patients undergoing percutaneous coronary intervention (PCI), it is still unclear whether free triiodothyronine to free thyroxine (FT3/FT4) ratio can predict the recurrence of cardiovascular events (CVEs). We aim to investigate its association with recurrent long-term adverse events in this population.

Methods: 3549 euthyroid patients with prior CVEs history undergoing PCI were consecutively enrolled in our study and subsequently divided into three FT3/FT4 ratio tertiles (T1<2. Read More

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Neonatal thyroxine activation modifies epigenetic programming of the liver.

Nat Commun 2021 07 21;12(1):4446. Epub 2021 Jul 21.

Section of Adult and Pediatric Endocrinology, Diabetes & Metabolism, University of Chicago, Chicago, IL, USA.

The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific Dio2 inactivation (Alb-D2KO) transiently increases H3K9me3 levels during post-natal days 1-5 (P1-P5), and results in methylation of 1,508 DNA sites (H-sites) in the adult mouse liver. Read More

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Effect of oral semaglutide on the pharmacokinetics of thyroxine after dosing of levothyroxine and the influence of co-administered tablets on the pharmacokinetics of oral semaglutide in healthy subjects: an open-label, one-sequence crossover, single-center, multiple-dose, two-part trial.

Expert Opin Drug Metab Toxicol 2021 Jul 22. Epub 2021 Jul 22.

Novo Nordisk A/S, Søborg, Denmark.

Background: : Oral semaglutide comprises the glucagon-like peptide-1 analog, semaglutide, and sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). Levothyroxine has similar dosing conditions to oral semaglutide. This trial investigated if oral semaglutide co-administered with levothyroxine affects thyroxine (T) exposure and if multiple placebo tablets co-administered with oral semaglutide affect semaglutide exposure. Read More

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High Iodine Nutrition May Be a Risk Factor for Cervical Lymph Node Metastasis in Papillary Thyroid Cancer Patients.

Ann Nutr Metab 2021 Jul 21:1-10. Epub 2021 Jul 21.

Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.

Purpose: The aim of this study was to retrospectively identify the effect of iodine on the papillary thyroid cancer (PTC) process and investigate the risk clinicopathologic characteristics of cervical lymph node metastasis (CLNM) for achieving a better preventive strategy of PTC.

Methods: Totally 187 patients with CLNM and 279 without CLNM (NCLNM) were enrolled, and their urinary iodine concentration (UIC) and serum iodine concentration (SIC) were measured. Logistic regressions were used to reveal the effects of iodine nutrition on the CLNM status of PTC. Read More

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Interpretative commenting in clinical chemistry with worked examples for thyroid function test reports.

Pract Lab Med 2021 Aug 9;26:e00243. Epub 2021 Jul 9.

Department of Laboratory Medicine, National University Hospital, Singapore.

Correct interpretation of pathology results is a requirement for accurate diagnosis and appropriate patient management. Clinical Pathologists and Scientists are increasingly focusing on providing quality interpretative comments on their reports and these comments are appreciated by clinicians who receive them. Interpretative comments may improve patient outcomes by helping reduce errors in application of the results in patient management. Read More

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Cardiac Hypertrophy Caused by Hyperthyroidism in Rats: Role of ATF-6 and TRPC1 Channels.

Can J Physiol Pharmacol 2021 Jul 20. Epub 2021 Jul 20.

Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, 64063, Faculty of Medicine Department of Histology and Embryology, Eskisehir, Turkey;

Hyperthyroidism influences the development of cardiac hypertrophy. Transient receptor potential canonical channels (TRPCs) and ER stress are regarded as critical pathways in cardiac hypertrophy.Hence, we aimed to identify the TRPCs associated with ER stress in hyperthyroidism-induced cardiac hypertrophy. Read More

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Over-the-counter protein supplement resulting in impaired thyroxine absorption in a hypothyroid patient.

Endocrinol Diabetes Metab Case Rep 2021 Jul 19;2021(21-0070). Epub 2021 Jul 19.

Diabetes and Endocrinology Unit, National Hospital Kandy, Kandy, Sri Lanka.

Summary: Whey protein is a popular dietary supplement that is claimed to provide multiple health benefits. It has been shown to delay gastric emptying and impair ileal nutrient absorption. Additionally, some of the other additives like papain enzyme, soy lecithin in these protein supplements could interfere with L-thyroxine absorption. Read More

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Thyroid hormones in persons with schizophrenia: A systematic review and meta-analysis.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Jul 15;111:110402. Epub 2021 Jul 15.

Department of Psychiatry, Wroclaw Medical University, Pasteura 10 Street, 50-367 Wroclaw, Poland.

There is accumulating evidence that individuals with schizophrenia show altered levels of thyroid hormones. However, a qualitative and quantitative synthesis of findings in this field has not been performed so far. Therefore, we aimed to perform a systematic review and meta-analysis of studies investigating the levels of thyroid-stimulating hormone (TSH), free thyroxine (fT4), total thyroxine (tT4), free triiodothyronine (fT3) and total triiodothyronine (tT3) in multiple-episode schizophrenia (MES) and first-episode psychosis (FEP). Read More

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Thyroid hormone system disrupting chemicals.

Best Pract Res Clin Endocrinol Metab 2021 Jul 7:101562. Epub 2021 Jul 7.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institut für Experimentelle Endokrinologie, Hessische Strasse 3-4, 10115, Berlin, Germany.

The thyroid hormone system is a main target of endocrine disruptor compounds (EDC) at all levels of its intricately fine-tuned feedback regulation, synthesis, distribution, metabolism and action of the 'prohormone' thyroxine and its active metabolites. Apart from classical antithyroid effects of EDC on the gland, the majority of known and suspected effects occurs at the pre-receptor control of T3 ligand availability to T3 receptors exerting ligand modulated thyroid hormone action. Tissue-, organ- and cell-specific expression and function of thyroid hormone transporters, deiodinases, metabolizing enzymes and T3-receptor forms, all integral components of the system, may mediate adverse EDC effects. Read More

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