12,888 results match your criteria synthetic ligands


2-Thiazolines: an update on synthetic methods and catalysis.

Org Biomol Chem 2021 Sep 15;19(35):7497-7517. Epub 2021 Sep 15.

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán C.P. 04510, CdMx, Mexico.

2-Thiazolines are important building blocks in organic synthesis and are of great importance in many areas of chemistry. At the end of the last century, the use of 2-thiazolines increased in a significant way, especially in synthesis and catalysis. This review highlights the synthetic and catalytic value of 2-thiazolines in the last two decades. Read More

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September 2021

Anchoring Ag(I) into Nitro-Functionalized Metal-Organic Frameworks: Effectively Catalyzing Cycloaddition of CO with Propargylic Alcohols under Mild Conditions.

ACS Appl Mater Interfaces 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Key Laboratory of Advanced Energy Material Chemistry, MOE, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.

Carboxylative cyclization of propargylic alcohols with CO is significant in synthetic chemistry, but harsh conditions are often needed according to reported results. Herein, a new stable nitro-functionalized metal-organic framework (MOF) of {[Co(L)(bpy)(HO)]·DMF·HO·bpy} () was fabricated through the solvothermal reaction, which exhibited excellent stability in acid and basic solutions. Owing to the porous structure, unsaturated metal sites, and uncoordinated 4,4'-bpy ligands, can serve as an excellent platform for catalytic applications. Read More

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September 2021

Are bis(pyridine)iodine(I) complexes applicable for asymmetric halogenation?

Org Biomol Chem 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.

Enantiopure halogenated molecules are of tremendous importance as synthetic intermediates in the construction of pharmaceuticals, fragrances, flavours, natural products, pesticides, and functional materials. Enantioselective halofunctionalizations remain poorly understood and generally applicable procedures are lacking. The applicability of chiral -chelating bis(pyridine)iodine(I) complexes in the development of substrate independent, catalytic enantioselective halofunctionalization has been explored herein. Read More

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September 2021

Facile synthesis of air-stable heterobimetallic osmium-silver hydride complexes.

Dalton Trans 2021 Sep 14;50(35):12093-12097. Epub 2021 Sep 14.

Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, P. R. China.

The synthesis and characterization of air-stable heterobimetallic Os-Ag hydrides are described. All of the new heterobimetallic Os-Ag hydrides are neutral, and the generated and presynthesized -[Os](H)-CC-R units in these frameworks act as organometallic bidentate chelating ligands coordinating with the AgPPh cation, which makes these complexes more stable. Our results provide a new synthetic route for the construction of stable heterobimetallic complexes. Read More

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September 2021

The Ascent of Alkyne Metathesis to Strategy-Level Status.

Authors:
Alois Fürstner

J Am Chem Soc 2021 Sep 14. Epub 2021 Sep 14.

Max-Planck-Institut für Kohlenforschung, 45470 Mülheim/Ruhr, Germany.

For numerous enabling features and strategic virtues, contemporary alkyne metathesis is increasingly recognized as a formidable synthetic tool. Central to this development was the remarkable evolution of the catalysts during the past decades. Molybdenum alkylidynes carrying (tripodal) silanolate ligands currently set the standards; their functional group compatibility is exceptional, even though they comprise an early transition metal in its highest oxidation state. Read More

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September 2021

Synthesis and crystal structure of poly[(3-amino-1,2,4-triazole)(μ-1-benzimidazole-5,6-di-carboxyl-ato)cobalt(II)].

Acta Crystallogr E Crystallogr Commun 2021 Jul 15;77(Pt 7):714-717. Epub 2021 Jun 15.

Beijing Key Laboratory for Green Catalysis and Separation and Department of Environmental Chemical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, People's Republic of China.

The asymmetric unit of the title coordination polymer, [Co(CHNO)(CHN)] or [Co( )( )] , consists of one crystallographically independent Co centre, one ligand and one ligand ( = 1-benzimidazole-5,6-di-carb-oxy-lic acid, = 3-amino-1,2,4-triazole). The Co centre is coordinated by two carboxyl-ato- atoms from two independent ligands and two nitro-gen atoms from and another ligand. Thus, the metal center adopts a four-coordinate mode, forming a tetra-hedral geometry. Read More

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Metal-Organic Frameworks as Versatile Media for Polymer Adsorption and Separation.

Acc Chem Res 2021 Sep 10. Epub 2021 Sep 10.

Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

ConspectusMolecular recognition is of paramount importance for modern chemical processes and has now been achieved for small molecules using well-established host-guest chemistry and adsorption-science principles. In contrast, technologies for recognizing polymer structure are relatively undeveloped. Conventional polymer separation methods, which are mostly limited in practice to size-exclusion chromatography and reprecipitation, find it difficult to recognize minute structural differences in polymer structures as such small structural alterations barely influence the polymer characteristics, including molecular size, polarity, and solubility. Read More

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September 2021

Dinuclear gold(I) complexes with -phosphanyl, N-heterocyclic carbene ligands: synthetic strategies, luminescence properties and anticancer activity.

Dalton Trans 2021 Sep 10. Epub 2021 Sep 10.

Dipartimento di Scienze Chimiche, Università di Padova, via Marzolo 1, 35131 Padova, Italy.

A small library of dinuclear gold(I) complexes with the title ligands has been prepared, encompassing neutral, mono- and dicationic complexes. The luminescence properties of the complexes in the solid state have been evaluated, and it turns out that neutral and monocationic complexes not presenting a rigid metallamacrocyclic structure can exhibit rather strong emissions that extend towards the red region of the visible spectrum. The anticancer activity of the complexes has been also preliminarly evaluated; cytotoxicity seems to correlate with complex lipophilicity, whereas selectivity towards cancer cells can be apparently enhanced upon a judicious choice of the ligands. Read More

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September 2021

Post-synthetic modifications (PSM) on metal-organic frameworks (MOFs) for visible-light-initiated photocatalysis.

Dalton Trans 2021 Sep 10. Epub 2021 Sep 10.

Research Institute of Photocatalysis, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China.

The utilization of green and sustainable solar energy photocatalysis is regarded as a promising strategy to tackle the ever-increasing energy shortage and environmental deterioration. In addition to traditional semiconductor-based photocatalysts, metal-organic frameworks (MOFs), a class of crystalline micro-mesoporous hybrid materials constructed from metal or metal nodes interconnected with multi-dentate organic linkers, are emerging as a new type of photocatalytic material. Post-synthetic modifications (PSM) on MOFs, in which chemical transformations or exchanges are made on pre-synthesized MOF materials, are found to be a powerful strategy for fabricating photoactive MOFs based on already existing MOFs. Read More

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September 2021

Enantioconvergent Cu-Catalyzed Radical C-N Coupling of Racemic Secondary Alkyl Halides to Access α-Chiral Primary Amines.

J Am Chem Soc 2021 Sep 10. Epub 2021 Sep 10.

Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China.

α-Chiral alkyl primary amines are virtually universal synthetic precursors for all other α-chiral N-containing compounds ubiquitous in biological, pharmaceutical, and material sciences. The enantioselective amination of common alkyl halides with ammonia is appealing for potential rapid access to α-chiral primary amines, but has hitherto remained rare due to the multifaceted difficulties in using ammonia and the underdeveloped C(sp)-N coupling. Here we demonstrate sulfoximines as excellent ammonia surrogates for enantioconvergent radical C-N coupling with diverse racemic secondary alkyl halides (>60 examples) by copper catalysis under mild thermal conditions. Read More

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September 2021

Macrocyclic Inorganic Tin Containing Oxo Clusters: Heterometallic Strategy for Configuration and Catalytic Activity Modulation.

Chemistry 2021 Sep 9. Epub 2021 Sep 9.

Fujian Institute of Research on the Structure of Matter, State Key Laboratory of Structural Chemistry, 155 Yangqiao Road West, 350002, Fuzhou, CHINA.

In this work, we report the first examples of inorganic macrocyclic tin-oxo clusters which are stabilized by sulfate ligands. As determined by X-ray diffraction and photoelectron spectroscopy analyses, the prepared inorganic Sn10-oxo cluster displays interesting mixed valence behaviors, with 8 Sn4+ located at the cyclic skeleton and two Sn2+ encapsulated in the center. When further introducing Ti4+ and In3+ ions to the synthetic systems, heterometallic Sn2Ti6 and SnIn5Ti6 complexes with Ti6(SO4)9 and SnIn5(SO4)12 macrocyclic skeletons were prepared whose configuration and packing models were affected by the ionic radius of incorporated metals. Read More

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September 2021

Intracellular TLRs of Mast Cells in Innate and Acquired Immunity.

Handb Exp Pharmacol 2021 Sep 10. Epub 2021 Sep 10.

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Mast cells (MCs) distribute to interface tissues with environment, such as skin, airway, and gut mucosa, thereby functioning as the sentinel against invading allergens and pathogens. To respond to and exclude these external substances promptly, MCs possess granules containing inflammatory mediators, including heparin, proteases, tumor necrosis factor, and histamine, and produce these mediators as a consequence of degranulation within minutes of activation. As a delayed response to external substances, MCs de novo synthesize inflammatory mediators, such as cytokines and chemokines, by sensing pathogen- and damage-associated molecular patterns through their pattern recognition receptors, including Toll-like receptors (TLRs). Read More

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September 2021

Crystallographic and Spectroscopic Investigations on Oxidative Coordination in the Heteroleptic Mononuclear Complex of Cerium and Benzoxazine Dimer.

Molecules 2021 Sep 6;26(17). Epub 2021 Sep 6.

Synchrotron Light Research Institute, 111 University Avenue, Suranaree, Muang, Nakhon Ratchasima 30000, Thailand.

Among lanthanide-based compounds, cerium compounds exhibit a significant role in a variety of research fields due to their distinct tetravalency, high economic feasibility, and high stability of Ce(IV) complexes. Herein, a systematic investigation of crystallographic information, chemical properties, and mechanistic formation of the novel Ce(IV) complex synthesized from cerium(III) nitrate hexahydrate and 2,2'-(methylazanediyl)bis(methylene)bis(4-methylphenol) (MMD) ligand has been explored. According to the analysis of the crystallographic information, the obtained complex crystal consists of the Ce(IV) center coordinated with two nitrate ligands and two bidentate coordinated (-protonated and O,O-deprotonated) MMD ligands. Read More

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September 2021

A New Synthetic Methodology in the Preparation of Bimetallic Chalcogenide Clusters via Cluster-to-Cluster Transformations.

Molecules 2021 Sep 5;26(17). Epub 2021 Sep 5.

Department of Chemistry, National Dong Hwa University, Hualien 974301, Taiwan.

A decanuclear silver chalcogenide cluster, [Ag(Se){SeP(OPr)}] () was isolated from a hydride-encapsulated silver diisopropyl diselenophosphates, [Ag(H){SeP(OPr)}], under thermal condition. The time-dependent NMR spectroscopy showed that was generated at the first three hours and the hydrido silver cluster was completely consumed after thirty-six hours. This method illustrated as cluster-to-cluster transformations can be applied to prepare selenide-centered decanuclear bimetallic clusters, [CuAg(Se){SeP(OPr)}] (x = 0-7, ), via heating [CuAg(H){SeP(OPr)}] (x = 1-6) at 60 °C. Read More

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September 2021

Ruthenium Olefin Metathesis Catalysts Featuring N-Heterocyclic Carbene Ligands Tagged with Isonicotinic and 4-(Dimethylamino)benzoic Acid Rests: Evaluation of a Modular Synthetic Strategy.

Molecules 2021 Aug 28;26(17). Epub 2021 Aug 28.

Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury Street 101, 02-089 Warsaw, Poland.

A modular and flexible strategy towards the synthesis of N-heterocyclic carbene (NHC) ligands bearing Brønsted base tags has been proposed and then adopted in the preparation of two tagged NHC ligands bearing rests of isonicotinic and 4-(dimethylamino)benzoic acids. Such tagged NHC ligands represent an attractive starting point for the synthesis of olefin metathesis ruthenium catalysts tagged in non-dissociating ligands. The influence of the Brønsted basic tags on the activity of such obtained olefin metathesis catalysts has been studied. Read More

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In silico evaluation of COVID-19 main protease interactions with honeybee natural products for discovery of high potential antiviral compounds.

Nat Prod Res 2021 Sep 9:1-7. Epub 2021 Sep 9.

Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

This research investigates antiviral potential of extracted honeybee products against COVID-19 main protease (Mpro) by computational methods. The crystal structure of COVID-19 Mpro was obtained from the protein data bank. Six synthetic drugs with antiviral properties were used as control samples in order to compare the results with those of natural ligands. Read More

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September 2021

Supramolecular Transmembrane Ion Channels Formed by Multiblock Amphiphiles.

Acc Chem Res 2021 Sep 8. Epub 2021 Sep 8.

Department of Applied Chemistry, Graduate School of Engineering and Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.

ConspectusTransmembrane proteins located within biological membranes play a crucial role in a variety of important cellular processes, such as energy conversion and signal transduction. Among them, ion channel proteins that can transport specific ions across the biological membranes are particularly important for achieving precise control over those processes. Strikingly, approximately 20% of currently approved drugs are targeted to ion channel proteins within membranes. Read More

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September 2021

Rapid Characterization of Human Serum Albumin Binding for Per- and Polyfluoroalkyl Substances Using Differential Scanning Fluorimetry.

Environ Sci Technol 2021 Sep 8. Epub 2021 Sep 8.

Center for Human Health and The Environment Department of Biological Sciences, North Carolina State University, 127 David Clark Labs Campus, P.O. Box 7617, Raleigh, North Carolina 27695, United States.

Per- and polyfluoroalkyl substances (PFAS) are a diverse class of synthetic chemicals that accumulate in the environment. Many proteins, including the primary human serum transport protein albumin (HSA), bind PFAS. The predictive power of physiologically based pharmacokinetic modeling approaches is currently limited by a lack of experimental data defining albumin-binding properties for most PFAS. Read More

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September 2021

Nitric oxide release and related light-induced cytotoxicity of ruthenium nitrosyls with coordinated nicotinate derivatives.

Dalton Trans 2021 Sep 8. Epub 2021 Sep 8.

Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russia.

The synthetic approaches for the preparation of (NO,OH)-(NO,NO)-[RuNO(L)(NO)OH], where L = ethyl nicotinate (I) and methyl nicotinate (II), are reported. The structures of the complexes are characterized by X-ray diffraction and analyzed by Hirshfeld surface analysis. Both compounds show a nitric oxide release reaction under 445 or 532 nm irradiation of dimethyl sulfoxide (DMSO) solutions, which is studied by combined ultraviolet-visible- (UV-vis), infrared- (IR), and electron paramagnetic resonance (EPR) spectroscopy and density functional theory (DFT) calculations. Read More

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September 2021

Detecting ligand-protein interactions inside cells using reactive peptide tags and split luciferase.

Chem Commun (Camb) 2021 Sep 8. Epub 2021 Sep 8.

Graduate School of Science and Technology, Gunma University, 1-5-1, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.

We report a method for detecting ligand-protein interactions occurring within cells using short peptide reactive tags appended to ligands and proteins, along with a split NanoLuc luciferase. This method can be applied to estimate the binding affinities of ligand-protein interactions and to detect the interactions of proteins with unstable synthetic ligands inside the cells. Read More

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September 2021

Synthesis, Structure, and Ammonia Oxidation Catalytic Activity of Ru-NH Complexes Containing Multidentate Polypyridyl Ligands.

Inorg Chem 2021 Sep 7. Epub 2021 Sep 7.

Institute of Chemical Research of Catalonia, Barcelona Institute of Science and Technology, Avda. Països Catalans 16, 43007 Tarragona, Spain.

Ammonia (electro)oxidation with molecular catalysts is a rapidly developing topic with wide practical applications ahead. We report here the catalytic ammonia oxidation reaction (AOR) activity using [Ru(tda-κ-NO)(py)], , (tda is 2,2':6',2''-terpyridine-6,6''-dicarboxylate; py is pyridine) as a catalyst precursor. Furthermore, we also describe the rich chemistry associated with the reaction of Ru-tda and Ru-tPa (tPa is 2,2':6',2''-terpyridine-6,6''-diphosphonate) complexes with NH and NH using [Ru(tda-κ-NO)(dmso)Cl] (dmso is dimethyl sulfoxide) and [Ru(tPa-κ-NO)(py)], , as synthetic intermediates, respectively. Read More

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September 2021

The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm.

Hum Reprod 2021 Sep 6. Epub 2021 Sep 6.

Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.

Study Question: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm?

Summary Answer: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affects human sperm function in vitro. Read More

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September 2021

Photoinduced Trifluoromethylation of Arenes and Heteroarenes Catalyzed by High-Valent Nickel Complexes.

Angew Chem Int Ed Engl 2021 Sep 3. Epub 2021 Sep 3.

Okinawa Institute of Science and Technology Graduate University, Coordination Chemistry and Catalysis Unit, 1919-1 Tancha, 904-0495, Onna-son, JAPAN.

We describe a series of air-stable Ni III complexes supported by a simple, robust naphthyridine-based ligand. Access to the high valent oxidation state is enabled by the CF 3 ligands on the nickel, while the naphthyridine exhibits either a monodentate or bidentate coordination mode that depends on the oxidation state and sterics, and enables facile aerobic oxidation of Ni II to Ni III . These Ni III complexes act as efficient photoredox catalysts for C(sp 2 )-H bond trifluoromethylation reactions of (hetero)arenes using versatile synthetic protocols. Read More

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September 2021

On the Metal-Aided Catalytic Mechanism for Phosphodiester Bond Cleavage Performed by Nanozymes.

ACS Catal 2021 Jul 2;11(14):8736-8748. Epub 2021 Jul 2.

Laboratory of Molecular Modeling and Drug Discovery, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy.

Recent studies have shown that gold nanoparticles (AuNPs) functionalized with Zn(II) complexes can cleave phosphate esters and nucleic acids. Remarkably, such synthetic nanonucleases appear to catalyze metal (Zn)-aided hydrolytic reactions of nucleic acids similar to metallonuclease enzymes. To clarify the reaction mechanism of these nanocatalysts, here we have comparatively analyzed two nanonucleases with a >10-fold difference in the catalytic efficiency for the hydrolysis of the 2-hydroxypropyl-4-nitrophenylphosphate (HPNP, a typical RNA model substrate). Read More

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Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method.

Biol Pharm Bull 2021 ;44(9):1202-1209

Lead Exploration Unit, Drug Discovery Initiative, The University of Tokyo.

Peroxisome proliferator-activated receptor (PPAR)α, a member of the nuclear receptor family, is a transcription factor that regulates the expression of genes related to lipid metabolism in a ligand-dependent manner, and has attracted attention as a target for hypolipidemic drugs. We have been developing phenylpropaonic acid derivatives as PPARα-targeted drug candidates for the treatment of metabolic diseases. Recently, we have developed the "ligand-exchange soaking method," which crystallizes the recombinant PPARα ligand-binding domain (LBD) as a complex with intrinsic fatty acids derived from an expression host Escherichia (E. Read More

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January 2021

Lobeglitazone attenuates fibrosis in corneal fibroblasts by interrupting TGF-beta-mediated Smad signaling.

Graefes Arch Clin Exp Ophthalmol 2021 Sep 1. Epub 2021 Sep 1.

Department of Ophthalmology, Wonju College of Medicine, Yonsei University, Wonju, Ilsan-ro, Gangwon-do, 26426, Republic of Korea.

Purpose: Transforming growth factor beta 1 (TGF-β1) is an important cytokine released after ocular surface injury to promote wound healing. However, its persistence at the injury site triggers a fibrotic response that leads to corneal scarring and opacity. Thiazolidinediones (TZDs) are synthetic peroxisome proliferator-activated receptor gamma (PPAR-γ) ligands used to regulate glucose and lipid metabolism in the management of type 2 diabetes. Read More

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September 2021

Controlling Radical-Type Single-Electron Elementary Steps in Catalysis with Redox-Active Ligands and Substrates.

JACS Au 2021 Aug 6;1(8):1101-1115. Epub 2021 Jul 6.

Homogeneous, Supramolecular and Bio-Inspired Catalysis Group, van 't Hoff Institute for Molecular Sciences (HIMS), University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.

Advances in (spectroscopic) characterization of the unusual electronic structures of open-shell cobalt complexes bearing redox-active ligands, combined with detailed mapping of their reactivity, have uncovered several new catalytic radical-type protocols that make efficient use of the synergistic properties of redox-active ligands, redox-active substrates, and the metal to which they coordinate. In this perspective, we discuss the tools available to study, induce, and control catalytic radical-type reactions with redox-active ligands and/or substrates, contemplating recent developments in the field, including some noteworthy tools, methods, and reactions developed in our own group. The main topics covered are () tools to characterize redox-active ligands; () novel synthetic applications of catalytic reactions that make use of redox-active carbene and nitrene substrates at open-shell cobalt-porphyrins; () development of catalytic reactions that take advantage of purely ligand- and substrate-based redox processes, coupled to cobalt-centered spin-changing events in a synergistic manner; and () utilization of redox-active ligands to influence the spin state of the metal. Read More

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Photostable Ruthenium(II) Isocyanoborato Luminophores and Their Use in Energy Transfer and Photoredox Catalysis.

JACS Au 2021 Jun 13;1(6):819-832. Epub 2021 May 13.

Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.

Ruthenium(II) polypyridine complexes are among the most popular sensitizers in photocatalysis, but they face some severe limitations concerning accessible excited-state energies and photostability that could hamper future applications. In this study, the borylation of heteroleptic ruthenium(II) cyanide complexes with α-diimine ancillary ligands is identified as a useful concept to elevate the energies of photoactive metal-to-ligand charge-transfer (MLCT) states and to obtain unusually photorobust compounds suitable for thermodynamically challenging energy transfer catalysis as well as oxidative and reductive photoredox catalysis. B(CF) groups attached to the CN ligands stabilize the metal-based t-like orbitals by ∼0. Read More

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Synthetic Control of Mitochondrial Dynamics: Developing Three-Coordinate Au(I) Probes for Perturbation of Mitochondria Structure and Function.

JACS Au 2021 Apr 9;1(4):439-449. Epub 2021 Mar 9.

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.

Mitochondrial structure and organization is integral to maintaining mitochondrial homeostasis and an emerging biological target in aging, inflammation, neurodegeneration, and cancer. The study of mitochondrial structure and its functional implications remains challenging in part because of the lack of available tools for direct engagement, particularly in a disease setting. Here, we report a gold-based approach to perturb mitochondrial structure in cancer cells. Read More

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Aptamer-based cell-free detection system to detect target protein.

Synth Syst Biotechnol 2021 Sep 13;6(3):209-215. Epub 2021 Aug 13.

XMU-China Team, Xiamen University, Xiamen, 361005, PR China.

Biomarkers of disease, especially protein, show great potential for diagnosis and prognosis. For detecting a certain protein, a binding assay implementing antibodies is commonly performed. However, antibodies are not thermally stable and may cause false-positive when the sample composition is complicated. Read More

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September 2021