Molecules 2019 Dec 17;24(24). Epub 2019 Dec 17.
Department of Molecular Sciences, Uppsala BioCentrum, Swedish University of Agricultural Sciences, P.O. Box 7015, SE-750 07 Uppsala, Sweden.
In the search for new microbial antibacterial secondary metabolites, two new compounds ( and ) were isolated from culture broths of Em19. Structure determination by nuclear magnetic resonance and mass spectrometry identified the compounds as 6,7-dihydroxy-5,10-dihydropyrrolo[1,2-]isoquinoline-3-carboxylic acid (, spathullin A) and 5,10-dihydropyrrolo[1,2-]isoquinoline-6,7-diol (, spathullin B). The two compounds displayed activity against both Gram-negative and -positive bacteria, including , , , , , and . Read More