15,163 results match your criteria synovitis


Analysis of cartilage injury patterns and risk factors for knee joint damage in patients with primary lateral patella dislocations.

PLoS One 2021 14;16(10):e0258240. Epub 2021 Oct 14.

Center for Musculoskeletal Surgery, Charité -Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Lateral patellar dislocation (LPD) frequently causes damage to the knee. Injury patterns and risk factors contributing to such injuries have not yet been examined in detail.

Methods: We retrospectively analyzed 50 consecutive patients with primary LPD. Read More

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October 2021

[Expression of peroxisome proliferator-activated receptor-gamma coactivator 1β in synovium in patients with rheumatoid arthritis and its clinical significance].

Zhonghua Yi Xue Za Zhi 2021 Feb;101(5):327-332

Department of Rheumatology and Immunology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

To investigate the expression of peroxisome proliferator-activated receptor-gamma coactivator (PGC)1β in synovium of patients with rheumatoid arthritis (RA) and its association with histological synovitis. This cross-sectional study recruited RA patients at the Department of Rheumatology, Sun Yat-Sen Memorial Hospital from May 2010 to October 2016. Clinical data were collected. Read More

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February 2021

Osteomyelitis on MR imaging as a key predictor of recurrent septic arthritis of the shoulder.

Eur Radiol 2021 Oct 12. Epub 2021 Oct 12.

Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, 20, Geumo-ro, Mulgeum-eup, Yangsan-si, 50612, Gyeongsananam-do, Korea.

Objectives: To investigate the clinical and radiologic predictors of postoperative recurrent septic arthritis of the shoulder (SAS) using multivariable analysis.

Methods: Forty-three patients (mean age, 65 years; 24 women) who underwent surgery for SAS between January 2011 and October 2019 were retrospectively enrolled. An orthopedic surgeon assessed clinical (age, sex, comorbidity, duration from symptom onset to MR imaging and surgery, surgical method, antibiotic usage), laboratory (serum white blood cell [WBC] count, C-reactive protein [CRP] level, synovial cell count), and surgical findings (culture/biopsy results). Read More

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October 2021

Clinical relevance of MRI knee abnormalities in Australian rules football players: a longitudinal study.

BMJ Open Sport Exerc Med 2021 29;7(3):e001097. Epub 2021 Sep 29.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Background/aim: The clinical relevance of MRI knee abnormalities in athletes is unclear. This study aimed to determine the prevalence of MRI knee abnormalities in Australian Rules Football (ARF) players and describe their associations with pain, function, past and incident injury and surgery history.

Methods: 75 male players (mean age 21, range 16-30) from the Tasmanian State Football League were examined early in the playing season (baseline). Read More

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September 2021

Inflammatory arthritis complicating galactosialidosis: a case report.

BMC Rheumatol 2021 Oct 11;5(1):41. Epub 2021 Oct 11.

Emma Children's Hospital, Amsterdam University Medical Centers, location Academic Medical Center, Pediatric Immunology, Rheumatology and Infectious Diseases, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.

Background: Galactosialidosis (GS) is a rare inherited lysosomal storage disorder (LSD) which is characterized by a defect in the lysosomal glycoprotein catabolism. We report, for the first time, the case of a child affected by GS presenting with recurrent episodes of extensive joint inflammation in both knee joints. The aim of this case-report is to describe the clinical presentation as well as the laboratory, radiologic and microscopic features of this unique presentation of GS. Read More

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October 2021

Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets.

EBioMedicine 2021 Oct 7;72:103618. Epub 2021 Oct 7.

Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, United Kingdom. Electronic address:

Background: Synovial inflammation is associated with pain severity in patients with knee osteoarthritis (OA). The aim here was to determine in a population with knee OA, whether synovial tissue from areas associated with pain exhibited different synovial fibroblast subsets, compared to synovial tissue from sites not associated with pain. A further aim was to compare differences between early and end-stage disease synovial fibroblast subsets. Read More

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October 2021

Photodynamic therapy for synovial hyperplasia in patients with refractory rheumatoid arthritis: a study protocol for a randomized, double-blind, blank-controlled prospective trial.

Trials 2021 Oct 9;22(1):685. Epub 2021 Oct 9.

Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.

Background: Persistent synovial hyperplasia with inflammation in rheumatoid arthritis is one of the main pathogeneses of refractory rheumatoid arthritis (RRA). Photodynamic therapy (PDT) causes less trauma than steroid injections or arthroscopic synovectomy while providing stronger targeting and more durable curative effects. The aim of this trial was to evaluate the short-, medium-, and long-term clinical efficacy of PDT when applied as a treatment for RRA synovial hyperplasia and synovitis. Read More

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October 2021

Characteristics of the descending genicular artery blood flow velocity in patients with knee osteoarthritis.

Knee 2021 Oct 5;33:143-149. Epub 2021 Oct 5.

Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan; Inclusive Medical Science Research Institute, Morinomiya University of Medical Sciences, Osaka, Japan; AR-Ex medical research center, Tokyo, Japan. Electronic address:

Background: In patients with knee osteoarthritis (KOA), the descending genicular artery (DGA) showed abnormal angiogenesis. However, the non-invasive assessment method of DGA remains unclear. The aim of this study was to clarify the characteristics of blood flow velocity of the DGA in patients with KOA and to examine the factors involved in the changes. Read More

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October 2021

Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-κB and Ang/Tie-2 pathways.

J Ethnopharmacol 2021 Oct 5;283:114714. Epub 2021 Oct 5.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China. Electronic address:

Ethnopharmacological Relevance: Nigella glandulifera Freyn et Sint. (N. glandulifera) seeds are widely used in traditional Uyghur medicine for a variety of immuno-inflammatory diseases. Read More

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October 2021

Can ultrasonography be used to assess capsular distention in the painful temporomandibular joint?

BMC Oral Health 2021 Oct 6;21(1):497. Epub 2021 Oct 6.

Department of Oral and Maxillofacial Surgery, College of Medicine, Ewha Womans University, Mok-Dong Hospital, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul, 07985, Republic of Korea.

Background: To determine whether capsular distention in the painful temporomandibular joint (TMJ) can be assessed by ultrasonography, we compared the capsular width between painful TMJs and painless TMJ. The risk factors for TMJ pain were also investigated including capsular width and other clinical factors such as TMJ sounds that may affect the occurrence and persistence of TMJ pain.

Methods: TMJ ultrasonography was performed on 87 temporomandibular disorder (TMD) patients, including 47 unilateral and 29 bilateral TMJ pain patients, and 11 patients without TMJ pain. Read More

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October 2021

Rice Bodies In The Wrist.

Mod Rheumatol Case Rep 2021 Oct 7. Epub 2021 Oct 7.

Department of Orthopaedic surgery, AZ St-Dimpna Geel, Geel, Belgium.

Rice bodies are a rare finding in medicine and remain to be a challenge to provide adequate treatment. As occurrence varies over multiple rheumatic as well as infectious diseases, multiple hypotheses have been made about their origin. While rice bodies are most frequently reported in the shoulder and knee joints, flexor tendon synovitis with accompanying rice bodies is more rare. Read More

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October 2021

Pulsed Electromagnetic Field Attenuates Osteoarthritis Progression in a Murine Destabilization-Induced Model through Inhibition of TNF-α and IL-6 Signaling.

Cartilage 2021 Oct 6:19476035211049561. Epub 2021 Oct 6.

Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China.

Objective: To investigate the anti-inflammatory effects and mechanisms of pulsed electromagnetic field (PEMF) in the treatment of osteoarthritis (OA) in the destabilization of the medial meniscus (DMM) mice.

Design: Ten-week-old male wild-type (WT), interleukin (IL)-6 and tumor necrosis factor (TNF)-α mice undergoing DMM surgery were randomly divided into 2 groups ( = 10 each): mice with PEMF exposure and mice with sham PEMF exposure. PEMF (75 Hz, 3. Read More

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October 2021

Role of peroxiredoxin 6 in the chondroprotective effects of microvesicles from human adipose tissue-derived mesenchymal stem cells.

J Orthop Translat 2021 Sep 20;30:61-69. Epub 2021 Sep 20.

Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), University of Valencia, Polytechnic University of Valencia, Av. Vicent A. Estellés s/n, 46100, Burjassot, Valencia, Spain.

Background: Osteoarthritis (OA) is a joint disease characterized by cartilage degradation, low-grade synovitis and subchondral bone alterations. In the damaged joint, there is a progressive increase of oxidative stress leading to disruption of chondrocyte homeostasis. The modulation of oxidative stress could control the expression of inflammatory and catabolic mediators involved in OA. Read More

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September 2021

Serotyping and Antibiotic Susceptibility of Invasive Streptococcus agalactiae in Egyptian Patients with or without Diabetes Mellitus.

Am J Trop Med Hyg 2021 Oct 4. Epub 2021 Oct 4.

Hepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt.

Streptococcus agalactiae serotype distribution and its antibiotic susceptibility affect disease prevention strategies, but the serotype distribution varies among patient groups. The objectives of this study were to establish the group B Streptococcus (GBS) serotype distribution in patients from Egypt and to assess antibiotic sensitivity of invasive GBS isolates. A total of 490 patients participated in this multicenter study; 160 had urinary tract infection, 115 complained of diabetic foot ulcers, 125 men had genital tract infections, and 30 women females had genital tract infections. Read More

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October 2021

Association between structural change over 18 months and subsequent symptom change in middle-aged persons treated for meniscal tear.

Arthritis Care Res (Hoboken) 2021 Oct 4. Epub 2021 Oct 4.

Section of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School.

Background: Middle-aged subjects with meniscal tear treated with arthroscopic partial meniscectomy (APM) experience greater progression of damage to joint structures on imaging than subjects treated nonoperatively. It is unclear whether these changes are clinically relevant.

Methods: We used data from the MeTeOR (Meniscal Tear in Osteoarthritis Research) Trial of APM vs. Read More

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October 2021

Quercetin suppresses inflammatory cytokine production in rheumatoid arthritis fibroblast-like synoviocytes.

Exp Ther Med 2021 Nov 6;22(5):1260. Epub 2021 Sep 6.

Laboratory of New Techniques of Restoration and Reconstruction of Orthopedics and Traumatology, The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.

Rheumatoid arthritis (RA) is a chronic, progressive and systemic autoimmune disease mainly characterized by symmetric multijoint synovitis. Quercetin has anti-inflammatory, anti-oxidation and immune regulation activities, and therefore shows high medicinal value. The present study aimed to observe the effect of quercetin on fibroblast-like synoviocytes (FLSs) in RA. Read More

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November 2021

Systemic serum amyloid A in early (<24 h) diagnosis of acute synovial structure involvement in horses with penetrating limb injuries.

Vet J 2021 Sep 30;277:105759. Epub 2021 Sep 30.

Equine Clinic (Surgery, Orthopaedics), Justus-Liebig-University, Frankfurter Str. 108, 35392 Giessen, Germany.

Synovial structure involvement secondary to limb injury is a common emergency in equine practice, requiring an accurate initial diagnosis for immediate treatment. This study aimed to investigate the clinical usefulness of Serum amyloid A (SAA) in the initial diagnosis of synovial structure involvement caused by acute (<24 h) penetrating limb injuries in horses and to correlate SAA with standard diagnostic parameters. Fifty-five horses with acute limb injuries were divided into two groups: Group 1 (G1, n = 26) with a diagnosis of penetrating synovial trauma and Group 2 (G2, n = 29) without synovial structure penetration. Read More

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September 2021

Ultrasonography of Shoulder in Rheumatoid Arthritis: A Reliability Exercise Using Consensual Definitions among Maghrebian Rheumatologists.

Ultrasound Med Biol 2021 Sep 29. Epub 2021 Sep 29.

Comité d'Experts Maghrébins en Imagerie Rhumatologique, Rabat, Morocco; Rheumatology Department, Mohamed V University, El Ayachi Hospital, Rabat-Salé, Morocco.

The shoulder may be affected in a large portion of patients with rheumatoid arthritis (RA) worldwide. However, this joint does not receive the attention required during follow-up. Indeed, although numerous clinical tests for diagnosis of a painful shoulder are available, differentiating articular from peri-articular lesions may be difficult in daily practice. Read More

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September 2021

Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes.

Chin Med 2021 Oct 2;16(1):96. Epub 2021 Oct 2.

Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen Peking University, The Hong Kong University of Science and Technology Medical Center, No.1120, Lianhua Road, Futian District, Shenzhen, 518036, China.

Background: Rheumatoid arthritis is a progressive and systemic autoimmune disease seriously compromises human health. Fibroblast like synoviocytes are the major effectors of proliferation and inflammation in rheumatoid arthritis synovial tissue. Shikonin has anti-inflammatory and immunomodulatory activities. Read More

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October 2021

Frequent injections of high-dose human umbilical cord mesenchymal stem cells slightly aggravate arthritis and skeletal muscle cachexia in collagen-induced arthritic mice.

Exp Ther Med 2021 Nov 7;22(5):1272. Epub 2021 Sep 7.

Henan Key Laboratory of Stem Cell Differentiation and Modification, Stem Cell Research Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.

A single injection of low-dose human umbilical cord-derived mesenchymal stem cells (UC-MSCs) has been previously demonstrated to relieve synovitis and bone erosion in animal models of arthritis, but whether frequent injections of high-dose UC-MSCs relieve arthritis and inhibit loss of muscle mass has remained elusive. In the present study, DBA/1 mice were randomly divided into three groups: Normal (wild-type mice; n=11), collagen-induced arthritis (CIA; n=12) and CIA treated with UC-MSCs (n=11; 5x10 UC-MSCs per week for 3 weeks). Arthritis and skeletal muscle cachexia were evaluated until the end of the experiment on day 84. Read More

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November 2021

Regarding Gravel et al "Oropharyngeal Carriage of Kingella kingae and Transient Synovitis of the Hip in Young Children: A Case-control Study".

Pediatr Infect Dis J 2021 Aug 24. Epub 2021 Aug 24.

Service of Pediatric Orthopedics Children's Hospital of Geneva University Hospitals of Geneva Switzerland.

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Pathological analysis of periprosthetic soft tissue and modes of failure in revision total joint arthroplasty patients.

SAGE Open Med 2021 22;9:20503121211047099. Epub 2021 Sep 22.

Department of Orthopaedic Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Objectives: Implant failure leading to revision total joint arthroplasty can occur through a variety of different mechanisms which are typically associated with a soft tissue response adjacent to the implant that provide insight into the underlying etiology of implant failure. The objective of this study was to elucidate mechanisms of implant failure as they relate to histological classification and findings of adjacent periprosthetic tissue.

Methods: Histological analysis of soft tissue adjacent to the implant was performed in 99 patients with an average age of 64 years old and grouped into four categories based on the study conducted by Morawietz et al. Read More

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September 2021

Tenosynovial giant cell tumor-diffuse type, treated with a novel colony-stimulating factor inhibitor, pexidartinib: initial experience with MRI findings in three patients.

Skeletal Radiol 2021 Sep 29. Epub 2021 Sep 29.

Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.

Tenosynovial giant cell tumor-diffuse type (diffuse TSGCT) is a benign but locally aggressive proliferative disorder of the synovium. Treatment is usually surgical, although in cases of extensive disease complete synovectomy is not possible and local recurrence rates are high. Pexidartinib (trade name Turalio®), a colony-stimulating factor-1 (CSF-1) inhibitor, was shown in a recent phase III trial to effectively treat diffuse TSGCT and is FDA approved for the treatment of adult patients with symptomatic diffuse TSGCT associated with severe morbidity or functional limitations and not amenable to improvement with surgery. Read More

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September 2021

Secukinumab reduces synovitis in PsA.

Authors:
Sarah Onuora

Nat Rev Rheumatol 2021 Sep 28. Epub 2021 Sep 28.

Nature Reviews Rheumatology, .

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September 2021

A Mouse Model for Studying Post-Acute Arthritis of Chikungunya.

Microorganisms 2021 Sep 21;9(9). Epub 2021 Sep 21.

Department of Global Health, Milken Institute School of Public Health, George Washington University, Washington, DC 20052, USA.

Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of CHIKV arthritis are lacking. Multiple mouse models of chikungunya have been developed to study acute CHIKV infection. Read More

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September 2021

[Progress on surgical treatment for hemophiliac arthropathy].

Zhongguo Gu Shang 2021 Sep;34(9):820-5

The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.

Surgical treatment is the main treatment for hemophilia arthritis, including synoviectomy, joint replacement and joint fusion. Synoviectomy is suitable for early hemophilia synovitis, and is divided into radiation, chemical, arthroscopy, and open operation. Radionuclides were recommended as the first choice due to its positive efficacy and less side effects, but exsit some problems such as scarcity of nuclides. Read More

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September 2021

Reliability and Convergent Construct Validity of Quantitative Ultrasound for Synovitis, Meniscal Extrusion, and Osteophyte in Knee Osteoarthritis With MRI.

J Ultrasound Med 2021 Sep 26. Epub 2021 Sep 26.

Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia.

Aims: To determine: 1) inter-rater reliability of quantitative measurements of ultrasound-detected synovitis, meniscal extrusion, and osteophytes; and 2) construct (convergent) validity via correlations and absolute agreements between ultrasound- and gold-standard magnetic resonance imaging (MRI)-outcomes in knee osteoarthritis.

Methods: Dynamic ultrasound images for supra-patellar synovitis, meniscal extrusion, and osteophytes were acquired and quantified by a physician operator, musculoskeletal ultrasonographer, and medical student independently. On the same day, 3T MRI images were acquired. Read More

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September 2021

Paclitaxel Inhibits Synoviocyte Migration and Inflammatory Mediator Production in Rheumatoid Arthritis.

Front Pharmacol 2021 9;12:714566. Epub 2021 Sep 9.

Department of Rheumatic and TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Activated fibroblast-like synoviocytes (FLSs) play a crucial role in the pathogenesis and progression of rheumatoid arthritis (RA). It is urgent to develop new drugs that can effectively inhibit the abnormal activation of RA-FLS. In our study, the RA-FLS cell line, MH7A, and mice with collagen-induced arthritis (CIA) were used to evaluate the effect of paclitaxel (PTX). Read More

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September 2021

A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy.

Insights Imaging 2021 Sep 25;12(1):132. Epub 2021 Sep 25.

Department of Diagnostic Imaging, Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada.

Background: Intra-articular bleeds in patients with inherited bleeding disorders lead to active synovitis which may progress to a chronic state over time. We explored the diagnostic value of color Doppler ultrasound in detecting synovitis in boys with bleeding disorders.

Results: Sixty boys with hemophilia and 3 boys with type 3 von Willebrand disease aged 5 to 18 years (median 12. Read More

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September 2021

Bee Venom Alleviated Edema and Pain in Monosodium Urate Crystals-Induced Gouty Arthritis in Rat by Inhibiting Inflammation.

Toxins (Basel) 2021 Sep 16;13(9). Epub 2021 Sep 16.

Department of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.

Bee venom (BV) acupuncture has anti-inflammatory and analgesic effects; therefore, it was used as a traditional Korean medicine for various musculoskeletal disorders, especially arthritis. In this study, we investigated the effect of BV on monosodium urate (MSU) crystal-induced acute gouty rats. An intra-articular injection of MSU crystal suspension (1. Read More

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September 2021