24,702 results match your criteria synergistic growth

Combination of resveratrol and green tea epigallocatechin gallate induces synergistic apoptosis and inhibits tumor growth in head and neck cancer models.

Oncol Rep 2021 May 13;45(5). Epub 2021 Apr 13.

Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA.

Despite widespread interest in chemoprevention and therapy due to the high margin of safety of dietary natural compounds, clinical intervention with single agents has failed to yield the expected outcomes, mostly due to poor bioavailability and low potency. Combinations of natural agents with synergistic effects are gaining increasing attention. In the present study, and antitumor effects of a combination of two natural dietary agents, green tea epigallocatechin gallate (EGCG) and resveratrol were investigated. Read More

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Combined effects of crude oil exposure and warming on eggs and larvae of an arctic forage fish.

Sci Rep 2021 Apr 16;11(1):8410. Epub 2021 Apr 16.

Department of Arctic and Marine Biology, UiT The Arctic University of Norway, 9037, Tromsø, Norway.

Climate change, along with environmental pollution, can act synergistically on an organism to amplify adverse effects of exposure. The Arctic is undergoing profound climatic change and an increase in human activity, resulting in a heightened risk of accidental oil spills. Embryos and larvae of polar cod (Boreogadus saida), a key Arctic forage fish species, were exposed to low levels of crude oil concurrently with a 2. Read More

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Effects of jasmonic acid on mycorrhizal Allium sativum.

New Phytol 1996 Dec;134(4):703-707

Department of Biology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1001 Ljubljana, Slovenia.

In experiments on spruce we have shown that jasmonic acid (JA), a cyclopentanone fatty acid, influences the ectomycorrhizal formation: we therefore also applied it to an endomycorrhizal symbiosis. Garlic (Allium sativum (L.)) bulbs were potted into substrates inoculated or not with arbuscular mycorrhizal fungi (AMF), and one half of the plants was foliar-treated with 5 μm JA. Read More

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December 1996

Role of synergy and antagonism in designing multidrug adaptive chemotherapy schedules.

Y Ma P K Newton

Phys Rev E 2021 Mar;103(3-1):032408

Department of Aerospace & Mechanical Engineering, Mathematics, and The Ellison Institute, University of Southern California, Los Angeles, California 90089-1191, USA.

Chemotherapeutic resistance via the mechanism of competitive release of resistant tumor cell subpopulations is a major problem associated with cancer treatments and one of the main causes of tumor recurrence. Often, chemoresistance is mitigated by using multidrug schedules (two or more combination therapies) that can act synergistically, additively, or antagonistically on the heterogeneous population of cells as they evolve. In this paper, we develop a three-component evolutionary game theory model to design two-drug adaptive schedules that mitigate chemoresistance and delay tumor recurrence in an evolving collection of tumor cells with two resistant subpopulations and one chemosensitive population that has a higher baseline fitness but is not resistant to either drug. Read More

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HDAC6 inhibitor WT161 performs antitumor effect on osteosarcoma and synergistically interacts with 5-FU.

Biosci Rep 2021 Apr 16. Epub 2021 Apr 16.

Central Laboratory of the Third Affiliated Hospital, Nanchang University, Nanchang, China.

Background:  WT161, as a selective HDAC6 inhibitor, has been shown to play anti-tumor effects on several kinds of cancers. The aim of this study is to explore the roles of WT161 in osteosarcoma and its underlying mechanisms.

Methods:  The anti-proliferative effect of WT161 on osteosarcoma cells was examined using MTT assay and colony formation assay. Read More

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Elevated GAS2L3 Expression Correlates With Poor Prognosis in Patients With Glioma: A Study Based on Bioinformatics and Immunohistochemical Analysis.

Front Genet 2021 30;12:649270. Epub 2021 Mar 30.

Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin, China.

Background: Growth arrest-specific 2 like 3 (GAS2L3) is a cytoskeleton-associated protein that interacts with actin filaments and tubulin. Abnormal GAS2L3 expression has been reported to be associated with carcinogenesis. However, the biological role of GAS2L3 in glioma remains to be determined. Read More

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Lipid-Polymer Hybrid Nanoparticle-Based Combination Treatment with Cisplatin and EGFR/HER2 Receptor-Targeting Afatinib to Enhance the Treatment of Nasopharyngeal Carcinoma.

Onco Targets Ther 2021 9;14:2449-2461. Epub 2021 Apr 9.

Department of Ear-Nose-Throat (ENT), The Second Hospital of Tianjin Medical University, Tianjin, 300211, People's Republic of China.

Purpose: Nasopharyngeal carcinoma (NPC) is one of the most prevalent carcinomas among the Cantonese population of South China and Southeast Asia (responsible for 8% of all cancers in China alone). Although concurrent platinum-based chemotherapy and radiotherapy have been successful, metastatic NPC remains difficult to treat, and the failure rate is high.

Methods: Thus, we developed stable lipid-polymer hybrid nanoparticles (NPs) containing cisplatin (CDDP) and afatinib (AFT); these drugs act synergistically to counter NPC. Read More

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RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma.

Cell Biosci 2021 Apr 15;11(1):74. Epub 2021 Apr 15.

Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.

Background: As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to investigate the effects of ribonucleotide reductase regulatory subunit M2 (RRM2) on malignant biological behaviors and activation of cGAS/STING pathway. We also explored the synergistic sensitization mechanisms of RRM2 and radiotherapy. Read More

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Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma.

Cancer Cell Int 2021 Apr 15;21(1):216. Epub 2021 Apr 15.

Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, Jiangsu Province, China.

Background: The third-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have shown significant therapeutic effects on patients with non-small cell lung carcinoma (NSCLC) who carry active EGFR mutations, as well as those who have developed acquired resistance to the first-generation of EGFR-TKIs due to the T790M mutation. However, most patients develop drug resistance after 8-10 months of treatment. Currently, the mechanism has not been well clarified, and new therapeutic strategies are urgently needed. Read More

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Grape Seed Proanthocyanidins play the roles of radioprotection on Normal Lung and radiosensitization on Lung Cancer via differential regulation of the MAPK Signaling Pathway.

J Cancer 2021 15;12(10):2844-2854. Epub 2021 Mar 15.

Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, 800 Xiangyin Road, Shanghai, China, 200433.

Radiation-induced lung injury (RILI) is a common serious complication and dose-limiting factor caused by radiotherapy for lung cancer. This study was to investigate radioprotective effects of grape seed proanthocyanidins (GSP) on normal lung as well as radiosensitizing effects on lung cancer. , we demonstrated radioprotective effects of GSP on normal alveolar epithelial cells (MLE-12 and BEAS/2B) and radiosensitizing effects on lung cancer cells (LLC and A549). Read More

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Evaluation of Antibacterial Activity of Essential Oils and Their Combination against Multidrug-Resistant Bacteria Isolated from Skin Ulcer.

Int J Microbiol 2021 26;2021:6680668. Epub 2021 Mar 26.

Department of Pharmacy, Health Science College, Madda Walabu University, Bale Robe, Ethiopia.

Background: Emerging of multidrug-resistant bacteria can compromise the effectiveness of antibiotics used to treat skin infections. Those bacteria imposed public health problems and questioning medical care in the 21 century. In this circumstance, essential oils of medicinal plants origin are supreme sources of structural and functionally divergent compounds, which inhibited the growth of common wound colonizing MRSA and ESBL producing The aim of this study was to evaluate the combined antibacterial activity of essential oils extracted from and against multidrug-resistant (MDR) isolates of skin ulcers. Read More

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Anticancer activity of repurposed hemostatic agent desmopressin on AVPR2-expressing human osteosarcoma.

Exp Ther Med 2021 Jun 26;21(6):566. Epub 2021 Mar 26.

Center of Molecular and Translational Oncology, National University of Quilmes, Bernal B1876BXD, Buenos Aires, Argentina.

Osteosarcoma is the most prevalent primary bone malignancy. Due to its high aggressiveness, novel treatment strategies are urgently required to improve survival of patients with osteosarcoma, especially those with advanced disease. Desmopressin (dDAVP) is a widely used blood-saving agent that has been repurposed as an adjuvant agent for cancer management due to its antiangiogenic and antimetastatic properties. Read More

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P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib.

Acta Pharmacol Sin 2021 Apr 13. Epub 2021 Apr 13.

Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Mantle cell lymphoma (MCL) is a lymphoproliferative disorder lacking reliable therapies. PI3K pathway contributes to the pathogenesis of MCL, serving as a potential target. However, idelalisib, an FDA-approved drug targeting PI3Kδ, has shown intrinsic resistance in MCL treatment. Read More

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Anti-Acanthamoeba synergistic effect of chlorhexidine and Garcinia mangostana extract or α-mangostin against Acanthamoeba triangularis trophozoite and cyst forms.

Sci Rep 2021 Apr 13;11(1):8053. Epub 2021 Apr 13.

School of Allied Health Sciences, Southeast Asia Water Team (SEA Water Team), World Union for Herbal Drug Discovery (WUHeDD), and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat, Thailand.

Acanthamoeba spp. can cause amoebic keratitis (AK). Chlorhexidine is effective for AK treatment as monotherapy, but with a relative failure on drug bioavailability in the deep corneal stroma. Read More

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Adhesion Engineering in Polymer-Metal Comolded Joints with Biomimetic Polydopamine.

ACS Appl Mater Interfaces 2021 Apr 13. Epub 2021 Apr 13.

Department of Materials Science and Technology of Polymers, University of Twente, Enschede 7522 NB, the Netherlands.

Joints that connect thermoplastic polymer matrices (TPMs) and metals, which are obtained by comolding, are of growing importance in numerous applications. The overall performance of these constructs is strongly impacted by the TPM-metal interfacial strength, which can be tuned by tailoring the surface chemistry of the metal prior to the comolding process. In the present work, a model TPM-metal system consisting of poly(methyl methacrylate) (PMMA) and titanium is used to prepare comolded joints. Read More

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Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans.

Biomed Pharmacother 2021 Apr 10;139:111568. Epub 2021 Apr 10.

Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, Shandong Province 250014, People's Republic of China. Electronic address:

Candida albicans (C. albicans) infection remains a challenge to clinicians due to the limited available antifungals. With the widespread use of antifungals in the clinic, the drug resistance has been emerging continuously, especially fluconazole. Read More

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Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation.

ACS Nano 2021 Apr 12. Epub 2021 Apr 12.

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.

The therapeutic effect of chemodynamic therapy (CDT) is significantly restricted by the stern reaction conditions and slow reaction rate of the Fenton reaction (pH 3-4). Herein, we report an ultrasmall trimetallic (Pd, Cu, and Fe) alloy nanozyme (PCF-a NEs) possessing dynamic active-site synergism, thus exhibiting a cascade glutathione peroxidase and peroxidase (POD) mimicking activities in circumneutral pH. PCF-a NEs exhibit photothermally augmented POD property and high photothermal conversion efficiency (62%) for synergistic tumor cell apoptosis. Read More

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Wnt5a/PRP synergistically inhibits IL-1β induced inflammatory activity through NF-κB signaling pathway and prevents cartilage damage and promotes meniscus regeneration.

J Tissue Eng Regen Med 2021 Apr 11. Epub 2021 Apr 11.

Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, P.R. China.

Objective: Non-canonical Wnt5a is a particularly attractive growth factor to maintain chondrogenesis. Platelet rich plasma (PRP) is an autologous blood-derived product and a source of bioactive growth factors involved in tissue regeneration. The present study aimed to investigate the effect and inflammation reaction of Wnt5a/PRP on meniscus cells, and evaluate meniscus regeneration and osteoarthritis prevention by the application of Wnt5a/PRP gel in a rabbit model of massive meniscal defect. Read More

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Antibacterial and Antibiofilm Photodynamic Activities of Lysozyme-Au Nanoclusters/Rose Bengal Conjugates.

ACS Omega 2021 Apr 24;6(13):9279-9290. Epub 2021 Mar 24.

Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8689, Japan.

Antibacterial photodynamic therapy (aPDT) utilizes reactive oxygen species such as singlet oxygen (O) and free radicals via photosensitizers, which are light and light-sensitive agents, to reduce bacterial infections. It has been utilized as a treatment for dental diseases in place of antibiotic therapies. However, aPDT does not always cause the desired therapeutic effect due to the instability of organic photosensitizers and the formation of bacterial biofilms. Read More

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Synergistic anti-tumor effect of anti-PD-L1 antibody cationic microbubbles for delivery of the miR-34a gene combined with ultrasound on cervical carcinoma.

Am J Transl Res 2021 15;13(3):988-1005. Epub 2021 Mar 15.

Medical College of China Three Gorges University Yichang, China.

This study explored the synergistic effect of anti-PD-L1 antibody cationic microbubbles (MBs) for delivery of the miR-34a gene combined with ultrasound in inhibiting the cervical cancer. H&E stain, TUNEL, immunohistochemistry and RT-PCR were used to detect the change of apoptosis regulatory factors, and immunofluorescence, Flow cytometry and LDH assays were applied to evaluate the changing of immunomodulatory. In this experiment the PD-L1 Ab/miR-34a-MBs were prepared successfully. Read More

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The Tubulin Inhibitor VERU-111 in Combination With Vemurafenib Provides an Effective Treatment of Vemurafenib-Resistant A375 Melanoma.

Front Pharmacol 2021 25;12:637098. Epub 2021 Mar 25.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, United States.

Melanoma is one of the deadliest skin cancers having a five-year survival rate around 15-20%. An overactivated MAPK/AKT pathway is well-established in BRAF mutant melanoma. Vemurafenib (Vem) was the first FDA-approved BRAF inhibitor and gained great clinical success in treating late-stage melanoma. Read More

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Combining inhibitors of Brd4 and cyclin-dependent kinase can decrease tumor growth in neuroblastoma with MYCN amplification.

J Pediatr Surg 2021 Mar 26:60215. Epub 2021 Mar 26.

Department of Surgery, Stanford University, Stanford, CA, USA. Electronic address:

Introduction: High-risk neuroblastoma is a deadly disease; poor prognosticators are MYCN-amplification and TERT-overexpression. We hypothesized that Gene Set Enrichment Analysis (GSEA) could identify pathways associated with MYCN-amplification and that inhibition of these pathways could decrease tumor growth.

Methods: We analyzed the Neuroblastoma-Kocak dataset (GSE45547, n = 649) and identified pathways associated with MYCN-amplification. Read More

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A co-delivery platform for synergistic promotion of angiogenesis based on biodegradable, therapeutic and self-reporting luminescent porous silicon microparticles.

Biomaterials 2021 Mar 26;272:120772. Epub 2021 Mar 26.

Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Insufficient angiogenesis happened in body defects such as ulceration, coronary heart disease, and chronic wounds constitutes a major challenge in tissue regeneration engineering. Owing to the poor bioactivity and maintenance of pro-angiogenic cells and factors during transplantation, new bioactive materials to tackle the barrier are highly desirable. Herein, we demonstrate a co-delivery platform for synergistic promotion of angiogenesis based on biodegradable, therapeutic, and self-reporting luminescent porous silicon (PSi) microparticles. Read More

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Enhancing microalgae growth and product accumulation with carbon source regulation: New perspective for the coordination between photosynthesis and aerobic respiration.

Chemosphere 2021 Mar 31;278:130435. Epub 2021 Mar 31.

College of Environmental Science and Engineering, Ocean University of China, Qingdao, 266100, China.

The coordination between photosynthesis and aerobic respiration under mixotrophic cultivation can make a difference to the growth and biochemical composition of microalgae. However, the response of carbon metabolism to carbon source composition under mixotrophic microalgae cultivation has not been well studied. In this study, the synergistic effects of inorganic carbon (IC) and organic carbon (OC) supply on the growth and carbon metabolism of Chlorella vulgaris under mixotrophic cultivation were investigated. Read More

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Inhibitors of DNA topoisomerases I and II applied to Candida dubliniensis reduce growth, viability, the generation of petite mutants and toxicity, while acting synergistically with fluconazole.

FEMS Yeast Res 2021 Apr 10. Epub 2021 Apr 10.

Laboratorio de Biología Molecular de Bacterias y Levaduras, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio y Plan de Ayala. Col. Sto. Tomás, 11340 México City, México.

The increasing resistance of Candida species to azoles emphasizes the urgent need for new antifungal agents with novel mechanisms of action. The aim of this study was to examine the effect of three DNA topoisomerase inhibitors of plant origin (camptothecin, etoposide and curcumin) on the growth of Candida dubliniensis. The phylogenetic analysis showed a close relationship between the topoisomerase enzymes of C. Read More

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Graphene ameliorates saline-alkaline stress-induced damage and improves growth and tolerance in alfalfa (Medicago sativa L.).

Plant Physiol Biochem 2021 Mar 21;163:128-138. Epub 2021 Mar 21.

College of Grassland Agriculture, Northwest A&F University, Yangling, 712100, Shaanxi Province, China. Electronic address:

Nanoscience is leading to the production of nanotech applications to enhance growth and environmental stress tolerance of plants. However, there are few studies on the morphological and physiological regulative mechanism of coupling effects between graphene (Nano-C) and pH in alfalfa, especially both in promotion and phytotoxicity effect by Nano-C under abiotic stress. The coupling effects of Nano-C and pH on plant growth, photosynthetic parameters and enzymes of the antioxidant defence system on leaves and roots were investigated at graphene concentrations of 0, 5, 10, and 20 g kg in pots trials. Read More

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Enhanced antibacterial activity of a novel biocompatible triarylmethane based ionic liquid-graphene oxide nanocomposite.

Colloids Surf B Biointerfaces 2021 Mar 26;203:111729. Epub 2021 Mar 26.

Department of Chemistry, Amity Institute of Applied Sciences, Amity University Kolkata, Major Arterial Road, Action Area II, Kadampukur Village, Rajarhat, Newtown, West Bengal, 700135, India. Electronic address:

Biofilm formation on medical implants and devices has been a severe concern that results in their impaired performance and life-threatening complications. Thus, development of novel functional coatings for infection prone surfaces with biofilm inhibiting characteristics is of prime significance considering the rapid emergence of multidrug resistant bacteria. Herein we present a novel nanocomposite derived from Graphene Oxide (GO) and a newly developed functional Ionic liquid (IL) obtained through a metathesis reaction between a triarylmethane dye hexamethyl pararosaniline chloride or crystal violet (CV) and sodium dodeceyl sulfate (SDS) to yield [CV][DS] (hexamethyl pararosaniline dodecyl sulfate). Read More

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Phenotypic and transcriptomic responses of the rotifer Brachionus koreanus by single and combined exposures to nano-sized microplastics and water-accommodated fractions of crude oil.

J Hazard Mater 2021 Mar 26;416:125703. Epub 2021 Mar 26.

Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address:

Sorption of organic pollutants on microplastics can be an alternative uptake route for organic pollutants in aquatic organisms. To assess the combined effects of microplastics and organic pollutants, we employed phenotypic and transcriptomic analyses to the responses of the marine rotifer Brachionus koreanus to environmentally relevant concentrations of nano-sized microplastic (0.05 µm), water-accommodated fractions of crude oil, and binary mixtures thereof. Read More

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Toxicological Response of Chironomus dilutus in Single Chemical and Binary Mixture Exposure Experiments with Six Perfluoralkyl Substances.

Environ Toxicol Chem 2021 Apr 9. Epub 2021 Apr 9.

Towson University, Towson, Maryland, USA.

Few studies have determined the toxicity of perfluoralkyl substances to aquatic invertebrates. Here, we exposed Chironomus dilutus to six different perfluoroalkyl substances (PFAS) to assess single chemical toxicity and relative or proportional toxicity among substances. A 10 d range finding test was conducted to inform 20 d assays for the following PFAS: (perfluorooctane sulfonate [PFOS], perfluorooctanoic acid [PFOA], perfluorononanoic acid [PFNA], perfluorobutanesulfonic acid [PFBS], perfluorohexanesulfonic acid [PFHxS], and perfluoroheptanoic acid [PFHpA]). Read More

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Understanding the Solution-Phase Growth of Cu and Ag Nanowires and Nanocubes from First Principles.

Langmuir 2021 Apr 9. Epub 2021 Apr 9.

Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.

In this feature article, we provide an account of the Langmuir Lecture delivered by Kristen Fichthorn at the Fall 2020 Virtual Meeting of the American Chemical Society. We discuss how multiscale theory and simulations based on first-principles DFT were useful in uncovering the intertwined influences of kinetics and thermodynamics on the shapes of Ag and Cu cubes and nanowires grown in solution. We discuss how Ag nanocubes can form through PVP-modified deposition kinetics and how the addition of chloride to the synthesis can promote thermodynamic cubic shapes for both Ag and Cu. Read More

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