164,136 results match your criteria syndrome reported

Clinical and psychological factors predict outcome in patients with Functional Dyspepsia: A prospective study.

Clin Gastroenterol Hepatol 2021 Jul 30. Epub 2021 Jul 30.

Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address:

Background & Aims: Symptoms of functional dyspepsia (FD) fluctuate over time but there is limited data on impact of factors on change in dyspepsia symptom severity over time. We aimed to evaluate the demographic, clinical and psychological factors associated with change in dyspepsia symptom severity.

Methods: Consecutive patients with FD presenting to a tertiary care center completed questionnaires assessing clinical and psychological symptoms at the time of initial visit (baseline) and 3-6-month follow-up. Read More

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Origin, phylogeny, variability and epitope conservation of SARS-CoV-2 worldwide.

Virus Res 2021 Jul 30:198526. Epub 2021 Jul 30.

Molecular Microbiology and Biotechnology Department, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal.

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses innumerous challenges, like understanding what triggered the emergence of this new human virus, how this RNA virus is evolving or how the variability of viral genome may impact the primary structure of proteins that are targets for vaccine. We analyzed 19471 SARS-CoV-2 genomes available at the GISAID database from all over the world and 3335 genomes of other Coronoviridae family members available at GenBank, collecting SARS-CoV-2 high-quality genomes and distinct Coronoviridae family genomes. Additionally, we analyzed 199,984 spike glycoprotein sequences. Read More

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Movement Patterns and their Associations with Pain, Function, and Hip Morphology in Individuals with Femoroacetabular Impingement Syndrome: A Scoping Review.

Phys Ther 2021 Aug 2. Epub 2021 Aug 2.

Department of Physical Therapy, The University of Alabama at Birmingham, Birmingham, AL, United States.

Objective: Synthesize studies of movement patterns and their association with hip pain, function/activity, and morphology in individuals with femoroacetabular impingement syndrome (FAIS).

Methods: PubMed, SPORTDiscus, CINAHL, Embase, and Scopus databases were searched using predefined terms. Two authors independently reviewed abstracts and full texts. Read More

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Multicenter Outcomes After Revision Hip Arthroscopy: Comparative Analysis of 2-Year Outcomes After Labral Repair Versus Labral Reconstruction.

Am J Sports Med 2021 Aug 2:3635465211030511. Epub 2021 Aug 2.

Section of Young Adult Hip Surgery, Division of Sports Medicine, Department of Orthopaedic Surgery, Hip Preservation Center, Rush University Medical Center, Chicago, Illinois, USA.

Background: There is a paucity of literature evaluating patient outcomes in patients undergoing revision labral repair and labral reconstruction.

Purpose: To compare outcomes in patients undergoing revision hip arthroscopy for treatment of labral tears by labral repair or labral reconstruction.

Study Design: Cohort study; Level of evidence, 3. Read More

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Impaired Lower Extremity Biomechanics, Hip External Rotation Muscle Weakness, and Proximal Femoral Morphology Predict Impaired Single-Leg Squat Performance in People With FAI Syndrome.

Am J Sports Med 2021 Aug 2:3635465211029032. Epub 2021 Aug 2.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA.

Background: Impairments in squat depth have been reported in patients with femoroacetabular impingement syndrome (FAIS). However, little is known about single-leg squat (SLS) performance in these patients, despite this task being commonly used in the rehabilitation and training settings.

Purpose/hypothesis: The aims of this study were (1) to investigate whether patients with FAIS demonstrate differences in SLS performance compared with healthy controls and (2) to determine whether dynamic range of motion (ROM), muscle strength, hip morphologic measures, hip pain, and hip-specific function predict SLS performance in patients with FAIS. Read More

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Fetal brain arrest broadens the spectrum of WDR81-related developmental brain malformations.

Neurogenetics 2021 Aug 2. Epub 2021 Aug 2.

Human Genetics and Genome Research Division, Clinical Genetics Department, National Research Centre, El-Tahrir Street, Dokki, Cairo, Egypt.

Fetal brain arrest is an extremely rare genetic disorder that was described in few patients and encompasses very unique findings of underdeveloped cerebral hemispheres in association with collapsed skull bones. Based on the recurrence among sibs, an autosomal recessive mode of inheritance was proposed; however, no causative gene was identified so far. Here, we report the identification of biallelic variants in the WDR81 gene in two unrelated families (4 patients) with fetal brain arrest including the originally described family and an additional new family. Read More

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New insights into Perrault syndrome, a clinically and genetically heterogeneous disorder.

Hum Genet 2021 Aug 2. Epub 2021 Aug 2.

Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, 20892, USA.

Hearing loss and impaired fertility are common human disorders each with multiple genetic causes. Sometimes deafness and impaired fertility, which are the hallmarks of Perrault syndrome, co-occur in a person. Perrault syndrome is inherited as an autosomal recessive disorder characterized by bilateral mild to severe childhood sensorineural hearing loss with variable age of onset in both sexes and ovarian dysfunction in females who have a 46, XX karyotype. Read More

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Genetic etiology of hereditary hearing loss in the Gulf Cooperation Council countries.

Hum Genet 2021 Aug 2. Epub 2021 Aug 2.

Department of Applied Biology, College of Sciences, University of Sharjah, Building W8-Room 107, 27272, Sharjah, United Arab Emirates.

The past 30 years have seen an exponential growth concerning the identification of genes and variants responsible for hereditary hearing loss (HL) worldwide. This has led to a huge gain in our understanding of molecular mechanisms of hearing and deafness, which improved diagnosis for populations with hereditary HL. Many communities around the world, especially in the Middle East and North Africa, have a high prevalence of consanguineous marriages. Read More

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Dental Mitigation Strategies to Reduce Aerosolization of SARS-CoV-2.

J Dent Res 2021 Aug 2:220345211032885. Epub 2021 Aug 2.

Division of Restorative Dentistry, School of Dentistry, University of Leeds, Leeds, UK.

Limiting infection transmission is central to the safety of all in dentistry, particularly during the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Aerosol-generating procedures (AGPs) are crucial to the practice of dentistry; it is imperative to understand the inherent risks of viral dispersion associated with AGPs and the efficacy of available mitigation strategies. In a dental surgery setting, crown preparation and root canal access procedures were performed with an air turbine or high-speed contra-angle handpiece (HSCAH), with mitigation via rubber dam or high-volume aspiration and a no-mitigation control. Read More

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Four-year outcomes of a single-center experience with coronary everolimus-eluting bioresorbable scaffolds.

Minerva Cardiol Angiol 2021 Aug 2. Epub 2021 Aug 2.

Division of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Background: Bioresorbable scaffolds (BRS) have been introduced to overcome the limitations of drug-eluting stents and the ABSORB (Everolimus-eluting BRS, Abbott Vascular, Santa Clara, CA) was the most extensively tested. Nevertheless, major RCTs reported higher rates of target lesion failures and BRS thrombosis at 3 years follow-up, bringing to the withdrawing of the device from the market. It has been suggested that a better lesions selection and an optimized implantation technique could mitigate the displayed adverse results. Read More

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Smoke Gets in the Eye: A systematic review of case reports of ocular complications of crack cocaine use.

Drug Alcohol Rev 2021 Aug 1. Epub 2021 Aug 1.

Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Issues: Use of crack cocaine and associated medical complications persists globally. Some reports in medical literature describe a sight-threatening condition commonly referred to as 'crack eye' or 'crack eye syndrome'. The purpose of this review is to describe what is known about crack eye from case reports in peer-reviewed literature. Read More

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The evaluation of the trachea as a new parameter in determining the prognosis of COVID-19: first pilot study.

Eur Rev Med Pharmacol Sci 2021 Jul;25(14):4835-4840

Department of Radiology, Malatya Training and Research Hospital, Malatya, Turkey.

Objective: Coronavirus disease-2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) follows a biphasic disease model consisting of an early viral response phase and an inflammation phase. SARS-CoV-2 has a high affinity for the upper respiratory tract and conjunctiva; hence, it can infect the upper respiratory tract and facilitate airway inflammation. COVID-19 also affects the tracheal epithelial cells. Read More

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Potential mechanisms of metformin-induced memory impairment.

A Alhowail

Eur Rev Med Pharmacol Sci 2021 Jul;25(14):4757-4761

Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Kingdom of Saudi Arabia.

Metformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus. In addition to its ability to lower glucose levels, it has recently been reported to be potentially useful for the treatment of other conditions because of its anticancer activity, cardiovascular protective effect, neuroprotective effect, and efficacy in the treatment of polycystic ovary syndrome. However, long-term use of metformin may lead to side-effects such as memory impairment. Read More

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Blockchain technologies to mitigate COVID-19 challenges: A scoping review.

Comput Methods Programs Biomed Update 2021 14;1:100001. Epub 2020 Dec 14.

Division of Information and Computing Technology, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.

As public health strategists and policymakers explore different approaches to lessen the devastating effects of novel coronavirus disease (COVID-19), blockchain technology has emerged as a resource that can be utilized in numerous ways. Many blockchain technologies have been proposed or implemented during the COVID-19 pandemic; however, to the best of our knowledge, no comprehensive reviews have been conducted to uncover and summarise the main feature of these technologies. This study aims to explore proposed or implemented blockchain technologies used to mitigate the COVID-19 challenges as reported in the literature. Read More

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December 2020

Critical Presentation of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection: A Case Report.

Open Forum Infect Dis 2021 Jul 23;8(7):ofab329. Epub 2021 Jun 23.

IrsiCaixa-AIDS Research Institute and Germans Trias i Pujol Health Research Institute, Badalona, Catalonia, Spain.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections have been reported; however, most cases are milder than the primary infection. We report the first case of a life-threatening critical presentation of a SARS-CoV-2 reinfection.

Methods: A 62-year-old man from Palamós (Spain) suffered a first mild coronavirus disease 2019 (COVID-19) episode in March 2020, confirmed by 2 independent SARS-CoV-2 nasopharyngeal polymerase chain reaction (PCR) assays and a normal radiograph. Read More

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Case Report: Rare Iliac Vein Compression (May-Thurner) Syndrome in a Pediatric Patient.

Front Pediatr 2021 15;9:694782. Epub 2021 Jul 15.

Department of Cardiology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Iliac vein compression syndrome (IVCS) or May-Thurner syndrome occurs predominantly in young to middle-aged women. Here we reported a case of IVCS in a 5-year-old boy. The child was admitted to our vasculocardiology department with left lower extremity that had been swollen for 1 month. Read More

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Case Report: Long-Term Tolvaptan Treatment in a Child With SIADH and Suprasellar Arachnoid Cyst.

Front Pediatr 2021 16;9:684131. Epub 2021 Jul 16.

Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Endocrinology Division, University of Verona, Verona, Italy.

Suprasellar arachnoid cysts represent a rare occurrence in the pediatric population and usually cause symptoms related to mass effect and can occasionally cause endocrine dysfunctions. The association between SAC and the syndrome of inappropriate antidiuretic hormone (SIADH) in the pediatric population has rarely been described previously. In most cases, SIADH is temporary and resolves by treating the underlying cause. Read More

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Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury.

Front Cell Infect Microbiol 2021 14;11:677902. Epub 2021 Jul 14.

Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Patients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported. However, the role of circulating NETs in the progression and thrombotic tendency of sepsis-induced lung injury remains elusive. Read More

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Successful Chimeric Antigen Receptor (CAR) T-Cell Treatment in Aggressive Lymphoma Despite Coronavirus Disease 2019 (CoVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication - Case Report.

Front Oncol 2021 14;11:706431. Epub 2021 Jul 14.

Department of Medicine, Hematology and Oncology, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.

In patients with compromised immune function, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (CoVID-19) impose particular challenges. Especially in hematological malignancies, including lymphoma, the demands by this novel virus disease are further enhanced during sophisticated treatments, such as chimeric antigen receptor (CAR) T-cell therapy. Here, we present the first case of a patient with refractory diffuse-large B-cell lymphoma, who underwent CAR T-cell treatment in the context of SARS-CoV-2. Read More

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COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series.

Anesth Pain Med 2021 Apr 18;11(2):e113760. Epub 2021 Apr 18.

Department of MESVA, University of L'Aquila, L'Aquila, Italy.

Background: A variety of skin manifestations have been associated with COVID-19 infection. Acral lesions on hands and feet, closely resembling chilblains, have been reported in association with COVID-19, which are nonspecific. These acro-ischemic painful lesions have been described mainly in asymptomatic and mildly symptomatic pediatric COVID-19 positive patients, without a precise pathogenetic mechanism. Read More

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Pneumothorax due to COVID-19: Analysis of case reports.

Respir Med Case Rep 2021 26;34:101490. Epub 2021 Jul 26.

Hospital General Regional No. 72, Instituto Mexicano del Seguro Social, Av. Gustavo Baz Prada S/N, Neighborhood Centro Industrial Tlalnepantla, CP 54000, Tlalnepantla de Baz, Estado de México, Mexico.

Cases of pneumothorax/pneumomediastinum have been reported in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the time to onset and hospital stay have rarely been studied. Coronavirus disease 2019 (COVID-19) patients with these complications are described to determine the time to onset, associated comorbidities, and location and duration of pneumothorax. A search in PubMed yielded simple frequencies and a bivariate analysis of deaths. Read More

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Stochastic modelling of the dynamics of infections caused by the SARS-CoV-2 and COVID-19 under various conditions of lockdown, quarantine, and testing.

Tiri Chinyoka

Results Phys 2021 Sep 24;28:104573. Epub 2021 Jul 24.

Center for Research in Computational & Applied Mechanics, University of Cape Town, Rondebosch 7701, South Africa.

We develop a mathematical model for the transmission and spread of infections caused by the severe acute respiratory syndrome coronavirus 2 (SAR-CoV-2) which causes the coronavirus disease 2019 (COVID-19), a disease that has since been classified, by the World Health Organization, as a global pandemic. We focus attention on virus transmissions in a closed population and hence use a compartmental epidemic model to study the inherent dynamics of infections between the various subgroups of the population. We assume random interactions between members from different subgroups and hence we employ stochastic modelling techniques. Read More

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September 2021

Fungal Infections Associated With the Use of Novel Immunotherapeutic Agents.

Curr Clin Microbiol Rep 2020 Dec 26;7(4):142-149. Epub 2020 Sep 26.

Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 417 E 68th, New York, NY 10065, USA.

Purpose Of The Review: Recent concerns have emerged regarding the potential of immunotherapy to cause infection. In this review, we summarize the current literature on invasive fungal infections that occur during treatment with immune checkpoint inhibitors and chimeric antigen receptor T cell therapy.

Recent Findings: Fungal infections are uncommon with the use of checkpoint inhibitors. Read More

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December 2020

Rare Case of Small Bowel Obstruction Secondary to Cryptosporidium in a Young Patient With Uncontrolled AIDS.

Cureus 2021 Jun 29;13(6):e16040. Epub 2021 Jun 29.

Internal Medicine, Jersey Shore University Medical Center, Neptune, USA.

Small bowel obstruction is a common cause of abdominal pain and accounts for approximately 20% of surgical admissions related to abdominal pain. In the United States alone, there are over 300,000 admissions annually for small bowel obstruction and account for every 15 out of 100 admissions for abdominal pain. If treated appropriately with medical management, over 80% of cases resolve without life-threatening, long-term complications or the need for surgical intervention. Read More

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Not All Pulmonary Densifications Are COVID-19: A Case Report About Lemierre's Syndrome.

Cureus 2021 Jun 28;13(6):e15984. Epub 2021 Jun 28.

Intensive Care Unit, Centro Hospitalar Tâmega e Sousa, Penafiel, PRT.

Lemierre's syndrome is a rare and a life-threatening disease characterized by anaerobic bacteraemia associated with thrombosis of the internal jugular vein. Odynophagia, otalgia, odontalgia, dyspnoea, cough and fever are the most frequent manifestations. We describe a case of a 37-year-old woman who was admitted to the emergency room due to fever, odynophagia, dyspnoea, myalgia, and pleuritic chest pain. Read More

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Irritable Bowel Syndrome: Prevalence and Risk Factors in Jazan Region, Saudi Arabia.

Cureus 2021 Jun 28;13(6):e15979. Epub 2021 Jun 28.

Faculty of Medicine, Jazan University, Jazan, SAU.

Background The prevalence of irritable bowel syndrome (IBS) worldwide remains heterogeneous. In Saudi Arabia, there are insufficient studies on the prevalence of IBS among the general population, yet the prevalence of IBS in certain professional groups has been reported. This study was conducted to determine the prevalence of IBS and its associated risk factors in the Jazan Region of Saudi Arabia. Read More

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Rare and Complicated Overlap of Stevens-Johnson Syndrome and Acute Generalized Exanthematous Pustulosis.

Cureus 2021 Jun 25;13(6):e15921. Epub 2021 Jun 25.

Research, Bangladesh Medical Association of North America, New York, USA.

Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and acute generalized exanthematous pustulosis (AGEP) are two separate pathological entities of severe cutaneous adverse reactions (SCARs) with different etiologies and treatment strategies. Diagnosis is, however, complicated by the similarity in their clinical presentation. Although there are few claims of AGEP-SJS/TEN overlap, a simultaneous true overlap of SJS/TEN and AGEP has rarely been described in the literature. Read More

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Acute Appendicitis Associated With Multisystem Inflammatory Syndrome in Children.

Cureus 2021 Jun 24;13(6):e15893. Epub 2021 Jun 24.

Pediatrics, Division of Pediatric Hospital Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, USA.

Multisystem inflammatory syndrome in children (MIS-C) has been reported to cause significant gastrointestinal symptoms. In this case series, we present four patients with MIS-C with documented acute appendicitis, which strengthens the association between SARS-CoV-2, MIS-C, and acute appendicitis. Read More

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A case of diffuse pulmonary ossification.

Respirol Case Rep 2021 Aug 28;9(8):e00812. Epub 2021 Jul 28.

Department of Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan.

Diffuse pulmonary ossification (DPO) is a rare condition characterized by the formation of bone tissues in the lung. DPO is considered to be accompanied by chronic lung diseases, such as idiopathic interstitial pneumonitis or chronic obstructive pulmonary disease, acute respiratory distress syndrome, or inhalation-related lung diseases. Most reported cases of DPO were diagnosed during autopsies or surgical specimen. Read More

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First case recognized as autoimmune polyglandular syndrome type 2 with myasthenia gravis in Palestine: A case report and literature review.

Ann Med Surg (Lond) 2021 Aug 16;68:102575. Epub 2021 Jul 16.

An-Najah National University Hospital, Nablus, Palestine.

Background: Myasthenia gravis is an organ specific autoimmune disorder that is potentially serious but treatable. It is characterized by fatigability of the voluntary muscles and weakness caused by antibodies against the nicotinic acetylcholine receptor (AChR) on the postsynaptic membrane at the neuromuscular junction.Sometimes, and in very rare cases, it can be associated with other autoimmune conditions in a so called autoimmune polyglandular syndrome type 2, which consists mainly of autoimmune adrenal insufficiency (Addison's disease) with autoimmune thyroid disease and/or type 1 diabetes mellitus. Read More

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