2,294 results match your criteria symptoms non-functioning


Hypoglycemia after bariatric surgery: importance of exhaustive hormonal study.

Endocrinol Diabetes Metab Case Rep 2021 Mar 20;2021. Epub 2021 Mar 20.

Endocrinology and Nutrition, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.

Summary: Hypoglycemia is an uncommon clinical problem in non-diabetic patients or patients not being treated for diabetes mellitus. It is a rare, but well-established complication of bariatric surgery and, in some cases, it can be the only symptom of another medical problem. A 50-year-old woman with a history of partially recovered hypopituitarism after transsphenoidal surgery for a non-functioning pituitary macroadenoma complained about symptomatic hypoglycemia after sleeve gastrectomy surgery. Read More

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A comparative study of functioning and non-functioning pituitary adenomas.

Medicine (Baltimore) 2021 Apr;100(14):e25306

Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Xi Cheng District.

Abstract: Pituitary tumors commonly cause visual impairment and the degree of impairment can depend on the size, location, and type of the tumor. However, no studies have been made regarding the differences caused by functioning pituitary adenoma (FPA) and non-functioning pituitary adenoma (NFPA). We aimed to investigate the relationship between clinical characteristics and visual impairment in patients with FPA and NFPA. Read More

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Heterogeneity of the Clinical Presentation of the MEN1 LRG_509 c.781C>T (p.Leu261Phe) Variant Within a Three-Generation Family.

Genes (Basel) 2021 Mar 31;12(4). Epub 2021 Mar 31.

Department of Endocrinology, Jagiellonian University Medical College, 31-008 Cracow, Poland.

Multiple neuroendocrine neoplasia type 1 (MEN1) is a rare genetic disorder with an autosomal dominant inheritance, predisposing carriers to benign and malignant tumors. The phenotype of MEN1 syndrome varies between patients in terms of tumor localization, age of onset, and clinical aggressiveness, even between affected members within the same family. We describe a heterogenic phenotype of the variant c. Read More

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Higher risk of chronic kidney disease and progressive kidney function impairment in primary aldosteronism than in essential hypertension. Case-control study.

Endocrine 2021 Apr 2. Epub 2021 Apr 2.

Endocrinology and Nutrition Department, Ramón y Cajal University Hospital & Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid, Spain.

Purpose: To study the differences in the prevalence, risk, and grade of control of different cardiometabolic comorbidities in patients with primary aldosteronism (PA) and essential hypertension (EH) matched by age, sex, and blood pressure levels at diagnosis.

Methods: Case-control study of a secondary base (PA patients in follow-up in a tertiary hospital between 2018 and 2020). Controls were patients with non-functioning adrenal incidentalomas and EH, matched by age, sex, and baseline diastolic blood pressure (DBP) and systolic blood pressure (SBP). Read More

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Adrenal incidentaloma as a novel independent predictive factor for periodontitis.

J Endocrinol Invest 2021 Mar 31. Epub 2021 Mar 31.

Department of Internal Medicine and Endocrine Unit, School of Medicine, Federal University of Rio de Janeiro, Clementino Fraga Filho University Hospital, Professor Rodolpho Paulo Rocco Street, 255. 9th floor-Endocrinology Unit Rio de Janeiro, Rio de Janeiro, RJ, 21941-913, Brazil.

Purpose: There are no data regarding periodontal derangements in patients with adrenal incidentalomas (AI). We assessed the frequency and severity of periodontitis in patients with AI [non-functioning adrenal incidentaloma (NFAI) and possible autonomous cortisol secretion (ACS)] and compared with individuals with normal adrenal.

Methods: A cross-sectional study evaluated thirty-five individuals with AI and 26 controls. Read More

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Contemporary Experience of Posterior Retroperitoneoscopic Adrenalectomy in the US.

J Am Coll Surg 2021 Mar 9. Epub 2021 Mar 9.

Yale School of Medicine, New Haven, CT.

Background: As the incidence of adrenalectomy steadily increases, so do the utilization of minimally invasive approaches like the Posterior Retroperitoneoscopic Adrenalectomy (PRA). To date, the largest studies of PRA have been from abroad, and we sought to provide a contemporary American update on the outcomes following PRA.

Methods: A retrospective chart review was conducted on all PRAs performed at a single tertiary care institution between 2013 and 2020. Read More

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First German Guideline on Diagnostics and Therapy of Clinically Non-Functioning Pituitary Tumors.

Exp Clin Endocrinol Diabetes 2021 Mar 9;129(3):250-264. Epub 2021 Mar 9.

Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.

Although non-functioning pituitary tumors are frequent, diagnostic and therapeutic concepts are not well standardized. We here present the first German multidisciplinary guideline on this topic. The single most important message is to manage the patients by a multidisciplinary team (consisting at least of an endocrinologist, a neurosurgeon, and a (neuro-) radiologist). Read More

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Pituitary surgery in elderly patients: a safe and effective procedure.

Endocrine 2021 Mar 4. Epub 2021 Mar 4.

Endocrinology Department, University Hospital of Santiago de Compostela, Santiago de Compostela (A Coruña), Spain.

Purpose: The incidence of pituitary adenoma (PA) increases with age. Transsphenoidal surgery (TSS) in elderly patients is often considered to have greater risk compared to the younger population. The aim of this study is to compare surgical results, evolution and postoperative complications between elderly and young patients undergoing TSS. Read More

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Rare cause of haemoptysis: bronchopulmonary sequestration.

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Respiratory Medicine, Basildon and Thurrock University Hospitals, Mid and South Essex NHS Foundation Trust, Basildon, UK

Bronchopulmonary sequestration is a rare congenital pulmonary abnormality of the lower airways, which includes an abnormal and non-functioning lung tissue not communicating with the tracheobronchial tree and having aberrant blood supply from systemic circulation with variable venous drainage. The incidence of sequestration is around 0.15%-6. Read More

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Non-functional recurrent pituitary adenoma with intracranial metastasis-Pituitary carcinoma: A case report and review of the literature.

Neurochirurgie 2021 Feb 27. Epub 2021 Feb 27.

Department of Neurosurgery, Bahçeşehir University School of Medicine, Göztepe Medical Park Training and Education Hospital, Istanbul, Turkey. Electronic address:

Introduction: Pituitary carcinomas are rare, with only a few case reports to date. We present a null cell type non-functioning pituitary carcinoma (NFPC) with intracranial metastases and a review of the literature.

Case Report: A 56-year-old male with a history of an aggressive pituitary adenoma was admitted. Read More

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February 2021

Plasma cell variant of Castleman lymphadenopathy presenting as an adrenal mass.

Urol Case Rep 2021 May 26;36:101583. Epub 2021 Jan 26.

Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.

Adrenal masses are commonly found on radiographic studies performed for unrelated reasons. We report on a case of a non-functioning adrenal mass from which a needle biopsy showed a nonspecific infiltrate of polyclonal plasma cells and small lymphocytes. A definitive diagnosis of the plasma cell variant of Castleman lymphadenopathy was made only after surgical excision. Read More

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Laser Ablation versus Radiofrequency Ablation for thyroid nodules: Twelve-month results of a randomized trial (LARA II study).

J Clin Endocrinol Metab 2021 Feb 20. Epub 2021 Feb 20.

Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy.

Context: Radiofrequency ablation (RFA) seems to achieve a significantly larger nodule volume reduction rate (VRR) than laser ablation (LA) in benign non-functioning thyroid nodules (BNTNs).

Objective: To compare the efficacy and safety of both treatments at 12-month follow-up in patients with solid or predominantly solid BNTN.

Design: Single-center, 12-month, randomized, superiority, open-label, parallel-group trial. Read More

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February 2021

Risk of bone fractures after the diagnosis of adrenal adenomas: a population-based cohort study.

Eur J Endocrinol 2021 Apr;184(4):597-606

Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

Objective: Several small studies reported increased prevalence and incidence of asymptomatic vertebral fractures in patients with non-functioning adrenal adenomas and adenomas with mild autonomous cortisol secretion. However, the risk of symptomatic fractures at vertebrae, and at other sites remains unknown. Our objective was to determine the prevalence and incidence of symptomatic site-specific fractures in patients with adrenal adenomas. Read More

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Consensus on molecular imaging and theranostics in neuroendocrine neoplasms.

Eur J Cancer 2021 Mar 12;146:56-73. Epub 2021 Feb 12.

Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nuclear medicine plays an increasingly important role in the management neuroendocrine neoplasms (NEN). Somatostatin analogue (SSA)-based positron emission tomography/computed tomography (PET/CT) and peptide receptor radionuclide therapy (PRRT) have been used in clinical trials and approved by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA). European Association of Nuclear Medicine (EANM) Focus 3 performed a multidisciplinary Delphi process to deliver a balanced perspective on molecular imaging and radionuclide therapy in well-differentiated neuroendocrine tumours (NETs). Read More

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A case of a borderline adrenal oncocytoma in a 62-year old female.

Acta Chir Belg 2021 Apr 9:1-4. Epub 2021 Apr 9.

Department of Abdominal Surgery, Centre Hospitalier Bois de l'Abbaye, Seraing, Belgium.

Introduction: Adrenal oncocytomas are a rare pathology and only about 160 cases have been reported in the literature.

Case Description: We describe the case of a 62-year old female with an incidentaloma found in the right adrenal gland on a CT scan. Endocrine testing showed a non-secreting lesion. Read More

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Case report: Giant pyonephrosis due to urolithiasis and diabetes.

Urol Case Rep 2021 May 27;36:101582. Epub 2021 Jan 27.

CHU IBN ROCHD, CASABLANCA, Morocco.

Pyonephrosis is a rare pathology causing destruction of the renal parenchyma.The diagnosis of pyonephrosis was made on the basis of radiological images and cytobacteriological examination of the urine.A patient of 49 years old, followed for 10 years under insulintherapy was admitted for a massive pyonephrosis of the left kidney. Read More

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Editorial Comment from Dr Yadav and Dr Kumar to Outcomes of ultrasound-guided percutaneous nephrolithotomy for the treatment of large stones within non-functioning atrophic kidneys.

Int J Urol 2021 03 7;28(3):260. Epub 2021 Feb 7.

Department of Urology, Robotics and Renal Transplant, Safdarjung Hospital and Vardhman Mahavir Medical College, New Delhi, India.

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Imaging neuroendocrine tumors: Characterizing the spectrum of radiographic findings.

Surg Oncol 2021 Jan 31;37:101529. Epub 2021 Jan 31.

Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St, Room 143, Baltimore, MD, 21287, USA. Electronic address:

Neuroendocrine tumors (NET) are a group of neoplasms with neuroendocrine differentiation affecting a wide range of organs. Functional NETs present with symptoms due to the particular hormone produced. Functional NETs are usually small at diagnosis and therefore can be challenging to diagnose. Read More

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January 2021

MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas.

Eur J Endocrinol 2021 Apr;184(4):521-531

Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

Objective: Current markers predicting tumour progression of pituitary adenomas after surgery are insufficient. Our objective was to investigate if minichromosome maintenance protein 7 (MCM7) expression predicts tumour progression in non-functioning pituitary adenomas (NFPAs).

Methods: In a cohort study of surgically treated NFPAs, two groups with distinctly different behaviour of a residual tumour were selected: one group requiring reintervention due to tumour progression (reintervention group, n = 57) and one with residual tumours without progression (radiologically stable group, n = 40). Read More

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[Ablative therapies of pancreatic neoplasms.]

Recenti Prog Med 2021 Jan;112(1):75-80

The interest for pancreatic neoplasm ablation under endoscopic ultrasound (EUS) guidance has increased during the last decade because of technology advancement and availability of dedicated devices for thermal ablation. The most commonly used technique is radiofrequency ablation (RFA). Currently, three needle-electrodes and one "through-the-needle" probe are available. Read More

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January 2021

A survey of surgically resected pituitary incidentalomas and a comparison of the clinical features and surgical outcomes of non-functioning pituitary adenomas discovered incidentally versus symptomatically.

Endocr J 2021 Jan 28. Epub 2021 Jan 28.

Dept. of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan.

Pituitary tumors are discovered either incidentally by imaging studies (incidentalomas) or via evaluation of certain clinical symptoms (symptomatic tumors). In this study, we first surveyed patients with incidentalomas who underwent surgery. Cases included 62. Read More

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January 2021

Multiple Endocrine Neoplasia Type 1 Syndrome: A Case Report and Review of Literature.

Cureus 2020 Dec 14;12(12):e12073. Epub 2020 Dec 14.

Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, IND.

Multiple endocrine neoplasia type 1 (MEN1) or Wermer's syndrome is a genetic disease characterized by involvement of multiple endocrine glands, primarily involving parathyroid, pancreas, and pituitary. Other additional features include foregut carcinoids; non-functioning adrenal tumors; and skin lesions such as lipomas, collagenomas, and angiofibromas. Here, we describe our experience in managing a patient who presented to us with spontaneous episodes of hypoglycemia and was diagnosed with insulinoma. Read More

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December 2020

Prevalence of thyroid cancer in patients with acromegaly and non-growth hormone secreting pituitary adenomas: A prospective cross-sectional study.

Growth Horm IGF Res 2021 Feb 12;56:101378. Epub 2021 Jan 12.

SEMPR, Serviço de Endocrinologia e Metabologia, Departamento de Clínica Médica, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil. Electronic address:

Objective: To evaluate the prevalence of differentiated thyroid cancer (DTC) in patients with non-GH secreting pituitary adenomas [NGHPA group: non-functioning (NFPA), prolactin (PRL) and corticotropin (ACTH)-secreting adenomas] compared to patients with acromegaly, a pituitary disease that has been associated with increased risk for thyroid cancer.

Patients And Methods: Prospective, cross-sectional study involving consecutive outpatients followed in our institution with diagnosis of acromegaly (n = 71; 43 women, median age 57 yrs) and NGHPA (n = 57; 38 women, median age 48 yrs.; PRL (n = 35), ACTH (n = 7), NFPA (n = 15). Read More

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February 2021

Acute pancreatitis secondary to non-functioning pancreatic neuroendocrine tumor: uncommon clinical presentation. Clinical case and review of literature.

Ann Ital Chir 2021 Jan 20;10. Epub 2021 Jan 20.

Background: Pancreatic neuroendocrine tumors (PNETs) are uncommon, representing <5% of all pancreatic neoplasms, divided into functioning PNETs with secreted hormone cause of specific symptoms, and non-functioning PNETs (nf- PNETs) characterized by delayed diagnosis with metastases and clinical manifestations of compressive effects. Surgical approach is recommended for functioning and nf-PNETs >2 cm in diameter.

Case Report: A 76-year-old woman was admitted to the UOC-University-Surgery Hospital "A. Read More

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January 2021

Outcomes of ureterolysis for primary retroperitoneal fibrosis: A single-center experience.

Int J Urol 2021 Jan 21. Epub 2021 Jan 21.

Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.

Objective: To report our experience with ureterolysis for the management of retroperitoneal fibrosis.

Methods: The data of 25 patients who underwent ureterolysis due to primary retroperitoneal fibrosis between 2002 and 2017 were reviewed retrospectively. Initial symptoms, laterality, renal function status (initial/final), operation complications and serum creatinine levels (diagnosis/preoperative/6 months, 12 months postoperatively) were recorded. Read More

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January 2021

Pituitary metastases of Hürthle cell carcinoma of the thyroid.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Diabetes and Endocrinology, Queen's Medical Centre Nottingham University Hospital NHS Trust, Nottingham, UK.

An 85-year-old man was referred to endocrinology following the discovery of an incidental pituitary mass on cranial imaging which was thought to be a non-functioning adenoma during an admission with headaches, lethargy, confusion and hyponatraemia. He had a history of Hürthle cell carcinoma of the thyroid treated with total thyroidectomy, ablative radioiodine therapy and thyroxine replacement. Subsequently, he developed metastatic spread to the neck, lungs and skeleton. Read More

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January 2021

Leiomyosarcoma of the inferior vena cava posing as an adrenal incidentaloma.

BMJ Case Rep 2021 Jan 18;14(1). Epub 2021 Jan 18.

Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Adrenal incidentalomas are incidentally detected adrenal lesions on imaging, which have a variety of differential diagnoses, the most common being a non-functioning adenoma. Surgical intervention for these lesions is needed when there is hypersecretion, for lesions larger than 4 cm and smaller lesions with suspicious characteristics. Here we present a young woman who was incidentally found to have a right suprarenal mass with loss of fat planes with the inferior vena cava (IVC). Read More

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January 2021

Therapeutic approach to non-functioning pituitary adenomas.

Med Clin (Barc) 2021 03 14;156(6):284-289. Epub 2021 Jan 14.

Servicio de Neurocirugía. Hospital Universitario La Paz, Madrid, España.

The treatment of non-functioning pituitary adenomas raises two questions: when should they be treated and what role does each available treatment play. We review the usefulness of the different treatments and propose a therapeutic scheme based on the existing literature. Active treatment of pituitary adenomas should be performed when they produce symptoms, have contact with the optic tract, or have grown on imaging tests. Read More

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Pitfalls and differential diagnosis on adrenal lesions: current concepts in CT/MR imaging: a narrative review.

Gland Surg 2020 Dec;9(6):2331-2342

Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

The purpose of this pictorial essay is to review the imaging findings of adrenal lesions. Adrenal lesions could be divided into functioning or non-functioning masses, primary or metastatic, and benign or malignant. Imaging techniques have undergone significant advances in recent years. Read More

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December 2020

Metastatic insulinoma presenting 14 years after benign tumour resection: a rare case and management dilemma.

Endocrinol Diabetes Metab Case Rep 2020 Sep 23;2020. Epub 2020 Sep 23.

Department of Diabetes and Endocrinology, Royal Glamorgan Hospital, Llantrisant, UK.

Summary: We present a 60-year-old woman who underwent successful surgical resection (partial pancreatectomy) for a low grade non-functioning pancreatic neuroendocrine tumour (pNET), with no biochemical or radiological features of recurrence on follow-up visits for 5 years. Fourteen years after the initial surgery, she developed spontaneous severe hypoglycaemic episodes which required hospitalisation, with subsequent investigations confirming the diagnosis of a metastatic insulin-secreting pNET (insulinoma). Medical management of her severe spontaneous hypoglycaemic episodes remained challenging, despite optimum use of diazoxide and somatostatin analogue therapy. Read More

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September 2020