354,278 results match your criteria symptoms diabetes


Evaluating a standardized protocol for the management of diabetes insipidus in pediatric neurosurgical patients.

J Pediatr Endocrinol Metab 2021 Sep 27. Epub 2021 Sep 27.

Department of Pediatrics, Division of Endocrinology, University of Tennessee Health Sciences Center, Memphis, TN, USA.

Objectives: Central diabetes insipidus (DI) is a known complication following surgical resection of a suprasellar mass. There are limited data analyzing the outcomes of a standardized protocol for the management of postoperative DI in the pediatric population. We sought to fill this gap and hypothesized that utilizing a standardized protocol for fluid management (3-bag system) would reduce serum sodium fluctuations in the postoperative period after suprasellar surgery. Read More

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September 2021

Continuous glucose monitoring and Rituximab treatment in insulin autoimmune syndrome.

Diabetes Metab Syndr 2021 Sep 20;15(6):102294. Epub 2021 Sep 20.

Department of Endocrinology and Metabolism, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

Insulin autoimmune syndrome (IAS) or Hirata's disease is a rare cause of hypoglycemia. It is characterized by hyperinsulinemic hypoglycemia, elevated insulin autoantibody titers, no prior exposure to exogenous insulin and no pathological abnormalities of pancreatic islets. Hypoglycemia usually occurs in the post prandial and post absorptive state. Read More

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September 2021

Clinical and biochemical characteristics and analysis of risk factors for euglycaemic diabetic ketoacidosis in type 2 diabetic individuals treated with SGLT2 inhibitors: A review of 72 cases over a 4.5-year period.

Diabetes Metab Syndr 2021 Sep 15;15(6):102275. Epub 2021 Sep 15.

Endocrinology & Nutrition Unit, Cliniques Universitaires St-Luc, and Pole of Cardiovascular Research, Institute of Experimental and Clinical Research, Catholic University of Louvain, Avenue Hippocrate 55, 1200, Brussels, Belgium.

Background And Aims: To study euglycemic diabetic ketoacidosis (euDKA) outcomes associated with sodium-glucose co-transporter 2 inhibitors (SGLT2is) METHODS: Review of 72 euDKA cases in T2DM between September 2015 and January 2020 (PUBMED).

Results: euDKA could occur at any time during SGLT2is treatment, with nausea, abdominal pain and vomiting as main symptoms. Hyperglycemia did not correlate with pH and β-hydroxybutyrates. Read More

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September 2021

Estimated effect of increased diagnosis, treatment, and control of diabetes and its associated cardiovascular risk factors among low-income and middle-income countries: a microsimulation model.

Lancet Glob Health 2021 Sep 22. Epub 2021 Sep 22.

Institute for Applied Health Research, University of Birmingham, Birmingham, UK; Centre for Global Surgery, Department of Global Health, Stellenbosch University, Cape Town, South Africa; Medical Research Council-Wits University Rural Public Health and Health Transitions Research Unit, Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

Background: Given the increasing prevalence of diabetes in low-income and middle-income countries (LMICs), we aimed to estimate the health and cost implications of achieving different targets for diagnosis, treatment, and control of diabetes and its associated cardiovascular risk factors among LMICs.

Methods: We constructed a microsimulation model to estimate disability-adjusted life-years (DALYs) lost and health-care costs of diagnosis, treatment, and control of blood pressure, dyslipidaemia, and glycaemia among people with diabetes in LMICs. We used individual participant data-specifically from the subset of people who were defined as having any type of diabetes by WHO standards-from nationally representative, cross-sectional surveys (2006-18) spanning 15 world regions to estimate the baseline 10-year risk of atherosclerotic cardiovascular disease (defined as fatal and non-fatal myocardial infarction and stroke), heart failure (ejection fraction of <40%, with New York Heart Association class III or IV functional limitations), end-stage renal disease (defined as an estimated glomerular filtration rate <15 mL/min per 1·73 m or needing dialysis or transplant), retinopathy with severe vision loss (<20/200 visual acuity as measured by the Snellen chart), and neuropathy with pressure sensation loss (assessed by the Semmes-Weinstein 5·07/10 g monofilament exam). Read More

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September 2021

The Role of Social Support in Diabetes Self-Management Activities Among African-Americans.

J Natl Black Nurses Assoc 2021 Sep;32(1):22-27

Southern Illinois University Edwardsville, Edwardsville, IL

Understanding the association between social support and diabetes self-management activities in low income African-Americans provides knowledge for increasing culturally competent care. Diabetes mellitus poses a huge socioeconomic burden on the African-American population.  Diabetes self-management is a complex process that requires the ability to manage symptoms, treatment, and physical and psychosocial changes in lifestyle. Read More

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September 2021

Diabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events.

Diabetologia 2021 Sep 25. Epub 2021 Sep 25.

Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

Aims/hypothesis: Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has an independent prognostic association with major coronary events (MCE). However, no study has investigated whether type 2 diabetes status modifies the effect of Lp-PLA2 activity or inhibition on the risk of MCE. We investigate the interaction between diabetes status and Lp-PLA2 activity with risk of MCE. Read More

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September 2021

The effect of the COVID-19 pandemic on metabolic control in children with type 1 diabetes: a single-center experience.

J Pediatr Endocrinol Metab 2021 Sep 27. Epub 2021 Sep 27.

Department of Pediatric Endocrinology, School of Medicine, Erciyes University, Kayseri, Turkey.

Objectives: Coronavirus disease 2019 has caused a major epidemic worldwide, and lockdowns became necessary in all countries to prevent its spread. This study aimed to evaluate the effects of staying-at-home practices on the metabolic control of children and adolescents with type 1 diabetes during the pandemic period.

Materials And Methods: Eighty-nine patients younger than 18 years old who were diagnosed with type 1 diabetes at least one year before the declaration of the pandemic were included in the study. Read More

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September 2021

Aortic valve disease in diabetes: Molecular mechanisms and novel therapies.

J Cell Mol Med 2021 Sep 24. Epub 2021 Sep 24.

Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, Bucharest, Romania.

Valve disease and particularly calcific aortic valve disease (CAVD) and diabetes (DM) are progressive diseases constituting a global health burden for all aging societies (Progress in Cardiovascular Diseases. 2014;56(6):565: Circulation Research. 2021;128(9):1344). Read More

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September 2021

Cardiac troponin and recurrent major vascular events after minor stroke or TIA.

Ann Neurol 2021 Sep 25. Epub 2021 Sep 25.

Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objective: To investigate whether high-sensitivity cardiac troponin T (hs-cTnT) is associated with major adverse cardiovascular events (MACE) in patients with minor stroke or transient ischemic attack (TIA), and whether this association differs after risk stratification based on the "Age, Blood pressure, Clinical features, Duration of symptoms, Diabetes" (ABCD ) score.

Methods: INSPiRE-TMS was a randomized controlled trial allocating patients with minor stroke or TIA to an intensified support program or conventional care. In this post-hoc analysis, participants were categorized using hs-cTnT levels (5 Generation, Roche, 99 percentile upper reference limit [URL] 14ng/L). Read More

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September 2021

Serum carcinoembryonic antigen elevation in benign lung diseases.

Sci Rep 2021 Sep 24;11(1):19044. Epub 2021 Sep 24.

Cancer Department, Daping Hospital, Army Medical University, No. 10 Changjiang Zhi Road, Daping Yuzhong District, Chongqing, 400042, China.

Carcinoembryonic antigen (CEA) is not only used to aid the diagnosis of lung cancer, but also help monitor recurrence and determine the prognosis of lung cancer as well as evaluate the therapeutic efficacy for lung cancer. However, studies have also shown that CEA is present at low levels in the serum of patients with benign lung diseases (BLD), which will interfere with the accurate judgment of the disease. Due to difference in sample size, detection methods, cutoff values and sources of BLD, the positive rate of CEA in BLD is different with different literature. Read More

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September 2021

Diabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age: A Meta-Regression Model.

Cornea 2021 Sep 23. Epub 2021 Sep 23.

Neuroscience (NEUROS) Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; Clinical Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; and Department of Biology, Faculty of Natural Sciences, Universidad del Rosario, Bogotá, Colombia.

Purpose: Patients with diabetes mellitus (DM) often have keratopathy. However, the compromise of the corneal endothelium in type 1 DM (T1DM) and type 2 DM (T2DM) has so far not been well characterized.

Methods: We performed a systematic literature search to find articles on humans combining T1DM and/or T2DM and the corneal endothelium. Read More

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September 2021

Impact of the COVID-19 Pandemic on Primary Health Care Disease Incidence Rates: 2017 to 2020.

Ann Fam Med 2021 Sep 24. Epub 2021 Sep 24.

Consorci d'Atenció Primària de Salut Barcelona Esquerra (CAPSBE), Barcelona, Spain.

We assessed the impact of the COVID-19 pandemic in Spain on new cases of diseases and conditions commonly seen in primary care. In 2020, there were significant reductions from 2017-2019 in the annual incidences of hypertension (40% reduction), hypercholesterolemia (36%), type 2 diabetes (39%), chronic kidney disease (43%), ischemic heart disease (48%), benign prostatic hypertrophy (38%), osteoporosis (40%), hypothyroidism (46%), chronic obstructive pulmonary disease (50%), alcohol use disorder (46%), benign colon polyps and tumors (42%), and melanomas (45%). Prioritization of COVID-19 care changed the physician-patient relationship to the detriment of face-to-face scheduled visits for chronic disease detection and monitoring, which fell by almost 41%. Read More

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September 2021

Barriers and facilitators of type 1 diabetes self-care in adolescents and young adults.

J Pediatr Nurs 2021 Sep 21. Epub 2021 Sep 21.

Department of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, Monza, Italy. Electronic address:

Purpose: This study explores the disease experience of adolescents and young adults with T1DM focusing on the barriers and facilitators that characterise their disease self-care. Self-care requires complex decision making and cooperation between patients, their families, the healthcare team, and the social support system. Personal and social factors affect self-care, and specific challenges impact adolescents and young adults, putting them at a higher risk of poor glycaemic control and more severe complications. Read More

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September 2021

Acute Invasive Fungal Rhinosinusitis and Coronavirus Disease 2019.

J Craniofac Surg 2021 Sep 22. Epub 2021 Sep 22.

Department of Otolaryngology Department of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Cairo, Egypt.

Abstract: Acute invasive fungal rhinosinusitis (mucormycosis) is a rare, highly fatal disease. This opportunistic fungal infection causes angioinvasion and ischemic tissue necrosis. It mainly affects immunocompromised patients. Read More

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September 2021

The real-world applications of the symptom tracking functionality available to menstrual health tracking apps.

Curr Opin Endocrinol Diabetes Obes 2021 Sep 24. Epub 2021 Sep 24.

Department of Environmental Health Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: The goal of this review was to evaluate whether the fields available in iOS mobile phone apps for recording menstrual cycle symptoms are able to be harmonized across platforms for potential use in research, such as aggregated data analysis.

Recent Findings: Symptom tracking capabilities are a common feature among menstrual health apps but have been the subject of limited investigations. Apps differ with respect to which symptoms are included and the rationale for these differences is unclear. Read More

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September 2021

Mechanism by which Huoxue Tongluo Qiwei Decoction improves the erectile function of rats with diabetic erectile dysfunction.

J Ethnopharmacol 2021 Sep 21:114674. Epub 2021 Sep 21.

First Clinical Medical College, Beijing University of Chinese Medicine, Beijing, 100029, China; Andrology Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. Electronic address:

Ethnopharmacological Relevance: Huoxue Tongluo Qiwei Decoction is a classical herbal formula, which can improve the symptoms of erectile dysfunction (ED) patients and has a good therapeutic effect on patients with diabetic erectile dysfunction (DIED). The main function of Huoxue Tongluo Qiwei Decoction is to stimulate the blood circulation and dredge collaterals, remove blood stasis, and calm wind.

Rationale: To further explore the mechanism of Huoxue Tongluo Qiwei Decoction in the treatment of DIED, related animal experiments were designed. Read More

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September 2021

Kidney disease in diabetes: from mechanisms to clinical presentation and treatment strategies.

Metabolism 2021 Sep 21:154890. Epub 2021 Sep 21.

School of Cardiovascular Medicine & Science, King's College London, London, UK. Electronic address:

Metabolic and haemodynamic perturbations and their interaction drive the development of diabetic kidney disease (DKD) and its progression towards end stage renal disease (ESRD). Increased mitochondrial oxidative stress has been proposed as the central mechanism in the pathophysiology of DKD, but other mechanisms have been implicated. In parallel to increased oxidative stress, inflammation, cell apoptosis and tissue fibrosis drive the relentless progressive loss of kidney function affecting both the glomerular filtration barrier and the renal tubulointestitium. Read More

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September 2021

Diffuse Idiopathic Skeletal Hyperostosis of the Spine: Pathophysiology, Diagnosis, and Management.

J Am Acad Orthop Surg 2021 Sep 22. Epub 2021 Sep 22.

From the Department of Orthopaedic Surgery, University of California Davis School of Medicine, Sacramento, CA.

Diffuse idiopathic skeletal hyperostosis (DISH) is an ankylosing condition affecting up to 32.5% of the general cohort. Although often asymptomatic, affected individuals may present with back pain, stiffness, dysphagia, functional decline, and neurologic deficits. Read More

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September 2021

The Role of Nurses in Taking Care of Children With Type 1 Diabetes.

Altern Ther Health Med 2021 Sep 24. Epub 2021 Sep 24.

Type 1 diabetes (T1D) is an autoimmune disease leading to an insulin deficiency that causes hyperglycemia and associated symptoms. It is considered the most common type of diabetes, with the 4Ts (going to the toilet a lot, being really thirsty, feeling more tired than usual, losing weight or looking thinner than usual) being the most prevalent symptoms. Non-specific signs and symptoms are also possible, and delaying or missing the diagnosis can have a devastating effect on a child's health. Read More

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September 2021

Evaluation of venous plasma glucose measured by point-of-care testing (Accu-Chek Inform II) and a hospital laboratory hexokinase method (Cobas c701) in oral glucose tolerance testing during pregnancy - a challenge in diagnostic accuracy.

Scand J Clin Lab Invest 2021 Sep 24:1-8. Epub 2021 Sep 24.

Department of Obstetrics and Gynecology, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

To diagnose gestational diabetes mellitus (GDM), plasma glucose measurements during oral glucose tolerance test (OGTT) put high demands on the methods in terms of accuracy. The aim was to evaluate and compare diagnostic performance of a point-of-care test and a glucose hexokinase laboratory method. Using risk-based screening, 175 pregnant women were included. Read More

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September 2021

MRP8/14 serum levels as diagnostic markers for systemic juvenile idiopathic arthritis in children with prolonged fever.

Rheumatology (Oxford) 2021 Sep 24. Epub 2021 Sep 24.

Department of Pediatric Hematology-Oncology University of Duisburg-Essen, Essen, Germany.

Objectives: Differential diagnosis in children with prolonged fever is challenging. In particular, differentiating systemic-onset juvenile idiopathic arthritis (SJIA) from infectious diseases is difficult. Biomarkers are needed supporting the diagnostic work-up. Read More

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September 2021

Independent Predictors of Mortality Among Patients With NAFLD Hospitalized With COVID-19 Infection.

Hepatol Commun 2021 Jul 21. Epub 2021 Jul 21.

Inova Medicine, Inova Health System, Falls Church, VA, USA.

The impact of the coronavirus disease 2019 (COVID-19) pandemic among patients with chronic liver disease is unknown. Given the high prevalence of nonalcoholic fatty liver disease (NAFLD), we determined the predictors of mortality and hospital resource use among patients with NAFLD admitted with COVID-19 by using electronic medical records data for adult patients with COVID-19 hospitalized in a multihospital health system who were discharged between March and December 2020. NAFLD was diagnosed by imaging or liver biopsy without other liver diseases. Read More

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SDHC phaeochromocytoma and paraganglioma: A UK-wide case series.

Clin Endocrinol (Oxf) 2021 Sep 24. Epub 2021 Sep 24.

Department of Clinical Genetics, Birmingham Women's Hospital, Birmingham, UK.

Objective: Phaeochromocytomas and paragangliomas (PPGL) are rare, but strongly heritable tumours. Variants in succinate dehydrogenase (SDH) subunits are identified in approximately 25% of cases. However, clinical and genetic information of patients with SDHC variants are underreported. Read More

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September 2021

Treatment outcomes of patients with tuberculosis and diabetes: A prospective cohort study from India.

Int J Mycobacteriol 2021 Apr-Jun;10(2):111-115

Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education; Manipal Center for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Introduction: Tuberculosis (TB) and diabetes mellitus (DM) are significant causes of morbidity and mortality in developing countries. This study aimed to explore the relationship between diabetes and TB.

Methods: This was a prospective cohort study in which all newly diagnosed inpatients with TB above the age of 18 years during the study period (September 2018 to August 2020) were included. Read More

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September 2021

Prevalence of obstructive sleep apnea in diabetic patients.

Ann Afr Med 2021 Jul-Sep;20(3):206-211

Department of Respiratory Medicine, KGMU, Lucknow, Uttar Pradesh, India.

Context: Obstructive sleep apnea (OSA)-related hypoxemia stimulates release of acute-phase proteins and reactive oxygen species that exacerbate insulin resistance and lipolysis and cause an augmented prothrombotic and proinflammatory state which can leads to premature death.

Aims: This study aims to study the prevalence of OSA in diabetic patients.

Setting And Design: It was a cross-sectional study, done over a period of 1 year in a tertiary care hospital. Read More

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September 2021

Imaging modalities for diagnosis and monitoring of cancer cachexia.

EJNMMI Res 2021 Sep 23;11(1):94. Epub 2021 Sep 23.

Department of Diagnostic and Interventional Radiology, Klinikum Rechts Der Isar, TUM School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight in cancer cachexia primarily implicates lean body mass, caused by an aberrant metabolism and systemic inflammation. This may lead to disease aggravation, poorer quality of life, and increased mortality. Read More

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September 2021

A Static Magnetic Field Improves Iron Metabolism and Prevents High-Fat-Diet/Streptozocin-Induced Diabetes.

Innovation (N Y) 2021 Feb 7;2(1):100077. Epub 2021 Jan 7.

High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P.R. China.

Type 2 diabetes (T2D) is a metabolic disorder with high prevalence and severe complications that has recently been indicated to be treatable by a combined static magnetic field (SMF) and electric field. We systematically compared four types of SMFs and found that a downward SMF of ∼100 mT could effectively reduce the development of hyperglycemia, fatty liver, weight gain, and tissue injury in high-fat-diet (HFD)/streptozocin-induced T2D mice, but not the upward SMF. The downward SMF markedly restored the Bacteroidetes population and reversed the iron complex outer membrane receptor gene reduction in the mice gut microbiota, and reduced iron deposition in the pancreas. Read More

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February 2021

Metabolic dysfunction-associated fatty liver disease increases risk of adverse outcomes in patients with chronic hepatitis B.

JHEP Rep 2021 Oct 8;3(5):100350. Epub 2021 Aug 8.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.

Background & Aims: A recent consensus document has defined metabolic dysfunction-associated fatty liver disease (MAFLD) as hepatic steatosis together with overweight, diabetes, and/or a combination of other metabolic risk factors. The clinical relevance of this novel diagnosis is unknown among patients with chronic hepatitis B (CHB). We studied the association between MAFLD (with or without steatohepatitis) and adverse clinical outcomes in patients with CHB. Read More

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October 2021

Rapidly Developing Cataract in Young Adult Patients: Always a Matter for Further Evaluation.

Cureus 2021 Aug 19;13(8):e17312. Epub 2021 Aug 19.

Medicine, All India Institute of Medical Sciences, Jodhpur, IND.

A cataract in the young age group is uncommon and it is usually secondary to eye trauma, intraocular inflammation, uncontrolled diabetes mellitus, and hypoparathyroidism. We report a case of a rapidly developing cataract over two years in a 21-year-old female with extensive intracranial calcification due to primary hypoparathyroidism. Chronic hypocalcemia due to underlying hypoparathyroidism results in cataract. Read More

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Venous thromboembolism in patients with COVID-19. A prevalent and a preventable complication of the pandemic.

J Interv Med 2021 May 26;4(2):62-65. Epub 2021 Feb 26.

Department of Interventional Radiology, Nanjing Medical University Third School of Clinical Medicine, Nanjing First Hospital, Nanjing, Jiangsu, 210006, China.

Coronavirus disease 2019 or most commonly known as COVID-19 is a trending global infectious disease which a few months ago was affirmed as a global health emergency or a pandemic by the WHO Emergency Committee. The common symptoms manifested in this pandemic disease are high grade fever, cough, fatigue, shortness of breath and flu like symptom which can evolve into severe respiratory disorders such as pneumonia, acute respiratory distress syndrome (ARDS) and/or end-organ failure. Factors that contribute to the severity or high mortality rate in COVID-19 include old age, comorbidities like hypertension, diabetes, hyperlipidaemia, neutrophilia, and organ and coagulation dysfunction. Read More

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