11,269,279 results match your criteria symptoms


Sexual Function and Mood Disorders Among Menopausal Women: A Systematic Scoping Review.

J Sex Med 2022 Jul;19(7):1098-1115

Department of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Kiel, Germany.

Background: Changes in sex hormones during menopause may have detrimental effects on a woman's sexual function and cause mood disorders. The treatment of both conditions is a challenge in gynecology.

Aim: To review the published literature on sexual function and mood disorders among peri- and postmenopausal women. Read More

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Case-based malaria surveillance and response: implementation of 1-3-7 approach in Jiangsu Province, China.

Adv Parasitol 2022 20;116:1-31. Epub 2022 May 20.

Key Laboratory of National Health Commission (NHC) on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address:

Following initiation of China's National Malaria Elimination Action Plan (NMEAP) in 2010, China's 1-3-7 surveillance and response approach was developed and rolled out in China to facilitate the malaria control programme and accelerate the progress of malaria elimination. Innovative strategies and interventions have been developed and implemented in Jiangsu Province to facilitate case-based malaria surveillance and response. A total of 9879 malaria cases were reported in Jiangsu Province from 2001 to 2020. Read More

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Food-dependent Exercise-induced Wheals, Angioedema, and Anaphylaxis: A Systematic Review.

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany.

Background: Food-dependent exercise-induced wheals, angioedema, and anaphylaxis remain insufficiently characterized.

Objective: We systematically reviewed the literature on clinical manifestations, laboratory investigations, culprit foods, triggering exercise, comorbidities, and treatment outcomes.

Methods: Using predefined search terms and Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) recommendations, we searched three electronic databases to identify relevant literature published before July 2021. Read More

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Application of Molecular Imaging in Immune Checkpoints Therapy: From Response Assessment to Prognosis Prediction.

Crit Rev Oncol Hematol 2022 Jun 22:103746. Epub 2022 Jun 22.

Department of Breast-Thyroid-Surgery and Cancer Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, 2000 East Xiang'an Road, Xiamen, China; Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer (Xiang'an Hospital of Xiamen University), 2000 East Xiang'an Road, Xiamen, China; Xiamen Key Laboratory for Endocrine Related Cancer Precision Medicine, Xiang'an Hospital of Xiamen University, 2000 East Xiang'an Road, Xiamen, China; Xiamen Research Center of Clinical Medicine in Breast & Thyroid Cancers, 2000 East Xiang'an Road, Xiamen, China; Cancer Research Center, School of Medicine, Xiamen University, 4221 South Xiang'an Road, Xiamen, China. Electronic address:

Recently, immune checkpoint therapy (ICT) represented by programmed cell death1 (PD-1) and its major ligands, programmed death ligand 1 (PD-L1), has achieved significant success. Detection of PD-L1 by immunohistochemistry (IHC) is a classic method to guide the treatment of ICT patients. However, PD-L1 expression in the tumor microenvironment is highly complex. Read More

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Supplementary Motor Area Syndrome after Brain Tumor Surgery: A Systematic Review.

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurological Surgery, Northwell Health, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine at Hofstra, New York, NY, USA.

Background: Supplementary motor area syndrome (SMAS) may occur after frontal tumor surgery, with variable presentation and outcomes. We reviewed the literature on postoperative SMAS following brain tumor resection.

Methods: PubMed, Web-of-Science, Scopus, and Cochrane were searched following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to include studies reporting SMAS after brain tumor resection. Read More

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Tectal plate gliomas masquerading as idiopathic aqueduct stenosis.

World Neurosurg 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurosurgery, Birmingham Children's Hospital, Steelhouse Lane, Birmingham, B4 6NH.

Aqueduct stenosis is a recognised cause of obstructive hydrocephalus in children and can be treated effectively with endoscopic third ventriculostomy. Magnetic resonance imaging pre-operatively is often diagnostic of the cause of aqueduct stenosis. We describe two paediatric cases with obstructive hydrocephalus secondary to a working diagnosis of idiopathic aqueduct stenosis. Read More

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Frequency of unscheduled visits to the Obstetrical Triage Assessment unit by pregnant adolescents in an urban Canadian Center compared to a matched cohort of pregnant women.

J Obstet Gynaecol Can 2022 Jun 22. Epub 2022 Jun 22.

Division of Pediatric and Adolescent Gynecology, Department of Surgery, Children's Hospital of Eastern Ontario; University of Ottawa, Department of Obstetrics and Gynecology, Ottawa, Canada; Clinical Research Unit, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Canada.

Objectives: People from marginalized and vulnerable populations present more frequently for unscheduled, emergency obstetrical services at labour and delivery triage units. Based on our clinical experience, pregnant adolescents visit the obstetrical triage assessment units (OTAU) more often than adults do. This study was designed to assess this phenomenon by quantifying and describing the frequency of unscheduled visits to the OTAU by pregnant adolescents (age <20 y) compared with a matched cohort of adult pregnant patients (age ≥20 y). Read More

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Drivers of Inpatient Hospitalization Costs, Joint-Specific Patient-Reported Outcomes, and Health-Related Quality of Life in Shoulder Arthroplasty for Cuff Tear Arthropathy.

J Shoulder Elbow Surg 2022 Jun 22. Epub 2022 Jun 22.

Department of Orthopaedics and Sports Medicine, University of Washington Medical Center, Seattle, WA, USA. Electronic address:

Background: Cuff tear arthropathy (CTA) can be successfully treated with various types of shoulder arthroplasty. While reverse total shoulder arthroplasty (RSA) is commonly used to treat CTA, CTA hemiarthroplasty (CTA-H, hemiarthroplasty with an extended humeral articular surface) can also be effective in patients with preserved glenohumeral elevation and an intact coracoacromial arch. As the value of arthroplasty is being increasingly scrutinized, cost containment has become a priority. Read More

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Symptom control and survival for people severely ill with COVID: a multicentre cohort study (CovPall-Symptom).

J Pain Symptom Manage 2022 Jun 22. Epub 2022 Jun 22.

International Observatory on End of Life Care, Division of Health Research, Lancaster University, Lancaster, UK.

Context: Evidence of symptom control outcomes in severe COVID is scant.

Objective: To determine changes in symptoms among people severely ill or dying with COVID supported by palliative care, and associations with treatments and survival.

Methods: Multicentre cohort study of people with COVID across England and Wales supported by palliative care services, during the pandemic in 2020 and 2021. Read More

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MicroRNA-29c-3p in dual-labeled exosome is a potential diagnostic marker of subjective cognitive decline.

Neurobiol Dis 2022 Jun 22:105800. Epub 2022 Jun 22.

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China. Electronic address:

Objective: The present study aimed to determine whether peripheral blood neural cell adhesion molecule (NCAM)/amphiphysin 1 dual-labeled exosomal proteins and microRNAs (miRs) might serve as a marker for the early diagnosis of Alzheimer's disease (AD).

Methods: This observational, retrospective, multicenter study used a two-stage design conducted in Beijing and Shanghai, China. The subjects included 76 patients with subjective cognitive decline (SCD), 80 with amnestic mild cognitive impairment (aMCI), 76 with dementia of Alzheimer's type (AD), 40 with vascular dementia (VaD), and 40 controls in the discovery stage. Read More

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Chitosan mediated layer-by-layer assembly based graphene oxide decorated surface plasmon resonance biosensor for highly sensitive detection of β-amyloid.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, Dist: Dhule, MS, India. Electronic address:

Alzheimer's disease (AD), and its consequent effect primarily clinical dementia, Parkinson's disease dementia, etc. currently bring potential avenues for diagnosis centered on identification of beta-amyloid (Aβ). Unfortunately, techniques engaged in AD core biomarker (Aβ) detection are majorly suffering from poor sensitivity and selectivity. Read More

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Identification of multidimensional phenotypes using cluster analysis in sarcoid uveitis patients.

Am J Ophthalmol 2022 Jun 22. Epub 2022 Jun 22.

Department of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69004 Lyon, France; University Claude Bernard Lyon 1, Research on Healthcare Performance (RESHAPE), INSERM U1290, Lyon, France.

Purpose: To identify multidimensional phenotypes of sarcoid uveitis patients Design: Retrospective cohort.

Methods: Study Population: Consecutive patients with biopsy-proven, presumed or probable sarcoid uveitis between December 2003 and December 2020 in Lyon.

Observation Procedure: Data were collected from the clinical notes, and consisted in laboratory and imaging findings, systemic treatments and outcome. Read More

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Reduced fetal growth velocity and weight loss are associated with adverse perinatal outcome in fetuses at risk of growth restriction.

Am J Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Institute of Developmental and Reproductive Biology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Department of Fetal Medicine, Queen Charlotte's and Chelsea Hospital, Imperial College NHS Trust, London, UK. Electronic address:

Background: While fetal size is associated with adverse perinatal outcome, the relationship between fetal growth velocity and adverse perinatal outcome is unclear.

Objectives: To evaluate the relationship between fetal growth velocity and signs of cerebral blood flow redistribution, and their association with birthweight and adverse perinatal outcome.

Study Design: Secondary analysis of the TRUFFLE 2 multicentre observational prospective feasibility study of fetuses at risk of fetal growth restriction between 32 and 36 weeks (n=856) evaluated by ultrasound biometry and umbilical and middle cerebral artery Doppler. Read More

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Ultrasonographical and molecular diagnosis of breast sparganosis due to Spirometra erinaceieuropaei.

Travel Med Infect Dis 2022 Jun 22:102393. Epub 2022 Jun 22.

Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 510180, China. Electronic address:

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BENRALIZUMAB REDUCES EOSINOPHILS AND INFLAMMATORY MARKERS IN PATIENTS WITH SEVERE EOSINOPHILIC ASTHMA AND CHRONIC RHINOSINUSITIS WITH NASAL POLYPS: A PILOT REAL-LIFE STUDY.

Immunol Lett 2022 Jun 22. Epub 2022 Jun 22.

Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Rome, Italy.

Chronic rhinosinusitis with nasal polyps (CRSwNP) and Severe Eosinophilic Asthma (SEA) are both frequently sustained by eosinophilic inflammation and are probably the manifestation of a unique disease of upper and lower respiratory tract. We retrospectively observe 11 patients with severe CRSwNP and concomitant SEA under add-on therapy with benralizumab evaluating symptoms using Sino Nasal Outcome Test-22 (SNOT-22), Visual Analogue Scale (VAS), and Asthma Control Test (ACT) and Nasal polyp size by endoscopic and radiological score by Nasal Polyp Score (NPS) and Lund-Mackay Score (LMS). At 6 and 12 months, the expression of cationic eosinophil protein (ECP), Interleukin 17 (IL-17), Interferon gamma (INF-γ) and vascular endothelial growth factor (VEGF) was measured by nasal scraping to assess mucosal inflammation. Read More

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Real-time, In Vivo Skin Cancer Triage by Laser-Induced Plasma Spectroscopy Combined with Deep Learning-based Diagnostic Algorithm.

J Am Acad Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Human-Computer Interaction, Hanyang University, Seoul, South Korea.

Background: Although various skin cancer detection devices have been proposed, most of them are not used owing to their insufficient diagnostic accuracies. Laser-induced plasma spectroscopy (LIPS) can noninvasively extract biochemical information of skin lesions using an ultrashort pulsed laser.

Objective: To investigate the diagnostic accuracy and safety of a real-time noninvasive in vivo skin cancer diagnostics utilizing non-discrete molecular LIPS combined with a deep neural network (DNN)-based diagnostic algorithm. Read More

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Clinical and dermoscopic findings of benign longitudinal melanonychia due to melanocytic activation differ by skin type and predict likelihood of nail matrix biopsy.

J Am Acad Dermatol 2022 Jun 22. Epub 2022 Jun 22.

Department of Dermatology, Weill Cornell Medicine New York, NY, USA. Electronic address:

Background: Longitudinal melanonychia (LM) is a common dermatologic finding in clinical practice with a broad differential diagnosis. Melanocytic activation is the most common LM etiology.

Objective: To investigate clinical and dermoscopic differences of benign LM based on Fitzpatrick skin type and in biopsied vs. Read More

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The role of Triggering Receptor Expressed on Myeloid Cells 2 in Parkinson's disease and other neurodegenerative disorders.

Behav Brain Res 2022 Jun 22:113977. Epub 2022 Jun 22.

Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität (FAU) Erlangen -Nürnberg, Erlangen, Germany. Electronic address:

Parkinson's disease (PD) is a progressive neurological disorder marked by cardinal clinical symptoms such as rigor, tremor, and akinesia. Albeit a loss of dopaminergic neurons from the substantia nigra pars compacta is causative for the movement impairments found in patients, molecular reasoning for this loss is still incomplete. In recent years, triggering factor expressed on myeloid cells (TREM2) gained attention in the field of neurodegeneration as it could be associated with different neurodegenerative disorders. Read More

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The relationship between adverse childhood experiences and common mental disorders among pregnant women living with HIV in Malawi.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Baylor College of Medicine Children's Foundation Malawi, Tingathe Outreach Community Program, Lilongwe, Malawi; Baylor International Pediatric AIDS Initiative at Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.

Introduction: Adverse childhood experiences (ACEs) have been linked to common mental disorders (CMDs) such as anxiety and depressive thoughts. We examined the prevalence of ACEs and their association with CMDs among pregnant women living with HIV (PWLHIV) in Malawi-an HIV endemic resource-limited setting.

Methods: This is a cross-sectional study of 798 PWLHIV enrolled in the VITAL Start trial in Malawi (10/2018 to 06/2021) (NCT03654898). Read More

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Correlation between cognitive deficits and dorsolateral prefrontal cortex functional connectivity in first-episode depression.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Introduction: Although depression is commonly accompanied by cognitive deficits, the underlying mechanism remains unclear. One possibility is that such deficits are related to abnormal brain network connections. The purpose of this study was thus to investigate changes in brain functional connectivity (FC) in depression and its relationship with cognitive deficits. Read More

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Sleep and affective disorders in relation to Parkinson's disease risk among older women from the Women's Health Initiative.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD 21225, USA.

Objectives: To evaluate sleep and affective (mood/anxiety) disorders as clinical predictors of incident Parkinson's disease (PD) among women ≥65 years of age.

Methods: We performed secondary analyses with available data from the Women's Health Initiative Clinical Trials and Observational Study linked to Medicare claims. Sleep, mood and anxiety disorders at baseline were defined using diagnostic codes. Read More

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Effect of intervention delivered by lay maternal care providers to improve outcome and parenting skills among adolescents with perinatal depression in Nigeria (the RAPiD study): A cluster randomized controlled trial.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Lady Davis Institute, Jewish General Hospital, Montreal, Canada.

Background: Perinatal depression is more common and is associated with greater negative consequences among adolescents than adults. Psychosocial interventions designed for adults may be inadequate at addressing the unique features of adolescent perinatal depression.

Methods: In a two-arm parallel cluster randomized trial conducted in thirty primary maternal care clinics in Ibadan, Nigeria (15-intervention and 15-control) we compared age-appropriate intervention consisting of problem-solving therapy, behavioral activation, parenting skills training, and parenting support from a self-identified adult to care as usual. Read More

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Emergency department cardiovascular disease encounters and associated mortality in patients with cancer: A study of 20.6 million records from the USA.

Int J Cardiol 2022 Jun 22. Epub 2022 Jun 22.

Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, UK; Department of Cardiology, Thomas Jefferson University Philadelphia, PA, USA; Institute of Population Health, University of Manchester, UK. Electronic address:

Background: there is limited data on Emergency department (ED) cardiovascular disease (CVD) presentations and outcomes amongst cancer patients.

Objectives: The present study aimed to describe the clinical characteristics, prevalence, and clinical outcomes of the most common cardiovascular ED admissions in patients with cancer.

Methods: All ED encounters with a primary CVD diagnosis from the US Nationwide Emergency Department Sample between January 2016 to December 2018 were stratified by cancer type as well as metastatic status. Read More

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Management of thyroid nodules.

Lancet Diabetes Endocrinol 2022 Jul;10(7):540-548

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

In the past 30 years, there has been a substantial rise in the detection of thyroid nodules. Largely asymptomatic, thyroid nodules are most often incidental findings that typically pose minimal risk. Data supporting these findings show a rapid rise in the incidental detection of thyroid nodules and cancer, but minimal effect on mortality rates, despite treatment. Read More

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Diagnosis of thyroid nodules.

Lancet Diabetes Endocrinol 2022 Jul;10(7):533-539

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Thyroid nodules are common, usually asymptomatic, and often pose minimal risk to the affected patient. However, 10-15% prove malignant and serve as the rationale for diagnostic assessment. Safely identifying and treating a relevant thyroid cancer through a cost-effective process is the primary goal of the treating practitioner. Read More

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Long COVID symptoms in SARS-CoV-2-positive children aged 0-14 years and matched controls in Denmark (LongCOVIDKidsDK): a national, cross-sectional study.

Lancet Child Adolesc Health 2022 Jun 22. Epub 2022 Jun 22.

Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: After the acute phase of SARS-CoV-2 infection, children can develop long COVID symptoms. We aimed to investigate the prevalence of long-lasting symptoms, the duration and intensity of symptoms, quality of life, number of sick days and absences from daycare or school, and psychological and social outcomes in children aged 0-14 years who had been infected with SARS-CoV-2 relative to controls with no history of SARS-CoV-2 infection.

Methods: A nationwide cross-sectional study was conducted including children with a confirmed SARS-CoV-2-positive PCR test (cases) and matched controls from Danish national registers. Read More

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Long-Term Results after Fallot Repair.

Thorac Cardiovasc Surg 2022 Dec 25;70(S 03):e7-e14. Epub 2022 Jun 25.

Universitäts-Kinderspital Zürich, Zurich, Switzerland.

Background:  The aim of this study was to evaluate the long-term outcome and freedom from pulmonary valve replacement (PVR) after initial repair of tetralogy of Fallot (TOF).

Patients And Methods:  The cohort of 306 patients treated between 1980 and 2017 was divided into anatomical subgroups according to the diagnosis of TOF-pulmonary stenosis, TOF-pulmonary atresia and TOF-double outlet right ventricle. Patients were treated with transannular patch (TAP), valve sparing repair (VSR), or conduits from the right ventricle to the pulmonary arteries (RVPA conduits). Read More

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December 2022

Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccination; a systematic review.

J Neurol Sci 2022 Jun 20;439:120327. Epub 2022 Jun 20.

Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, CA, USA. Electronic address:

Introduction: One of the rare but potentially serious side effects of COVID-19 vaccination is arterial and venous thrombosis. Acute ischemic stroke (AIS) cases have been reported post COVID-19 vaccination. Herein, we systematically reviewed the reported cases of AIS after COVID-19 vaccination. Read More

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Plasma biomarkers of brain injury in COVID-19 patients with neurological symptoms.

J Neurol Sci 2022 Jun 17;439:120324. Epub 2022 Jun 17.

Kirsehir Ahi Evran University Faculty of Medicine, Department of Clinical Microbiology and Infectious Diseases, Kirsehir, Turkey.

Objective: Neurological symptoms (NS) were often reported in COVID-19 infection. We examined the plasma levels of glial fibrillary acidic protein (GFAP) and S100B together, as brain injury biomarkers, in relation to persistent NS in a cohort of patients with COVID-19 during the acute phase of the disease.

Methods: A total of 20 healthy controls and 58 patients with confirmed COVID-19 were enrolled in this prospective study. Read More

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Deep collaborative network with alpha matte for precise knee tissue segmentation from MRI.

Comput Methods Programs Biomed 2022 Jun 17;222:106963. Epub 2022 Jun 17.

Department of Imaging and Interventional Radiology, CU lab of AI in radiology (CLAIR), Chinese University of Hong Kong, Prince of Wales Hospital, Shatin N.T., Hong Kong, China. Electronic address:

Background And Objective: Precise segmentation of knee tissues from magnetic resonance imaging (MRI) is critical in quantitative imaging and diagnosis. Convolutional neural networks (CNNs), being state of the art, often challenged by the lack of image-specific adaptation, such as low tissue contrasts and structural inhomogeneities, thereby leading to incomplete segmentation results.

Methods: This paper presents a deep learning-based automatic segmentation framework for precise knee tissue segmentation. Read More

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