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Discrepancies in persons with dementia, family members, and physician perspectives of dementia treatment: a descriptive study.

Psychogeriatrics 2021 May 4. Epub 2021 May 4.

National Centre for Geriatrics and Gerontology, Obu, Japan.

Background: This study aims to reconsider diagnostic approaches to dementia where pharmacological approaches are not available to reverse the pathological changes caused by dementia.

Methods: A questionnaire survey was conducted with 524 physicians specialising in dementia management in Aichi, Japan, with 163 (31.1%) valid responses. Read More

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[Mastoid cavity obliteration with allogenic and autologous material].

Laryngorhinootologie 2021 May 4. Epub 2021 May 4.

Universitätsmedizin Rostock, Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Rostock, Germany.

Introduction Surgical obliteration is the treatment of choice for symptomatic mastoid cavities. Various methods and materials are available. Allogeneic material is easily available but can lead to wound infections due to rejection, granulation and inflammatory reactions. Read More

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Metabolomic Biomarkers in Polycystic Ovary Syndrome: A Review of the Evidence.

Semin Reprod Med 2021 May 4. Epub 2021 May 4.

Monash Centre for Health Research and Implementation (MCHRI), School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Polycystic ovary syndrome (PCOS) is an endocrinologic condition affecting one in five women of reproductive age. PCOS is often characterized by disruptions to the menstrual cycle, development of male-pattern hair growth (hirsutism), and polycystic ovary morphology. Recently, PCOS has been linked to metabolic dysfunction, with 40 to 80% of women characterized as overweight or obese. Read More

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Effect of Nosodes on Lettuce, Parasitized or Not by Meloidogyne enterolobii.

Homeopathy 2021 May 4. Epub 2021 May 4.

Department of Entomology and Plant Pathology, Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Brazil.

Background:  Nosodes are homeopathic preparations (HPs) obtained from tissues or substances associated with the targeted disease or from culture of the pathogenic agent. Nosodes are thought to modulate host resistance, easing symptoms or promoting cure. A few studies have been published about control of plant-parasitic nematodes with HPs, but none with nosodes. Read More

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[The Current Therapy of Asbestos-Associated Malignant Pleural Mesothelioma - An Expert Consensus Paper].

Pneumologie 2021 May 4. Epub 2021 May 4.

Internistische Onkologie der Thoraxtumoren, Thoraxklinik - Universitätsklinikum Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL).

Asbestos-related mesotheliomas belong to the group of the most frequent occupational diseases in Germany, reaching about 1,000 new cases per year. The disease has a dismal prognosis because most tumors remain asymptomatic for a long time and therefore are diagnosed as incidental findings at later stages.During the last decade the German Social Accident Insurance (DGUV) has made considerable efforts to prepone the diagnosis in order to detect the disease at earliest possible stages. Read More

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Indications for Maternal Echocardiography in Detecting Disease and the Impact on Pregnancy Management.

Am J Perinatol 2021 May 4. Epub 2021 May 4.

Department of Cardiology, TriHealth Heart Institute, TriHealth-Good Samaritan Hospital, Cincinnati, Ohio.

Objective: Few obstetric-specific guidelines detail the indications for screening echocardiography in pregnancy. The objective of the study is to examine the association of common indications for maternal echocardiography with the likelihood of abnormality identification, pregnancy management alteration, and conformity with current American College of Cardiology Foundation (ACCF) guidelines.

Study Design:  This retrospective cohort analysis categorized all echocardiograms performed within pregnancy and the first month postpartum within a tertiary health system to correlate indications with abnormal findings. Read More

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Papillary Fibroelastoma in Differential Diagnosis of Left Atrial Appendage Masses.

Tex Heart Inst J 2021 Jan;48(1)

Department of Cardiology, University of Rostock Heart Center, Rostock, Germany.

Papillary fibroelastomas are benign tumors that usually originate from cardiac valves but may have other endocardial origins. We report the cases of 2 patients in whom left atrial appendage masses were initially diagnosed as thrombus. They were treated for embolic stroke and their symptoms resolved; however, their left atrial appendage masses did not regress. Read More

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January 2021

Routine Outpatient Electrocardiogram: What Is the Diagnosis?

Tex Heart Inst J 2021 Jan;48(1)

Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas.

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January 2021

Digital Pathology Initiatives and Experience of a Large Academic Institution During the Coronavirus Disease 2019 (COVID-19) Pandemic.

Arch Pathol Lab Med 2021 May 4. Epub 2021 May 4.

All authors are in the Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.

Context.: Pathology practices have begun integrating digital pathology tools into their routine workflow. During 2020 the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a pandemic causing a global health crisis that significantly affected the world population in several areas, including medical practice, and pathology was no exception. Read More

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α2-Adrenergic Agonists or Stimulants for Preschool-Age Children With Attention-Deficit/Hyperactivity Disorder.

JAMA 2021 May 4. Epub 2021 May 4.

Perelman School of Medicine at University of Pennsylvania.

Importance: Attention-deficit/hyperactivity disorder (ADHD) is diagnosed in approximately 2.4% of preschool-age children. Stimulants are recommended as first-line medication treatment. Read More

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From HIV to Coronavirus Disease 2019 (COVID-19): Hematologic Complications in Viral Pandemics.

Donald S Karcher

Arch Pathol Lab Med 2021 May 4. Epub 2021 May 4.

From the Department of Pathology, George Washington University Medical Center, Washington, District of Columbia.

Context.—: From the onset of the human immunodeficiency virus (HIV) pandemic in the 1980s to the recent coronavirus disease 2019 (COVID-19) pandemic, multiple viral pandemics have occurred and all have been associated with hematologic complications of varying severity.

Objective. Read More

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Some Reactive Lesions of Bone Are Probably Neoplasms: A Review.

Arch Pathol Lab Med 2021 May 4. Epub 2021 May 4.

From the Departments of Pathology & Genetics, University of Alabama at Birmingham.

Context.—: A number of fibro-osseous and osteocartilaginous lesions, especially common in the small bones of hand and feet, pose a diagnostic challenge and have historically been thought to be reactive lesions. However, modern molecular techniques when supplementing clinical, radiographic, and histologic evaluation suggest they may, in fact, be neoplasms. Read More

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Graves' Disease Presenting as Autoimmune Hemolytic Anemia.

Am J Case Rep 2021 Apr 23;22:e930705. Epub 2021 Apr 23.

Hematology and Medical Oncology Unit, Department of Internal Medicine, Dr. Soetomo General Academic Hospital - Faculty of Medicine Airlangga University, Surabaya, Indonesia.

BACKGROUND Atypical manifestations of Graves' disease (GD) such as anemia have been noticed in the last decades. Anemia is present in up to 34% of patients with GD, yielding various anemia types such as GD anemia, pernicious anemia, iron deficiency anemia, and autoimmune hemolytic anemia (AIHA). So far, AIHA is the rarest manifestation of anemia in GD. Read More

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Retrospective Analysis of the Clinical Presentation, Treatment and Outcome of Angiosarcoma in a Sarcoma Referral Center.

Oncol Res Treat 2021 May 4:1-10. Epub 2021 May 4.

Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.

Introduction: Angiosarcoma (AS) is a rare subtype of soft tissue sarcoma. We performed a retrospective analysis of patient characteristics, treatments and prognostic factors in patients treated in a single sarcoma center.

Methods: We reviewed records of patients treated between 1987 and 2018, categorized in 7 different subtypes according to tissue of origin and underlying risk factors. Read More

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Think Twice before Interpreting the Skin Prick Test as Age, Body Mass Index, and Atopy Affect Reaction Time and Size.

Int Arch Allergy Immunol 2021 May 4:1-9. Epub 2021 May 4.

Department of Pediatric Allergy and Immunology, Trakya University School of Medicine, Edirne, Turkey.

Introduction: The skin prick test (SPT) is a reliable method to confirm sensitization in IgE-mediated allergic diseases; however, it has been reported to be affected by several personal and environmental factors. Our objective was to determine the factors affecting the skin reactivity to histamine and allergens and investigate whether it differs according to age in terms of reading time.

Methods: A total of 500 patients, aged 4 months-18 years, were enrolled in the study. Read More

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Clinical Characteristics of Chinese Male Patients with Aquaporin-4 Antibody-Positive Late-Onset Neuromyelitis Optica Spectrum Disorder.

Neuroimmunomodulation 2021 May 4:1-7. Epub 2021 May 4.

Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background And Objective: Limited studies are available for male patients with anti-aquaporin-4 antibody (AQP4-Ab)-positive late-onset neuromyelitis optica spectrum disease (LONMOSD). The aim of this study was to investigate the clinical characteristics of Chinese male patients with AQP4-Ab-positive LONMOSD.

Methods: We retrospectively reviewed the medical records of 12 male patients with LONMOSD, 16 male patients with early-onset NMOSD (EONMOSD), and 64 female patients with LONMOSD. Read More

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Effectiveness of a Guided Web-Based Intervention to Reduce Depressive Symptoms before Outpatient Psychotherapy: A Pragmatic Randomized Controlled Trial.

Psychother Psychosom 2021 May 4:1-10. Epub 2021 May 4.

Department of Rehabilitation Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany.

Introduction: Psychotherapy is a first-line treatment for depression. However, capacities are limited, leading to long waiting times for outpatient psychotherapy in health care systems. Web-based interventions (WBI) could help to bridge this treatment gap. Read More

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Application of Cellular Resolution Full-Field Optical Coherence Tomography in vivo for the Diagnosis of Skin Tumours and Inflammatory Skin Diseases: A Pilot Study.

Dermatology 2021 May 4:1-11. Epub 2021 May 4.

Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.

Background: Optical coherence tomography (OCT) has been shown to provide non-invasive diagnosis of common skin neoplasms, especially basal cell carcinoma. OCT produces a cross-sectional view of the tissue, similar to a traditionally sectioned histopathological view, but the resolution of conventional OCT is low and thus limits clinical application.

Objectives: This study aimed to investigate the application ability of a full-field (FF)OCT system which was newly developed to scan the skin at the cellular level. Read More

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Integrative analysis identifies key mRNA biomarkers for diagnosis, prognosis, and therapeutic targets of HCV-associated hepatocellular carcinoma.

Aging (Albany NY) 2021 May 4;13. Epub 2021 May 4.

Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, P.R. China.

Hepatitis C virus-associated HCC (HCV-HCC) is a prevalent malignancy worldwide and the molecular mechanisms are still elusive. Here, we screened 240 differentially expressed genes (DEGs) of HCV-HCC from Gene expression omnibus (GEO) and the Cancer Genome Atlas (TCGA), followed by weighted gene coexpression network analysis (WGCNA) to identify the most significant module correlated with the overall survival. 10 hub genes (CCNB1, AURKA, TOP2A, NEK2, CENPF, NUF2, CDKN3, PRC1, ASPM, RACGAP1) were identified by four approaches (Protein-protein interaction networks of the DEGs and of the significant module by WGCNA, and diagnostic and prognostic values), and their abnormal expressions, diagnostic values, and prognostic values were successfully verified. Read More

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Evaluation of an antigen-based test for hospital point-of-care diagnosis of SARS-CoV-2 infection.

J Clin Virol 2021 Apr 21;139:104838. Epub 2021 Apr 21.

Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.

Background: An accurate diagnosis is essential to identify and manage SARS-CoV-2 infected patients and implement infection control measures. Although real-time reverse transcription polymerase chain reaction (RT-PCR) is the current recommended laboratory method, several rapid antigen point-of-care tests (POCTs) were developed as frontline testing for SARS-CoV-2 infection diagnosis.

Objectives: The aim of this study was to assess a recently CE-approved POCT, SARS-CoV-2 Ag Test on the LumiraDx™ Platform (LumiraDx GmbH, Cologne, Germany) for the identification of SARS-COV-2 infected subjects at hospital setting. Read More

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Prevalence of celiac disease in children with type 1 diabetes: A review.

Diabetes Metab Syndr 2021 Apr 28;15(3):969-974. Epub 2021 Apr 28.

Nursing Department, Nursing and Midwifery School, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background And Aims: Diabetes mellitus is a chronic disease and a major health threat. Comorbidity of celiac disease and diabetes is associated with many complications in children, and if not diagnosed in time in diabetes children, caused complications, including gastrointestinal disorders, most importantly, growth disorders. Thus, this study aims to summarize the evidence about prevalence of celiac disease in children with type 1 diabetes through a systematic review approach. Read More

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Automated EEG pathology detection based on different convolutional neural network models: Deep learning approach.

Comput Biol Med 2021 Apr 25;133:104434. Epub 2021 Apr 25.

Birla Institute of Technology & Science, Pilani, K K Birla Goa Campus, Goa, 403 726, India.

The brain electrical activity, recorded and materialized as electroencephalogram (EEG) signals, is known to be very useful in the diagnosis of brain-related pathology. However, manual examination of these EEG signals has various limitations, including time-consuming inspections, the need for highly trained neurologists, and the subjectiveness of the evaluation. Thus, an automated EEG pathology detection system would be helpful to assist neurologists to enhance the treatment procedure by making a quicker diagnosis and reducing error due to the human element. Read More

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Machine learning in diagnosis and disability prediction of multiple sclerosis using optical coherence tomography.

Comput Biol Med 2021 Apr 26;133:104416. Epub 2021 Apr 26.

Group of Biomaterials, Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain; Department of Mechanical Engineering, University of Zaragoza, Zaragoza, Spain. Electronic address:

Background: Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system, especially the brain, spinal cord, and optic nerve. Diagnosis of this disease is a very complex process and generally requires a lot of time. In addition, treatments are applied without any information on the disability course in each MS patient. Read More

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Epidemiology and prognostic factors of pediatric brain tumor survival in the US: Evidence from four decades of population data.

Cancer Epidemiol 2021 May 1;72:101942. Epub 2021 May 1.

Program of Epidemiology, College of Health Sciences, University of Delaware, 100 Discovery Blvd, Newark, DE, 19713, United States.

Brain tumors, a group of heterogeneous diseases, are the second most common cancer and the leading cause of cancer-related deaths in children. Insight into the prognosis of pediatric brain tumor survival has led to improved outcomes and could be further advanced through precision in prognosis. We analyzed the United States SEER population-based dataset of 15,723 pediatric brain tumor patients diagnosed and followed between 1975 and 2016 using a stratified Cox proportional hazards model. Read More

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CCN3 Proteins as a diagnostic marker in osteosarcoma patients: A case control study.

Cancer Treat Res Commun 2021 Apr 22;28:100381. Epub 2021 Apr 22.

Department of Paediatric Orthopaedic, King George's Medical University, Lucknow U.P., India.

Background: Osteosarcoma is the most prevalent type of primary bone sarcoma and is the major cause of deaths associated with cancer in children and adolescents. Despite novel and innovative therapies, early diagnosis of the osteosarcoma is still critically needed. Our study aimed to analyse the CCN3 proteins as a diagnostic marker and correlate their expression level with the severity of primary osteosarcoma patients. Read More

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The associations between autistic and communication traits in parents and developmental outcomes in children at familial risk of autism at 6 and 24 months of age.

Infant Behav Dev 2021 May 1;63:101570. Epub 2021 May 1.

CliniKids, Telethon Kids Institute, 100 Roberts Rd, Subiaco, Western Australia 6008, Australia.

Background: Several studies have explored relationships between parent broader autism phenotype and offspring communication, and have reported that autistic-like traits in parents are related to offspring communication difficulties and autism severity. However, past research has focused on studying such associations in childhood and we know very little about them in infancy. With accumulating evidence that interventions administered during infancy may be most effective in reducing ASD symptoms, it is imperative to examine whether relationships between parent autistic-like traits and child communication appear even earlier during this critical period of life. Read More

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Pediatric adverse reactions to antiseizure medications - An analysis of data from the Italian spontaneous reporting system (2001-2019).

Epilepsy Behav 2021 May 1;119:107989. Epub 2021 May 1.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. Electronic address:

Introduction: Spontaneous reports of adverse drug reactions (ADRs) are a valuable supplement to clinical studies in informing about the safety of medications. This is especially relevant for pediatric populations, which are not often included in large-scale clinical trials.

Objectives: To evaluate patterns of pediatric ADRs to antiseizure medications (ASMs) reported to the Italian Spontaneous Reporting System (SRS) database during the period November 1, 2001─May 31, 2019. Read More

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Emergency department bounceback characteristics for patients diagnosed with COVID-19.

Am J Emerg Med 2021 Apr 19;47:239-243. Epub 2021 Apr 19.

NorthShore University HealthSystem, 2650 Ridge Ave, Evanston, IL 60201, USA; University of Chicago Pritzker School of Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.

Background: The global healthcare burden of COVID-19 continues to rise. There is currently limited information regarding the disease progression and the need for hospitalizations in patients who present to the Emergency Department (ED) with minimal or no symptoms.

Objectives: This study identifies bounceback rates and timeframes for patients who return to the ED due to COVID-19 after initial discharge on the date of testing. Read More

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Can we determine recurrent epistaxis by hemogram parameters in children?

Int J Pediatr Otorhinolaryngol 2021 Apr 27;146:110747. Epub 2021 Apr 27.

Nizip State Hospital, Otorhinolaryngology Department, Gaziantep, Turkey.

Objective: Epistaxis in children is a common reason for admission at otolaryngology outpatient clinics. Patients are diagnosed by clinical examination and laboratory tests. We aimed to evaluate epistaxis using simple blood parameters useful for diagnosis. Read More

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