Trials 2020 Aug 17;21(1):724. Epub 2020 Aug 17.
Anaesthesia and Intensive Care Unit, Terapia Intensiva Polivalente, Policlinico di Modena, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Via del Pozzo, 71, 41124, Modena, Italy.
Objectives: To assess the hypothesis that an adjunctive therapy with methylprednisolone and unfractionated heparin (UFH) or with methylprednisolone and low molecular weight heparin (LMWH) are more effective in reducing any-cause mortality in critically-ill ventilated patients with pneumonia from SARS-CoV-2 infection compared to LMWH alone.
Trial Design: The study is designed as a multi-centre, interventional, parallel group, superiority, randomized, investigator sponsored, three arms study. Patients, who satisfy all inclusion criteria and no exclusion criteria, will be randomly assigned to one of the three treatment groups in a ratio 1:1:1. Read More