1,796 results match your criteria sustainable manner

Sustaining Meaningful Patient Engagement Across the Lifecycle of Medicines: A Roadmap for Action.

Ther Innov Regul Sci 2021 May 10. Epub 2021 May 10.

EURORDIS-Rare Diseases Europe, Paris, France.

Background: There is increased recognition that incorporating patients' perspectives and insights into the medicines development process results in better health outcomes and benefits for all involved stakeholders. Despite the increased interest and the existence of frameworks and practical recommendations, patient engagement (PE) is not yet considered standard practice. The objective of this work was to provide a roadmap to support systematic change in all stakeholder organisations involved in medicines development across Europe, patients and patient organisations, medicines developers, academia, regulatory authorities, Health Technology Assessment bodies, payers, policy-makers and public research funders, to sustain PE practices. Read More

View Article and Full-Text PDF

Adaptation of community-based distribution of family planning services to context-specific social networks: a case of marriage counsellors in Lusaka district, Zambia.

BMC Health Serv Res 2021 May 7;21(1):437. Epub 2021 May 7.

Asia Pacific College of Business and Law, Charles Darwin University, Darwin, Australia.

Background: The significant contribution of community-based distribution (CBD) of family planning services and contraceptives to the uptake of contraceptives in hard-to-reach communities has resulted in the scaling-up of this approach in many Sub-Saharan countries. However, contextual factors need to be taken into consideration. For example, social network influence (e. Read More

View Article and Full-Text PDF

Biofouling control: the impact of biofilm dispersal and membrane flushing.

Water Res 2021 Apr 18;198:117163. Epub 2021 Apr 18.

Laboratory of Microbiology, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands; Wetsus, European Centre of Excellence for Sustainable Water Technology, Oostergoweg 9, 8911 MA Leeuwarden, The Netherlands. Electronic address:

Pure culture studies have shown that biofilm dispersal can be triggered if the nutrient supply is discontinued by stopping the flow. Stimulating biofilm dispersal in this manner would provide a sustainable manner to control unwanted biofilm growth in industrial settings, for instance on synthetic membranes used to purify water. The response of multispecies biofilms to nutrient limitation has not been thoroughly studied. Read More

View Article and Full-Text PDF

The implementation, use and sustainability of a clinical decision support system for medication optimisation in primary care: A qualitative evaluation.

PLoS One 2021 3;16(5):e0250946. Epub 2021 May 3.

Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, United Kingdom.

Background: The quality and safety of prescribing in general practice is important, Clinical decision support (CDS) systems can be used which present alerts to health professionals when prescribing in order to identify patients at risk of potentially hazardous prescribing. It is known that such computerised alerts may improve the safety of prescribing in hospitals but their implementation and sustainable use in general practice is less well understood. We aimed to understand the factors that influenced the successful implementation and sustained use in primary care of a CDS system. Read More

View Article and Full-Text PDF

Emerging Applications of 3D Printing in Biomanufacturing.

Trends Biotechnol 2021 Apr 27. Epub 2021 Apr 27.

College of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, PR China; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211816, PR China.

The combination of 3D printing and synthetic biology is a sustainable strategy to fabricate biological objects and systems that behave in a preprogrammed manner. Many microorganisms have been genetically engineered as cell factories for the biosynthesis of chemicals using fermentation, and 3D printing of living materials using these cells could lead to a new paradigm for biomanufacturing. Read More

View Article and Full-Text PDF

The Ghd7 Transcription Factor Represses the ARE1 Expression to Enhance Nitrogen Utilization and Grain Yield in Rice.

Mol Plant 2021 Apr 27. Epub 2021 Apr 27.

State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Beijing 100101, China; Hainan Yazhou Bay Seed Laboratory, Sanya, 572025, China. Electronic address:

The genetic improvement of nitrogen use efficiency (NUE) of crops is vital for grain productivity and sustainable agriculture. However, the regulatory mechanism of NUE remains largely elusive. Here, we find that the rice Grain number, plant height, and heading date7 (Ghd7) gene genetically acts upstream of ABC1 REPRESSOR1 (ARE1), a negative regulator of NUE, to positively regulate nitrogen utilization. Read More

View Article and Full-Text PDF

Application of a Fuzzy Logic Based Methodology to Validate the Hydrochemical Characterization and Determining Seasonal Influence of a Watershed Affected by Acid Mine Drainage.

Int J Environ Res Public Health 2021 Apr 28;18(9). Epub 2021 Apr 28.

Department of Water, Mining and Environment, Scientific and Technological Center of Huelva, University of Huelva, 21007 Huelva, Spain.

The Odiel River Basin, located in the Iberian Pyrite Belt (IPB), is heavily affected by acid mine drainage (AMD), which occurs when pyritic minerals from sulfide mining areas are exposed to atmospheric, hydrological or biological weathering. This paper presents a hydrochemical characterization of parameters in the Odiel River Basin by means of Fuzzy Logic and data mining methodologies to determine the seasonal influence of AMD in polluted waters that have not been used before for a basin in this environmental area. This technique was proven to be effective, providing results that could not be achieved by using classic statistics, because it allows us to characterize the different parameters separately and also their relationships in waters affected by AMD in a qualitative manner based on the antecedents and according to the conditions (rules) imposed by the consequents (in this case, the Fe(II) and accumulated rainfall over 30 days). Read More

View Article and Full-Text PDF

Mechanochemistry as an Alternative Method of Green Synthesis of Silver Nanoparticles with Antibacterial Activity: A Comparative Study.

Nanomaterials (Basel) 2021 Apr 28;11(5). Epub 2021 Apr 28.

Department of Mechanochemistry, Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04001 Košice, Slovakia.

This study shows mechanochemical synthesis as an alternative method to the traditional green synthesis of silver nanoparticles in a comparative manner by comparing the products obtained using both methodologies and different characterization methods. As a silver precursor, the most commonly used silver nitrate was applied and the easily accessible lavender ( L.) plant was used as a reducing agent. Read More

View Article and Full-Text PDF

Cellular Phosphorylation Signaling and Gene Expression in Drought Stress Responses: ABA-Dependent and ABA-Independent Regulatory Systems.

Plants (Basel) 2021 Apr 13;10(4). Epub 2021 Apr 13.

Gene Discovery Research Group, RIKEN Center for Sustainable Resource Science, 3-1-1 Koyadai, Tsuku-ba, Ibaraki 305-0074, Japan.

Drought is a severe and complex abiotic stress that negatively affects plant growth and crop yields. Numerous genes with various functions are induced in response to drought stress to acquire drought stress tolerance. The phytohormone abscisic acid (ABA) accumulates mainly in the leaves in response to drought stress and then activates subclass III SNF1-related protein kinases 2 (SnRK2s), which are key phosphoregulators of ABA signaling. Read More

View Article and Full-Text PDF

Characteristics of Nutraceutical Chewing Candy Formulations Based on Fermented Milk Permeate, Psyllium Husk, and Apple By-Products.

Foods 2021 Apr 5;10(4). Epub 2021 Apr 5.

Department of Food Safety and Quality, Veterinary Academy, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.

The aim of this study was to develop nutraceutical chewing candy (CCN) formulations based on fermented milk permeate (MP) (source of galactooligosaccharides (GOS) and viable lactic acid bacteria (LAB)), psyllium husk (source of desirable hydrocolloids), and apple by-products (source of phenolic compounds). For CCN preparation, gelatin (Gel) and agar were tested; also, to provide CCN prepared using agar with a desirable hard texture, citric acid (cit) was changed to ascorbic acid. To select the optimal quantities of the ingredients, overall acceptability (OA) and emotions (EMs) induced in consumers by different CCN formulations were evaluated. Read More

View Article and Full-Text PDF

Donnan Dialysis-Osmotic Distillation (DD-OD) Hybrid Process for Selective Ammonium Recovery Driven by Waste Alkali.

Environ Sci Technol 2021 Apr 27. Epub 2021 Apr 27.

Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, College of Environment and Ecology, Chongqing University, Chongqing 400045, PR China.

This work proposed an innovative and energy-efficient Donnan Dialysis (DD) and Osmotic Distillation (OD) hybrid process for alkali-driven ammonium recovery from wastewater. The efficiency and feasibility of ammonium removal and recovery from synthetic and real wastewater using NaOH and waste alkali were investigated. Ammonium in the feed first transported across the cation exchange membrane and accumulated in the receiver chamber. Read More

View Article and Full-Text PDF

Degradation of the photosystem II core complex is independent of chlorophyll degradation mediated by Stay-Green Mg dechelatase in Arabidopsis.

Plant Sci 2021 Jun 3;307:110902. Epub 2021 Apr 3.

Institute of Low Temperature Science, Hokkaido University, Sapporo, Japan. Electronic address:

During leaf senescence, the degradation of photosystems and photosynthetic pigments proceeds in a coordinated manner, which would minimize the potential photodamage to cells. Both photosystem I and II are composed of core complexes and peripheral antenna complexes, with the former binding chlorophyll a and the latter binding chlorophyll a and b. Although the degradation of peripheral antenna complexes is initiated by chlorophyll degradation, it remains unclear whether the degradation of core complexes and chlorophyll is coordinated. Read More

View Article and Full-Text PDF

Selective screening and characterization of plant growth promoting bacteria for growth enhancement of tomato, .

Iran J Microbiol 2021 Feb;13(1):121-129

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objectives: Plant Growth-promoting Bacteria (PGPB) can replace the dangerous chemical fertilizers and pesticides. The aim of this study was to isolate the PGPBs for plant and to determine the appropriate volume for inoculation.

Materials And Methods: Plants samples were collected from tomato fields. Read More

View Article and Full-Text PDF
February 2021

Cooperative Ligands in Dissolution of Gold.

Chemistry 2021 Apr 21. Epub 2021 Apr 21.

University of Helsinki, Department of Chemistry, PO Box 55 A.I. Virtasen aukio 1, Laboratory of Inorganic Chemistry, FIN-00014, Helsinki, FINLAND.

Development of new, environmentally benign dissolution methods for metallic gold is driven by needs in the circular economy. Gold is widely used in consumer electronics, but sustainable and selective dissolution methods for Au are scarce. Herein we describe a quantitative dissolution of gold in organic solution under mild conditions using hydrogen peroxide as an oxidant. Read More

View Article and Full-Text PDF

Integrating dairy manure for enhanced resource recovery at a WRRF: Environmental life cycle and pilot-scale analyses.

Water Environ Res 2021 Apr 20. Epub 2021 Apr 20.

Department of Civil and Environmental Engineering, University of Idaho, Moscow, ID, USA.

The Twin Falls, Idaho wastewater treatment plant (WWTP), currently operates solely to achieve regulatory permit compliance. Research was conducted to evaluate conversion of the WWTP to a water resource recovery facility (WRRF) and to assess the WRRF environmental sustainability; process configurations were evaluated to produce five resources-reclaimed water, biosolids, struvite, biogas, and bioplastics (polyhydroxyalkanoates, PHA). PHA production occurred using fermented dairy manure. Read More

View Article and Full-Text PDF

BPA and BPA alternatives BPS, BPAF, and TMBPF, induce cytotoxicity and apoptosis in rat and human stem cells.

Ecotoxicol Environ Saf 2021 Jun 15;216:112210. Epub 2021 Apr 15.

Saint Mary's College of California, Department of Biology, Moraga, CA, USA. Electronic address:

Bisphenol A (BPA) is a ubiquitous industrial chemical found in everyday plastic products and materials. Due to scientific findings on the reproductive, developmental, and cellular defects caused by BPA and heightened public awareness, manufacturers have begun to use new chemicals in place of BPA in "BPA-free" products. These alternatives are chemical analogs of BPA and include dozens of new compounds that have undergone relatively little testing and oversight, including: bisphenol S (BPS), bisphenol AF (BPAF), and the recently developed tetramethyl bisphenol F (TMBPF; the monomer of valPure V70). Read More

View Article and Full-Text PDF

The EU Green Deal's ambition for a toxic-free environment: filling the gap for science-based policy making.

Integr Environ Assess Manag 2021 Apr 16. Epub 2021 Apr 16.

School of Interdisciplinary Studies, University of Glasgow, Dumfries Campus, Rutherford/McCowan Building, Crichton University Campus, Dumfries, Scotland, U.K., DG1 4ZL.

Around the world, many ambitious conventions and regulations have been implemented over recent decades. Despite this, the environment is still deteriorating. An increase in the volume and diversity of chemicals is one of the main drivers of this deterioration, of which biodiversity loss is a telling indicator. Read More

View Article and Full-Text PDF

Physiological and metagenomic strategies uncover the rhizosphere bacterial microbiome succession underlying three common environmental stresses in cassava.

J Hazard Mater 2021 Jun 14;411:125143. Epub 2021 Jan 14.

Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Tropical Crops, Hainan University, Haikou, Hainan 570228, China. Electronic address:

The most common environmental pollutants such as cadmium (Cd), glyphosate and tetracycline have led to profoundly adverse impacts on plant productivity. However, how tropical crops such as cassava sense these pollutants via roots and how rhizosphere microbiome interacts with the host and pollutants remain largely unknown. In this study, we found these stresses significantly inhibited plant growth and triggered cell damage in a dosage-dependent manner, and the toxic effect on redox homeostasis was correlated with antioxidant metabolism. Read More

View Article and Full-Text PDF

Immuno-protective efficiency of feed-based whole-cell inactivated bivalent vaccine against Streptococcus and Aeromonas infections in red hybrid tilapia (Oreochromis niloticus × Oreochromis mossambicus).

Fish Shellfish Immunol 2021 Jun 12;113:162-175. Epub 2021 Apr 12.

Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia; Aquatic Animal Health and Therapeutics Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. Electronic address:

Streptococcosis and motile aeromonad septicemia (MAS) are well-known diseases in tilapia culture, which cause mass mortality with significant economic losses. The development of feed-based bivalent vaccines in controlling these diseases has been initiated, however, the mechanisms of immunities and cross-protection in fish remain unclear. This study was conducted to assess the immuno-protective as well as the cross-protective efficacy of a newly developed feed-based bivalent vaccine against Streptococcus and Aeromonas infections in red hybrid tilapia. Read More

View Article and Full-Text PDF

Nurses' team communication in hospitals: A quasi-experimental study using a modified TeamSTEPPS.

J Public Health Res 2021 Apr 14;10(2). Epub 2021 Apr 14.

School of Nursing, Faculty of Medicine, Universitas Brawijaya, Malang.

Background: Communication is a bridge of transaction between the health team, patients, and families that applies in the service units of hospitals, which are closely related to the patient safety culture. TeamSTEPPS is a team strategies and tools to enhance performance and patient safety. Therefore, this study aims to analyze the effect of modified TeamSTEPPS training on the team communication of nurses in hospitals. Read More

View Article and Full-Text PDF

Early stage risk communication and community engagement (RCCE) strategies and measures against the coronavirus disease 2019 (COVID-19) pandemic crisis.

Glob Health J 2021 Mar 14;5(1):44-50. Epub 2021 Feb 14.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; WHO Collaborating Centre for Tropical Diseases, Shanghai 200025, China.

Coronavirus disease 2019 (COVID-19) pandemic has proven to be tenacious and shows that the global community is still poorly prepared to handling such emerging pandemics. Enhancing global solidarity in emergency preparedness and response, and the mobilization of conscience and cooperation, can serve as an excellent source of ideas and measures in a timely manner. The article provides an overview of the key components of risk communication and community engagement (RCCE) strategies at the early stages in vulnerable nations and populations, and highlight contextual recommendations for strengthening coordinated and sustainable RCCE preventive and emergency response strategies against COVID-19 pandemic. Read More

View Article and Full-Text PDF

Multifunctional manganese-based carboxymethyl chitosan hydrogels for pH-triggered pesticide release and enhanced fungicidal activity.

Carbohydr Polym 2021 Jun 15;262:117933. Epub 2021 Mar 15.

Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, PR China. Electronic address:

Carboxymethyl chitosan (CMCS) has emerged as a promising biopolymer carrier for controlled release formulations of pesticide. In this study, manganese-based carboxymethyl chitosan hydrogel was facilely prepared to encapsulate and release fungicide prothioconazole in a controllable manner. The loading content (LC) and encapsulation efficiency (EE) of prothioconazole were optimized by orthogonal test. Read More

View Article and Full-Text PDF

Functional characterization of Kid-Kis and MazF-MazE in Sf9 cells and Mythimna separata embryos.

Pestic Biochem Physiol 2021 May 3;174:104814. Epub 2021 Mar 3.

Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, Hubei, China. Electronic address:

Toxin-antitoxin (TA) systems are comprised of a toxin and its antidote antitoxin and are widely present in bacterial and in eukaryotic systems. However, no work regarding TA systems has been reported in insects. We characterized the Kid-Kis and MazF-MazE TA systems in Spodoptera frugiperda cells and Mythimna separata embryos and observed that the Kid and MazF toxins were highly toxic. Read More

View Article and Full-Text PDF

Sublethal effects of bistrifluron on key biological traits, macronutrients contents and vitellogenin (SeVg) expression in Spodoptera exigua (Hübner).

Pestic Biochem Physiol 2021 May 23;174:104802. Epub 2021 Feb 23.

State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Zhejiang Academy of Agricultural Sciences, Institute of Plant Protection and Microbiology, Hangzhou 310021, PR China. Electronic address:

The beet armyworm, Spodoptera exigua, is a highly polyphagous pest originated from Southeast Asia but has spread globally, attacking economically important crops and fruits. Bistrifluron insecticide is one of the highly active insect growth regulators that has been reported to inhibit development and longevity in other lepidopteran species and could be used in the control of S. exigua. Read More

View Article and Full-Text PDF

Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry.

ChemSusChem 2021 Apr 9. Epub 2021 Apr 9.

Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička c. 54, 10000, Zagreb, Croatia.

In recent years, mechanochemistry has been growing into a widely accepted alternative for chemical synthesis. In addition to their efficiency and practicality, mechanochemical reactions are also recognized for their sustainability. The association between mechanochemistry and Green Chemistry often originates from the solvent-free nature of most mechanochemical protocols, which can reduce waste production. Read More

View Article and Full-Text PDF

Emerging Materials and Methods toward Ammonia-Based Energy Storage and Conversion.

Adv Mater 2021 Apr 8:e2005721. Epub 2021 Apr 8.

Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

Efficient storage and conversion of renewable energies is of critical importance to the sustainable growth of human society. With its distinguishing features of high hydrogen content, high energy density, facile storage/transportation, and zero-carbon emission, ammonia has been recently considered as a promising energy carrier for long-term and large-scale energy storage. Under this scenario, the synthesis, storage, and utilization of ammonia are key components for the implementation of ammonia-mediated energy system. Read More

View Article and Full-Text PDF

[Strategy for a Risk-stratified Use of Rapid Antigen Testing: Containing the SARS-CoV-2 Pandemic by Integrating Rapid Testing into Case and Contact Tracing Management].

Gesundheitswesen 2021 May 8;83(5):349-353. Epub 2021 Apr 8.

Institut fur medizinische Informationsverarbeitung Biometrie und Epidemiologie, Ludwig-Maximilians-Universität München, München, Deutschland.

The use of rapid testing offers an opportunity to contain the SARS-CoV-2 pandemic; however, the impact of false-positive and false-negative test results and population response must be anticipated and taken into consideration to avoid or mitigate harm. Untargeted use of rapid testing is associated with high direct and indirect costs and will have limited impact on the pandemic if resources are used inefficiently. We suggest using a risk-stratified testing strategy, based on targeted testing directly integrated with the Public Health Service's case and contact tracing management. Read More

View Article and Full-Text PDF

Influence of wet oxidation pretreatment with hydrogen peroxide and addition of clarified manure on anaerobic digestion of oil palm empty fruit bunches.

Bioresour Technol 2021 Jul 23;332:125033. Epub 2021 Mar 23.

Bioproducts, Sciences and Engineering Laboratory, Washington State University Tricities, Biological Systems Engineering, Washington State University, United States.

Food and energy requirements are increasing globally, and the challenge is to meet these demands in a sustainable manner. Oil palm has a relatively high productivity, but produces the lignocellulosic residue of empty fruit bunches (OPEFB). In this study, wet oxidation pretreatment is utilized to overcome the recalcitrance of OPEFB during semi-continuous anaerobic digestion (AD) with between 19. Read More

View Article and Full-Text PDF

Complete solar-driven dual-photoelectrode fuel cell for water purification and power generation in the presence of peroxymonosulfate.

J Hazard Mater 2021 Mar 18;416:125682. Epub 2021 Mar 18.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, PR China.

This study reports the development of complete solar-driven dual-photoelectrode fuel cell (PFC) based on WO photoanode and CuO photocathode with peroxymonosulfate (PMS) serving as cathodic electron acceptor. As indicated by photoelectrochemical measurements, the PMS was able to improve thermodynamic properties of photocathode, achieving an increased open circuit potential from 0.42 V to 0. Read More

View Article and Full-Text PDF

A cross cultural meat paradox: A qualitative study of Australia and India.

Appetite 2021 Apr 2;164:105227. Epub 2021 Apr 2.

School of Psychology and Public Health La Trobe University 133 McKoy Street, Wodonga, Victoria, 3690, Australia. Electronic address:

The 'meat paradox' is the psychological conflict between people's enjoyment of meat and their moral discomfort in relation to animal suffering. To date, most studies on the meat paradox have been in Western contexts where meat-eating is a cultural norm. In comparison, little is known about how the meat paradox is experienced in emerging economies such as India, where the longstanding cultural commitment to vegetarianism is under challenge. Read More

View Article and Full-Text PDF