1,183 results match your criteria suspected cytological


Correlation between US-FNAC with BRAF V600E Mutation Analysis and Central Neck Lymph Node Metastasis in cN0 Papillary Thyroid Cancer.

Biomed Res Int 2021 1;2021:9937742. Epub 2021 Jul 1.

Department of Ultrasound Medicine, Gansu Provincial Hospital, Lanzhou 730000, China.

The aim of this study was to explore the correlation between ultrasound-guided fine-needle aspiration cytology(US-FNAC) combined with BRAF V600E mutation analysis and central neck lymph node metastasis in cN0 papillary thyroid cancer, so as to provide reliable molecular evidence to use it for preoperative evaluation, operation procedure design, and postoperative follow-up planning in clinic. Specimens were obtained from 250 patients with cN0 thyroid cancer (TI-RADS≥4a, highly suspected of PTC by US-FNAC) after bilateral thyroidectomy and central neck lymph node dissection with accessible postoperative pathologic results of PTC and central neck lymph nodes and used for cytological diagnosis by H&E stain and BRAF V600E mutation detection. Single-factor analysis showed that differences between the central neck lymph node metastasis and nonmetastasis groups were statistically significant in gender, BRAF V600E mutation, and extracapsular extension. Read More

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Giant Pilomatrical Tumor With Broad Epidermal Components: An Example of Histological Diversity and a Potential Diagnostic Pitfall of Tumors With Pilomatrical Differentiation.

Am J Dermatopathol 2021 Jul 20. Epub 2021 Jul 20.

Departments of Diagnostic Pathology, and Dermatology, Kyoto University Hospital, Kyoto, Japan; Department of Dermatology, Kagawa University Hospital, Kagawa, Japan; and National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Abstract: The diagnosis of pilomatricoma, the most common matrical tumor, is generally straightforward; however, it exhibits diverse histology associated with various morphological stages and several clinical variants, and matrical differentiation can occur in various neoplastic diseases. A 56-year-old man was admitted to our hospital to resect an 11.0-cm skin tumor on his right shoulder. Read More

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Cytological Appearances of Ovarian Seromucinous Borderline Tumor in Ascites: Presentation of 2 Cases.

Acta Cytol 2021 Jul 20:1-8. Epub 2021 Jul 20.

Department of Pathology, Saga University Hospital, Saga, Japan.

Background: Seromucinous borderline tumor (SMBT) is a rare neoplasm which was newly defined in the 2014 WHO classification. Although the clinical and histopathological characteristics of SMBT have been well described, its cytological characteristics have not. We recently experienced 2 cases of SMBT which were defined by cytological findings of ascites. Read More

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Diagnostic Concordance of Cytology and Histology in Samples Obtained via Endoscopic Ultrasound-Guided Fine-Needle Biopsy (EUS-FNB).

Cureus 2021 Jun 11;13(6):e15596. Epub 2021 Jun 11.

Gastroenterology and Hepatology; Advanced Endoscopy, University of Miami Miller School of Medicine, Miami, USA.

Introduction Endoscopic ultrasound (EUS)-guided fine-needle aspiration and biopsy (FNA/FNB) to obtain cytological aspirates and histological core samples, respectively, are the standard of care for diagnosing lesions in/adjacent to the upper/lower gastrointestinal tract. Due to the lack of standardization of tissue processing, it is unclear whether core samples should be sent only for histology (formalin) or cytology (CytoLyt), or both. The aim of this study was to investigate the diagnostic concordance rates between cytology and histology on EUS-FNB core samples. Read More

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A Case of Spontaneous Regression and Recurrence of Primary Vitreoretinal Lymphoma.

Ocul Immunol Inflamm 2021 Jul 13:1-4. Epub 2021 Jul 13.

Department of Ophthalmology, Institute of Vision Research, Severance Eye Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

: To report a case of primary vitreoretinal lymphoma (PVRL) showing recurrence after spontaneous regression, diagnosed with the aid of next-generation sequencing (NGS).: Retrospective case report.: A 61-year-old immunocompetent Korean woman presented with subretinal lesions suspected of PVRL, which resolved spontaneously in 2 months. Read More

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Development and validation of a clinical prediction model for endocervical curettage decision-making in cervical lesions.

BMC Cancer 2021 Jul 13;21(1):804. Epub 2021 Jul 13.

Department of Obstetrics and Gynecology, the Second Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.

Background: In the absence of practical and reliable predictors for whether the endocervical curettage (ECC) procedure should be performed, decisions regarding patient selection are usually based on the colposcopists' clinical judgment instead of evidence. We aimed to develop and validate a practical prediction model that uses available information to reliably estimate the need to perform ECC in patients suspected of having cervical lesions.

Methods: In this retrospective study, 2088 patients who underwent colposcopy, colposcopically directed biopsy (CDB) and ECC procedures between September 2019 and September 2020 at the Second Hospital of Shanxi Medical University were included. Read More

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Diagnosis and management of hyalinizing trabecular tumor of the thyroid: a single-institution experience.

Endocr J 2021 Jul 6. Epub 2021 Jul 6.

Departments of Surgery, Kuma Hospital, Kobe, Hyogo 650-0011, Japan.

Hyalinizing trabecular tumor (HTT) of the thyroid is a mostly benign disease. Its cytological and pathological diagnosis is often difficult, because HTT cells and papillary thyroid carcinoma (PTC) cells share similar features (e.g. Read More

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Comparison of the diagnostic effectiveness between an expert and a student in the diagnosis of sarcoidosis by transbronchial biopsy of mediastinal lymph nodes under the control of endosonography.

Adv Respir Med 2021 ;89(3):241-246

Department of Lung Diseases and Tuberculosis, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) of mediastinal lymph nodes is currently considered to be the most effective minimally invasive diagnostic method in patients with suspected stage I and II sarcoidosis. However, diagnostic effectiveness depends on the experience and skills of the doctor which is dependent on the number of correctly performed procedures. The aim of the study is to compare the diagnostic effectiveness of the EBUS-TBNA test obtained by an expert in this field vs that of his student. Read More

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January 2021

Protection measures against SARS-CoV-2 infection for cytopathology and histopathology laboratories personnel: practical recommendations.

Rom J Morphol Embryol 2020 Oct-Dec;61(4):1067-1076

Department of Surgery II, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania; Socola Institute of Psychiatry, Iaşi, Romania;

In the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, healthcare workers are at high risk to be infected with this new coronavirus, particularly when they handle not only patients, but also their body fluids. In Romania, even though the protective measures to be used by medical staff in emergency departments, clinical departments, radiology departments, clinical laboratories and morgues services are well known, there is little information about the protection of medical staff in the laboratories of cytopathology and histopathology. In this article, we will discuss the transmission routes of the new coronavirus, the surfaces it could contaminate in a hospital, as well as the modalities of its inactivation. Read More

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'Rollover' abdominal paracentesis versus standard technique: protocol of a crossover randomized comparative trial.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.

The sensitivity of single abdominal paracentesis for diagnosis of peritoneal carcinomatosis in patients with malignant ascites is 40-70%. Tumor cells shed from the peritoneum settle preferentially in certain recesses of the peritoneum. We aim to compare the standard technique of abdominal paracentesis versus a rollover technique in a randomized crossover study to assess the cytological yield in patients suspected to have peritoneal carcinomatosis. Read More

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Predictive factors of malignancy in pediatric patients with thyroid nodules and performance of the Italian classification (SIAPEC 2014) in the outcome of the cytological FNA categories.

Endocrine 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatric Endocrinology, Regina Margherita Children's Hospital, Turin, Italy.

Purpose: The rate of malignancy (ROM) among pediatric studies using the Bethesda System is 39.5% and 41.5% for atypia of undetermined significance/follicular lesion of undetermined significance and for suspected follicular neoplasm, respectively. Read More

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Indeterminate thyroid cytology: detecting malignancy using analysis of nuclear images.

Endocr Connect 2021 Jun 29;10(7):707-714. Epub 2021 Jun 29.

Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University (Unesp), Botucatu, São Paulo, Brazil.

Background: Thyroid nodules diagnosed as 'atypia of undetermined significance/follicular lesion of undetermined significance' (AUS/FLUS) or 'follicular neoplasm/suspected follicular neoplasm' (FN/SFN), according to Bethesda's classification, represent a challenge in clinical practice. Computerized analysis of nuclear images (CANI) could be a useful tool for these cases. Our aim was to evaluate the ability of CANI to correctly classify AUS/FLUS and FN/SFN thyroid nodules for malignancy. Read More

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White discharge formation following a subepithelial connective tissue graft for anterior fixed partial denture pontics: a case report based on clinical and histological findings.

J Prosthodont Res 2021 May 28. Epub 2021 May 28.

Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama.

Patient: A 54-year-old woman presenting with anterior alveolar ridge resorption was submitted to a connective tissue graft (CTG) for esthetic improvement before rehabilitation with a fixed partial denture. Palate-harvested connective tissue was used as a graft after extra-oral removal of the epithelium. Unexpectedly, complete wound healing was not observed. Read More

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Evaluation of the Utilization of FilmArray Meningitis/Encephalitis in Children With Suspected Central Nervous System Infection: A Retrospective Case Series.

Pediatr Emerg Care 2021 May 26. Epub 2021 May 26.

From the Senne Liquor Diagnóstico Virology Section (LIM-52), Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil.

Background: The etiology of central nervous system infections is often difficult to establish. FilmArray meningitis/encephalitis (ME) panel is a multiplex polymerase chain reaction for rapid identification of 14 pathogens. The aim of this study was to evaluate potential real-life contributions of the use of this method in the pediatric population. Read More

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Diffusion-weighted imaging diagnostic algorithm in patients with suspected pleural malignancy.

Eur Radiol 2021 May 28. Epub 2021 May 28.

Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, China.

Objectives: The purpose of this study was to analyze the diagnostic performance and clinical application of diffusion-weighted imaging (DWI) in patients with suspected pleural malignancy (PM).

Methods: A retrospective review of patients with suspected PM was performed from March 2014 to August 2018 (NCT02320617). All patients underwent chest DWI and computed tomography (CT) with cytological or histopathological findings as reference standards. Read More

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Imprint cytology: Invaluable technique to evaluate fresh specimens received in the pathology department for Lymphoma workup.

Cancer Cytopathol 2021 May 20. Epub 2021 May 20.

Department of Pathology, McGill University, Montreal, Canada.

At the time of intraoperative consultation, cytologic preparations including smears and imprints can be used in combination with frozen sections to increase diagnostic yield; however, these simple and rapid techniques are not adopted by all pathologists and their use varies considerably between institutions. In patients under investigation for suspected lymphoma, optimal triaging of tissue received fresh in pathology for lymphoma workup is paramount to maximize the odds of obtaining an accurate and clinically meaningful diagnosis and to avoid the need for additional procedures and delays in management, particularly in the current context in which core biopsies have become common practice as a first attempt to attain this goal. Imprint cytology is invaluable in this regard, also as these patients may not have a lymphoma but rather one of its clinical mimics. Read More

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Hepatosplenic T-cell lymphoma with hepatocytotropism in a cat.

JFMS Open Rep 2021 Jan-Jun;7(1):20551169211005914. Epub 2021 Apr 20.

Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Case Summary: A 14-year 3-month-old spayed female mixed-breed cat presented with jaundice, anaemia and thrombocytopenia. Haemophagocytic syndrome associated with lymphoma was suspected after cytological examination of the spleen. Despite treatment with prednisolone, L-asparaginase and nimustine, the cat died 176 days after the initial presentation. Read More

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Morphometric analysis of nuclear symmetry in urothelial carcinoma for predicting tumor recurrence.

Microsc Res Tech 2021 Apr 30. Epub 2021 Apr 30.

Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Urothelial carcinoma is the ninth most common cancer in the world. Cytological analysis of the urine is used for screening, as well as for cases suspected for neoplasia of the urinary tract. However, the sensitivity of urine cytology examination is low. Read More

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Evaluation of the diagnostic accuracy of bronchial brushing cytology in lung cancer: A meta-analysis.

Cancer Cytopathol 2021 Apr 22. Epub 2021 Apr 22.

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Flexible bronchoscopy is commonly used to examine patients suspected to have lung cancer. Bronchial brushing is one of the cytological technologies for lung specimens obtained through a bronchoscope. However, the accuracy of bronchial brushing cytology (BBC) for lung cancer diagnosis is still inconclusive. Read More

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in a central Texas cat: clinical presentation, molecular identification, sandfly vector collection and novel management.

JFMS Open Rep 2021 Jan-Jun;7(1):2055116921999595. Epub 2021 Mar 22.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA.

Case Summary: This case report documents the clinical appearance, diagnosis and novel treatment of a central Texas cat with cutaneous leishmaniosis. The cat presented with a linear erosion on the right pinnal margin, an ulcerated exophytic nodule on the right hock and a swelling in the right nostril. Cytological and histopathological findings were consistent with leishmaniosis. Read More

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Is Subdivision of Atypia of Undetermined Significance AUS/Follicular Lesion of Undetermined Significance Cases According to Detailed Nuclear Features Vital for Assessing the Risk of Malignancy?

J Cytol 2020 Oct-Dec;37(4):204-209. Epub 2020 Nov 6.

Department of Medical Statistics, Faculty of Medicine, Zonguldak Bulent Ecevit Universtiy, Kozlu, Zonguldak, Turkey.

Background: It has been known that the "atypia of undetermined significance (AUS)/follicular lesion of undetermined significance (FLUS)" category is the most problematic category in Bethesda system due to its highly heterogeneous morphological features. Recently, it has been reported that aspirates including nuclear atypia in the AUS/FLUS category have a higher risk of malignancy.

Aims: This study aimed to assess each nuclear property in aspirates with cytological atypia and also to determine the relationship with the risk of malignancy. Read More

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November 2020

Cytomorphological Evaluation of Synovial Lesions in a Tertiary Care Centre in North India: A Retrospective Study.

J Cytol 2020 Oct-Dec;37(4):166-169. Epub 2020 Nov 6.

Department of Radio-Diagnosis and Imaging, Government Medical College, Jammu (J&K), India.

Background: Numerous pathological processes involve synovium and periarticular tissues that are characteristic and in some cases specific to a particular disease. Synovial fluid is a thick, stringy fluid found in the cavity of synovial joint. Examination of the synovium plays a key role in the diagnosis of many joint diseases. Read More

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November 2020

Pericardial metastasis of parotid mucoepidermoid carcinoma diagnosed by pericardial biopsy.

Auris Nasus Larynx 2021 Mar 6. Epub 2021 Mar 6.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1, Shinjuku-ku, Tokyo, Nishishinjuku 160-0023, Japan.

A 30-year-old man presented with swelling in the lower left ear. Close examination led to a diagnosis of parotid gland cancer, T4N0M0 Stage IVA, so total resection of the left parotid gland and left neck dissection were performed. Pathological examination led to a diagnosis of high-grade malignant-type mucoepidermoid, and chemoradiotherapy was performed as postoperative treatment. Read More

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A narrative review of invasive diagnostics and treatment of early lung cancer.

Transl Lung Cancer Res 2021 Feb;10(2):1110-1123

Department of Thoracic Surgery, Medical University of Gdansk, Gdansk, Poland.

The diagnosis and treatment of early-stage lung cancer remains a clinical challenge. The broadening implementation of lung cancer screening has resulted in positive findings in numerous patients that are mostly non-malignant. Many other patients have indeterminate nodules that are difficult to assess through simple observation. Read More

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February 2021

Incidence of microcarcinoma and non-microcarcinoma in ultrasound-found thyroid nodules.

BMC Endocr Disord 2021 Mar 4;21(1):38. Epub 2021 Mar 4.

Department of Endocrinology, The Second Affiliated Hospital, Guangzhou Medical University, No.250 Changgang Road East, Haizhu District, 510260, Guangzhou, China.

Backgrounds: The incidence of thyroid nodules is increasing year by year around the world. However, ultrasound is not recommended as a screening test for the general population or patients with a normal thyroid on palpation by the American Association of Clinical Endocrinologists (AACE). In practice, some individuals with normal thyroid palpation have nodules that can just be found out by ultrasound. Read More

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Orthopedic Surgeons' Nightmare: Rare Case of Retained Gauze Piece after Wrist Surgery Masquerading as Soft-Tissue Tumor.

J Orthop Case Rep 2020 Jul;10(4):59-62

Department of Orthopaedics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

Introduction: Retention of cotton-based gauze or sponge in surgical field, variously called as gauzoma, gossypiboma, textiloma, and muslinoma, is an unexpected and untoward human error that carries sinister consequences for patients and surgeons. Although reported at various surgical sites, no such case has been reported so far in upper limb after wrist surgery.

Case Report: Here, we present a case of gauzoma in a 24-year-old male who was operated for his right side distal radius fracture at a private hospital. Read More

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Pulmonary wedge aspiration cytology for the rapid diagnosis of pulmonary tumor thrombotic microangiopathy: A case report.

Diagn Cytopathol 2021 Jul 15;49(7):E277-E280. Epub 2021 Feb 15.

Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Oita, Japan.

Pulmonary tumor thrombotic microangiopathy (PTTM) is a cancer-related pulmonary complication characterized by rapid progression of dyspnea and pulmonary hypertension, occasionally causing sudden death. Given the condition of patients with dyspnea, lung biopsies are limited because of their invasiveness. A 72-year-old man presented with chronic atrial fibrillation and a high right heart load, as determined using ultrasonography. Read More

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Anterior chamber tap cytology in acute postoperative endophthalmitis: a case-control study.

Br J Ophthalmol 2021 Feb 11. Epub 2021 Feb 11.

Ophthalmology, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, Île-de-France, France

Aims: To determine anterior chamber tap cytology characteristics in acute postoperative bacterial endophthalmitis.

Methods: 488 eyes of 488 patients were included in this retrospective case-control study. The study group included 93 eyes with bacteriologically documented endophthalmitis and 85 eyes with clinical endophthalmitis. Read More

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February 2021

Consensus study on the health system and patient-related barriers for lung cancer management in South Africa.

PLoS One 2021 11;16(2):e0246716. Epub 2021 Feb 11.

Division of the Wits Health Consortium, Non-Communicable Diseases Research (NCDR), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Lung cancer is the highest incident cancer globally and is associated with significant morbidity and mortality particularly if identified at a late stage. Poor patient outcomes in low- and middle-income countries (LMIC's) might reflect contextual patient and health system constraints at multiple levels, that act as barriers to prevention, disease recognition, diagnosis, and treatment. Lung cancer screening, even for high-risk patients, is not available in the public health sector in South Africa (SA), where the current HIV and tuberculosis (TB) epidemics often take precedence. Read More

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Clinico-pathological assessment of surgically removed abdominal wall endometriomas following cesarean section.

Ann Med Surg (Lond) 2021 Feb 21;62:219-224. Epub 2021 Jan 21.

Department of Pathology, National Liver Institute, Menoufia University, Shebin El Kom, Egypt.

Background: Over the past few decades, the rate of Cesarean Section (CS) delivery has been rising rapidly and the prevalence of CS-associated complications including Abdominal Wall Endometriomas (AWE) increases with each additional operation. The aim of this study was to evaluate the clinical characteristics, histopathological diagnostic role and surgical management of post-CS AWE through a retrospective case review.

Methods: We calculated the incidence of AWE and reviewed all the patients underwent surgical removal of Post-CS AWE during the period of 2012-2018 who were diagnosed, treated and followed up for 2-8 years at our tertiary hospital. Read More

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February 2021