506,078 results match your criteria survival rates

Stop the Bleed in Rural Sierra Leone: One Year of Interventions and Outcomes by Nursing Trainees.

J Surg Res 2022 Jan 12;273:79-84. Epub 2022 Jan 12.

Rutgers New Jersey Medical School, Department of Surgery, Newark, New Jersey.

Background: Low- and middle-income countries (LMICs) bear the bulk of the global burden of traumatic injury, yet many lack adequate prehospital trauma care systems. The Stop the Bleed (STB) course, designed to equip bystanders with bleeding control skills, is infrequently offered in LMICs, and its impact in these settings is unknown. To examine the frequency and effectiveness of STB interventions in LMICs, we quantified nursing student trainees' encounters with bleeding victims after STB training in rural Sierra Leone. Read More

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January 2022

Cannibalism rate and mLeptin expression are influenced by photoperiod and diets in Piracanjuba, Brycon orbignyanus (Valenciennes, 1850) larvae.

Res Vet Sci 2022 Jan 8;143:142-147. Epub 2022 Jan 8.

Universidade Federal de Lavras, Campus Universitário, Caixa Postal 3037, CEP 37200-000 Minas Gerais, Brazil. Electronic address:

Piracanjuba (Brycon orbignyanus) is a species with great productive potential, and during its larval phase, it presents intense cannibal activity. The photoperiod and diet are primary feed behaviour and cannibalism modulators to fishes. This experiment aimed to verify the effect of different photoperiods and diets in Piracanjuba larviculture. Read More

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January 2022

Compliance with recommended Varroa destructor treatment regimens improves the survival of honey bee colonies over winter.

Res Vet Sci 2021 Dec 31;144:1-10. Epub 2021 Dec 31.

Agroscope, Swiss Bee Research Centre, Bern, Switzerland; Department of Ecology and Evolution, Biophore, UNIL-Sorge, University of Lausanne, Lausanne, Switzerland.

The ectoparasitic mite Varroa destructor affects honey bee colony health and survival negatively, thus compelling beekeepers to treat their colonies every year. A broadly used mite control regimen is based on two organic molecules: formic and oxalic acids. To ensure optimal efficiency, several applications of these acids at pre-defined time points are recommended. Read More

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December 2021

A social worker intervention to reduce post-hospital mortality in HIV-infected adults in Tanzania (Daraja): Study protocol for a randomized controlled trial.

Contemp Clin Trials 2022 Jan 12:106680. Epub 2022 Jan 12.

Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania; London School of Hygiene and Tropical Medicine, Department of Infectious Disease Epidemiology, Keppel Street, London WC1E 7HT, UK. Electronic address:

Background: In sub-Saharan Africa (SSA), hospitalized HIV-infected patients who are discharged home have been shown to experience extremely high mortality rate. Daraja is an individual-level, time-limited, five-session case management intervention aiming to link hospitalized HIV-infected patients to outpatient HIV care upon discharge.

Methods: A randomized control trial will aim at evaluating the efficacy of Daraja intervention on reducing mortality in hospitalized HIV-infected patients upon discharge from hospital. Read More

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January 2022

Influence of pH on physiological and behavioral responses of Pomacea canaliculata.

Comp Biochem Physiol A Mol Integr Physiol 2022 Jan 12:111153. Epub 2022 Jan 12.

Graduate Program in Pharmacology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil; Department of Physiology and Pharmacology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil. Electronic address:

The physiological and behavioral responses of Pomacea canaliculata exposed to different pH values (4, 5, 6, 7, 8, 9, and 10) were evaluated. Survival, behavior (avoidance), metabolites (mantle), net ion fluxes (Na and K), and ATPase activity (gills) were the parameters analyzed. The final survival rates were 100% (pH 4-9) and 90% (pH 10), and the groups did not differ significantly. Read More

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January 2022

CT/bioluminescence dual-modal imaging tracking of stem cells labeled with [email protected]@PEG nanotracers and RfLuc in nintedanib-assisted pulmonary fibrosis therapy.

Nanomedicine 2022 Jan 12:102517. Epub 2022 Jan 12.

School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei 230026, China; CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China. Electronic address:

Mesenchymal stem cells (MSCs) are promising in idiopathic pulmonary fibrosis (IPF) therapy. However, low survival rate and ambiguous behavior of MSCs after transplantation impede their clinical translation. To this end, we have developed a new strategy to improve the survival rate and monitor the behavior of the transplanted MSCs simultaneously. Read More

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January 2022

Seed banks can help to maintain the diversity of interacting phytoplankton species.

J Theor Biol 2022 Jan 12:111020. Epub 2022 Jan 12.

Institute of Mathematics of Bordeaux, University of Bordeaux and CNRS, Talence, France; Integrative and Theoretical Ecology, LabEx COTE, University of Bordeaux, Pessac, France.

Seed formation is part of the reproductive cycle, leading to the accumulation of resistance stages that can withstand harsh environmental conditions for long periods of time. At the community level, multiple species with such long-lasting life stages can be more likely to coexist. While the implications of this process for biodiversity have been studied in terrestrial plants, seed banks are usually neglected in phytoplankton multispecies dynamic models, in spite of widespread empirical evidence for such seed banks. Read More

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January 2022

Vitrification of manually stage-selected embryos of Drosophila have significantly higher survival and emergence - Consequences for insect germplasm storage.

Cryobiology 2022 Jan 12. Epub 2022 Jan 12.

USDA-ARS Red River Valley Agricultural Research Center, Biosciences Research Laboratory, 1605 Albrecht Boulevard North, Fargo, ND, 58102-2765, USA.

Embryonic selection for vitrification and cryostorage in Drosophila and other dipterans is generally carried out by gross observation of the embryonic development at a constant temperature. In this study, the effect of embryo developmental temperature (19, 20 and 21 °C) on the stage specific convergence of the embryonic development to the developmental stages 15-17, that is useful for cryopreservation, was studied in a flightless mutant strain of Drosophila melanogaster and compared with the Ore-R strain. The temperature that allowed for the best convergence to stage 16 was chosen for further selection and treatment of the embryos. Read More

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January 2022

Systemic Inflammatory Markers as Predictors of Postoperative Complications and Survival in Patients With Advanced Head and Neck Squamous Cell Carcinoma Undergoing Free-Flap Reconstruction.

J Oral Maxillofac Surg 2021 Dec 22. Epub 2021 Dec 22.

Associate Professor, Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Centre Sestre milosrdnice, Zagreb, Croatia; University of Zagreb School of Medicine, Zagreb, Croatia.

Purpose: The aim of this study was to determine the prognostic value of systemic inflammatory indices as factors for postoperative complications and survival in patients with advanced stages of p16-negative head and neck squamous cell carcinoma undergoing free-flap reconstruction.

Methods: This was a retrospective cohort study. The primary predictor variables were inflammatory markers such as neutrophil, lymphocyte, monocyte, and platelet count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, lymphocyte-monocyte ratio, derived NLR, systemic immune-inflammation, and systemic inflammatory marker index (SIM). Read More

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December 2021

Peritoneal Dialysis-Related Peritonitis: Rate, Clinical Outcomes and Patient Survival.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2021 Dec 30;42(3):47-55. Epub 2021 Dec 30.

Acibadem Sistina Hospital, Skopje, R. North Macedonia.

Peritoneal dialysis-related peritonitis remains the major complication and primary challenge to the long-term success of peritoneal dialysis (PD). The study aimed to analyze the peritonitis rate, the cause, the outcomes, and the association of peritonitis with the survival of patients on peritoneal dialysis. Patient data were collected retrospectively from medical charts. Read More

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December 2021

Lung transplantation in the septuagenarian can be successfully performed though long-term results impacted by diseases of aging.

Clin Transplant 2022 Jan 15:e14593. Epub 2022 Jan 15.

Division of Cardiac Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.

Background: Advanced age is considered a risk factor for lung transplantation (LTX). We sought to evaluate the long-term outcomes of LTX in the septuagenarian.

Methods: LTX recipients in the UNOS transplant registry (May 1, 2005 to June 12, 2020) were stratified into 18-59, 60-69, and > = 70 years of age. Read More

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January 2022

Comparison of the long-term oncologic outcomes of robotic-assisted and video-assisted thoracoscopic lobectomy for resectable non-small cell lung carcinoma.

J Robot Surg 2022 Jan 15. Epub 2022 Jan 15.

Division of Thoracic Surgery, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, N846a Doan Hall, Columbus, OH, 43210, USA.

The current oncologic outcomes of robotic-assisted lobectomy compared to video-assisted thoracoscopic lobectomy are currently not well defined. This study compares the overall survival and recurrence-free survival rates between the two approaches for patients with resectable non-small cell lung carcinoma. This is a retrospective review of 200 patients diagnosed with resectable primary lung carcinoma who underwent minimally invasive lobectomy from March 2014 to May 2018. Read More

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January 2022

Importance of long-term surveillance after curative esophagectomy for esophageal squamous cell carcinoma.

Dis Esophagus 2022 Jan 15. Epub 2022 Jan 15.

Background: The long-term outcomes after esophagectomy for esophageal cancer remain uncertain and the optimal surveillance strategy after curative surgery remains controversial.

Methods: In this study, the clinicopathological characteristics of patients who underwent curative thoracic esophagectomy between 1991 and 2015 at Toranomon Hospital were retrospectively analyzed and reviewed until December 2020. We evaluated the accumulated data regarding the pattern and rates of recurrence and second malignancy. Read More

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January 2022

Valve replacement or repair in native mitral valve infective endocarditis-Which is better? A meta-analysis and systematic review.

J Card Surg 2022 Jan 14. Epub 2022 Jan 14.

Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Background: Native mitral valve infective endocarditis (IE) plagues patients and surgeons alike because of its high mortality and recurrence rates as well as poor prognosis. Mitral valve repair (MVP) and mitral valve replacement (MVR) are two main surgical methods. However, the question of which benefits patients more remains controversial. Read More

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January 2022

NUDT15 intermediate metabolisers are associated with lower loss of response in paediatric Crohn's disease patients treated by combination treatment with infliximab and azathioprine.

Aliment Pharmacol Ther 2022 Jan 14. Epub 2022 Jan 14.

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: NUDT15 polymorphisms are associated with leukopenia during treatment with thiopurines. However, data regarding its effect on treatment outcomes are scarce.

Aims: To investigate the outcomes between NUDT15 normal and intermediate metabolisers in paediatric patients with Crohn's disease (CD) treated with a combination therapy of infliximab (IFX) and azathioprine (AZA). Read More

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January 2022

MiR-590 suppresses the progression of non-small cell lung cancer by regulating YAP1 and Wnt/β-catenin signaling.

X Hao A Su

Clin Transl Oncol 2022 Jan 15. Epub 2022 Jan 15.

General Department, Bejing Chaoyang District Sanhuan Cancer Hospital, Beijing, 100122, China.

Objective: Accumulating evidence has been revealed that miR-590 is involved in the progression and carcinogenesis of various cancers. However, the molecular mechanism of miR-590 in non-small-cell lung cancer (NSCLC) remains unclear.

Methods: Quantitative reverse transcription-PCR (qRT-PCR), western blot, MTT, and transwell assay were applied to investigate the functional role of miR-590 in this study. Read More

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January 2022

Bendamustine versus chlorambucil in treatment of chronic lymphocytic leukaemia in China: a randomized, open-label, parallel-controlled, phase III clinical trial.

Invest New Drugs 2022 Jan 15. Epub 2022 Jan 15.

Department of Hematology, Sun Yat-Sen University Cancer Center, Sun Yat-sen, China.

Background: Chronic lymphoblastic leukemia (CLL) is the most common adult leukemia and mainly affects the elderly. Chemoimmunotherapy still has a role in the standard frontline therapy for specific population. However, the clinical activity of bendamustine has not been investigated in unfit Chinese patients with CLL. Read More

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January 2022

CT-guided transthoracic pulmonary artery catheterization: an experimental study in a porcine model.

Eur Radiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Road, Chengdu, 610041, China.

Objectives: We investigated the safety and feasibility of CT-guided transthoracic pulmonary artery catheterization (TPAC) in a porcine model.

Methods: Procedures were conducted on ten mature Bama miniature pigs. After anesthesia, chest CT was performed in the left lateral decubitus position to determine the puncture route. Read More

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January 2022

Prevalence, interpretation, and management of unexpected positive cultures in revision TKA: a systematic review.

Knee Surg Sports Traumatol Arthrosc 2022 Jan 15. Epub 2022 Jan 15.

Department of Orthopaedic Surgery, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Purpose: Unexpected positive intraoperative cultures (UPIC) found in revision total knee arthroplasty (TKA) are difficult to interpret. Management goes along with risks for both over- and undertreating a potential periprosthetic joint infection (PJI). The objective of this systematic review was to determine the prevalence of UPIC in revision TKA surgery, evaluate the diagnostic workup process and the postoperative treatment, and assess outcome regarding re-revision rates. Read More

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January 2022

Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer.

Exp Mol Med 2022 Jan 14. Epub 2022 Jan 14.

Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, 110000, Shenyang, P.R. China.

The neuronally expressed developmentally downregulated 4 (NEDD4) gene encodes a ubiquitin ligase that targets the epithelial sodium channel for degradation and has been implicated in tumor growth in various cancers. Hence, in this study, we intended to characterize the functional relevance of the NEDD4-mediated Kruppel-like factor 8/microRNA-132/nuclear factor E2-related factor 2 (KLF8/miR-132/NRF2) axis in the development of bladder cancer. NEDD4 and KLF8 were overexpressed in bladder cancer tissues and were associated with poorer patient survival rates. Read More

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January 2022

Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatment.

Sci Rep 2022 Jan 14;12(1):734. Epub 2022 Jan 14.

Department of Intensive Care Medicine, Maastricht University Medical Center + (Maastricht UMC+), P. Debyelaan 25, 6229 HX, Maastricht, the Netherlands.

Although male Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients have higher Intensive Care Unit (ICU) admission rates and a worse disease course, a comprehensive analysis of female and male ICU survival and underlying factors such as comorbidities, risk factors, and/or anti-infection/inflammatory therapy administration is currently lacking. Therefore, we investigated the association between sex and ICU survival, adjusting for these and other variables. In this multicenter observational cohort study, all patients with SARS-CoV-2 pneumonia admitted to seven ICUs in one region across Belgium, The Netherlands, and Germany, and requiring vital organ support during the first pandemic wave were included. Read More

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January 2022

Survival, treatment regimens and medical costs of women newly diagnosed with metastatic triple-negative breast cancer.

Sci Rep 2022 Jan 14;12(1):729. Epub 2022 Jan 14.

Department of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Individuals diagnosed with metastatic triple-negative breast cancer (mTNBC) suffer worse survival rates than their metastatic non-TNBC counterparts. There is little information on survival, treatment patterns, and medical costs of mTNBC patients in Asia. Therefore, this study aimed to examine 5-year survival, regimens of first-line systemic therapy, and healthcare costs of mTNBC patients in Taiwan. Read More

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January 2022

Cabozantinib Plus Nivolumab Phase I Expansion Study in Metastatic Urothelial Carcinoma Patients Refractory to Immune Checkpoint Inhibitor Therapy.

Clin Cancer Res 2022 Jan 14. Epub 2022 Jan 14.

Department of Health and Human Services, National Cancer Institute.

Purpose: This study investigated the efficacy and tolerability of cabozantinib plus nivolumab (CaboNivo) in patients with metastatic urothelial carcinoma (mUC) that progressed on checkpoint inhibition (CPI).

Experimental Design: A phase I expansion cohort of mUC patients who received prior CPI was treated with cabozantinib 40 mg/day and nivolumab 3 mg/kg every 2 weeks until disease progression/unacceptable toxicity. The primary goal was objective response rate (ORR) per RECIST v. Read More

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January 2022

Optimal first-line treatment for platinum-eligible metastatic urothelial carcinoma: Comparison of chemo-immunotherapy, immunotherapy, and chemotherapy- A systematic review and meta-analysis.

Clin Immunol 2022 Jan 11:108927. Epub 2022 Jan 11.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, PR China; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, PR China. Electronic address:

Background: The role of first-line of immunotherapy in metastatic urothelial carcinoma (mUC) remains unclear. This meta-analysis aimed to explore an optimal first-line treatment strategy for mUC patients.

Methods: We carried out a meta-analysis between chemo-immunotherapy, immunotherapy, and chemotherapy in mUC based on randomized trials. Read More

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January 2022

Transcriptome analysis of grass carp (Ctenopharyngodon idella) and Holland's spinibarbel (Spinibarbus hollandi) infected with Ichthyophthirius multifiliis.

Fish Shellfish Immunol 2022 Jan 11. Epub 2022 Jan 11.

College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, 321004, China; Key Lab of Wildlife Biotechnology and Conservation and Utilization of Zhejiang Province, Zhejiang Normal University, Jinhua, 321004, China; Xinzhi College, Zhejiang Normal University, Jinhua, 321004, China. Electronic address:

Ichthyophthirius multifiliis is a protozoan ciliate that causes white spot disease (also known as ichthyophthiriasis) in freshwater fish. Holland's spinibarbel (Spinibarbus hollandi) was less susceptible to white spot disease than grass carp (Ctenopharyngodon Idella). In this study, grass carp and Holland's spinibarbel are infected by I. Read More

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January 2022

Cardiorenal Function and Survival in In-Hospital Cardiac Arrest: A Nationwide Study of 22,819 Cases.

Resuscitation 2022 Jan 11. Epub 2022 Jan 11.

University of Gothenburg, Institute of Medicine, Department of Molecular and Clinical Medicine, Gothenburg, Sweden; The Swedish Cardiopulmonary Resuscitation Registry, Centre of Registries, Gothenburg, Sweden; The Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: We studied the association between cardiorenal function and survival, neurological outcome and trends in survival after in-hospital cardiac arrest (IHCA).

Methods: We included cases aged ≥18 years in the Swedish Cardiopulmonary Resuscitation Registry during 2008 to 2020. The CKD-EPI equation was used to calculate estimated glomerular filtration rate (eGFR). Read More

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January 2022

Bioprosthetic Pulmonary Valve Dysfunction in Congenital Heart Disease.

Ann Thorac Surg 2022 Jan 11. Epub 2022 Jan 11.

Division of Thoracic and Cardiovascular Surgery, Emory University School of Medicine, Atlanta, Georgia; Emory University School of Medicine, Atlanta, Georgia; Children's Hospital of Atlanta, Atlanta, Georgia.

Background: We aim to identify the incidence and timing of dysfunction and failure of stented bioprosthetic valves in the pulmonary position in congenital heart disease patients.

Methods: 482 congenital heart disease patients underwent 484 stented bioprosthetic pulmonary valve implantations between 2008 and 2018. There were 164 porcine valves (Porcine) and 320 bovine pericardial valves (Pericardial) implanted. Read More

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January 2022

CivaSheet intraoperative radiation therapy for pancreatic cancer.

Brachytherapy 2022 Jan 12. Epub 2022 Jan 12.

Department of Radiation Oncology, Virginia Commonwealth University Health System, Massey Cancer Center, Richmond, VA. Electronic address:

The treatment of borderline resectable (BR) pancreatic cancer is challenging and requires a multidisciplinary approach with chemotherapy, radiation and surgical resection. Despite using chemotherapy and radiotherapy in the neoadjuvant setting, achievement of negative surgical margins remains technically challenging. Positive margins are associated with increased local recurrences and worse overall survival and there are no standard options for treatment. Read More

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January 2022

Oocyte donation: not all oocyte cryobanks are the same.

Reprod Biomed Online 2021 Oct 29. Epub 2021 Oct 29.

SISMER, Reproductive Medicine Unit, Via Mazzini 12, Bologna 40138, Italy.

Research Question: Is the efficacy of imported vitrified oocyte donation affected by the cryobank of origin?

Design: Longitudinal cohort study, including 249 completed oocyte warming cycles from 200 recipients (January 2016-July 2020). No severe male factor was included. Vitrified oocytes were provided by three Spanish cryobanks. Read More

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October 2021

The Potential for Overtreatment With Total Neoadjuvant Therapy (TNT): Consider One Local Therapy Instead.

Clin Colorectal Cancer 2021 Nov 18. Epub 2021 Nov 18.

University of Vermont Cancer Center, Burlington, VT; Department of Medicine, University of Vermont Larner College of Medicine, Burlington, VT.

With increased therapeutic options in rectal cancer, a central question has become how to tailor therapy to patient preferences to avoid both over and under treatment. Total Neoadjuvant Therapy (TNT), defined as delivering all planned chemotherapy and radiation therapy (RT) before surgery, was developed with the primary goal of improving overall survival through early elimination of micrometastatic disease. In this narrative review assessing patients with operable adenocarcinoma of the rectum, we sought to evaluate TNT versus alternative options with regard to both quality of life (QoL) and oncologic outcomes. Read More

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November 2021