41,699 results match your criteria survival percent

Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma.

Pathol Res Pract 2021 Jul 20;225:153558. Epub 2021 Jul 20.

Department of Molecular Biology and Endocrinology, "Vinca" Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Republic of Serbia.

Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults (<1% of all adult malignancies). Altered expression and molecular abnormalities of cell-cycle-regulatory proteins are one of the most prominent features in RMS. Therefore, we evaluated the expression of cyclin-dependent kinase inhibitors p57 and p16, as well as p16 methylation status, along with clinicopathological characteristics and overall survival (OS) in RMS patients. Read More

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Characteristics of burn casualties treated at role 2 in Afghanistan.

J Trauma Acute Care Surg 2021 Aug;91(2S Suppl 2):S233-S240

From the United States Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.

Background: Role 2 medical treatment facilities (MTFs) are frequently located in austere settings and have limited resources. A dedicated assessment of burn casualties treated at this level of care has not been performed. Therefore, the objective of this study was to characterize burn casualties presenting to role 2 MTFs in Afghanistan, along with the procedures they required, complications, and mortality to begin understanding the resources consumed by their care. Read More

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Case-control analysis of prehospital death and prolonged field care survival during recent US military combat operations.

J Trauma Acute Care Surg 2021 Aug;91(2S Suppl 2):S186-S193

From the Joint Trauma System, Defense Health Agency (S.A.S., D.J.d.J., E.L.M., R.S.K., H.R.M., M.A.R., J.M.G., S.K.), Joint Base San Antonio Fort Sam Houston, Texas; 10th Special Forces Group (Airborne) (J.C.R.), US Army Special Operations Command, Fort Carson, Colorado; West Virginia University Heart and Vascular Institute (D.P.), Morgantown, West Virginia; USASOC Surgeon's Office (D.P.), Fort Bragg, North Carolina; Armed Forces Medical Examiner System (E.L.M.), Defense Health Agency, Dover AFB, Delaware; U.S. Army John F. Kennedy Special Warfare Center and School (P.L.), Fort Bragg, North Carolina and; US Army Institute of Surgical Research (J.M.G.), Joint Base San Antonio Fort Sam Houston, Texas.

Background: Quantification of medical interventions administered during prolonged field care (PFC) is necessary to inform training and planning.

Materials And Methods: Retrospective cohort study of Department of Defense Trauma Registry casualties with maximum Abbreviated Injury Scale (MAIS) score of 2 or greater and prehospital records during combat operations 2007 to 2015; US military nonsurvivors were linked to Armed Forces Medical Examiner System data. Medical interventions administered to survivors of 4 hours to 72 hours of PFC and nonsurvivors who died prehospital were compared by frequency-matching on mechanism (explosive, firearm, other), injury type (penetrating, blunt) and injured body regions with MAIS score of 3 or greater. Read More

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Left atrial appendage thrombus and cerebrovascular events post-transcatheter aortic valve implantation.

Eur Heart J Cardiovasc Imaging 2021 Jul 28. Epub 2021 Jul 28.

Department of Interventional Cardiology, Erasmus University Medical Center, Thoraxcenter, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Aims: To elucidate the frequency and clinical impact of left atrial appendage thrombus (LAAT) in patients set for transcatheter aortic valve implantation (TAVI).

Methods And Results: All patients undergoing TAVI between January 2014 and June 2020 with analysable multislice computed tomography (MSCT) for LAAT were included. Baseline and procedural characteristics were collected, pre-procedural MSCT's were retrospectively analysed for LAAT presence. Read More

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What necessitates obstetric transfers? Experience from a secondary care hospital in India.

J Family Med Prim Care 2021 Jun 2;10(6):2331-2335. Epub 2021 Jul 2.

Department of Community Health, Christian Medical College, Vellore, Tamil Nadu, India.

Background: India attributes to about 15% of the maternal mortality globally. Many a time poor maternal and neonatal outcomes occur unanticipated during intrapartum and postpartum period. An efficient referral system identifies the indications necessitating prompt referrals besides ensuring patient friendliness and continuity of care. Read More

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Metabolic complications of childhood obesity.

J Family Med Prim Care 2021 Jun 2;10(6):2325-2330. Epub 2021 Jul 2.

Department of Pediatrics, PGIMER, Chandigarh, India.

Context: Childhood obesity is a global health problem. A percentage of 2.3 of Indian boys and 2. Read More

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Biologically Active α-Amino Amide Analogs and γδ T Cells-A Unique Anticancer Approach for Leukemia.

Front Oncol 2021 12;11:706586. Epub 2021 Jul 12.

Department of Chemistry, College of Sciences, University of Ha'il, Ha'il, Saudi Arabia.

Advanced stage cancers are aggressive and difficult to treat with mono-therapeutics, substantially decreasing patient survival rates. Hence, there is an urgent need to develop unique therapeutic approaches to treat cancer with superior potency and efficacy. This study investigates a new approach to develop a potent combinational therapy to treat advanced stage leukemia. Read More

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Surgical revascularization in stable coronary artery disease with ventricular dysfunction: a single-center cohort study.

Am J Cardiovasc Dis 2021 15;11(3):273-282. Epub 2021 Jun 15.

Department of Rehabilitation Science, College of Applied Medical Science, King Saud University Riyadh, Kingdom of Saudi Arabia.

Purpose: Stress-gated myocardial perfusion scintigraphy (MPS) is used for prognosis in stable coronary artery disease (CAD). We sought to assess coronary artery bypass grafting (CABG) outcomes in stable coronary artery disease patients who had myocardial perfusion scintigraphy and left ventricular (LV) dysfunction.

Methods: Stable CAD patients who underwent CABG (2012-2019) and had stress-gated MPS were identified retrospectively. Read More

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Detection of Viral and Bacterial Respiratory Pathogens Identified by Molecular Methods in COVID-19 Hospitalized Patients and Its Impact on Mortality and Unfavorable Outcomes.

Infect Drug Resist 2021 21;14:2795-2807. Epub 2021 Jul 21.

Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú.

Purpose: The purpose of this study is to evaluate the frequency of viral and bacterial respiratory pathogens detected by molecular methods in sputum samples of patients hospitalized for COVID-19 and to evaluate its impact on mortality and unfavorable outcomes (in-hospital death or mechanical ventilation).

Patients And Methods: The prospective cohort included patients with diagnosis of COVID-19 hospitalized at Hospital Nacional Hipólito Unanue. Sociodemographic and clinical data were collected from clinical records. Read More

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Cattle-Related Trauma: A 5-Year Retrospective Review in a Adult Major Trauma Center.

J Emerg Trauma Shock 2021 Apr-Jun;14(2):86-91. Epub 2021 Apr 27.

Royal Stoke University Hospital, Stoke-on-Trent, England.

Introduction: Bovine injuries are a common and significant cause of trauma, often requiring admission and operative treatment. We review all bovine-related injuries over 5 years, both emergency and general practitioner (GP) referrals at an adult major trauma center in England.

Methods: Retrospective evaluation was undertaken using the keywords through radiology referrals and hospital admissions speciality databases. Read More

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Comparative effectiveness of second-line immune checkpoint inhibitor therapy versus chemotherapy for malignant pleural mesothelioma.

Lung Cancer 2021 Jul 17;159:107-110. Epub 2021 Jul 17.

Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA. Electronic address:

Objectives: Second-line immune checkpoint inhibition (ICI) was recently shown to have a survival advantage over placebo in malignant pleural mesothelioma (MPM), but the survival comparison to chemotherapy in patients with MPM receiving routine clinical care is unknown. Our objective was to examine the effectiveness of second-line ICI versus chemotherapy on overall survival (OS) outcomes in real-world patients with advanced MPM.

Materials And Methods: We performed a multicenter retrospective cohort study of real-world adult patients with advanced MPM who received first-line platinum-based chemotherapy and at least two total lines of systemic therapy. Read More

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Temporal Trend of Mortality Due to Ischemic Heart Diseases in Northeastern Brazil (1996-2016): An Analysis According to Gender and Age Group.

Arq Bras Cardiol 2021 Jul;117(1):51-60

Universidade Federal de Alagoas, Maceió, AL - Brasil.

Background: Ischemic heart disease (IHD) is the leading cause of death among cardiovascular diseases (CVD).

Objective: To describe the sociodemographic profile and analyze the trend in the mortality rate due to IHD, according to sex and by age group, in the states of the Northeast region of Brazil, from 1996 to 2016.

Methods: Ecological study involving IHD mortality in the northeastern states. Read More

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Portable Magnetofluidic Device for Point-of-Need Detection of African Swine Fever.

Anal Chem 2021 Jul 28. Epub 2021 Jul 28.

Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.

With a nearly 100% mortality rate, African swine fever (ASF) has devastated the pork industry in many countries. Without a vaccine in sight, mitigation rests on rapid diagnosis and immediately depopulating infected or exposed animals. Unfortunately, current tests require centralized laboratories with well-trained personnel, take days to report the results, and thus do not meet the need for such rapid diagnosis. Read More

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Use of bivalirudin for anticoagulation in pediatric extracorporeal membrane oxygenation (ECMO).

Perfusion 2021 Jul 28:2676591211034314. Epub 2021 Jul 28.

Congenital Heart Center, Shands Children's Hospital, University of Florida at Gainesville, Gainesville, FL, USA.

This study describes the use of bivalirudin in children on extracorporeal membrane oxygenation (ECMO). Pediatric patients receiving bivalirudin were compared to patients receiving heparin as the anticoagulant on ECMO. Data was collected for children under 18 years of age supported by ECMO from January 2016 to December 2019. Read More

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Exchange Transfusion for Hyperbilirubinemia among Term and Near Term in NICU of a Tertiary Care Hospital of Bangladesh: Findings from a Prospective Study.

Euroasian J Hepatogastroenterol 2021 Jan-Jun;11(1):21-26

Department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Background: Exchange transfusion in newborns is recommended as emergency management of hyperbilirubinemia to prevent bilirubin encephalopathy and kernicterus.

Aim: This study aimed to determine the frequency and document common side effects of exchange transfusion and outcomes of newborns requiring exchange transfusion.

Materials And Methods: This prospective study was done in the Neonatal Intensive Care Unit (NICU) of Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh, from January 2016 to December 2019. Read More

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Necrotizing Enterocolitis in Neonates: Has the Brain Taken a Hit 10 Years Later?

J Pediatr Neurosci 2021 Jan-Mar;16(1):30-34. Epub 2021 Jun 25.

Royal London Hospital, London, UK.

Background: The neonate with necrotizing enterocolitis (NEC) is at risk of developing poor neurodevelopmental outcomes. There is a dearth of long-term follow-up studies in this field, with a majority of studies reporting a follow-up duration of 2 years. The aim of this study was to assess neurodevelopment of babies diagnosed with NEC more than a decade ago. Read More

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Role of Invasive Mechanical Ventilation and ECMO in the Management of COVID-19: A Systematic Review.

Indian J Crit Care Med 2021 Jun;25(6):691-698

Centre for Trials Research, College of Biomedical and Life Sciences, Cardiff University, Cardiff, Wales, United Kingdom.

Objectives: This systematic review aims to provide insight into the outcome of extracorporeal membrane oxygenation (ECMO) and invasive mechanical ventilation use in critically ill COVID-19 patients.

Data Sources: Electronic databases PubMed Central and PubMed were searched from January 2020 to June 2020 for published studies about ECMO and/or invasive mechanical ventilation use in COVID-19 patients. Data Extraction and Study Selection: The search strategy retrieved 766 articles, of which 19 studies consisting of 204 patients fulfilled the inclusion criteria and were included in the analysis. Read More

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A Study of the Outcome of Critically Ill Elderly Patients in a Tertiary Care Hospital Using SOFA Score.

Indian J Crit Care Med 2021 Jun;25(6):655-659

Department of Medicine, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.

Background: With a rapidly rising geriatric population, the magnitude of elderly patients requiring intensive care is a major cause of concern. Data on critically ill geriatric patients is scarce, especially in developing countries.

Aim And Objective: The aim of the study is to identify the etiology, clinical profile, and outcome in elderly patients admitted to the intensive care unit (ICU) and to predict their survival using the sequential organ failure assessment (SOFA) score. Read More

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Intoxicated Donors and Heart Transplant Outcomes: Long-Term Safety.

Circ Heart Fail 2021 Jul 28:CIRCHEARTFAILURE120007433. Epub 2021 Jul 28.

Lutheran Hospital, Fort Wayne, IN (H.C.).

Background: The opioid crisis has led to an increase in available donor hearts, although questions remain about the long-term outcomes associated with the use of these organs. Prior studies have relied on historical information without examining the toxicology results at the time of organ offer. The objectives of this study were to examine the long-term survival of heart transplants in the recent era, stratified by results of toxicological testing at the time of organ offer as well as comparing the toxicology at the time of donation with variables based on reported history. Read More

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Comparison of phenotypes and outcomes following resection of incidental versus symptomatic pancreatic neuroendocrine tumors.

Rev Esp Enferm Dig 2021 07 28. Epub 2021 Jul 28.

Cirugía General, Clínica Universidad de Navarra, España.

Background/Aim Fifty to 70 percent of pancreatic neuroendocrine tumors are diagnosed incidentally. The objective of this study is to compare the phenotype and oncological outcomes of incidental versus symptomatic pancreatic neuroendocrine tumors. Methods A retrospective study was conducted identifying all incidental and symptomatic tumors resected between 2000 and 2019. Read More

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Molecular characterization of Malaysian fowl adenovirus (FAdV) serotype 8b species E and pathogenicity of the virus in specific-pathogen-free chicken.

J Vet Sci 2021 Jul;22(4):e42

Laboratory of Vaccine and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Background: Inclusion body hepatitis (IBH) is an economically important viral disease primarily affecting broiler and breeder chickens. All 12 serotypes of fowl adenovirus (FAdV) can cause IBH.

Objectives: To characterize FAdV isolates based on phylogenetic analysis, and to study the pathogenicity of FAdV-8b in specific-pathogen-free (SPF) chickens following virus inoculation via oral and intramuscular (IM) routes. Read More

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Improved Tumor Response in Patients on Metformin Undergoing Yttrium-90 Radioembolization Segmentectomy for Hepatocellular Carcinoma.

Cardiovasc Intervent Radiol 2021 Jul 26. Epub 2021 Jul 26.

Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.

Purpose: Metformin is associated with improved outcomes after external radiation and chemotherapy but has not been studied for Y-90 radiation segmentectomy (RS). This study evaluates the effect of metformin on tumor response after Y-90 RS in patients with hepatocellular carcinoma (HCC).

Methods And Materials: A retrospective analysis of patients with HCC who underwent Y-90 RS between 2014-2018 was performed. Read More

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Survival, discharge destination, and referral for rehabilitation after metastatic spinal cord compression surgery.

Spinal Cord Ser Cases 2021 Jul 26;7(1):63. Epub 2021 Jul 26.

REHPA, The Danish Knowledge Centre on Rehabilitation and Palliative Care, University of Southern Denmark, Nyborg, Denmark.

Study Design: A retrospective review of medical records.

Objective: The objective of this study was to examine probability of survival after 90- and 180-days after surgery, to document the rehabilitation needs, patients discharge destination, and whether discharge destination, re-admission, and probability of survival among patients with metastatic spinal cord compression (MSCC) were associated with potential risk factors.

Setting: Copenhagen University Hospital, Rigshospitalet that serves a population of 2. Read More

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Secondarily estimated cure fraction and five-year recurrence-free conditional survival probabilities among patients undergoing surgical resection for hepatocellular carcinoma presenting with minor gross vascular invasion.

World J Surg Oncol 2021 Jul 26;19(1):222. Epub 2021 Jul 26.

Department of Surgery, Catholic Kwandong University International St. Mary's Hospital, Catholic Kwandong University College of Medicine, 25 Simgokro 100gil, Seo-gu, 22711, Incheon, Korea.

Background: Surgical resection (SR) has been selectively applied in hepatocellular carcinoma (HCC) presenting with minor gross vascular invasion (mGVI) which is defined when tumor invasion is confined to second-order portal branches or segmental branches of hepatic vein. However, little data of long-term outcomes are available for supporting the role of SR as a potentially curable therapeutic option for HCC presenting with mGVI. This study is aimed to estimate a statistical cure fraction and the improvement of recurrence-free conditional survival (RFCS) over time among patients undergoing SR for HCC presenting with mGVI. Read More

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Octopromycin: Antibacterial and antibiofilm functions of a novel peptide derived from Octopus minor against multidrug-resistant Acinetobacter baumannii.

Fish Shellfish Immunol 2021 Jul 23. Epub 2021 Jul 23.

College of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon, 34134, Republic of Korea. Electronic address:

The emergence of carbapenem-resistant Acinetobacter baumannii has increased the risk of nosocomial infections, which pose a huge health threat. There is an urgent need to develop alternative therapies, including broad-spectrum antimicrobial peptides. In this study, we designed, characterized, and studied the antibacterial, antibiofilm effects and possible mode of actions of a novel synthetic peptide Octopromycin, derived from the proline-rich protein 5 of Octopus minor. Read More

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Sedentary Behavior in United States Adults: Fall 2019.

Med Sci Sports Exerc 2021 Jul 23. Epub 2021 Jul 23.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, MO Risk Factor Assessment Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD Division of Nutrition, Physical Activity, and Obesity, Centers for Disease Control, Atlanta, GA Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Department of Geography, University of Hong Kong, Hong Kong, China Department of Kinesiology, California Polytechnic State University, San Luis Obispo, CA Health Behaviors Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD.

Purpose: Higher levels of sedentary behavior are associated with early mortality, but the distribution of sedentary time by classes of behavior and demographic groups is poorly described in United States (US) adults. To quantify the amount and sources of sedentary time in US adults we conducted a nationwide survey using a novel validated self-administerd previous-day recall method and compare these values with a commonly used sitting time question.

Methods: Participants from the AmeriSpeak panel aged 20 to 75 years (N = 2,640) completed up to two Activities Completed over Time in 24 Hours (ACT24) previous day recalls. Read More

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Global Incidence and Mortality of Gastric Cancer, 1980-2018.

JAMA Netw Open 2021 Jul 1;4(7):e2118457. Epub 2021 Jul 1.

Division of Gastroenterology, Department of Medicine, NYU Langone Health, New York, New York.

Importance: Gastric cancer is one of the most common cancers, with a high mortality-to-incidence ratio. It is uncertain whether developed nations may encounter an increasing burden of gastric cancer in young adults, as occurs for other cancers.

Objectives: To evaluate the incidence and mortality of gastric cancer and compare the global incidence trends between younger (<40 years) and older (≥40 years) populations. Read More

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Long-term All-Cause Mortality Risk in Obstructive Sleep Apnea Using Hypopneas Defined by a ≥3 Percent Oxygen Desaturation or Arousal.

Southwest J Pulm Crit Care 2021 ;23:23-35

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA.

Study Objectives: Some prior studies have demonstrated an increase in mortality associated with obstructive sleep apnea (OSA) utilizing a definition of OSA that requires a minimum 4% oxygen desaturation to identify a hypopnea. No large community-based studies have determined the risk of long-term mortality with OSA with hypopneas defined by a ≥3% O desaturation or arousal (AHI3%A).

Methods: Data from 5591 Sleep Heart Health Study participants without prevalent cardiovascular disease at baseline who underwent polysomnography were analyzed regarding OSA diagnosed using the AHI3%A criteria and all-cause mortality over a mean follow up period of 10. Read More

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January 2021

Plant-plant interactions change during succession on nurse logs in a northern temperate rainforest.

Ecol Evol 2021 Jul 20;11(14):9631-9641. Epub 2021 Jun 20.

Biology Department University of Puget Sound Tacoma WA USA.

Plant-plant interactions change through succession from facilitative to competitive. At early stages of succession, early-colonizing plants can increase the survival and reproductive output of other plants by ameliorating disturbance and stressful conditions. At later stages of succession, plant interactions are more competitive as plants put more energy toward growth and reproduction. Read More

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Phenotypic and Genetic Characterization of Temperature-Induced Mutagenesis and Mortality in .

Front Microbiol 2021 9;12:698330. Epub 2021 Jul 9.

Department of Microbial and Molecular Systems, Faculty of Bioscience Engineering, KU Leuven, Leuven, Belgium.

strains display a decreased viability when incubated in rich medium at a temperature of 37°C compared to their normal growth temperature of 30°C, a phenomenon coined "temperature-induced mortality and mutagenesis" (TIMM). To scrutinize this aberrant phenotype further, the contributions of specific inducers and protective agents were determined. Different growth media, including lysogeny broth (LB) and Schatz, and components, including casamino acids, in particular amino acids (proline, cysteine, glycine, glutamine, leucine, histidine and phenylalanine) and ammonium, were found to induce TIMM at 37°C. Read More

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