3,922 results match your criteria survival dss

Surgical treatment for squamous cell carcinoma of the temporal bone: predictors of survival.

Acta Otorhinolaryngol Ital 2021 Aug;41(4):308-316

Department of Otolaryngology & Head and Neck Surgery, Amsterdam University Medical Centre, location VU University Medical Centre, Amsterdam, The Netherlands.

Objective: Evaluation of the management and survival in patients treated for temporal bone squamous cell carcinoma (TBSCC) in a tertiary referral centre.

Methods: Forty-nine patients underwent primary treatment for TBSCC. Thirty-six patients underwent a lateral temporal bone resection (LTBR) or subtotal temporal bone resection (STBR). Read More

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Poor tumor differentiation is an independent adverse prognostic variable in patients with locally advanced oral cavity cancer--Comparison with pathological risk factors according to the NCCN guidelines.

Cancer Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, Republic of China.

Methods: We sought to compare the prognostic impact of tumor differentiation with respect to adverse risk factors (RFs) identified by the National Comprehensive Cancer Network (NCCN) guidelines--including extranodal extension (ENE), positive/close margins, perineural invasion, lymphatic invasion, and vascular invasion--in patients with locally advanced oral cavity squamous cell carcinoma (OCSCC).

Results: Between 1996 and 2018, 1179 consecutive patients with first primary pT3-4 OCSCC were included. A three-level grading system was adopted--in which the final classification was assigned according to the most prevalent tumor grade. Read More

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September 2021

Selenium-Enriched Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice by Regulating Inflammatory Cytokines and Intestinal Microbiota.

Front Med (Lausanne) 2021 31;8:716816. Epub 2021 Aug 31.

Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China.

To evaluate the effect of Selenium-enriched (Se-enriched ) on dextran sulfate sodium (DSS)-induced colitis in mice. Mice were randomly divided into four groups: a control group, a control + Se-enriched group, a chronic colitis group, and a chronic colitis + Se-enriched group ( = 10 each group). The mice were sacrificed on the 26th day. Read More

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The Immune-Related Gene ELF3 is a Novel Biomarker for the Prognosis of Ovarian Cancer.

Int J Gen Med 2021 10;14:5537-5548. Epub 2021 Sep 10.

Department of Gynecology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, People's Republic of China.

Background: Ovarian cancer (OC) is a fatal gynaecological malignancy. The study aimed to conduct a comprehensive study to determine the role of ELF3 in OC through bioinformatic analysis.

Methods: Kruskal-Wallis test, Wilcoxon sign-rank test, and logistic regression were used to evaluate the relationship between clinical characteristics and ELF3 expression. Read More

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September 2021

Treatment Outcome of External Auditory Canal Carcinoma: The Utility of Lateral Temporal Bone Resection.

Front Surg 2021 30;8:708245. Epub 2021 Aug 30.

Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

We examined the role of lateral temporal bone resection (LTBR) in the treatment of external ear canal (EAC) carcinoma between 2007 and 2018. The estimated 3-year disease-free survival (DFS) and disease-specific survival (DSS) according to the tumor stage and treatments were investigated in 36 patients with EAC squamous cell carcinoma. T stage classification according to the University of Pittsburgh staging system was as follows: 14 patients in T1, four patients in T2, nine patients in T3, and nine patients in T4. Read More

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Primary Tumor Location Predicts Survival in Melanoma: A Retrospective Cohort Study of 239,257 Melanoma Patients.

Skinmed 2021 1;19(4):288-296. Epub 2021 Aug 1.

Department of Dermatology, University of Illinois at Chicago, Chicago, IL, USA;

The link between primary tumor location and overall survival in melanoma has been studied in the past, but its associated population and prognostic significance is less understood. The purpose of this study was to characterize melanoma demographics and disease-specific survival (DSS) in relation to primary tumor site. Data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program were retrospectively analyzed; from 1973 to 2015, 239,257 patients diagnosed with cutaneous melanoma were included in the study and separated into three cohorts based on primary tumor site. Read More

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Outcomes of Management of Sinonasal Malignancies at a Dedicated Cancer Institution: A Retrospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):115-120. Epub 2021 Jul 24.

Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.

Introduction: Sinonasal malignancies (SNMs) are a rare and heterogeneous group of cancers with an incidence of 3%-5% of all head-and-neck tumours. The aim of the present study was to identify the characteristic features of SNMs and to analyze the treatment outcomes and the prognostic factors affecting it.

Materials And Methods: A retrospective review of patients with SNM treated at a dedicated cancer center of Pakistan between 2004 and 2018 was carried out. Read More

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Peripheral blood values as predictors of autoimmune status in oral cavity squamous cell carcinoma.

Transl Oncol 2021 Sep 11;14(12):101220. Epub 2021 Sep 11.

Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States. Electronic address:

Background: Recent literature has highlighted the role of the host in prognosis in oral squamous cell carcinoma (OSCC). Autoimmune (AI) disease represents a macroscopic depiction of host status. The goal of this study was to predict an AI "status" and to analyze the utility of this "status" as a prognostic indicator in OSCC. Read More

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September 2021

Comparison of outcomes between neoadjuvant imatinib and upfront surgery in patients with localized rectal GIST: An inverse probability of treatment weighting analysis.

J Surg Oncol 2021 Sep 8. Epub 2021 Sep 8.

Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background And Objectives: This study aimed to compare outcomes between neoadjuvant imatinib and upfront surgery in patients with localized rectal gastrointestinal stromal tumors (GIST) patients.

Methods: Eighty-five patients with localized rectal GIST were divided into two groups: upfront surgery ± adjuvant imatinib (Group A, n = 33) and the neoadjuvant imatinib + surgery + adjuvant imatinib (Group B, n = 52). Baseline characteristics between groups were controlled for with inverse probability of treatment weighting (IPTW) adjusted analysis. Read More

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September 2021

Merkel Cell Carcinoma: Changing Practice Patterns and Impact on Recurrence-Free and Overall Survival at a Single Institution and Nationally.

Ann Surg Oncol 2021 Sep 7. Epub 2021 Sep 7.

Division of Surgical Oncology, Department of Surgery, Yale School of Medicine, New Haven, CT, USA.

Background: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin. Our report describes the evolution of management and characteristics associated with recurrence, disease-specific survival (DSS) and overall survival (OS) in the treatment of MCC.

Methods: A single institution retrospective review of MCC and SEER data to determine factors associated with RFS, DSS, and OS using a multivariable Cox regression on inverse-probability weighted cohorts. Read More

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September 2021

Radiotherapy as nose preservation treatment strategy for cancer of the nasal vestibule: the Dutch experience.

Radiother Oncol 2021 Sep 3. Epub 2021 Sep 3.

Department of Radiation Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 32, 6525 GA Nijmegen, The Netherlands.

Background And Purpose: Primary radiotherapy is often preferred for early-stage cancer of the nasal vestibule (CNV), combining high disease control with preservation of nasal anatomy. However, due to practice variation and an absence of comparative trials, no consensus exists on preference for brachytherapy (BT) or external beam radiotherapy (EBRT). We compared these modalities in terms of disease control, nose preservation rates and toxicity. Read More

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September 2021

Insurance Status Effect on Laryngeal Cancer Survival: A Population Based Study.

Ann Otol Rhinol Laryngol 2021 Sep 4:34894211044231. Epub 2021 Sep 4.

Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Objective: To analyze insurance status effect on overall survival (OS) and disease-specific survival (DSS) in laryngeal cancer.

Study Design: Cross-sectional population analysis.

Setting: Surveillance, Epidemiology, and End Results (SEER) database. Read More

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September 2021

Functional Heterogeneity of Reelin in the Oral Squamous Cell Carcinoma Microenvironment.

Front Oncol 2021 17;11:692390. Epub 2021 Aug 17.

Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Background: Reelin, an extracellular glycoprotein, is expressed on neuronal cells and participates in neuronal migration during brain development. Recently, Reelin also has a vital role in carcinogenesis. However, its role in oral squamous cell carcinoma (OSCC) remains to be explored. Read More

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Prognostic impact of tumor length in esophageal Cancer: a systematic review and Meta-analysis.

BMC Cancer 2021 Sep 3;21(1):988. Epub 2021 Sep 3.

Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing wu Road, Jinan, 250021, Shandong, China.

Background: In clinical studies, it has been observed that esophageal cancer (EC) patient prognosis can be very different even for those patients with tumors of the same TNM stage. Tumor length has been analysed as a possible independent prognostic factor in many studies, but no unanimous conclusion has been reached. Therefore, this review used a meta-analysis to evaluate the association between tumor length and prognosis in EC patients. Read More

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September 2021

Prognostic Value of Preoperative Albumin-to-Fibrinogen Ratio in Patients with Bladder Cancer.

J Cancer 2021 4;12(19):5864-5873. Epub 2021 Aug 4.

Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Both nutritional status and coagulation function are closely associated with prognosis in patients with bladder cancer (BC). This study aimed to investigate the prognostic value of albumin-to-fibrinogen ratio (AFR) for BC patients underwent radical cystectomy (RC) or transurethral resection of bladder tumor (TURBT), and develop predictive nomograms based on AFR. We retrospectively collected medical records of 358 BC patients who underwent RC or TURBT between January 2012 and December 2018. Read More

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FGF-Receptors and PD-L1 in Anaplastic and Poorly Differentiated Thyroid Cancer: Evaluation of the Preclinical Rationale.

Front Endocrinol (Lausanne) 2021 12;12:712107. Epub 2021 Aug 12.

Department of Internal Medicine I, Division of Endocrinology/Diabetology, University of Würzburg, Würzburg, Germany.

Background: Treatment options for poorly differentiated (PDTC) and anaplastic (ATC) thyroid carcinoma are unsatisfactory and prognosis is generally poor. Lenvatinib (LEN), a multi-tyrosine kinase inhibitor targeting fibroblast growth factor receptors (FGFR) 1-4 is approved for advanced radioiodine refractory thyroid carcinoma, but response to single agent is poor in ATC. Recent reports of combining LEN with PD-1 inhibitor pembrolizumab (PEM) are promising. Read More

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Clinical impact of PD-L1 expression in triple-negative breast cancer patients with residual tumor burden after neoadjuvant chemotherapy.

World J Surg Oncol 2021 Sep 2;19(1):264. Epub 2021 Sep 2.

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Studies on PD-L1 expression in breast cancer have gained importance in recent years, especially in triple-negative breast cancer (TNBC). Our aim was to analyze the differential expression of PD-L1 to explore its correlation with response to neoadjuvant chemotherapy (NACT) and patient survival.

Methods: PD-L1 expression was evaluated immunohistochemically (Ventana SP263 clone kit) by staining tumor specimen. Read More

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September 2021

Identification of subtypes correlated with tumor immunity and immunotherapy in cutaneous melanoma.

Comput Struct Biotechnol J 2021 6;19:4472-4485. Epub 2021 Aug 6.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Because immune checkpoint inhibitors (ICIs) are effective for a subset of melanoma patients, identification of melanoma subtypes responsive to ICIs is crucial. We performed clustering analyses to identify immune subtypes of melanoma based on the enrichment levels of 28 immune cells using transcriptome datasets for six melanoma cohorts, including four cohorts not treated with ICIs and two cohorts treated with ICIs. We identified three immune subtypes (Im-H, Im-M, and Im-L), reproducible in these cohorts. Read More

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Clinical Presentation Patterns and Survival Outcomes of Hispanic Patients with Gastric Cancer.

J Surg Res 2021 Aug 29;268:606-615. Epub 2021 Aug 29.

Department of Surgery, New York University Langone Health, New York, NY, USA. Electronic address:

Background: Hispanic patients have a higher incidence of gastric cancer when compared to non-Hispanics. Outlining clinicodemographic characteristics and assessing the impact of ethnicity on stage-specific survival may identify opportunities to improve gastric cancer care for this population.

Methods: Patients with gastric cancer in the US Safety Net Collaborative (2012-2014) were retrospectively reviewed. Read More

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Immediate breast reconstruction in locally advanced breast cancer: is it safe?

Breast Cancer Res Treat 2021 Aug 31. Epub 2021 Aug 31.

Division of General Surgery, Department of Surgery, Providence Health Care Breast Centre, Providence Breast Centre & University of British Columbia, Mount Saint Joseph Hospital, 3rd Floor, 3080 Prince Edward Street, Vancouver, BC, V5T 3N4, Canada.

Purpose: Immediate breast reconstruction (IBR) following mastectomy remains controversial for locally advanced breast cancer over concerns regarding recurrence and complications which may delay adjuvant therapies. This study aimed to compare the oncologic outcomes and surgical safety of IBR following mastectomy with mastectomy alone (MA) for locally advanced breast cancer.

Methods: All patients treated at the Providence Breast Center between 2012 and 2017 for biopsy-proven locally advanced breast cancer, AJCC (8th edition) clinical stages (IIB-IIIC), were included. Read More

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Regional variation in the survival of patients with a soft-tissue sarcoma of the extremity and trunk wall under a centralized care system : what has been the impact of national policies in the UK?

Bone Joint J 2021 Sep;103-B(9):1541-1549

The Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, UK.

Aims: While a centralized system for the care of patients with a sarcoma has been advocated for decades, regional variations in survival remain unclear. The aim of this study was to investigate regional variations in survival and the impact of national policies in patients with a soft-tissue sarcoma (STS) in the UK.

Methods: The study included 1,775 patients with a STS who were referred to a tertiary sarcoma centre. Read More

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September 2021

Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates with unfavorable outcomes post-laryngectomy.

BMC Cancer 2021 Aug 30;21(1):973. Epub 2021 Aug 30.

Department of Pathology & Microbiology, Saga University Faculty of Medicine, Saga, Japan.

Background: The prognosis of advanced laryngeal cancer is unfavorable despite advances in multidisciplinary therapy. Dendritic cells (DCs) play a central role in antitumor immunity. Tumor-infiltrating CD1a DCs have been reported to be associated with clinical outcomes in carcinomas of various organs, but the clinical impact of CD1a DCs in laryngeal cancer remains to be unequivocally established. Read More

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Enhanced Region Growing for Brain Tumor MR Image Segmentation.

J Imaging 2021 Feb 1;7(2). Epub 2021 Feb 1.

College of Natural and Computational Science, Addis Ababa University, Addis Ababa 1176, Ethiopia.

A brain tumor is one of the foremost reasons for the rise in mortality among children and adults. A brain tumor is a mass of tissue that propagates out of control of the normal forces that regulate growth inside the brain. A brain tumor appears when one type of cell changes from its normal characteristics and grows and multiplies abnormally. Read More

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February 2021

Primary High Grade Non-Anaplastic Thyroid Carcinoma: A Retrospective Study of 364 Cases.

Histopathology 2021 Aug 27. Epub 2021 Aug 27.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: High grade non-anaplastic thyroid carcinomas (HGTC) are carcinomas of follicular cells with prognosis intermediate between well-differentiated and anaplastic carcinoma.

Methods: This study includes 364 HGTC patients: 200 patients (54.9%) were diagnosed as poorly differentiated thyroid carcinoma based on Turin consensus (HGTC-PDTC) and 164 with high grade features that did not meet Turin criteria (HGTC-nonPDTC). Read More

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Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling.

Cells 2021 Aug 11;10(8). Epub 2021 Aug 11.

Department of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si 26339, Gangwon-do, Korea.

Many researchers have argued that Western diet (WD)-induced obesity accelerates inflammation and that inflammation is a link between obesity and colorectal cancer (CRC). This study investigated the effect of WDs on the development and progression of colitis-associated colon cancer (CAC) and the efficacy of the anti-obesity agent orlistat on WD-driven CAC in mice. The results revealed that the WD exacerbated CAC in azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mice, which showed increased mortality, tumor formation, and aggravation of tumor progression. Read More

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Nomograms for Individualized Evaluation of Prognosis in Adrenocortical Carcinomas for the Elderly: A Population-Based Analysis.

J Invest Surg 2021 Aug 25:1-8. Epub 2021 Aug 25.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Adrenocortical carcinoma (ACC) is extremely rare in elderly patients. Thus, this study aimed to identify the incidence rate and develop nomogram models for predicting survival in elderly ACC patients.

Methods: Data of ACC patients aged >60 years from 1975 to 2016 were obtained from the Surveillance, Epidemiology, and End Results dataset. Read More

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Pretreatment prognostic nutritional index as a prognostic marker in head and neck cancer: a systematic review and meta-analysis.

Sci Rep 2021 Aug 24;11(1):17117. Epub 2021 Aug 24.

Department of Pediatrics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, 539, Zhongxiao Road, 600, Chiayi, Taiwan.

The predictive value of the pretreatment prognostic nutritional index (PNI) for head and neck cancer (HNC) remains controversial. We conducted a meta-analysis to assess the predictive value of PNI in HNC patients. A systematic search through internet databases including PubMed, Embase, and Cochrane Library for qualified studies estimating the association of PNI with HNC patient survival was performed. Read More

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Juglone Suppresses Inflammation and Oxidative Stress in Colitis Mice.

Front Immunol 2021 5;12:674341. Epub 2021 Aug 5.

School of Public Health, Xinxiang Medical University, Xinxiang, China.

Juglone (JUG), a natural product found in walnut trees and other plants, shows potent antioxidant, antimicrobial, and immunoregulatory activities. However, it remains unknown whether JUG can alleviate ulcerative colitis. This study aims to explore the effect of JUG on dextran sulfate sodium (DSS)-induced colitis in mice. Read More

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Utility of stromal tumor infiltrating lymphocyte scoring (sTILs) for risk stratification of patients with muscle-invasive urothelial bladder cancer after radical cystectomy.

Urol Oncol 2021 Aug 20. Epub 2021 Aug 20.

Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany; BRIDGE-Consortium Germany e.V., Mannheim, Germany; Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany. Electronic address:

Background: Multi-omics analyses of muscle-invasive bladder cancer (MIBC) demonstrated that specific patterns of tumor infiltrating lymphocytes (TILs) associates with improved outcomes in patients treated with radical cystectomy. However, methodologies for simple and robust quantification of TILs, especially for daily practice purposes, are lacking. Thus, we investigated the feasibility of stromal TIL scoring on hematoxylin/eosin stained (HE) slides in MIBC. Read More

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Machine Learning to Improve Prognosis Prediction of Early Hepatocellular Carcinoma After Surgical Resection.

J Hepatocell Carcinoma 2021 10;8:913-923. Epub 2021 Aug 10.

Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

Background: Improved prognostic prediction is needed to stratify patients with early hepatocellular carcinoma (EHCC) to refine selection of adjuvant therapy. We aimed to develop a machine learning (ML)-based model to predict survival after liver resection for EHCC based on readily available clinical data.

Methods: We analyzed data of surgically resected EHCC (tumor≤5 cm without evidence of extrahepatic disease or major vascular invasion) patients from the Surveillance, Epidemiology, and End Results (SEER) Program to train and internally validate a gradient-boosting ML model to predict disease-specific survival (DSS). Read More

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