1,825 results match your criteria surrounding alveolar

The recent advances in scaffolds for integrated periodontal regeneration.

Bioact Mater 2021 Oct 18;6(10):3328-3342. Epub 2021 Mar 18.

Center for Dental and Craniofacial Research, Columbia University Medical Center, 630 W. 168 St., VC12-212, New York, NY, 10032, USA.

The periodontium is an integrated, functional unit of multiple tissues surrounding and supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be destructed by chronic periodontal disease, which can lead to tooth loss. In support of the treatment for periodontally diseased tooth, various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration (GTR) that is the current gold standard in dental clinic. Read More

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October 2021

Microdont Developing Outside the Alveolar Process and Within Oral Diffuse and Plexiform Neurofibroma in Neurofibromatosis Type 1.

Anticancer Res 2021 Apr;41(4):2083-2092

Private Practice in Orthodontics, Hamburg-Lokstedt, Germany.

Background/aim: Numerical aberrations of permanent dentition and dystopic tooth eruption are part of the phenotype of the tumor predisposition syndrome neurofibromatosis type 1 (NF1). In these cases, surplus tooth germs usually develop in the alveolar processes of the jaw. This report attests to the dystopic development of a dysplastic supernumerary tooth in NF1 arising outside the jaw. Read More

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Short (6 mm) and Regular Dental Implants in the Posterior Maxilla-7-Years Follow-up Study.

J Clin Med 2021 Mar 1;10(5). Epub 2021 Mar 1.

Department of Dental Surgery, Wrocław Medical University, 50-425 Wrocław, Poland.

Short 6 mm dental implants are considered as an alternative to the maxillary sinus elevation and bone augmentation procedure where there is a reduced alveolar ridge height. The aim of this study was to compare the implant survival rate between short dental implants (6 mm) and regular length implants (11-13 mm) when placed in combination with bone grafting and loaded with a single non splinted crown, seven years after placing the implant. It was conducted as a controlled clinical study of 30 patients with partial edentulism in the posterior maxilla. Read More

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Increased Presence of Complement Factors and Mast Cells in Alveolar Bone and Tooth Resorption.

Int J Mol Sci 2021 Mar 9;22(5). Epub 2021 Mar 9.

Center for Trauma Research Ulm (ZTF), University of Ulm, 89081 Ulm, Germany.

Periodontitis is the inflammatory destruction of the tooth-surrounding and -supporting tissue, resulting at worst in tooth loss. Another locally aggressive disease of the oral cavity is tooth resorption (TR). This is associated with the destruction of the dental mineralized tissue. Read More

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EphB6 Regulates TFEB-Lysosomal Pathway and Survival of Disseminated Indolent Breast Cancer Cells.

Cancers (Basel) 2021 Mar 3;13(5). Epub 2021 Mar 3.

Department of Molecular Medicine, University of Padua, Viale G. Colombo, 3, 35126 Padua, Italy.

Late relapse of disseminated cancer cells is a common feature of breast and prostate tumors. Several intrinsic and extrinsic factors have been shown to affect quiescence and reawakening of disseminated dormant cancer cells (DDCCs); however, the signals and processes sustaining the survival of DDCCs in a foreign environment are still poorly understood. We have recently shown that crosstalk with lung epithelial cells promotes survival of DDCCs of estrogen receptor-positive (ER+) breast tumors. Read More

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Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review.

J Control Release 2021 Mar 30;333:269-282. Epub 2021 Mar 30.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China.

Periodontitis is a chronic inflammation of the soft tissue surrounding and supporting the teeth, which causes periodontal structural damage, alveolar bone resorption, and even tooth loss. Its prevalence is very high, with nearly 60% of the global population affected. Hence, periodontitis is an important public health concern, and the development of effective healing treatments for oral diseases is a major target of the health sciences. Read More

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Matrix composition modulates vitamin D3's effects on 3D collagen fiber organization by MCF10A cells.

Tissue Eng Part A 2021 Apr 1. Epub 2021 Apr 1.

Tufts University School of Medicine, 12261, Boston, Massachusetts, United States;

Vitamin D3 (vitD3) has been implicated in various cellular functions affecting multiple tissue types. Epidemiological and laboratory studies suggest that vitD3 may be effective as a preventive or therapeutic option for breast cancer. However, randomized clinical trials have yet to confirm these suggestions. Read More

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Analysis of complications after the removal of 339 third molars.

Dent Med Probl 2021 Jan-Mar;58(1):75-80

Department of Cranio-Maxillofacial, Oncological and Reconstructive Surgery, Jagiellonian University Medical College, Kraków, Poland.

Background: Extractions of third molars constitute about 90% of the scheduled surgical procedures performed by oral surgeons. Wisdom tooth surgery is associated with complications, such as the lingual and inferior alveolar nerve damage, bleeding, tooth/jaw fractures, tooth displacement into the adjacent anatomical spaces, trismus, infections, and other.

Objectives: The aim of the study was to analyze complications after wisdom tooth extraction in patients treated at the Department of Oral Surgery of Jagiellonian University Medical College in Kraków, Poland, in the years 2016-2018. Read More

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Changes in the microcirculation in periodontal tissue due to experimental peri-implantitis.

J Oral Biosci 2021 Mar 18. Epub 2021 Mar 18.

Department of Oral Science, Kanagawa Dental University, Graduate School of Dentistry. Electronic address:

Objectives: Peri-implantitis causes dislodgement of dental implants due to inflammation in the peri-implant tissue. The microcirculation in the periodontal tissue undergoes morphological and physiological changes due to inflammation. The immune mechanism of peri-implantitis differs from that of periodontitis. Read More

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The effect of corticotomy on the compensatory remodeling of alveolar bone during orthodontic treatment.

BMC Oral Health 2021 Mar 19;21(1):134. Epub 2021 Mar 19.

Department of Orthodontics, Capital Medical University, School of Stomatology, Beijing, 100050, China.

Background: This study aimed to explore whether compensatory remodeling of the alveolar bone surface occurred during the buccal palatal movement of orthodontic teeth. We preliminarily explored whether corticotomy could activate or accelerate osteogenesis in the alveolar bone surface by measuring the expression of TGF-β1 (transforming growth factor-β1), which can facilitate the proliferation and differentiation of osteoblasts and regulate the maturity and formation of bone.

Methods: Sixty 10-week-old male Wistar rats were selected. Read More

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Does local injection of reveromycin A inhibit tooth movement without causing systemic side effects?

Eur J Orthod 2021 Mar 19. Epub 2021 Mar 19.

Department of Orthodontics, School of Dentistry, Aichi Gakuin University, Chikusa-ku, Nagoya, Aichi, Japan.

Objective: To determine the feasibility of local inhibition of osteoclast activity and control of tooth movement with local intraoral reveromycin A (RMA) injection in model mice for experimental tooth movement.

Materials And Methods: Eight-week-old wild-type mice (n = 6 per group) were divided into four groups consisting of two non-RMA groups that received normal saline for 14 (14-day non-RMA group) or 21 consecutive days (21-day non-RMA group) and 2 RMA groups that received RMA (1.0 mg/kg of weight) for 14 (14-day RMA group) or 21 consecutive days (21-day RMA group). Read More

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Evaluation of facial and palatal alveolar bone thickness and sagittal root position of maxillary anterior teeth on cone beam computerized tomograms.

Niger J Clin Pract 2021 Mar;24(3):329-334

Periodontics, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India.

Background: Amount of bone covering the facial and palatal surface of the root and the sagittal root position are important parameters while considering an immediate implant placement.

Aims: This study measures the distance from cement-enamel junction (CEJ) to alveolar crest and thickness of alveolar bone of maxillary anterior teeth facially and palatally at 5 different points.

Materials And Methods: CBCT scans of 79 systemically healthy patients were evaluated by two calibrated and independent examiners. Read More

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The effect of post-extraction socket preservation laser treatment on bone density 4 months after extraction: Randomized controlled trial.

Clin Implant Dent Relat Res 2021 Mar 8. Epub 2021 Mar 8.

Università Cattolica del Sacro Cuore di Roma, Rome, Italy.

Background: Post-extraction bone resorption may affect the outcome of ensuing restorations.

Purpose: This study aimed to evaluate a comprehensive laser post-extraction protocol by comparing resulting alveolar bone regeneration with that obtained after standard extraction procedure.

Materials And Methods: About 53 simple extractions were randomized to either laser or control group. Read More

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Diagnosis of Biofilm-Associated Peri-Implant Disease Using a Fluorescence-Based Approach.

Dent J (Basel) 2021 Feb 27;9(3). Epub 2021 Feb 27.

Department of Preventive and Restorative Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Dental implants have become a routine component of daily dental practice and the demand for dental implants is expected to increase significantly in the future. Despite the high success rates of dental implants, failures do occur, resulting in discomfort, rampant destruction of the oral health, or painful and costly surgical replacement of a failed implant. Peri-implant diseases are inflammatory conditions affecting the soft/hard tissues surrounding a functional dental implant. Read More

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February 2021

Osteogenic potential of dental and oral derived stem cells in bone tissue engineering among animal models: An update.

Tissue Cell 2021 Feb 24;71:101515. Epub 2021 Feb 24.

Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences-I, Lebanese University, Hadath- Beirut, Lebanon. Electronic address:

Small bone defects can heal spontaneously through the bone modeling process due to their physiological environmental conditions. The bone modeling cycle preserves the reliability of the skeleton through the well-adjusted activities of its fundamental cell. Stem cells are a source of pluripotent cells with a capacity to differentiate into any tissue in the existence of a suitable medium. Read More

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February 2021

Transcriptional and Proteomic Characterization of Telomere-Induced Senescence in a Human Alveolar Epithelial Cell Line.

Front Med (Lausanne) 2021 9;8:600626. Epub 2021 Feb 9.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Cellular senescence due to telomere dysfunction has been hypothesized to play a role in age-associated diseases including idiopathic pulmonary fibrosis (IPF). It has been postulated that paracrine mediators originating from senescent alveolar epithelia signal to surrounding mesenchymal cells and contribute to disease pathogenesis. However, murine models of telomere-induced alveolar epithelial senescence fail to display the canonical senescence-associated secretory phenotype (SASP) that is observed in senescent human cells. Read More

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February 2021

Evaluation of different surgical approaches to remove dental implants from the maxillary sinus.

Sci Rep 2021 Feb 24;11(1):4440. Epub 2021 Feb 24.

North End Medical Centre, London, UK.

Dental implant surgery on atrophied maxilla has many risks; in some patients, simultaneous sinus lifting with implant placement must be performed to increase the chances of successful implantation; this procedure can cause implant migration. Eleven patients were diagnosed with implant migration into the maxillary sinus in four anatomical areas: the sinus floor above the alveolar bone, near the junction of the sinus and nasal floor, near the floor of the orbit, and the most posterior aspect of the sinus. Surgical removal was performed through four different direct non-endoscopic transoral approaches depending on the location of the displaced implant. Read More

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February 2021

A Case of Mandibular Prognathism with Generalized Aggressive Periodontitis and Crowding.

Bull Tokyo Dent Coll 2021 Mar 15;62(1):27-39. Epub 2021 Feb 15.

Department of Orthodontics, Tokyo Dental College.

Aggressive periodontitis during adolescence has a poor prognosis due to rapid alveolar bone resorption. Few studies have investigated long-term follow-up after surgical orthodontic treatment performed in conjunction with that for invasive periodontitis. Here, we report a case of mandibular prognathism accompanied by generalized aggressive periodontitis and crowding. Read More

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Ridge Preservation Using a Novel Freeze-dried Enzyme-deantigenic Bone Paste: A Histomorphometric-retrospective Pilot Case Series.

J Contemp Dent Pract 2020 Sep 1;21(9):1059-1067. Epub 2020 Sep 1.

Department of Biomedical Surgical and Dental Sciences, Università Degli Studi di Milano, Milan, Italy.

Aim And Objective: The aim of this study is to provide preliminary retrospective evidence concerning the histologic and histomorphometric outcome of a novel freeze-dried equine-derived bone paste (EDEBEX) for ridge preservation of sockets following tooth extraction.

Materials And Methods: This pilot retrospective case series describes the histologic and histomorphometric outcome of three patients who received the equine-derived bone paste in post-extractive sockets to allow the preservation of the alveolar ridge. Patients were later rehabilitated with monolithic-zirconia, implant-supported prostheses. Read More

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September 2020

Semaphorin 3A promotes the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells in inflammatory environments by suppressing the Wnt/β-catenin signaling pathway.

J Mol Histol 2021 Feb 10. Epub 2021 Feb 10.

Department of Periodontology, School and Hospital of Stomatology, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Cheeloo College of Medicine, No .44-1 Wenhua Road West, Jinan, 250012, Shandong, China.

After periodontal treatment, the local inflammatory environment surrounding periodontal tissues cannot be entirely eliminated. The means by which alveolar bone repair and regeneration are promoted in inflammatory environments have important clinical significance. As a powerful protein that promotes the differentiation of osteocytes, semaphorin 3A (Sema3A) shows potential for bone regeneration therapy. Read More

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February 2021

A conservative approach for an adult patient with a fractured tooth and crowding: Autotransplantation at the fracture site.

Am J Orthod Dentofacial Orthop 2021 Feb;159(2):234-245

Department of Orthodontics, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:

Autotransplantation of a mature premolar in adults can be a treatment of choice for tooth replacement when combined with well-planned orthodontic treatment. This case report describes the successful treatment of a 39-year-old patient with severe crowding and a hopelessly fractured tooth on the maxillary left side. Maxillary dental crowding was relieved by extraction of a premolar on the right side, and this extracted tooth was autotransplanted to replace the fractured tooth. Read More

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February 2021

Curcumin reduces apoptosis and promotes osteogenesis of human periodontal ligament stem cells under oxidative stress in vitro and in vivo.

Life Sci 2021 Apr 26;270:119125. Epub 2021 Jan 26.

Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, 56 Lingyuanxi Road, Guangzhou 510055, China. Electronic address:

Aims: Human periodontal ligament stem cells (hPDLSCs) tether the teeth to the surrounding bone and are considered as major functional stem cells responsible for regeneration of the alveolar bone and periodontal ligament tissue. However, the outcome of stem cell regenerative therapy is affected by the survival rate and their differentiation potential of transplanted cells. This is primarily because of local oxidative stress and chronic inflammation at the transplantation site. Read More

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Reduced Periodontal Support for Lower Central Incisor - A 3D Finite Element Analysis of Compressive Stress in the Periodontium.

J Int Acad Periodontol 2021 Jan 1;23(1):65-71. Epub 2021 Jan 1.

Departament of Dentistry, Universidade Federal de Sergipe, SE, Brazil.

Background: The aim of this study was to assess the stress concentration in simulated periodontal alveolar bone containing healthy teeth with and without attachment loss.

Methods: Six 3-D models of a lower central incisor were created simulating the teeth structure, cancellous and cortical bone and periodontal ligament. Each model presented a 1mm increasing distance between cement-enamel junction (CEJ) and alveolar bone crest (ABC) (1 to 6mm). Read More

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January 2021

Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review.

J Pers Med 2021 Jan 18;11(1). Epub 2021 Jan 18.

Department of Pharmacology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, Daegu 41940, Korea.

Aging is characterized by a progressive decline or loss of physiological functions, leading to increased susceptibility to disease or death. Several aging hallmarks, including genomic instability, cellular senescence, and mitochondrial dysfunction, have been suggested, which often lead to the numerous aging disorders. The periodontium, a complex structure surrounding and supporting the teeth, is composed of the gingiva, periodontal ligament, cementum, and alveolar bone. Read More

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January 2021

An In-Vitro Analysis of Peri-Implant Mucosal Seal Following Photofunctionalization of Zirconia Abutment Materials.

Biomedicines 2021 Jan 15;9(1). Epub 2021 Jan 15.

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia.

The presence of epithelial and connective tissue attachment at the peri-implant-soft tissue region has been demonstrated to provide a biological barrier of the alveolar bone from the oral environment. This barrier can be improved via surface modification of implant abutment materials. The effect of photofunctionalization on creating a bioactive surface for the enhancement of the epithelial and connective tissue attachment of zirconia implant abutment's peri-implant mucosal interface using organotypic model has not been investigated. Read More

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January 2021

The peri-implant phenotype and implant esthetic complications. Contemporary overview.

J Esthet Restor Dent 2021 Jan 18;33(1):212-223. Epub 2021 Jan 18.

Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.

Objective: To provide a contemporary and comprehensive overview of the hard and soft tissue biological structures surrounding an osseointegrated dental implant (peri-implant referred to as the peri-implant phenotype), in the context of peri-implant esthetic complications.

Overview: The individual components of the peri-implant phenotype (keratinized mucosa width, mucosal thickness, supracrestal tissue height, and the peri-implant buccal bone) have been linked to different aspects of implant esthetics, as well as health-related aspects. At the time of implant therapy, respecting the biology of the peri-implant hard and soft tissues, and anticipating their remodeling patterns can alleviate future esthetic complications. Read More

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January 2021

Dental Fluorosis and Periodontium: an Original Research Report of In Vitro and In Vivo Institutional Studies.

Biol Trace Elem Res 2021 Jan 6. Epub 2021 Jan 6.

Department of Oral and Maxillofacial Surgery, College of Dental Sciences, Davangere, 577004, India.

Fluorosis is one of the global problems that have persisted for a very long time now without any specific treatment and cure. Fluoride is known for its influence on the tooth structures like enamel and dentin, but little information exists on its effect on the surrounding periodontal structures and bone. With this background, we conducted multiple studies assessing etiological, diagnostic, therapeutic and clinical criteria in subjects with and without dental fluorosis in a single group of the population residing in high fluoride water areas (1. Read More

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January 2021

Finite-Element Study of Biomechanical Explanations for Bone Loss around Dental Implants.

J Long Term Eff Med Implants 2020 ;30(1):21-30

Laboratory of Mechanical and Physical of Materials (LMPM), Djillali Liabes University, Sidi Bel-Abbes, Algeria; Department of Mechanical Engineering, College of Engineering, King Saud University, Riyadh Saudi Arabia.

Since the advent of osteointegrated implantology and its precepts issued by the Swedish School, assessment of peri-implant bone loss criteria has often been debated by professionals in this field. Long-term success of dental implants is highly reliant on structural and functional osseointegration between implant and surrounding intraoral tissues. In this context, the current study aims to provide biomechanical explanations for causes of bone loss around the dental implant after osseointegration by computational analysis, using a three-dimensional finite-element (FE) method. Read More

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January 2020

Missing teeth after maxillofacial trauma: a case report and management protocol.

J Korean Assoc Oral Maxillofac Surg 2020 Dec;46(6):422-427

Department of Oral and Maxillofacial Surgery, K.V.G. Dental College and Hospital, Sullia, India.

Management of maxillofacial trauma includes primary care, in which diagnosis and management of dentoalveolar injury play a vital role. Due to the impact sustained during a maxillofacial injury (whether direct or indirect), dentoalveolar injuries can occur, leading to fracture and displacement of teeth and associated alveolar bone into the surrounding soft tissues and associated structures, such as the maxillary sinus, nasal cavity, upper respiratory tract, tracheobronchial tree, or gastrointestinal tract. Undiagnosed displaced teeth may cause complications such as airway obstruction. Read More

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December 2020

Immunohistological detection of small particles of Echinococcus multilocularis and Echinococcus granulosus in lymph nodes is associated with enlarged lymph nodes in alveolar and cystic echinococcosis.

PLoS Negl Trop Dis 2020 12 28;14(12):e0008921. Epub 2020 Dec 28.

Institute of Pathology, University Ulm, Ulm, Germany.

Background: Alveolar (AE) and cystic echinococcosis (CE) in humans are caused by the metacestode of the tapeworms Echinococcus multilocularis and Echinococcus granulosus sensu lato (s.l.). Read More

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December 2020