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A Comparison of Acute Complications and Mortality Between Geriatric Knee and Hip Fractures: A Matched Cohort Study.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Granovsky Gluskin Division of Orthopaedics, Sinai Health System (Wolfstadt, Backstein), Institute of Medical Science, Faculty of Medicine (Nowak), the Division of Orthopaedics, St. Michael's Hospital (Atrey, Melo, Nauth, Khoshbin), University of Toronto, Toronto, Ontario, Canada, the Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA (Stavrakis), and the Division of Orthopaedics, Department of Surgery, University of Western Ontario, London, Ontario, Canada (Schemitsch).

Introduction: To compare acute complication and mortality rates for operatively treated, closed, isolated, low-energy geriatric knee fractures (distal femur [DFF] or tibial plateau [TPF]) with hip fractures (HFs).

Methods: This is a retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program. We identified all patients ≥ 70 years from 2011 to 2016 who underwent surgery for DFF, TPF, or HF. Read More

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November 2020

A Comparison of Acute Complications and Mortality Between Geriatric Knee and Hip Fractures: A Matched Cohort Study.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Granovsky Gluskin Division of Orthopaedics, Sinai Health System (Wolfstadt, Backstein), Institute of Medical Science, Faculty of Medicine (Nowak), the Division of Orthopaedics, St. Michael's Hospital (Atrey, Melo, Nauth, Khoshbin), University of Toronto, Toronto, Ontario, Canada, the Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA (Stavrakis), and the Division of Orthopaedics, Department of Surgery, University of Western Ontario, London, Ontario, Canada (Schemitsch).

Introduction: To compare acute complication and mortality rates for operatively treated, closed, isolated, low-energy geriatric knee fractures (distal femur [DFF] or tibial plateau [TPF]) with hip fractures (HFs).

Methods: This is a retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program. We identified all patients >= 70 years from 2011 to 2016 who underwent surgery for DFF, TPF, or HF. Read More

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November 2020

A systematic review and meta-analyses of regional perfusion in donation after circulatory death solid organ transplantation.

Transpl Int 2021 Sep 27. Epub 2021 Sep 27.

Transplantation Research Group, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.

In donation after circulatory death (DCD), (thoraco)abdominal regional perfusion (RP) restores circulation to a region of the body following death declaration. We systematically reviewed outcomes of solid organ transplantation after RP by searching PubMed, Embase, and Cochrane libraries. Eighty-eight articles reporting on outcomes of liver, kidney, pancreas, heart, and lung transplants or donor/organ utilisation were identified. Read More

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September 2021

Cerebroplacental doppler ratio and perinatal outcome in late-onset foetal growth restriction.

J Obstet Gynaecol 2021 Sep 27:1-6. Epub 2021 Sep 27.

Department of Perinatology, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Health Science University, Istanbul, Turkey.

The purpose of this study was to determine whether gestational age-specific levels of the cerebroplacental ratio (CPR) as a third-trimester ultrasound marker has benefits in the prediction of perinatal morbidity and mortality on foetuses with late-onset foetal growth restriction (FGR). A retrospective study of singleton pregnancies diagnosed with late-onset FGR was performed. Of 407 pregnancies meeting our inclusion criteria, 313 had normal (Group 1) and 94 had abnormal CPR (Group 2). Read More

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September 2021

Hypertrophic cardiomyopathy in children.

Asian Cardiovasc Thorac Ann 2021 Sep 27:2184923211041285. Epub 2021 Sep 27.

Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, 571193Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Hypertrophic cardiomyopathy (HCM) characterized by asymmetric ventricular septal hypertrophy, is the commonest cause of sudden cardiac death (SCD) in the young. The underlying etiology of HCM in the childhood and adolescent patients is diverse. Moreover, the prognosis of pediatric HCM depends on the age of presentation and etiology. Read More

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September 2021

Incidence and Outcome of Acute Myocardial Infarction in Patients With Aortic Dissection and Risk Factor Control.

Front Surg 2021 9;8:678806. Epub 2021 Sep 9.

Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

The contradiction of management modality between acute myocardial infarction(AMI) and aortic dissection(AD) may result in clinical catastrophe. Data on risk factors, incidence, and outcome of AD and AMI are limited, and there have been no studies on the long-term outcomes of AMI in patients with AD. So we aimed to investigate long-term outcomes after AMI in patients with AD, and propose a useful diagnostic paradigm. Read More

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September 2021

Regenerative Medicine for the Treatment of Ischemic Heart Disease; Status and Future Perspectives.

Front Cell Dev Biol 2021 10;9:704903. Epub 2021 Sep 10.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Cardiovascular disease is now the leading cause of adult death in the world. According to new estimates from the World Health Organization, myocardial infarction (MI) is responsible for four out of every five deaths due to cardiovascular disease. Conventional treatments of MI are taking aspirin and nitroglycerin as intermediate treatments and injecting antithrombotic agents within the first 3 h after MI. Read More

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September 2021

Histone H3 Cleavage in Severe COVID-19 ICU Patients.

Front Cell Infect Microbiol 2021 10;11:694186. Epub 2021 Sep 10.

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.

The severity of coronavirus disease 19 (COVID-19) is associated with neutrophil extracellular trap (NET) formation. During NET formation, cytotoxic extracellular histones are released, the presence of which is linked to the initiation and progression of several acute inflammatory diseases. Here we study the presence and evolution of extracellular histone H3 and several other neutrophil-related molecules and damage-associated molecular patterns (DAMPs) in the plasma of 117 COVID-19-positive ICU patients. Read More

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September 2021

Cavernous Sinus Thrombosis: Efficiently Recognizing and Treating a Life-Threatening Condition.

Authors:
Selma Ali

Cureus 2021 Aug 20;13(8):e17339. Epub 2021 Aug 20.

Department of Family Medicine, Premier Family Medicine, Denver, USA.

Cavernous sinus thrombosis (CST) can develop as a result of both infectious and noninfectious conditions. Infections in the middle part of the face caused by Staphylococcus aureus are the most common cause of septic thrombosis of the cavernous sinuses. Paranasal (typically sphenoid) sinusitis, dental abscess, and, less commonly, otitis media are other antecedent sources of infection. Read More

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Vaccination Against Cervical Cancer: Hopes and Realities.

Am J Cancer (Auckl) 2005 Jul;4(4):207-219

Norris Comprehensive Cancer Center and Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California, USA.

Globally, carcinomas of the anogenital tract, in particular cervical cancer, remain some of the most common cancers in women, cervical cancer represents the second most frequent gynecological malignancy and the third leading cause of cancer-related death in women worldwide. The causal relationship between human papilomavirus (HPV) infection and anogenital cancer has prompted substantial interest in the development of both preventive and therapeutic vaccines against high-risk HPV types. In the past decade, several groups have shown encouraging results using experimental vaccination systems in animal models and these results have led to several current prophylactic and therapeutic vaccine clinical trials in humans. Read More

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Evaluation of Bone Marrow Findings of COVID-19 by Minimally Invasive Autopsies: A Single Tertiary Care Centre Experience from India.

Indian J Hematol Blood Transfus 2021 Sep 20:1-6. Epub 2021 Sep 20.

Department of Surgical Oncology, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan India.

The 2019 novel coronavirus (2019-nCoV) originated in Wuhan City of China. In India, first confirmed case of coronavirus disease (COVID-19) was reported on January 30, 2020 and India is presently hit by second wave of COVID-19. The aim of the present study was to evaluate bone marrow findings of COVID-19 by minimally invasive autopsies to aid in understanding pathophysiology of the disease. Read More

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September 2021

Cost-Effectiveness Analysis of Minimally Invasive Trabecular Meshwork Stents with Phacoemulsification.

Ophthalmol Glaucoma 2021 Sep 23. Epub 2021 Sep 23.

New York University, Grossman School of Medicine, Department of Ophthalmology; New York University, Grossman School of Medicine, Department of Population Health. Electronic address:

Objective: To investigate costs and effects of implanting trabecular meshwork bypass stents during cataract surgery from a societal perspective in the United States.

Design: Cost-utility analysis using Markov models and efficacy/safety data from published pivotal or randomized control trials of devices investigated.

Subjects: Patients with mild to moderate primary open angle glaucoma with or without visually significant cataract aged 65 years and older. Read More

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September 2021

Ovarian Cancer Incidence and Death in Average-Risk Women Undergoing Bilateral Salpingo-Oophorectomy at Benign Hysterectomy.

Am J Obstet Gynecol 2021 Sep 23. Epub 2021 Sep 23.

Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada; ICES (formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada; Department of Surgery, University of Toronto, Toronto, ON, Canada; Melbourne School of Population and Global Health, University of Melbourne, Melbourne VIC, Australia. Electronic address:

Background: Opportunistic bilateral salpingo-oophorectomy (BSO) is often offered to patients undergoing benign hysterectomy to prevent ovarian cancer, but the magnitude of risk reduction obtained with BSO in this population remains unclear, and must be weighed against potential risks of ovarian hormone deficiency.

Objective: To quantify the relative and absolute risk reduction in ovarian cancer incidence and death associated with BSO at the time of benign hysterectomy.

Study Design: We performed a population-based cohort study of all adult women (>20 years) undergoing benign hysterectomy from 1996 to 2010 in Ontario, Canada. Read More

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September 2021

Early postoperative mortality in liver transplant recipients involving indications other than hepatocellular carcinoma. A retrospective cohort study.

Med Intensiva (Engl Ed) 2021 Oct;45(7):395-410

Intensive Care Medicine, Reina Sofia University Hospital and Maimonides Biomedical Research Institute (IMIBIC), Cordoba, Spain.

Aims: To analyze the perioperative differences in a consecutive cohort of liver transplant recipients (LTRs) classified according to the indication of transplantation, and assess their impact upon early mortality 90 days after transplantation.

Design: A retrospective cohort study was carried out.

Scope: A single university hospital. Read More

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October 2021

Cardiac surgery under cardiopulmonary bypass in pregnancy: report of four cases.

J Cardiothorac Surg 2021 Sep 25;16(1):268. Epub 2021 Sep 25.

Thoracic and Cardiovascular Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: Open heart surgery during pregnancy is relatively rare at home and abroad, and there is a higher risk and probability of maternal and infant death. How to carry out heart valve replacement under cardiopulmonary bypass (CPB) under the premise of ensuring the safety of mother and child is the focus of attention at home and abroad.

Case Introduction: We reported four cases of cardiac surgeries under CPB during pregnancy performed in our hospital from March 2020 to March 2021. Read More

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September 2021

A novel pN3 gastric cancer staging system with superior prognostic utility based upon the examination of over 31 lymph nodes: a propensity score-matching analysis.

BMC Gastroenterol 2021 Sep 25;21(1):352. Epub 2021 Sep 25.

Department of Operating Room, Shengjing Hospital of China Medical University, the Sanhao Street 36, Shenyang, 110001, China.

Background: Individuals with pN3 gastric cancer (GC) account for a large proportion of pN + GC, and exhibit poor survival outcomes. The pN3 stage is defined based upon the number of metastatic lymph nodes (mLNs), but the subclassification of pN3 patients based upon the number of examined LNs (eLNs) is rarely performed.

Methods: In total, 2894 pTxN3M0 GC patients in the Surveillance, Epidemiology, and End Results database that had undergone surgery from 2000 to 2016 were selected for analysis. Read More

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September 2021

Practice patterns and survival in FIGO 2009 stage 3B endometrial cancer.

Gynecol Oncol 2021 Sep 21. Epub 2021 Sep 21.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, Moores Cancer Center, La Jolla, CA, USA.

Objective: To describe the practice patterns and outcomes of patients with stage 3B endometrial cancer.

Methods: We queried the National Cancer Database for all surgically staged, stage 3 patients between 2012 and 2016. Patients who received any pre-operative therapy were excluded. Read More

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September 2021

Nanodelivery of oxiracetam enhances memory, functional recovery and induces neuroprotection following concussive head injury.

Prog Brain Res 2021 12;265:139-230. Epub 2021 Aug 12.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Military personnel are the most susceptible to concussive head injury (CHI) caused by explosion, blast or missile or blunt head trauma. Mild to moderate CHI could induce lifetime functional and cognitive disturbances causing significant decrease in quality of life. Severe CHI leads to instant death and lifetime paralysis. Read More

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In-hospital and one-year outcomes are similar for women and men following transcarotid artery revascularization in symptomatic and asymptomatic patients.

J Vasc Surg 2021 Sep 21. Epub 2021 Sep 21.

Division of Vascular Surgery and Endovascular Therapy, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Objectives: In randomized controlled trials and retrospective series, women have higher rates of periprocedural stroke and death following carotid endarterectomy and transfemoral carotid artery stenting compared to men. We sought to compare outcomes by sex following transcarotid artery revascularization (TCAR) among patients in the Vascular Quality Initiative (VQI).

Methods: We reviewed all patients in the VQI who underwent TCAR from 2017 to 2020. Read More

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September 2021

What Are the Long-term Surgical Outcomes of Compressive Endoprosthetic Osseointegration of the Femur with a Minimum 10-year Follow-up Period?

Clin Orthop Relat Res 2021 Sep 24. Epub 2021 Sep 24.

Department of Orthopedic Surgery, University of California, Davis, UC Davis Medical Center, Sacramento, CA, USA.

Background: Endoprosthetic reconstruction after oncologic resection of bone tumors requires stable fixation between the prosthesis and residual host bone. Compressive osseointegration has been developed as an alternative to traditional stemmed implants to address the challenges and complications of achieving this fixation. Sufficient time has now passed from the advent of compressive implants to allow for an assessment of the intermediate-term and long-term results of this form of fixation. Read More

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September 2021

Surgical and radiological interventions for treating symptomatic extracranial cervical artery dissection.

Cochrane Database Syst Rev 2021 Feb 1;2:CD013118. Epub 2021 Feb 1.

School of Nursing and Midwifery, National University of Ireland Galway, Galway, Ireland.

Background: Cervical artery dissection (CeAD) is a pathological bleed or tear, or both, in the wall of the carotid or vertebral arteries as they course through the neck, and is a leading cause of stroke in young people.

Objectives: To assess the effectiveness of surgical and radiological interventions versus best medical treatment alone for treating symptomatic cervical artery dissection.

Search Methods: We performed comprehensive searches of the Cochrane Stroke Group Trials Register (last searched March 2020), the Cochrane Central Register of Controlled Trials (CENTRAL), 2020, Issue 4, in the Cochrane Library (searched March 2020), MEDLINE (1946 to March 2020) and Embase (1974 to March 2020). Read More

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February 2021

Repeat angiography in patients undergoing conventional catheter-directed thrombolysis for submassive pulmonary embolism: a large single-center experience.

Diagn Interv Radiol 2021 Sep;27(5):664-670

Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, US.

Purpose: Few studies have examined conventional catheter directed thrombolysis (CDT) for the treatment of submassive pulmonary embolism (PE). Moreover, angiographic resolution of thrombus burden following CDT has infrequently been characterized. This study describes a single-center experience treating submassive PE with CDT while utilizing repeat angiography to determine treatment efficacy. Read More

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September 2021

Three-Dimensional Computed Tomography Bronchography and Angiography-Guided Thoracoscopic Segmentectomy for Pulmonary Nodules.

Surg Innov 2021 Sep 24:15533506211044389. Epub 2021 Sep 24.

Department of Thoracic Surgery, ShanXi Cancer Hospital (the Affiliated Cancer Hospital of Shanxi Medical University), Taiyuan, China.

Background: Three-dimensional computed tomography bronchography and angiography (3D-CTBA) provides detailed imaging information for pulmonary segmentectomy. This study was performed to verify the feasibility of 3D-CTBA-guided thoracoscopic segmentectomy for the treatment of pulmonary nodules.

Methods: A retrospective analysis was performed on all patients who underwent 3D-CTBA-guided uniport thoracoscopic segmentectomies or subsegmentectomies for pulmonary nodules in the period from May 2019 to May 2020. Read More

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September 2021

Key Characteristics of Cardiovascular Toxicants.

Environ Health Perspect 2021 Sep 24;129(9):95001. Epub 2021 Sep 24.

Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA.

Background: The concept of chemical agents having properties that confer potential hazard called key characteristics (KCs) was first developed to identify carcinogenic hazards. Identification of KCs of cardiovascular (CV) toxicants could facilitate the systematic assessment of CV hazards and understanding of assay and data gaps associated with current approaches.

Objectives: We sought to develop a consensus-based synthesis of scientific evidence on the KCs of chemical and nonchemical agents known to cause CV toxicity along with methods to measure them. Read More

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September 2021

Experimental nerve transfer model in the neonatal rat.

Neural Regen Res 2022 May;17(5):1088-1095

Christian Doppler Laboratory for the Restoration of Extremity Function; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Surgery; Division of Plastic and Reconstructive Surgery, Medical University of Vienna, Vienna, Austria.

Clinically, peripheral nerve reconstructions in neonates are most frequently applied in brachial plexus birth injuries. Most surgical concepts, however, have investigated nerve reconstructions in adult animal models. The immature neuromuscular system reacts differently to the effects of nerve lesion and surgery and is poorly investigated due to the lack of reliable experimental models. Read More

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Comparison of PD-L1, EGFR, ALK, and ROS1 Status Between Surgical Samples and Cytological Samples in Non-Small Cell Lung Carcinoma.

Balkan Med J 2021 Sep;38(5):287-295

Department of Pathology, Ege University School of Medicine, İzmir, Turkey.

Background: The expression levels of Programmed death ligand-1 (PD-L1), epidermal growth factor receptor (EGFR), anaplastic lymphoma tyrosine kinase gene (ALK), and proto-oncogene tyrosineprotein kinase 1 ROS (ROS1) are important for targeted treatment selection in advanced lung cancer. Most patients with lung cancer are diagnosed at an advanced stage and have no chance of surgery. For this reason, the accuracy and reliability of cytology samples for detecting those markers is important in patients whose histological sampling cannot be performed. Read More

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September 2021

One-stage thoracoscopic resection of bilateral bronchiectasis.

Asian Cardiovasc Thorac Ann 2021 Sep 24:2184923211044399. Epub 2021 Sep 24.

Department of Surgery, 63300Tainan Municipal Hospital, Show Chwan Medical Care Corporation, Tainan, Taiwan.

Objective: To evaluate the results of one-stage thoracoscopic resection of bilateral bronchiectasis.

Methods: Between June 2009 and December 2020, there were 23 patients selected for one-stage thoracoscopic resection of bilateral bronchiectasis. Their average age was 58. Read More

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September 2021

Management of Necrotizing Fasciitis with Proximal Tibia Fracture.

J Orthop Case Rep 2021 May;11(5):80-83

Department of Orthopaedics Surgery, SRMMCH and RC, Kattankulathur, Tamil Nadu, India.

Introduction: Necrotizing fasciitis is a rare disease of soft tissue infection with a high mortality. It is characterized by rapidly spreading inflammation and necrosis of fascial planes. It usually follows an injury, though the cause may be a small abrasion or an insect bite or surgical incisions. Read More

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Whole-Blood Mitochondrial DNA Copies Are Associated With the Prognosis of Acute Respiratory Distress Syndrome After Sepsis.

Front Immunol 2021 7;12:737369. Epub 2021 Sep 7.

Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.

Acute respiratory distress syndrome (ARDS) is an inflammatory process of the lungs that develops primarily in response to pulmonary or systemic sepsis, resulting in a disproportionate death toll in intensive care units (ICUs). Given its role as a critical activator of the inflammatory and innate immune responses, previous studies have reported that an increase of circulating cell-free mitochondrial DNA (mtDNA) is a biomarker for fatal outcome in the ICU. Here we analyzed the association of whole-blood mtDNA (wb-mtDNA) copies with 28-day survival from sepsis and sepsis-associated ARDS. Read More

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September 2021

5-Year Outcomes Comparing Surgical Versus Transcatheter Aortic Valve Replacement in Patients With Chronic Kidney Disease.

JACC Cardiovasc Interv 2021 Sep;14(18):1995-2005

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart & Lung Institute, Laval University, Québec, Québec, Canada.

Objectives: The aim of this study was to compare 5-year cardiovascular, renal, and bioprosthetic valve durability outcomes in patients with severe aortic stenosis (AS) and chronic kidney disease (CKD) undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR).

Background: Patients with severe AS and CKD undergoing TAVR or SAVR are a challenging, understudied clinical subset.

Methods: Intermediate-risk patients with moderate to severe CKD (estimated glomerular filtration rate <60 mL/min/m) from the PARTNER (Placement of Aortic Transcatheter Valve) 2A trial (patients randomly assigned to SAPIEN XT TAVR or SAVR) and SAPIEN 3 Intermediate Risk Registry were pooled. Read More

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September 2021