967,885 results match your criteria surgical biopsy

Melanoma Metastases to the Adrenal Gland Are Highly Resistant to Immune Checkpoint Inhibitors.

J Natl Compr Canc Netw 2021 Aug 4. Epub 2021 Aug 4.

3Center for Rare Melanomas.

Background: Adrenal gland metastases (AGMs) are common in advanced-stage melanoma, occurring in up to 50% of patients. The introduction of immune checkpoint inhibitors (ICIs) has markedly altered the outcome of patients with melanoma. However, despite significant successes, anecdotal evidence has suggested that treatment responses in AGMs are significantly lower than in other metastatic sites. Read More

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Determinants of surgical approach and survival among women with endometrial carcinoma.

J Minim Invasive Gynecol 2021 Aug 1. Epub 2021 Aug 1.

Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio.

Objective: To investigate determinants of surgical approach among women with endometrial carcinoma (EC) and associations between surgical approach and overall survival (OS).

Design: Retrospective cohort.

Setting: The National Cancer Database (NCDB), 2010-2015. Read More

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Surgical treatment of uterine neoplasia in 13 production size pigs with a comparison to pot-bellied pigs.

Vet Surg 2021 Aug 4. Epub 2021 Aug 4.

Department of Clinical Sciences, Cornell University, Ithaca, New York, USA.

Objectives: The primary objective of this study was to describe the clinical management and surgical treatment of production size pigs (PrdP) with uterine neoplasia. A secondary objective was to compare tumor diagnoses as well as short- and long-term survival between PrdP and a published report of pot-bellied pigs (PBP) following surgical intervention.

Study Design: Retrospective clinical study. Read More

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Risk Stratification of Ductal Carcinoma In Situ and Texture Analysis of Contrast-Enhanced Breast Magnetic Resonance Imaging.

J Comput Assist Tomogr 2021 Aug 2. Epub 2021 Aug 2.

From the Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objective: The aim of this study was to investigate whether texture analysis of contrast-enhanced T1 weighted images could predict risk of ductal carcinoma in situ (DCIS).

Methods: The study included 185 DCIS lesions that were classified as either low risk or non-low risk using surgical pathology records. All magnetic resonance imaging texture analyses were performed using postprocessing software, and texture-derived parameters were extracted. Read More

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Ovarian Metastasis by Gastric-type Endocervical Adenocarcinoma: A Clinicopathologic Description of 12 Cases.

Int J Gynecol Pathol 2021 Aug 4. Epub 2021 Aug 4.

Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province (B.L.) Departments of Surgical Pathology (B.L., H.S., Y.S.) Gynecologic Oncology (J.X.), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Cervical gastric-type adenocarcinoma has a propensity for ovarian metastasis, but the clinicopathologic findings and possible routes of tumor spread have not been well characterized to date. To address these points, we reported 12 cervical gastric-type adenocarcinomas with ovarian metastases from a single institution. Seven patients with gastric-type adenocarcinoma had concurrent endometrial fallopian tube involvement, 5 of which showed tumors confined to the fallopian tube mucosa. Read More

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Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy.

Stem Cell Rev Rep 2021 Aug 4. Epub 2021 Aug 4.

Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.

Multipotent stromal cells (MSCs) are widely utilized in therapy for their immunomodulatory properties, but their usage in infectious viral diseases is less explored. This review aimed to collate the current novel use of MSCs in virus-associated conditions, including MSC's susceptibility to virus infection, antiviral properties of MSCs and their effects on cell-based immune response and implementation of MSC therapy in animal models and human clinical trials of viral diseases. Recent discoveries shed lights on MSC's capability in suppressing viral replication and augmenting clearance through enhancement of antiviral immunity. Read More

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Anorectal Melanoma-Brownish Black Mass Not Always a Hemorrhoid.

J Gastrointest Cancer 2021 Aug 4. Epub 2021 Aug 4.

Department of Surgical Oncology, All India Institute of Medical Science, Patna, Bihar, India.

The non-specific clinical symptoms of anorectal brownish-black mass do not help to differentiate colorectal cancer, hemorrhoids, rectal ulcers which result in a delayed diagnosis or lead to inadequate management of lethal anorectal melanoma. Primary malignant melanoma of the anorectal region is an uncommon tumor, constituting approximately 1% of anal canal tumors which may be misdiagnosed clinically as hemorrhoids. Because of aggressive behavior and poor prognosis, efficient and prompt diagnosis is required in these cases. Read More

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Congenital lumbar herniae: a systematic review.

Hernia 2021 Aug 4. Epub 2021 Aug 4.

Second Department of Surgery, Athens Naval and Veterans Hospital, Dinokratous 70, Kolonaki, Athens, Greece.

Purpose: Congenital lumbar hernia is defined as the protrusion of intraperitoneal or extraperitoneal viscera through a defect of the posterior abdominal wall, present at birth. The aim of our study was to perform a systematic review of this rare pathology, with emphasis on surgical decision-making.

Methods: The English literature (2000-2020) was reviewed, using PubMed, EMBASE and GoogleScholar databases, combining the terms "hernia", "lumbar", "flank", "Grynfeltt", "Petit" and "congenital". Read More

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Evidence of disrupted rhombic lip development in the pathogenesis of Dandy-Walker malformation.

Acta Neuropathol 2021 Aug 4. Epub 2021 Aug 4.

Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, USA.

Dandy-Walker malformation (DWM) and Cerebellar vermis hypoplasia (CVH) are commonly recognized human cerebellar malformations diagnosed following ultrasound and antenatal or postnatal MRI. Specific radiological criteria are used to distinguish them, yet little is known about their differential developmental disease mechanisms. We acquired prenatal cases diagnosed as DWM and CVH and studied cerebellar morphobiometry followed by histological and immunohistochemical analyses. Read More

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[Transbronchial cryobiopsies: an alternative for surgical lung biopsy].

Ned Tijdschr Geneeskd 2021 Jun 17;165. Epub 2021 Jun 17.

CWZ, Nijmegen: Afd. Longziekten.

Cryobiopsy is an endobronchial technique to obtain peripheral lung biopsies with the use of a flexible bronchoscopic cryo probe. This technique can be used to diagnose diffuse lung diseases when histological evidence is required. This new technique was used for the first time in 2009 and in 2014 we introduced this new method in the Netherlands at the CWZ in Nijmegen. Read More

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Current Surgical Management of Inflammatory Breast Cancer.

Ann Surg Oncol 2021 Aug 3. Epub 2021 Aug 3.

Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Inflammatory breast cancer (IBC) is a rare and aggressive breast cancer characterized by erythema and edema of at least one-third of the breast. The diagnosis remains a clinical one. Standard of care involves trimodality therapy with anthracycline-based neoadjuvant chemotherapy and human epidermal growth factor receptor 2 (HER2)-directed therapy if HER2 positive, followed by modified radical mastectomy and post-mastectomy radiation therapy to the chest wall in addition to regional nodal basins including supraclavicular and internal mammary nodes. Read More

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The effects of palbociclib in combination with radiation in preclinical models of aggressive meningioma.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab085. Epub 2021 Jun 24.

Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Background: Meningiomas are the most common tumor arising within the cranium of adults. Despite surgical resection and radiotherapy, many meningiomas invade the brain, and many recur, often repeatedly. To date, no chemotherapy has proven effective against such tumors. Read More

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The Diagnosis and Management of Pediatric Spine Infections.

Cureus 2021 Jul 30;13(7):e16748. Epub 2021 Jul 30.

Department of Orthopedics, Oakland University William Beaumont School of Medicine, Rochester, USA.

The management of pediatric spine infections requires a multidisciplinary approach that includes orthopedic surgeons, infectious disease specialists, interventional radiologists, and others. The prevalence of the disease has increased in frequency, virulence, and degree of soft tissue involvement over the past several years; there has also been a resurgence of some types of infections, such as tuberculosis, fungal, and viral pathogens. The diagnosis can often be reached with a detailed history, physical examination, laboratory tests, and imaging studies. Read More

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Recurrent solitary bone plasmacytoma: A case report.

Surg Neurol Int 2021 19;12:356. Epub 2021 Jul 19.

Department of Spine Surgery, Sancheti Institute of Orthopedics and Rehabilitation, Pune, Maharashtra, India.

Background: Plasmacytoma is an hematological malignancy that originates in bone. It may involve a single skeletal location. Notably, these lesions can progress to involve multiple segments in 50% of cases, at which point they are classified as having multiple myeloma (MM). Read More

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Ganglioglioma of the cervicothoracic spinal cord in a patient with neurofibromatosis type 1: A case report.

Surg Neurol Int 2021 28;12:313. Epub 2021 Jun 28.

Departament of Surgical Specialities and Neurosurgery, Neurosurgery Teaching and Assistance Unit, Pedro Ernesto University Hospital, Rio de Janeiro, Brazil.

Background: Gangliogliomas are rare tumors of the central nervous system. They are usually located intracranially and rarely in the spinal cord. There is no clear correlation between this tumor and neurofibromatosis type 1 (NF1) with only four cases described. Read More

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Ectopic intraconal orbital meningioma - A rare case report.

Surg Neurol Int 2021 28;12:305. Epub 2021 Jun 28.

Department of Neurosurgery, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Background: Ectopic orbital meningiomas (OM) are a rare subset of OMs which are neither attached to the optic nerve sheath nor to the surrounding bone.

Case Description: We report the case of a 65-year-old female who presented with a 1 year history of proptosis followed by visual loss and restricted right eye movements since 3 months. Radiology of the orbits was suggestive of intraorbital, intraconal, and heterogeneous contrast enhancing right eye lesion which was completely excised through supraorbital orbitotomy approach. Read More

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A primary solitary vascular tumor of calcaneum: case report and review of literature.

Radiol Case Rep 2021 Sep 15;16(9):2680-2686. Epub 2021 Jul 15.

Department of Radiology, West Virginia University, Morgantown, WV.

Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor with metastatic potential and estimated prevalence of less than one case per million. Among the musculoskeletal system, the long bones are commonly involved with approximately half patients experiencing multicentric involvement. Clinical course of EHE is often variable and nonspecific. Read More

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September 2021

Orthopedic surgery in hemophilic patients with musculoskeletal disorders: A systematic review.

Exp Ther Med 2021 Sep 14;22(3):995. Epub 2021 Jul 14.

Department of Pathophysiology, Morfo-Functional Sciences (II), Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.

Hemophilia is a hereditary coagulopathy caused by factor VIII (hemophilia type A) or by coagulation factor IX (hemophilia type B) dysfunction, characterized by an increased bleeding predisposition, which is either spontaneous or secondary to minimal trauma. Currently, hemophilia may also be considered an 'orthopedic' condition, due to the fact that it affects the musculoskeletal system of most hemophilic patients. In recent years, constant prophylaxis using coagulation factors has led to a significant improvement in the hemophilic patient's quality of life, by reducing both life-threatening hemorrhagic phenomena, as well as the occurrence of chronic complications. Read More

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September 2021

Crosstalk between hypoxia-sensing ULK1/2 and YAP-driven glycolysis fuels pancreatic ductal adenocarcinoma development.

Int J Biol Sci 2021 5;17(11):2772-2794. Epub 2021 Jul 5.

General Surgical Laboratory, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, Guangdong, P.R.China.

Autophagy and glycolysis are two catabolic processes that manipulate pancreatic ductal adenocarcinoma (PDAC) development in response to hypoxia sensing, yet the underlying mechanism of how they are interlinked remain elusive. The functional roles of Unc-51 like kinase 1 and 2 (ULK1/2) in pyruvate kinase M2 (PKM2) transcription and glycolysis under hypoxia were assessed by chromatin immunoprecipitation, luciferase reporter, glucose consumption and lactate production assay. Co-immunoprecipitation, cellular ubiquitination, His-pulldown, protein kinase assay, immunofluorescence, immunohistochemistry, CRISPR technology, in silico studies were adopted to determine the molecular mechanism. Read More

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Iris reconstruction: A perspective on the modern surgical armamentarium.

Oman J Ophthalmol 2021 May-Aug;14(2):69-73. Epub 2021 Jun 28.

Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

The surgical reconstruction of eyes with iris defects is almost invariably complex and challenging. A number of prosthetic iris devices are available including large-incision, rigid diaphragm, aniridic intraocular lens style devices, small-incision devices incorporating a capsular ring, and flexible, customized, small-incision iris prostheses. The surgical techniques for rehabilitation are dictated by the configuration of the iris defect, the presence of concurrent ocular pathology, and the functional complaint of the patient. Read More

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The future of medical thoracoscopy in the Kingdom of Saudi Arabia.

Saudi Med J 2021 Aug;42(8):903-907

From the Department of Medicine, Pulmonary Division, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.

Medical thoracoscopy (MT) has changed how we manage exudative pleural effusion. It is a minimally invasive procedure used as a diagnostic and therapeutic tool in pleural disease. Here, we report a case of a lymphocytic exudative pleural effusion that needed a pleural biopsy for diagnosis. Read More

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Compliance of healthcare workers to the proper use of personal protective equipment during the first wave of COVID-19 pandemic.

J Infect Public Health 2021 Jul 28. Epub 2021 Jul 28.

Community, Occupational and Environmental Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt; Health Sciences Department, Health Sciences & Rehabilitation College, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Background: In limited resource settings, compliance to proper personal protective equipment (PPE) use is challenging. This study aims to characterize the pattern of PPE use among healthcare workers (HCWs) during the first wave of coronavirus diseases-2019 (COVID-19) in Egypt and to determine the factors associated with compliance to the proper use of PPE.

Methods: A cross-sectional study was conducted among Egyptian HCWs using an online self-administered questionnaire. Read More

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Endourological treatment for lumbar ureteral stones. What are the benefits of flexible ureterorenoscopy?

Actas Urol Esp 2021 Jul 31. Epub 2021 Jul 31.

Servicio de Urología, Hospital Clínico Universitario de Valladolid, Valladolid, España.

Introduction And Objectives: Currently, there are no established criteria regarding treatment for lumbar ureteral stones. The objective of this work is to present our results in the endourological treatment of this pathology, analyzing the variables associated with the use of the flexible ureterorenoscope.

Material And Methods: Retrospective review of 103 patients who underwent retrograde URS with semi-rigid or flexible ureterorenoscope. Read More

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Refined prognostic staging for resected pancreatic cancer by modified stage grouping and addition of tumour grade.

Eur J Surg Oncol 2021 Jul 26. Epub 2021 Jul 26.

Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany. Electronic address:

Background: With changes in T and N categories the 8th edition of the AJCC/UICC TNM staging system for pancreatic cancer resulted in improved prognostic staging, but inconsistencies were observed with specific stage groups. Tumour grading remains disregarded in prognostic staging. We aimed to validate the current staging system and to investigate the possibility of further optimization by integration of grading. Read More

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Diagnostic Accuracy of Optical Frequency Domain Imaging for Identifying Necrotic Cores with Intraplaque Hemorrhage in Advanced Human Carotid Plaques.

Am J Cardiol 2021 Jul 31. Epub 2021 Jul 31.

Department of Neurosurgery, Hyogo College of Medicine, Nishinomiya, Japan.

This study investigated whether optical frequency domain imaging (OFDI) can identify carotid artery vulnerable plaque characteristics, focusing on lipid-rich necrotic core (NC) and intraplaque hemorrhage (IPH). Fourteen patients scheduled for carotid endarterectomy underwent OFDI scan during preoperative angiography. Atherosclerotic plaque specimens obtained from carotid endarterectomy were cut every 3-4 mm into 4-μm transverse cross-sections and stained with standard methods. Read More

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Using a BonE BiOPsy (BeBoP) to determine the causative agent in persons with diabetes and foot osteomyelitis: study protocol for a multicentre, randomised controlled trial.

Trials 2021 Aug 3;22(1):517. Epub 2021 Aug 3.

Department of Internal Medicine, Amsterdam Movement Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.

Background: Diabetic foot osteomyelitis (DFO) poses a major disease burden. It can generally be treated with long-term antibacterial therapy. International guidelines recommend to base antibacterial therapy choices on percutaneous bone biopsy culture, while in practice, therapy is frequently based on (less invasive) ulcer bed cultures. Read More

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Clinical outcome of renal cancer patients who early interrupted immunotherapy due to serious immune-related adverse events. Meet-Uro 13 trial on behalf of the MeetUro investigators.

J Transl Med 2021 08 3;19(1):328. Epub 2021 Aug 3.

Department of Medical Oncology, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128, Rome, Italy.

Background: Severe immune-related Adverse Events (irAEs) develop in 10-27% of patients treated with Immune-Oncology (IO) [Powles (Lancet 391:748-757, 2018); Galsky (Lancet 395:1547-1557, 2020); Haanen (Ann Oncol 28:119-142, 2017)]. The aim of our study was to evaluate efficacy and clinical outcome of metastatic renal cell carcinoma (mRCC) patients who stopped Immune Checkpoint Inhibitors (ICIs) due to early Grade (G) 3-G4 irAEs.

Methods: We retrospectively collected data from 204 mRCC patients treated with ICIs in 6 Italian referral centers adhering to the Meet-Uro group, between February 2017 and January 2020. Read More

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[Secretory carcinoma of salivary gland: a clinicopathological and prognostic analysis of twelve cases].

Y S Cao X Q Lyu

Zhonghua Bing Li Xue Za Zhi 2021 Aug;50(8):899-903

Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To study the clinical manifestations, pathological features, molecular features, differential diagnosis and prognosis of secretory carcinoma of salivary gland (SCSG). Twelve cases of SCSG diagnosed in the Department of Pathology, the First Affiliated Hospital of Zhengzhou University from January 2017 to December 2019 were collected and analyzed in terms of histological morphology, immunohistochemistry (Envision method) and molecular detection. Among the 12 patients, there were 6 males and 6 females, aged 12-67 years old, with a median age of 41. Read More

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[MAML2 gene rearrangement, fusion patterns and clinicopathological characteristics in primary pulmonary mucoepidermoid carcinoma].

Zhonghua Bing Li Xue Za Zhi 2021 Aug;50(8):891-898

Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To investigate MAML2 gene rearrangement, gene fusion patterns, and the clinicopathological characteristics of primary pulmonary mucoepidermoid carcinoma (PMEC). Forty-six cases of primary PMEC from Fudan University Zhongshan Hospital and Fudan University Shanghai Cancer Center between 2017 and 2020 were collected. MAML2 gene rearrangement in all cases was detected by fluorescence in situ hybridization (FISH). Read More

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[Current status of postoperative pathological diagnosis of lung cancer in China: a multicenter big data study].


Zhonghua Bing Li Xue Za Zhi 2021 Aug;50(8):882-890

To reveal the current status and problem of surgical pathological diagnosis and to construct a structured pathological database of lung cancer in China, and to further improve the level of pathological standards and scientific data. Case report form (CRF) was made according to the diagnostic criteria of radical resection specimens of lung cancer, including general information, smoking history, pathological report (including molecular data), treatment and prognosis, etc. The original clinicopathological data of patients with primary lung cancer who underwent surgical resection in 23 centers from January 2013 to December 2017 were retrospectively collected. Read More

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