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[Bilateral pedicled gracilis muscle flap and bilateral gluteus muscle flap for multiple-stage reconstruction of vagina, pelvis and perineal region].

Handchir Mikrochir Plast Chir 2021 Sep 23. Epub 2021 Sep 23.

St. Vinzenz-Hospital, Plastische und Ästhetische Chirurgie.

Plastic reconstructions of oncological anorectal defects often prove to be very difficult and lead to prolonged hospitalisation due to severe bacterial contamination, neoadjuvant radiotherapy and chemotherapy and difficult anatomical conditions. There is no common standard for plastic reconstruction in such cases. We present a patient diagnosed with distal rectal cancer with infiltration of the anus and vagina, who underwent radical tumour resection of the rectum and anus as well as partial resection of the vagina. Read More

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September 2021

Clinicopathological and Prognostic Features of 67 Cases with Pulmonary Sarcomatoid Carcinoma: An 18-Year Single-Centre Experience.

Oncol Res Treat 2021 Sep 23:1-10. Epub 2021 Sep 23.

Department of Medical Oncology, Istanbul University Institute of Oncology, Istanbul, Turkey.

Introduction: Pulmonary sarcomatoid carcinoma (PSC) is a very rare subtype of non-small-cell lung cancer (NSCLC). It is frequently diagnosed in the advanced stage and is resistant to conventional chemotherapeutics. Due to the unique nature and rarity, we evaluated the epidemiological, clinicopathological, and survival data of PSC patients treated at our centre. Read More

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September 2021

High CTSL2 expression predicts poor prognosis in patients with lung adenocarcinoma.

Aging (Albany NY) 2021 Sep 23;13(undefined). Epub 2021 Sep 23.

Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun 130021, China.

Cathepsin like 2 (CTSL2) is a lysosomal cysteine protease, and may be associated with tumor metastasis. However, CTSL2 has not been reported as a biomarker in lung adenocarcinoma (LUAD). In this study, bioinformatics analysis using data from The Cancer Genome Atlas was performed. Read More

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September 2021

Effectiveness of 4-1BB-costimulated HER2-targeted chimeric antigen receptor T cell therapy for synovial sarcoma.

Transl Oncol 2021 Sep 20;14(12):101227. Epub 2021 Sep 20.

Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuou-ku, Niigata City, Niigata 951-8510, Japan. Electronic address:

Background: Synovial sarcoma is a rare malignant soft-tissue tumor that is prevalent in adolescents and young adults, and poor prognosis has been reported in patients with metastatic lesions. Chimeric antigen receptor (CAR) T-cell therapy is an emerging novel therapy for solid tumors; however, its application in synovial sarcoma has not yet been explored.

Methods: A novel human epidermal growth factor receptor 2 (HER2)-targeted CAR containing scFv-FRP5, CD8α hinge and transmembrane domains as well as 4-1BB costimulatory and CD3ζ signaling domains was developed. Read More

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September 2021

Periosteal ostoesarcoma of the femur treated with modified capanna procedure: A case report.

Int J Surg Case Rep 2021 Sep 15;87:106414. Epub 2021 Sep 15.

Orthopaedic and Traumatology Resident, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Electronic address:

Introduction: Periosteal osteosarcoma is a rare type of primary bone tumor. A vascularized fibula graft incorporates this revolutionary approach with a traditional massive allograft to reconstruct large femur and tibia defects during oncological resection. A structurally competent reconstruction with improved vascular and osteogenic capacities with the ability to achieve lower rates of fracture, infection, and non-union is obtained by integrating the benefits of the separate components. Read More

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September 2021

Tailored axillary surgery in patients with clinically node-positive breast cancer: Pre-planned feasibility substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101).

Breast 2021 Sep 8;60:98-110. Epub 2021 Sep 8.

Breast Center Bern, Lindenhof Group, Bern, Switzerland.

Aim: We developed tailored axillary surgery (TAS) to reduce the axillary tumor volume in patients with clinically node-positive breast cancer to the point where radiotherapy can control it. The aim of this study was to quantify the extent of tumor load reduction achieved by TAS.

Methods: International multicenter prospective study embedded in a randomized trial. Read More

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September 2021

Longitudinal prognostication in retroperitoneal sarcoma survivors: Development and external validation of two dynamic nomograms.

Eur J Cancer 2021 Sep 20;157:291-300. Epub 2021 Sep 20.

Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

Purpose: The aim of this study was to create and validate dynamic nomograms to predict overall survival (OS) and disease-free survival (DFS) at different time points during follow-up in patients who had undergone resection of primary retroperitoneal sarcoma (RPS).

Methods: Patients with primary RPS operated upon between 2002 and 2017 at four and six referral centres comprised the development and external validation cohorts, respectively. Landmark analysis and multivariable Cox models were used to develop dynamic nomograms. Read More

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September 2021

Fusiform Dilatation of the Internal Carotid Artery in Childhood-Onset Craniopharyngioma- A Systematic Review.

World Neurosurg 2021 Sep 20. Epub 2021 Sep 20.

Department of Neurological Surgery, University of Miami - Miller School of Medicine, c/o Ingrid Menendez, 1095 NW 14 Terrace D4-6, Miami, FL 33136.

Objective: Patients with fusiform dilation of the internal carotid artery (FDCA) following pediatric craniopharyngioma resection typically have a benign clinical course. We sought to review the neurosurgical literature for FDCA outcomes after resection of these tumors.

Methods: Using PubMed, Web of Science, and Cochrane databases we identified surgical series or case reports reporting incidences of FDCA following craniopharyngioma resection. Read More

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September 2021

Strategies for active tumor targeting-an update.

Eur J Pharmacol 2021 Sep 20:174512. Epub 2021 Sep 20.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra, 400056, India. Electronic address:

A complete cure for cancer is still the holy grail for scientists. The existing treatment of cancer is primarily focused on surgery, radiation and conventional chemotherapy. However, chemotherapeutic agents also affect healthy tissues or organs due to a lack of specificity. Read More

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September 2021

Desquamative esophagitis followed by esophageal cancer in a stem cell transplant recipient.

Gastrointest Endosc 2021 Sep 20. Epub 2021 Sep 20.

Department of Gastroenterology and Hepatology, Okayama 700-8558, Japan.

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September 2021

Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial.

Lancet 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine, Division of Oncology, Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA, USA.

Background: Novel adjuvant strategies are needed to optimise outcomes after complete surgical resection in patients with early-stage non-small-cell lung cancer (NSCLC). We aimed to evaluate adjuvant atezolizumab versus best supportive care after adjuvant platinum-based chemotherapy in these patients.

Methods: IMpower010 was a randomised, multicentre, open-label, phase 3 study done at 227 sites in 22 countries and regions. Read More

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September 2021

CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c-Met signaling pathway.

FEBS Open Bio 2021 Sep 23. Epub 2021 Sep 23.

Department of general Surgery, The First Affiliated Hospital of Harbin Medical University, No.23 YouZheng Street, Harbin, 150001, Heilongjiang, China.

C-X-C motif chemokine receptor 4 (CXCR4) expression is associated with poor prognosis of hepatocellular carcinoma (HCC). The aim of this study was to explore the biological role of CXCR4 in gefitinib resistance of HCC. Compared with a normal, non-gefitinib-resistant, human HCC cell line (Huh7), CXCR4 mRNA and protein were highly expressed in gefitinib-resistant Huh7 cells (Huh7-R). Read More

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September 2021

Assessment of a new 150 W single-antenna microwave ablation system in the treatment of malignant liver tumors: The first worldwide experience.

J Surg Oncol 2021 Sep 23. Epub 2021 Sep 23.

Department of Endocrine Surgery, Cleveland Clinic, Cleveland, Ohio, USA.

Background And Objectives: Data in literature regarding liver microwave ablation pertain to systems delivering 100 W of maximum power. Our aim is to assess a new 150 W microwave system for liver tumor ablation.

Methods: This was an institutional review board-approved study of patients undergoing ablation of malignant liver tumors using a 150 W microwave system. Read More

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September 2021

Impact of the methylation classifier and ancillary methods on CNS tumor diagnostics.

Neuro Oncol 2021 Sep 23. Epub 2021 Sep 23.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Background: Accurate CNS tumor diagnosis can be challenging, and methylation profiling can serve as an adjunct to classify diagnostically difficult cases.

Methods: An integrated diagnostic approach was employed for a consecutive series of 1,258 surgical neuropathology samples obtained primarily in a consultation practice over 2-year period. DNA methylation profiling and classification using the DKFZ/Heidelberg CNS tumor classifier was performed, as well as unsupervised analyses of methylation data. Read More

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September 2021

Epigenetic-based targeted therapies for well-differentiated pancreatic neuroendocrine tumors: recent advances and future perspectives.

Expert Rev Endocrinol Metab 2021 Sep 23:1-13. Epub 2021 Sep 23.

F.I.R.M.O. Italian Foundation for the Research on Bone Diseases, Florence, Italy.

Introduction: Well-differentiated pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of primary tumors of the endocrine pancreas. Dysregulation of chromatin remodeling, gene expression alteration, global DNA hypomethylation of non-coding regions, DNA hypermethylation and silencing of tumor suppressor gene promoters are frequent epigenetic changes in PanNETs. These changes exert a role in neoplastic transformation and progression. Read More

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September 2021

Evaluation of pro-angiogenic properties of an inorganic silica gel fibre fleece.

J Wound Care 2021 Sep;30(9):729-736

Department of Orthopedics and Trauma Surgery, Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Hard-to-heal wounds represent an increasing health and economic burden on society. At present, therapy options for hard-to-heal wounds are often unsatisfactory, and the development of more effective wound treatments is urgently needed. We have shown that orthosilicic acid-releasing silica fibre fleece (SIFIB), via its pronounced anti-inflammatory properties, exhibited a significantly enhanced effect on wound closure kinetics in a porcine wound model in vivo. Read More

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September 2021

Efficacy of Intrawound Treatments to Prevent Surgical Site Infection after Spine Surgery: A Systematic Review and Network Meta-analysis.

Pain Physician 2021 Sep;24(6):E709-E720

Department of Orthopedic Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Intrawound treatments have been reported to have favorable efficacy for preventing surgical site infection (SSI); however, the best strategy remains unknown.

Objective: The aim of this systematic review and network meta-analysis was to evaluate the efficacy of intrawound treatments to prevent SSI after spine surgery.

Study Design: A systematic review and network meta-analysis. Read More

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September 2021

Knockdown of circ_0004104 Alleviates Oxidized Low-Density Lipoprotein-Induced Vascular Endothelial Cell Injury by Regulating miR-100/TNFAIP8 Axis.

J Cardiovasc Pharmacol 2021 Aug;78(2):269-279

Department of Thoracic Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.

Abstract: Coronary artery disease (CAD) is a common cardiovascular disease, mainly due to vascular endothelial cell (VEC) injury caused by atherosclerosis. Circular RNA has been shown to be involved in the regulation of various diseases. However, the role and mechanism of circ_0004104 in CAD are still unclear. Read More

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Comprehensive ability evaluation and trend analysis of patients with malignant intracranial tumors in the perisurgery period.

Brain Behav 2021 Sep 23:e02192. Epub 2021 Sep 23.

Departments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Prognostic situations differ in patients with malignant intracranial tumors. We focused on the quality of life, ability of daily living, and cognitive function of patients in the perisurgery period and investigated the correlation between them and the prognosis of patients.

Materials And Methods: Patients with malignant intracranial tumors admitted to Peking Union Medical College Hospital from May 2018 to August 2020 for surgery were included. Read More

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September 2021

Delivery of Cationic Platinum Prodrugs via Reduction Sensitive Polymer for Improved Chemotherapy.

Small 2021 Sep 23:e2101804. Epub 2021 Sep 23.

Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.

A cationic monofunctional platinum anticancer drug, phenanthriplatin (PhenPt(II)), exhibits promising anticancer effect on various cancer cell lines. Unlike the conventional platinum(II) drugs, PhenPt(II) is more likely to bind the N7 adenosine base of DNA in situ, and consequently resulting in a unique cellular response profile and unusual potency. However, since this drug is positively charged, it can easily bind to plasma protein that leads to rapid systematic clearance and deleterious toxicities, which greatly limits its in vivo application. Read More

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September 2021

Glycogen synthase kinase-3β inactivation promotes cervical cancer progression, invasion, and drug resistance.

Biotechnol Appl Biochem 2021 Sep 23. Epub 2021 Sep 23.

Department of Life Sciences, School of Natural Sciences, Central University of Jharkhand, Ratu, Jharkhand, Ranchi-835205, INDIA.

Human papillomavirus (HPV) infection-dependent cervical cancer is one of the most common gynecological cancers and often becomes aggressive, with rapid proliferation, invasion/migration, and drug resistance. Here, 135 fresh human CSCC tissue specimens, comprising: 21 adjacent normals (AN), 30 cervical-intraepithelial-neoplasia (CIN ), 45 CSCC, and 39 drugs (chemo-radiation)-resistant cervical tumor (DRCT) tissues were included. HPV-positive (HeLa, SiHa), HPV-negative (C33A), and cisplatin-resistant (CisR-HeLa/-SiHa/-C33A) cell lines were used for in vitro studies. Read More

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September 2021

Spontaneous extracapsular parathyroid adenoma hemorrhage: when surgery is required?

Endocrine 2021 Sep 23. Epub 2021 Sep 23.

Department of Otolaryngology-Head and Neck Surgery, Scientific Institute of Hospitalization and Care San Raffaele Hospital, Vita-Salute University, Milan, Italy.

Purpose: Spontaneous bleeding is a rare but serious complication of parathyroid adenomas and few cases were reported in the literature. Clinical manifestations and treatment may vary but sometimes an immediate surgery is required. In other cases a conservative approach can be preferred based on clinical stability and patients' conditions. Read More

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September 2021

Pancreatic actinomycosis treated by antibiotics after diagnosis using endoscopic ultrasound-guided fine-needle biopsy.

Clin J Gastroenterol 2021 Sep 23. Epub 2021 Sep 23.

Department of Internal Medicine, Tsuyama Chuo Hospital, 1756 Kawasaki, Tsuyama-shi, Okayama, 708-0841, Japan.

A 71-year-old man who had undergone total gastrectomy, partial pancreatectomy, and splenectomy with Roux-en-Y reconstruction for gastric cancer was referred for a possible pancreatic tail tumor. Contrast-enhanced computed tomography showed mold-like, poor contrast lesion in the dilated main pancreatic duct in the pancreatic tail. Endoscopic ultrasonography revealed a slightly hyperechoic solid lesion that occupied the lumen of the main pancreatic duct. Read More

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September 2021

Trend and survival benefit of contralateral prophylactic mastectomy among men with stage I-III unilateral breast cancer in the USA, 1998-2016.

Breast Cancer Res Treat 2021 Sep 23. Epub 2021 Sep 23.

Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200000, China.

Purpose: Our study aimed to explore temporal trends and survival benefit of contralateral prophylactic mastectomy (CPM) in male breast cancer (MBC).

Methods: Men with stage I-III unilateral breast cancer between 1998 and 2016 were identified from the surveillance, epidemiology, and end results (SEER). We compared CPM rate over the study period using the Cochrane-Armitage test for trend. Read More

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September 2021

Insulin and the insulin receptor collaborate to promote human gastric cancer.

Gastric Cancer 2021 Sep 23. Epub 2021 Sep 23.

Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, University of Newcastle-upon-Tyne, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.

Background: Gastric adenocarcinoma is common and consequent mortality high. Presentation and mortality are increased in obese individuals, many of whom have elevated circulating insulin concentrations. High plasma insulin concentrations may promote, and increase mortality from, gastric adenocarcinoma. Read More

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September 2021

Lighting up ATP in cells and tissues using a simple aptamer-based fluorescent probe.

Mikrochim Acta 2021 Sep 23;188(10):352. Epub 2021 Sep 23.

Nanobioengineering/Bioelectronics Laboratory, Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street, Miami, FL, 33174, USA.

Extracellular ATP as a purinergic signaling molecule, together with ATP receptor, are playing an important role in tumor growth, therapy resistance, and host immunity suppression. Meanwhile ATP is a crucial indicator for cellular energy status and viability, thus a vital variable for tissue regeneration and in vitro tissue engineering. Most recent studies on COVID-19 virus suggest infection caused ATP deficit and release as a major characterization at the early stage of the disease and major causes for disease complications. Read More

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September 2021

PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer.

Clin Exp Med 2021 Sep 23. Epub 2021 Sep 23.

Department of Breast Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.

Pseudopodium-enriched atypical kinase 1 (PEAK1) has been reported to be upregulated in human malignancies and is correlated with a poor prognosis. Enhanced PEAK1 expression facilitates tumor cell survival, invasion, metastasis and chemoresistance. However, the role of PEAK1 in breast cancer is unclear. Read More

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September 2021

Using CT to evaluate mediastinal great vein invasion by thymic epithelial tumors: measurement of the interface between the tumor and neighboring structures.

Eur Radiol 2021 Sep 23. Epub 2021 Sep 23.

Department of Thoracic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

Objectives: For thymic epithelial tumors, simple contact with adjacent structures does not necessarily mean invasion. The purpose of our study was to develop a simple noninvasive technique for evaluating organ invasion using routine pretreatment computed tomography (CT).

Methods: This retrospective study analyzed the pathological reports on 95 mediastinal resections performed between January 2003 and June 2020. Read More

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September 2021

Decreased income, unemployment, and disability after craniotomy for brain tumor removal: a South Korean nationwide cohort study.

Support Care Cancer 2021 Sep 23. Epub 2021 Sep 23.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

Purpose: We aimed to investigate the prevalence of quality-of-life deterioration and associated factors in patients who underwent craniotomies for brain tumor removal. Additionally, we examined whether deteriorating quality of life after surgery might affect mortality.

Methods: As a national population-based cohort study, data were extracted from the National Health Insurance Service database of South Korea. Read More

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September 2021

Adaptation of laser interstitial thermal therapy for tumor ablation under MRI monitoring in a rat orthotopic model of glioblastoma.

Acta Neurochir (Wien) 2021 Sep 23. Epub 2021 Sep 23.

Department of Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI, 48202-2689, USA.

Background: Laser interstitial thermal therapy (LITT) under magnetic resonance imaging (MRI) monitoring is being increasingly used in cytoreductive surgery of recurrent brain tumors and tumors located in eloquent brain areas. The objective of this study was to adapt this technique to an animal glioma model.

Methods: A rat model of U251 glioblastoma (GBM) was employed. Read More

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September 2021