1,261,334 results match your criteria surgery clinical

Lung donation following SARS-CoV-2 infection.

Am J Transplant 2021 Jul 31. Epub 2021 Jul 31.

Division of Thoracic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

There have been over 177 million cases of COVID-19 worldwide, many of whom could be organ donors. Concomitantly, there is an anticipated increase in the need for donor lungs due to expanding indications. Given that the respiratory tract is most commonly affected by COVID-19, there is an urgent need to develop donor assessment criteria while demonstrating safety and "efficacy" of lung donation following COVID-19 infection. Read More

View Article and Full-Text PDF

Transanal approach after preoperative imatinib treatment of a rectal gastrointestinal stromal tumors with external anal sphincter invasion: A case report.

Int J Surg Case Rep 2021 Jul 19;85:106217. Epub 2021 Jul 19.

Department of Surgery, Japan Community Health Care Organization Isahaya General Hospital, Nagasaki, Japan.

Introduction And Importance: Rectal gastrointestinal stromal tumors (GISTs) are rare, and preserving anorectal function can be challenging. We report the case of a patient with rectal GIST with external anal sphincter invasion, treated via the laparoscopic and transanal approaches.

Case Presentation: A 61-year-old man with locally advanced GIST in the right anterolateral wall of the lower rectum was examined. Read More

View Article and Full-Text PDF

Perforated Meckel's diverticulum in omphalocele in a newborn: A case report of an uncommon presentation from northern Tanzania.

Int J Surg Case Rep 2021 Jul 27;85:106246. Epub 2021 Jul 27.

Kilimanjaro Christian Medical University College, Faculty of Medicine, P O Box 2240, Moshi, Tanzania; Department of Pediatrics, Kilimanjaro Christian Medical Centre, P O Box 3010, Moshi, Tanzania.

Introduction And Importance: The concurrent existence of Omphalocele and Meckel's diverticulum is not unheard of but is relatively uncommon. A few cases of their coexistence have been reported. Due to the uncommon dual presentation, it is easy to delay or even miss the diagnosis, delaying management. Read More

View Article and Full-Text PDF

Translation and cross-cultural adaptation of the Clinical Care Classification system.

Int J Med Inform 2021 Jul 16;153:104534. Epub 2021 Jul 16.

Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, Rome 00131, Italy.

Introduction: The Clinical Care Classification (CCC) system is one of the standard nursing terminologies recognized by the American Nurses Association, developed to describe nursing care through electronic documentation in different healthcare settings. The translation of the CCC system into languages other than English is useful to promote its widespread use in different countries and to provide the standard nursing data necessary for interoperable health information exchange. The aim of this study was to translate the CCC system from English to Italian and to test its clinical validity. Read More

View Article and Full-Text PDF

A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma.

Neoplasia 2021 Jul 28;23(9):939-950. Epub 2021 Jul 28.

Department of Clinical Immunology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan; Institute for Biomedical Sciences Molecular Pathophysiology, Iwate Medical University, Yahaba, Iwate, Japan; Division of Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan. Electronic address:

An antibody-drug conjugate (ADC) is a promising therapeutic modality because selective and effective delivery of an anti-cancer drug is achieved by drug-conjugated antibody-targeting cancer antigen. Glypican 1 (GPC1) is highly expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC) and esophageal squamous cell carcinoma (ESCC). Herein, we describe the usefulness of GPC1-targeting ADC. Read More

View Article and Full-Text PDF

Lesser toe deformity classification: A simplified approach with treatment influence.

Foot (Edinb) 2021 May 4;48:101819. Epub 2021 May 4.

Podiatric Medicine and Surgery Residency and Fellowship Program, Director, Department of Orthopedics, University of Louisville, 142 Chenoweth Lane, Louisville, KY, 40207, USA.

Deformities of the lesser toes are one of the most commonly treated conditions by foot and ankle surgeons. Despite their frequency, a standardized classification has yet to take hold among providers. Generic nomenclature with the addition of multiple adjunctive descriptors continues to be the standard leading to international confusion. Read More

View Article and Full-Text PDF

Neurology trial registrations on ClinicalTrials.gov between 2007 and 2018: A cross-sectional analysis of characteristics, early discontinuation, and results reporting.

J Neurol Sci 2021 Jul 14;428:117579. Epub 2021 Jul 14.

Stanford University School of Medicine, Stanford, CA, United States of America.

Background: Increasing neurological disease burden and advancing treatment options require clinical trials to expand the evidence base of clinical care. We aimed to characterize neurology clinical trials registered between October 2007 and April 2018 and identify features associated with early discontinuation and results reporting.

Methods: We compared 16,994 neurology (9. Read More

View Article and Full-Text PDF

Cytogenetic findings of ectopic endometriotic tissue in women with endometriosis and review of the literature.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 22;264:212-218. Epub 2021 Jul 22.

Laboratory of Health Physics, Radiobiology & Cytogenetics, National Center for Scientific Research (NCSR) "Demokritos", Athens, Greece.

Objective: To determine chromosome and gene alterations in ectopic endometrial (EM) tissue which may be implicated in the clinical course or the progression of endometriosis and to review the literature concerning the cytogenetic findings of women with endometriosis.

Study Design: 15 women who underwent laparoscopic endometriosis surgery at the Athens Genesis Clinic were enrolled in the study. Ectopic endometrial tissue was surgically removed and further analyzed by conventional and molecular cytogenetic techniques. Read More

View Article and Full-Text PDF

Endocytosis of peroxiredoxin 1 links sterile inflammation to immunoparalysis in pediatric patients following cardiopulmonary bypass.

Redox Biol 2021 Jul 28;46:102086. Epub 2021 Jul 28.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taiwan; Center of Precision Medicine, College of Medicine, National Taiwan University, Taiwan. Electronic address:

After cardiopulmonary bypass (CPB), the occurrence of systemic inflammatory response is often accompanied by a persistent compensatory anti-inflammatory response syndrome that can lead to a compromised immune competence termed immunoparalysis, rendering the patients susceptible to infections which is a leading complication following cardiac surgery. However, the underlying mechanisms of CPB-elicited immunoparalysis remain obscure. In this study we showed that peroxiredoxin 1 (Prdx1), a putative cytosolic antioxidant, was released immediately after CPB in a cohort of pediatric patients receiving congenital cardiac surgery. Read More

View Article and Full-Text PDF

Are oral lichen planus patients at high risk of hepatitis C? A case-control study.

J Stomatol Oral Maxillofac Surg 2021 Jul 28. Epub 2021 Jul 28.

Department of Oral and Maxillofacial Surgery, University Hospital of Giessen and Marburg, UKGM GmbH, Campus Marburg, Faculty of Medicine, Philipps-University of Marburg, Marburg, Germany.

Objective: To assess the correlation between oral lichen planus (OLP) and viral hepatitis C (HCV).

Methods: This retrospective case-control study included a sample of OLP patients in a 3-year interval. The predictor variable was the presence of OLP (yes/no). Read More

View Article and Full-Text PDF

Long-term outcome after midline lumbar fusion for the treatment of lumbar spine instability due to degenerative disease.

World Neurosurg 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurosurgery, Tomas Bata Regional Hospital, Zlin, Czech Republic (Havlickovo nabrezi 600, 762 75 Zlin). Electronic address:

Background: New surgical techniques have been developed to minimize perioperative damage to paravertebral stabilizing musculotendinous system. Among them, midline lumbar fusion (MIDLF) shows to be a viable option. With data on MIDLF remaining scarce, we assessed its long-term clinical and radiological effects. Read More

View Article and Full-Text PDF

Comparison of Frame-Based Versus Frameless Image-Guided Intracranial Stereotactic Brain Biopsy: A Retrospective Analysis of Safety and Efficacy.

World Neurosurg 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurosurgery, Sheba Medical Center, Ramat Gan, Israel. Electronic address:

Background: A definitive diagnosis of brain lesions not amenable to surgery is mainly made by stereotactic needle biopsy. The diagnostic yield and safety of the frameless vs frame-based image-guided stereotactic techniques is unclear.

Objective: To evaluate the safety and accuracy of frameless vs frame-based stereotactic brain biopsy techniques. Read More

View Article and Full-Text PDF


Clin Res Hepatol Gastroenterol 2021 Jul 28:101767. Epub 2021 Jul 28.

Service d'hépatologie, Hôpital Rangueil, CHU Toulouse, Toulouse.

Compensated advanced chronic liver disease (cACLD) describes the spectrum of advanced fibrosis/cirrhosis in asymptomatic patients at risk of developing clinically significant portal hypertension (CSPH, defined by a hepatic venous pressure gradient (HVPG) ≥10 mmHg). Patients with cACLD are at high risk of liver-related morbidity and mortality. In patients at risk of chronic liver disease, cACLD is strongly suggested by a liver stiffness (LSM) value >15 kPa or clinical/biological/radiological signs of portal hypertension, and ruled out by LSM <10 kPa, or Fibrotest® ≤0. Read More

View Article and Full-Text PDF

Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying epigenetic drugs.

Nanomedicine 2021 Jul 28:102450. Epub 2021 Jul 28.

Department of Surgery, National Cheng Kung University, Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Epigenetic inhibitors have shown anticancer effects. Combination chemotherapy with epigenetic inhibitors has shown high effectiveness in gastric cancer clinical trials, but severe side effect and local progression are the causes of treatment failure. Therefore, we sought to develop an acidity-sensitive drug delivery system to release drugs locally to diminish unfavorable outcome of gastric cancer. Read More

View Article and Full-Text PDF

Extracellular Matrix Remodeling precedes Atrial Fibrillation. Results of the PREDICT-AF trial.

Heart Rhythm 2021 Jul 28. Epub 2021 Jul 28.

Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam, The Netherlands. Electronic address:

Background: To which extent atrial remodeling occurs prior to atrial fibrillation (AF) is unknown.

Objective: The PREDICT-AF study investigated such subclinical remodeling, that may be used for risk stratification and AF prevention.

Methods: Patients (n=150) without a history of AF with a CHADS-VASc score ≥2 at increased risk of developing AF, were included. Read More

View Article and Full-Text PDF

Bone Block Augmentation of the Posterior Glenoid for Recurrent Posterior Shoulder Instability is Associated with High Rates of Clinical Failure: A Systematic Review.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

San Antonio Military Medical Center, San Antonio, Texas.

Purpose: To determine if posterior glenoid bone block augmentation performed for the treatment of recurrent posterior shoulder instability succeeds in restoring stability and is associated with rates of complications and/or clinical failures comparable to other glenoid bone augmentation procedures.

Methods: A comprehensive search of the PubMed, MEDLINE, and EMBASE databases was performed. Level of evidence studies I-IV pertaining to posterior bone block augmentation reporting on outcomes and/or complications were included. Read More

View Article and Full-Text PDF

Anterior Shoulder Instability Part III - Revision Surgery, Rehabilitation and Return to Play, and Clinical Follow-Up - An International Consensus Statement.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Purpose: The purpose of this study was to establish consensus statements via a modified Delphi process on revision surgery, rehabilitation and return to play, and clinical follow-up for anterior shoulder instability.

Methods: A consensus process on the treatment utilizing a modified Delphi technique was conducted, with 65 shoulder surgeons from 14 countries across 5 continents participating. Experts were assigned to one of 9 working groups defined by specific subtopics of interest within anterior shoulder instability. Read More

View Article and Full-Text PDF

Pathology-pain relationships in different osteoarthritis animal model phenotypes: it matters what you measure, when you measure, and how you got there.

Osteoarthritis Cartilage 2021 Jul 28. Epub 2021 Jul 28.

Raymond Purves Bone and Joint Research Laboratory, Kolling Institute, University of Sydney Faculty of Medicine and Health, At Royal North Shore Hospital, Australia. Electronic address:

Objective: To determine whether osteoarthritis (OA) pain characteristics and mechanistic pathways in pre-clinical models are phenotype-specific.

Design: Male 11-week-old C57BL6 mice had unilateral medial-meniscal-destabilization (DMM) or antigen-induced-arthritis (AIA), versus sham-surgery/immunised-controls (Sham/Im-CT). Pain-behaviour (allodynia, mechanical- and thermal-hyperalgesia, hindlimb static weight-bearing, stride-length) and lumbar dorsal-root-ganglia (DRG) gene-expression were measured at baseline, day-3, week-1/-2/-4/-8/-16, and pain-behaviour:gene-expression:joint-pathology associations investigated. Read More

View Article and Full-Text PDF

Characterization of endogenous bile acid composition in individuals with cold-activated brown adipose tissue.

Mol Cell Endocrinol 2021 Jul 28:111403. Epub 2021 Jul 28.

Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address:

Introduction: Bile acid signaling has been suggested to promote BAT activity in various experimental models. However, little is known if and how physiologic bile acid metabolism is linked to BAT function in humans. Here we investigated the association between BAT activity and circulating bile acid concentrations in lean and obese individuals. Read More

View Article and Full-Text PDF

Inkk Trial - Intraoperative ketamine for perioperative pain management following total knee endoprosthetic replacement in oncology: a double-blinded randomized trial.

Braz J Anesthesiol 2021 Jul 28. Epub 2021 Jul 28.

Tata Memorial Hospital and Homi Bhabha National Institute, Department of Physiotherapy, Mumbai, India.

Background: There has been a growing interest in the use of ketamine following orthopedic surgeries. We hypothesized that low dose intravenous ketamine during surgery would help in mobilization following total knee replacement (TKR) in oncology patients as assessed by the timed to up and go (TUG) test at 72 hours post-surgery. Our secondary objectives were to compare the opioid requirement at end of 72 hours, pain scores, satisfaction with pain management, adverse effects, range of joint movement achieved in the post-operative period and the functional recovery at the end of 1 month. Read More

View Article and Full-Text PDF

The relationship between diabetes and surgical site infection following coronary artery bypass graft surgery in current-era models of care.

J Hosp Infect 2021 Jul 28. Epub 2021 Jul 28.

Department of Diabetes and Endocrinology, Royal Melbourne Hospital; Department of Medicine, Royal Melbourne Hospital, University of Melbourne.

Background: Although diabetes is a recognised risk factor for post-operative infections, the seminal Portland Diabetic Project studies in cardiac surgery demonstrated intravenous insulin infusions following open-cardiac surgery achieved near normal glycaemia and decreased deep sternal wound infection to similar rates to those without diabetes.

Aim: We sought to examine a contemporary cohort of patients undergoing coronary artery bypass graft surgery (CABGS) to evaluate the relationship between diabetes, hyperglycaemia and risk of surgical site infection (SSI) in current-era models of care.

Methods: Consecutive patients who underwent CABGS between 2016 and 2018 were identified through a state-wide data repository for healthcare-associated infections. Read More

View Article and Full-Text PDF

Number and Type of Blood Products are Negatively Associated With Outcomes Following Cardiac Surgery.

Ann Thorac Surg 2021 Jul 28. Epub 2021 Jul 28.

Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD.

Background: The association between blood transfusion and adverse outcome is documented in cardiac surgery. However, the incremental significance of each unit transfused, whether red blood cell (RBC) or non-RBC, is uncertain. This study examined the relationship of patient outcomes with type and number of blood product units transfused. Read More

View Article and Full-Text PDF

Hypothermia Promotes Mitochondrial Elongation In Cardiac Cells Via Inhibition Of Drp1.

Cryobiology 2021 Jul 28. Epub 2021 Jul 28.

Cedars-Sinai Smidt Heart Institute, Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Hypothermia is a valuable clinical tool in mitigating against the consequences of ischemia in surgery, stroke, cardiac arrest and organ preservation. Protection is afforded principally by a reduction of metabolism, manifesting as reduced rates of oxygen uptake, preservation of ATP levels, and a curtailing of ischemic calcium overload. The effects of non-ischemic hypothermic stress are relatively unknown. Read More

View Article and Full-Text PDF

Isolated pelvic bone involvement as a presentation of alveolar echinococcosis.

Lancet Infect Dis 2021 Aug;21(8):1192

ECHINO-LIEGE, CHU de Liège, Liège, Belgium; Department of General Internal Medicine and Infectious Diseases, CHU de Liège, Liège, Belgium.

View Article and Full-Text PDF

Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease.

Immunity 2021 Jul 27. Epub 2021 Jul 27.

Gustave Roussy Cancer Campus, Villejuif, France; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.

Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages (MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We integrated 178,651 MNPs from 13 tissues across 41 datasets to generate a MNP single-cell RNA compendium (MNP-VERSE), a publicly available tool to map MNPs and define conserved gene signatures of MNP populations. Next, we generated a MoMac-focused compendium that revealed an array of specialized cell subsets widely distributed across multiple tissues. Read More

View Article and Full-Text PDF

Sialendoscopy: A 4-Year Single Center Experience.

J Oral Maxillofac Surg 2021 Jun 22. Epub 2021 Jun 22.

OMFS IMPATH research group, Faculty of Medicine, Clinical intern, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium; Professor and Chairperson, Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.

Purpose: Sialendoscopy is a relatively new technique designed to diagnose and treat benign obstructive salivary gland disease using a minimally invasive approach. The purpose of this study is to present our experiences regarding the use of sialendoscopy in the form of a 4-year, single center experience and to demonstrate its usefulness in oral and maxillofacial practice.

Methods: We collected data on patients who underwent sialendoscopy at the Oral-Maxillofacial Surgery Department of UZ Leuven between November 2015 and August 2019, including age, gender, sex, initial clinical presentation and symptoms, gland involvement, type of diagnostic investigations, diagnosis, localization of the obstruction, therapeutic intervention, surgeon, type of anesthesia, materials used, complications, secondary treatment, duration of follow-up, and outcome. Read More

View Article and Full-Text PDF

Early diagnosis of fibrotic interstitial lung disease: challenges and opportunities.

Lancet Respir Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Respiratory Medicine, National Reference Coordinating Centre for Rare Pulmonary Diseases, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France; Department of Respiratory Medicine, Université de Lyon, Université Claude Bernard Lyon 1, UMR754, IVPC, Lyon, France.

Many patients with interstitial lung disease (ILD) develop pulmonary fibrosis, which can lead to reduced quality of life and early mortality. Patients with fibrotic ILD often have considerable diagnostic delay, and are exposed to unnecessary and costly diagnostic procedures, and ineffective and potentially harmful treatments. Non-specific and insidious presenting symptoms, along with scarce knowledge of fibrotic ILD among primary care physicians and non-ILD experts, are some of the main causes of diagnostic delay. Read More

View Article and Full-Text PDF

Final 3-year clinical outcomes following transcatheter aortic valve implantation with a supra-annular self-expanding repositionable valve in a real-world setting: Results from the multicenter FORWARD study.

Catheter Cardiovasc Interv 2021 Jul 31. Epub 2021 Jul 31.

Department of Medicine, University of Bonn, Bonn, Germany.

Objectives: The Evolut R FORWARD study confirmed safety and effectivenesss of the Evolut R THV in routine clinical practice out to 1 year. Herein, we report the final 3-year clinical follow up of the FORWARD study.

Background: Transcatheter aortic valve replacement (TAVR) is a proven alternative to surgery in elderly patients with symptomatic severe aortic stenosis. Read More

View Article and Full-Text PDF

Day-by-day blood pressure variability in hospitalized patients with COVID-19.

J Clin Hypertens (Greenwich) 2021 Jul 31. Epub 2021 Jul 31.

The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

In a retrospective analysis, the authors investigated day-by-day blood pressure variability (BPV) and its association with clinical outcomes (critical vs. severe and discharged) in hospitalized patients with COVID-19. The study participants were hospitalized in Tongji Hospital, Guanggu Branch, Wuhan, China, between February 1 and April 1, 2020. Read More

View Article and Full-Text PDF

Bilateral lung transplantation during pregnancy after ECMO for influenza-A caused ARDS.

Am J Transplant 2021 Jul 31. Epub 2021 Jul 31.

Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.

Pregnant women with influenza-A have an increased risk of developing acute respiratory distress syndrome (ARDS). Extracorporeal membrane oxygenation (ECMO) can be used as salvage therapy, with lung transplantation as a therapeutic option. However, successful bilateral lung transplantation during pregnancy has never been reported before. Read More

View Article and Full-Text PDF