10,008 results match your criteria supramolecular assembly

Deep Blue Circularly Polarized Luminescence Response Behavior of an Achiral Pyrene-Based Emitter Regulated by Chiral Co-assembly Helical Nanofibers.

J Phys Chem Lett 2021 Apr 12:3767-3772. Epub 2021 Apr 12.

Key Laboratory of High Performance Polymer Material and Technology of Ministry of Education, Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Supramolecular co-assembly provides a brand-new powerful strategy for regulating simple organic molecules into various hierarchical nano- and microstructures as smart functional materials. In particular, chiral supramolecular assemblies with strong fluorescent emission have received extensive attention for their application as circularly polarized luminescence (CPL) emitters. Herein, we synthesized three achiral pyrene derivatives, but only the chiral co-assembly (-NMe2-Py-2) can exhibit the regular and orderly helical nanofiber via π-π stacking interaction between chiral ,'-dimethyl-binaphthyldiamine enantiomers (-NMe2) and the achiral pyrene derivative (Py-2). Read More

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Chiral Metal Nanoparticle Superlattices Enabled by Porphyrin-Based Supramolecular Structures.

Angew Chem Int Ed Engl 2021 Apr 11. Epub 2021 Apr 11.

Shandong University, School of Chemistry and Chemical Engineering, 27 Shanda Nanlu, 250100, Jinan, CHINA.

Self-assembly is a universal and practical means to create chirality from achiral building blocks. Herein, we show that chiral metal nanoparticle superlattices can be produced through coassembly of achiral metal nanoparticles and porphyrin-based organic molecules. This chirality-transfer from molecules to nanoparticle superstructures across three orders of magnitude in length scale is enabled by the hetero chain-chain van der Waals interactions. Read More

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Supramolecular Copolymerization of Bichromophoric Chiral and Achiral Perylenediimide Dyes.

Front Chem 2021 26;9:652703. Epub 2021 Mar 26.

Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Ikoma, Japan.

Propagation and amplification of chirality are considered to play an important role in the chemical evolution of biological homochirality. Stereochemical communications have been demonstrated to have a significant effect on the formation of chiral hierarchical structures in helical polymers, surface assemblies and supramolecular polymers. The formation of supramolecular copolymers based on chiral and achiral bichromophoric perylenediimide (PDI) dyes having a binaphtyl- and biphenyl-core-bridging unit, respectively, was investigated in terms of chiral amplification and propagation. Read More

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Fragile-Tough Mechanical Reversion of Silk Materials via Tuning Supramolecular Assembly.

ACS Biomater Sci Eng 2021 Apr 9. Epub 2021 Apr 9.

Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States.

Regenerated silk nanofibers are interesting as protein-based material building blocks due to their unique structure and biological origin. Here, a new strategy based on control of supramolecular assembly was developed to regulate interactions among silk nanofibers by changing the solvent, achieving tough mechanical features for silk films. Formic acid was used to replace water related to charge repulsion of silk nanofibers in solution, inducing interactions among the nanofibers. Read More

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Higher-order assemblies in immune signaling: supramolecular complexes and phase separation.

Protein Cell 2021 Apr 9. Epub 2021 Apr 9.

Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, 43210, USA.

Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the functions of immune cells. Higher-order assemblies have recently emerged as a central principle that governs immune signaling and, by extension, cellular communication in general. There are mainly two types of higher-order assemblies: 1) ordered, solid-like large supramolecular complexes formed by stable and rigid protein-protein interactions, and 2) liquid-like phase-separated condensates formed by weaker and more dynamic intermolecular interactions. Read More

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Triple-Modulated Chiral Inversion of Co-Assembly System Based on Alanine Amphiphile and Cyanostilbene Derivative.

ACS Appl Mater Interfaces 2021 Apr 9. Epub 2021 Apr 9.

State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China.

The construction of chiroptical materials with controllable chirality is of special importance in biology and chemistry. Although tunable chirality can be realized in various systems, it remains a fundamental challenge to realize multimodulated chiral inversion. Herein, we report that chiral alanine derivative and fluorescent cyanostilbene derivative co-assemble to prepare supramolecular chiral systems, where twist nanofibers with totally inverted supramolecular chirality and circularly polarized luminescence are obtained through stoichiometric modulation. Read More

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A Self-Assembled Pd(II) Barrel for Binding of Fullerenes and Photosensitization Ability of the Fullerene Encapsulated Barrel.

Angew Chem Int Ed Engl 2021 Apr 8. Epub 2021 Apr 8.

Indian Institute of Science, Inorganic and Physical Chemistry, INDIA.

Fullerene extracts obtained from fullerene shoot lack their real application due to poor solubility in common solvents and difficulty in purification. Their encapsulation in a suitable host is an important approach to address these issues. We present a new Pd 6 barrel ( 1) , which is composed of three 1,4-dihydropyrrolo[3,2-b]pyrrole panels, clipped through six cis -Pd(II) acceptors. Read More

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Supramolecular Template-Directed In Situ Click Chemistry: A Bioinspired Approach to Synthesize G-Quadruplex DNA Ligands.

Org Lett 2021 Apr 8. Epub 2021 Apr 8.

School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.

The assembly of guanosine and boronic acids produces anionic hydrogels (G-B hydrogels) that mimic the topology of the DNA G-quadruplex. We herein demonstrate an unconventional approach of using the G-B hydrogel as a supramolecular template that assembles the irreversible formation of DNA G-quadruplex-selective 1,4-triazole ligands from a pool of alkyne-azide building blocks. These generated ligands could also stabilize and strengthen the gel assembly. Read More

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From Photoinduced Supramolecular Polymerization to Responsive Organogels.

J Am Chem Soc 2021 Apr 8. Epub 2021 Apr 8.

Center for System Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Controlling supramolecular polymerization by external stimuli holds great potential toward the development of responsive soft materials and manipulating self-assembly at the nanoscale. Photochemical switching offers the prospect of regulating the structure and properties of systems in a noninvasive and reversible manner with spatial and temporal control. In addition, this approach will enhance our understanding of supramolecular polymerization mechanisms; however, the control of molecular assembly by light remains challenging. Read More

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Rational Design of Multi-color-emitting Chiral Carbonized Polymer Dots for Full-color and White Circularly Polarized Luminescence.

Angew Chem Int Ed Engl 2021 Apr 8. Epub 2021 Apr 8.

Zhengzhou University, No.100 Science Avenue, Zhengzhou City, Henan Province P.R.China., CHINA.

Light-emitting chiral carbonized polymer dots (Ch-CPDs) are attracting great interest due to their extraordinary photonic properties, but modulating their bandgap emission, especially at long wavelength, and maintaining their chiral structure to achieve multi-color, high-emission Ch-CPDs remains challenging. Here we report for the first time the synthesis of red- and multi-color emitting Ch-CPDs using the common precursors L-/D-tryptophan and o-phenylenediamine and a solvothermal approach at one temperature. The quantum yield of the Ch-CPDs was between 31% and 54%. Read More

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Single-Photon Near Infrared Responsiveness From Molecular to Supramolecular Levels via Platination of Pentacenes.

Angew Chem Int Ed Engl 2021 Apr 7. Epub 2021 Apr 7.

University of Science and Technology of China, Department of Polymer Science and Engineering, 96 Jinzhai Road, 230026, Hefei, CHINA.

Near-infrared (NIR) responsiveness is important for various applications. Currently, single-photon NIR-responsive systems are rare compared to those achieved by two-photon absorption and triplet-triplet annihilation processes. Supramolecular stacking of photo-responsive chromophores results in the decreased efficiency due to the space confining effects. Read More

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Modulating the Molecular Geometry and Solution Self-Assembly of Amphiphilic Polypeptoid Block Copolymers by Side Chain Branching Pattern.

J Am Chem Soc 2021 Apr 6. Epub 2021 Apr 6.

Department of Chemistry and Macromolecular Studies Group, Louisiana State University, Baton Rouge, Louisiana 70803, United States.

Solution self-assembly of coil-crystalline diblock copolypeptoids has attracted increasing attention due to its capability to form hierarchical nanostructures with tailorable morphologies and functionalities. While the N-substituent (or side chain) structures are known to affect the crystallization of polypeptoids, their roles in dictating the hierarchical solution self-assembly of diblock copolypeptoids are not fully understood. Herein, we designed and synthesized two types of diblock copolypeptoids, i. Read More

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Supramolecular Interaction of Molecular Cage and β-Galactosidase: Application in Enzymatic Inhibition, Drug Delivery and Antimicrobial Activity.

Chembiochem 2021 Apr 4. Epub 2021 Apr 4.

Indian Institute of Science, Organic Chemistry, Bangalore, 560094, Bangalore, INDIA.

Enzyme inhibitor plays a crucial role in diagnosis of a wide spectrum of diseases related to bacterial infections. We report here the effect of a water-soluble self-assembled Pd II 8 molecular cage towards β-Galactosidase enzyme activity. The molecular cage is composed of a tetrapyridyl donor ( L ) and cis -[(en)Pd(NO 3 ) 2 ] (en = ethane-1,2-diamine) acceptor and it has a hydrophobic internal cavity. Read More

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Aggregation and Supramolecular Self-Assembly of Low-Energy Red Luminescent Alkynylplatinum(II) Complexes for RNA Detection, Nucleolus Imaging, and RNA Synthesis Inhibitor Screening.

J Am Chem Soc 2021 Apr 4. Epub 2021 Apr 4.

Institute of Molecular Functional Materials, State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China.

As an important nuclear substructure, the nucleolus has received increasing attention because of its significant functions in the transcription and processing of ribosomal RNA in eukaryotic cells. In this work, we introduce a proof-of-concept luminescence assay to detect RNA and to accomplish nucleolus imaging with the use of the supramolecular self-assembly of platinum(II) complexes. Noncovalent interactions between platinum(II) complexes and RNA can be induced by the introduction of a guanidinium group into the complexes, and accordingly, a high RNA affinity can be achieved. Read More

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DNA-Mediated Stack Formation of Nanodiscs.

Molecules 2021 Mar 16;26(6). Epub 2021 Mar 16.

Biophysics Department, Institute of Resource Ecology, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany.

Membrane-scaffolding proteins (MSPs) derived from apolipoprotein A-1 have become a versatile tool in generating nano-sized discoidal membrane mimetics (nanodiscs) for membrane protein research. Recent efforts have aimed at exploiting their controlled lipid protein ratio and size distribution to arrange membrane proteins in regular supramolecular structures for diffraction studies. Thereby, direct membrane protein crystallization, which has remained the limiting factor in structure determination of membrane proteins, would be circumvented. Read More

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Kinked Bisamides as Efficient Supramolecular Foam Cell Nucleating Agents for Low-Density Polystyrene Foams with Homogeneous Microcellular Morphology.

Polymers (Basel) 2021 Mar 30;13(7). Epub 2021 Mar 30.

Macromolecular Chemistry I, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany.

Polystyrene foams have become more and more important owing to their lightweight potential and their insulation properties. Progress in this field is expected to be realized by foams featuring a microcellular morphology. However, large-scale processing of low-density foams with a closed-cell structure and volume expansion ratio of larger than 10, exhibiting a homogenous morphology with a mean cell size of approximately 10 µm, remains challenging. Read More

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Supramolecular Structuring of Hyaluronan-Lactose-Modified Chitosan Matrix: Towards High-Performance Biopolymers with Excellent Biodegradation.

Biomolecules 2021 Mar 5;11(3). Epub 2021 Mar 5.

Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Carbohydrate Science Department, 20133 Milan, Italy.

Non-covalent interactions in supramolecular chemistry provide useful systems to understand biological processes, and self-assembly systems are suitable assets to build-up innovative products for biomedical applications. In this field, polyelectrolyte complexes are interesting, especially when polysaccharides are involved, due to their non-toxicity and bio-absorbability. In this work, we investigated a polyelectrolyte formed by hyaluronic acid (HA), a negatively charged linear polysaccharide, with Chitlac (Ch), a positively charged lactose-modified chitosan. Read More

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Molecular Dynamics Simulations of a Catalytic Multivalent Peptide-Nanoparticle Complex.

Int J Mol Sci 2021 Mar 31;22(7). Epub 2021 Mar 31.

Istituto Nanoscienze, CNR-NANO S3, via G. Campi 213/A, 41125 Modena, Italy.

Molecular modeling of a supramolecular catalytic system is conducted resulting from the assembling between a small peptide and the surface of cationic self-assembled monolayers on gold nanoparticles, through a multiscale iterative approach including atomistic force field development, flexible docking with Brownian Dynamics and µs-long Molecular Dynamics simulations. Self-assembly is a prerequisite for the catalysis, since the catalytic peptides do not display any activity in the absence of the gold nanocluster. Atomistic simulations reveal details of the association dynamics as regulated by defined conformational changes of the peptide due to peptide length and sequence. Read More

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Nanostructure, Self-Assembly, Mechanical Properties, and Antioxidant Activity of a Lupin-Derived Peptide Hydrogel.

Biomedicines 2021 Mar 13;9(3). Epub 2021 Mar 13.

Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.

Naturally occurring food peptides are frequently used in the life sciences due to their beneficial effects through their impact on specific biochemical pathways. Furthermore, they are often leveraged for applications in areas as diverse as bioengineering, medicine, agriculture, and even fashion. However, progress toward understanding their self-assembling properties as functional materials are often hindered by their long aromatic and charged residue-enriched sequences encrypted in the parent protein sequence. Read More

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Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology.

Life (Basel) 2021 Mar 15;11(3). Epub 2021 Mar 15.

Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.

Under aerobic conditions, mitochondrial oxidative phosphorylation (OXPHOS) converts the energy released by nutrient oxidation into ATP, the currency of living organisms. The whole biochemical machinery is hosted by the inner mitochondrial membrane (mtIM) where the protonmotive force built by respiratory complexes, dynamically assembled as super-complexes, allows the FF-ATP synthase to make ATP from ADP + Pi. Recently mitochondria emerged not only as cell powerhouses, but also as signaling hubs by way of reactive oxygen species (ROS) production. Read More

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pH-Responsive Self-Assembly of Designer Aromatic Peptide Amphiphiles and Enzymatic Post-Modification of Assembled Structures.

Int J Mol Sci 2021 Mar 27;22(7). Epub 2021 Mar 27.

Department of Applied Chemistry, School of Engineering, Kyushu University, Fukuoka 819-0395, Japan.

Supramolecular fibrous materials in biological systems play important structural and functional roles, and therefore, there is a growing interest in synthetic materials that mimic such fibrils, especially those bearing enzymatic reactivity. In this study, we investigated the self-assembly and enzymatic post-modification of short aromatic peptide amphiphiles (PAs), Fmoc-LQG ( = 2 or 3), which contain an LQG recognition unit for microbial transglutaminase (MTG). These aromatic PAs self-assemble into fibrous structures via π-π stacking interactions between the Fmoc groups and hydrogen bonds between the peptides. Read More

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Evaluation of a Model Photo-Caged Dehydropeptide as a Stimuli-Responsive Supramolecular Hydrogel.

Nanomaterials (Basel) 2021 Mar 11;11(3). Epub 2021 Mar 11.

Center of Chemistry, University of Minho, 4710-057 Braga, Portugal.

Short peptides capped on the -terminus with aromatic groups are often able to form supramolecular hydrogels, via self-assembly, in aqueous media. The rheological properties of these readily tunable hydrogels resemble those of the extracellular matrix (ECM) and therefore have potential for various biological applications, such as tissue engineering, biosensors, 3D bioprinting, drug delivery systems and wound dressings. We herein report a new photo-responsive supramolecular hydrogel based on a "caged" dehydropeptide (CNB-Phe-ΔPhe-OH ), containing a photo-cleavable carboxy-2-nitrobenzyl (CNB) group. Read More

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Polymer-templated supramolecular co-assemblies of proteins and metal oxide clusters as versatile platform for chemo-enzymatic catalysis.

J Colloid Interface Sci 2021 Mar 19;594:874-881. Epub 2021 Mar 19.

South China Advanced Institute for Soft Matter Science and Technology & State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, PR China. Electronic address:

The hybridization of enzymes and inorganics in controlled manner is challenging, however, critical for the development of chemo-enzymatic cascade catalyst with high efficiency and selectivity. Here, proteins and metal oxide clusters can be facilely co-assembled on the surface of colloid of poly(4-vinylpyridine) (P4VP) via hydrogen bonding, due to their enriched surface hydrogen bonding donors. The co-assembly method can be generally applied for preparing chemo-enzymatic catalyst within the selected database of various proteins and metal oxide clusters while the assembly units retain their structures and activities. Read More

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Elastic-Modulus-Dependent Macroscopic Supramolecular Assembly of Poly(dimethylsiloxane) for Understanding Fast Interfacial Adhesion.

Langmuir 2021 Apr 1;37(14):4276-4283. Epub 2021 Apr 1.

State Key Laboratory of Chemical Resource Engineering & Beijing Laboratory of Biomedical Materials & Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

Macroscopic supramolecular assembly (MSA) is a new concept of supramolecular science with an emphasis on noncovalent interactions between macroscopic building blocks with sizes exceeding 10 μm. Owing to a similar noncovalently interactive nature with the phenomena of bioadhesion, self-healing, etc. and flexible features in tailoring and designing modular building blocks, MSA has been developed as a simplified model to interpret interfacial phenomena and a facile method to fabricate supramolecular materials. Read More

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Collagen Pentablock Copolymers Form Smectic Liquid Crystals as Precursors for Mussel Byssus Fabrication.

ACS Nano 2021 Apr 1. Epub 2021 Apr 1.

Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.

Protein-based biological materials are important role models for the design and fabrication of next generation advanced polymers. Marine mussels ( spp.) fabricate hierarchically structured collagenous fibers known as byssal threads bottom-up supramolecular assembly of fluid protein precursors. Read More

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Molecular Triangles: A New Class of Macrocycles.

Acc Chem Res 2021 Apr 1. Epub 2021 Apr 1.

Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.

ConspectusMacrocycles have had a profound influence on the establishment of supramolecular chemistry because of their abundant molecular recognition and self-assembly characteristics. The design of new macrocyclic receptors that can be tailored by synthesis to display new and exotic properties is an important research objective for chemists and materials scientists. Rigid macrocycles with π-conjugated aromatic units, in contrast with flexible ones, tend to possess large interior and exterior π-surfaces in addition to persistent shapes. Read More

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Surface modification of silica nanoparticles by hexarhenium anionic cluster complexes for pH-sensing and staining of cell nuclei.

J Colloid Interface Sci 2021 Mar 19;594:759-769. Epub 2021 Mar 19.

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov str., 420088 Kazan, Russian Federation.

The surface deposition of luminescent anionic cluster complex [{ReS}(OH)] advantages to the design and synthesis of composite luminescent silica nanoparticles (SNs) for intracellular imaging and sensing, while the encapsulation of the cluster units into SNs lacks for efficient luminescence. The deposition of the Re clusters resulted from their assembly at the silica surface functionalized by amino-groups provides the synthetic route for the composite SNs with bright cluster-centered luminescence invariable in pH range from 4.0 to 12. Read More

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Photoresponsive supramolecular strategy for controlled assembly in light-inert double-chain surfactant system.

J Colloid Interface Sci 2021 Mar 10;594:727-736. Epub 2021 Mar 10.

Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China. Electronic address:

Hypothesis: One of the main advances in double-chain surfactant systems has been their progress from the construction of assemblies to the transformation application in medicine and material science, especially to the drug delivery systems. Thus, it is critical to develop stimuli-responsive assemblies based on double-chain surfactants. We predicted that reversible assembly switching can be achieved by manipulation of the ternary host-guest competitive complexation among β-cyclodextrin (β-CD), surfactants, and designed azobenzene (Azo). Read More

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Structure-based design of novel polyhedral protein nanomaterials.

Curr Opin Microbiol 2021 Mar 27;61:51-57. Epub 2021 Mar 27.

Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, USA. Electronic address:

Organizing matter at the atomic scale is a central goal of nanotechnology. Bottom-up approaches, in which molecular building blocks are programmed to assemble via supramolecular interactions, are a proven and versatile route to new and useful nanomaterials. Although a wide variety of molecules have been used as building blocks, proteins have several intrinsic features that present unique opportunities for designing nanomaterials with sophisticated functions. Read More

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Coordination-Driven Self-Assembly of Cyclometalated Iridium Squares Using Linear Aromatic Diisocyanides.

Inorg Chem 2021 Mar 30. Epub 2021 Mar 30.

Department of Chemistry, University of Houston, 112 Fleming Building, Houston, Texas 77204-5003, United States.

Here, we demonstrate facile [4 + 4] coordination-driven self-assembly of cyclometalated iridium(III) using linear aryldiisocyanide bridging ligands (BLs). A family of nine new [Ir(C^N)(μ-BL)] coordination cages is described, where C^N is the cyclometalating ligand-2-phenylpyridine (ppy), 2-phenylbenzothiazole (bt), or 1-phenylisoquinoline (piq)-and BL is the diisocyanide BL, with varying spacer lengths between the isocyanide binding sites. These supramolecular coordination compounds are prepared via a one-pot synthesis, with isolated yields of 40-83%. Read More

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