257,296 results match your criteria suppression post-synaptic


Clonal osteoblastic cell lines with CRISPR/Cas9-mediated ablation of Pit1 or Pit2 show enhanced mineralization despite reduced osteogenic gene expression.

Bone 2021 Jun 9;151:116036. Epub 2021 Jun 9.

Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Osaka Prefectural Hospital Organization, Izumi, Osaka 594-1101, Japan. Electronic address:

Multiple actions of extracellular Pi on the skeletal cells are likely to be partly mediated by type III sodium/phosphate (Na/Pi) cotransporters Pit1 and Pit2, although the details are not fully understood. In the current study, to determine the roles of Pit1 and Pit2 in osteoblasts, we generated Pit1-knockout (KO) and Pit2-KO osteoblastic cells by applying CRISPR/Cas9 genome editing to an osteoblastic cell line MC3T3-E1 subclone 4. The extracellular Pi level was increased in the Pit1-KO and Pit2-KO clones due to the reduced Pi uptake. Read More

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Anti-seizure activity of African medicinal plants: the identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model.

J Ethnopharmacol 2021 Jun 9:114282. Epub 2021 Jun 9.

Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa, 0001. Electronic address:

Ethnopharmacological Relevance: Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available antiepileptic drugs (AEDs) which are also effective in only two-thirds of the patients. Accordingly, the identification of scaffolds with promising anti-seizure activity remains an important first step towards the development of new anti-epileptic therapies, with improved efficacy and reduced adverse effects. Read More

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Attention modulates repetition effects in a context of low periodicity.

Brain Res 2021 Jun 9:147559. Epub 2021 Jun 9.

Centre National de la Recherche Scientifique (CNRS), Integrative Neuroscience and Cognition Center (INCC), Unité Mixte de Recherche, 8002, 75006 Paris, France; Université de Paris, 75006 Paris, France; Fondation Ophtalmologique Rothschild, Paris, France. Electronic address:

Stimulus repetition can result in a reduction in neural responses (i.e., repetition suppression) in neuroimaging studies. Read More

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FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

No. 1 Department of Orthopedics, The Third People's Hospital, Cixi, China.

Background: Wound healing is an essential physiological process in recovery after microsurgery.

Objectives: To further understand the functions of fibroblast growth factor 21 (FGF21), the roles of this factor were examined and its correlations with inflammation, vascular endothelial growth factor A (VEGFA) and ERK1/2 signaling pathway activation were analyzed.

Material And Methods: Rat brain microvascular endothelial cells (RBMECs) were treated with interleukin (IL)-1β and used for the experiments. Read More

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The B-Natural study-The outcome of immune tolerance induction therapy in patients with severe haemophilia B.

Haemophilia 2021 Jun 12. Epub 2021 Jun 12.

Indiana Haemophilia and Thrombosis Centre, Indianapolis, Indiana, USA.

Introduction: Inhibitors develop less frequently in haemophilia B (HB) than haemophilia A (HA). However, when present, the success of tolerization by immune tolerance induction (ITI) therapy is lower and the risk of complications higher.

Aim: To evaluate the use and outcome of ITI in patients with HB and inhibitors. Read More

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Treg cells in atherosclerosis.

Mol Biol Rep 2021 Jun 12. Epub 2021 Jun 12.

Department of Translational Research, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA.

Atherosclerosis involves both innate and adaptive immunity. Here, we provide an overview of the role of regulatory T (Treg) cells in atherosclerotic diseases. Treg cells and their inhibitory cytokines, IL-10 and TGF-β, have been identified in atherosclerotic lesions and to inhibit progression through lipoprotein metabolism modulation. Read More

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Manipulating the soil microbiomes during a community recovery process with plant beneficial species for the suppression of Fusarium wilt of watermelon.

AMB Express 2021 Jun 12;11(1):87. Epub 2021 Jun 12.

Jiangsu Provincial Key Lab for Solid Organic Waste Utilization, National Engineering Research Center for Organic-Based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Nanjing Agricultural University, Nanjing, 210095, China.

Fusarium wilt is a devastating disease which impacts watermelon production. Soil fumigation using dazomet followed by biological organic fertilizer was applied to suppress the Fusarium wilt disease. We propose that fumigation suppresses the soil indigenous community, especially the soil-borne pathogens, while the utilization of bio-organic fertilizer facilitates the recovery of the soil microbiome to a beneficial, suppressive state through the introduction of plant growth-promoting microorganisms. Read More

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ACTH Stimulation Maximizes the Accuracy of Peripheral Steroid Profiling in Primary Aldosteronism Subtyping.

J Clin Endocrinol Metab 2021 Jun 12. Epub 2021 Jun 12.

Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.

Background: ACTH can contribute to aldosterone excess in primary aldosteronism (PA) via increased melanocortin type 2 receptor expression. Dynamic manipulation of the hypothalamic-pituitary-adrenal axis could assist PA subtyping, but a direct comparison of dynamic tests is lacking.

Methods: We conducted comprehensive dynamic testing in 80 patients: 40 with aldosterone-producing adenoma (APA) and 40 bilateral PA (BPA). Read More

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Naringenin prevents pregnancy-induced hypertension via suppression of JAK/STAT3 signaling pathway in mice.

Int J Clin Pract 2021 Jun 12:e14509. Epub 2021 Jun 12.

Department of Obstetrics, ZiBo Central Hospital, No.54 of Gongqingtuan West Road, Zhangdian District, Zibo, 255000, Shandong, China.

Background: Pregnancy-induced hypertension (PIH) is characterized by high blood pressure during pregnancy, which causes perinatal and maternal mortality. Inflammation, oxidative stress and the JAK2/STAT3 signaling pathway have been reported to play critical roles in the pathogenies of PIH. Due to the safety and side effects of current treatments for PIH, searching for new therapeutic agents is urgently needed. Read More

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Heterogeneous histories of recombination suppression on stickleback sex chromosomes.

Mol Biol Evol 2021 Jun 12. Epub 2021 Jun 12.

Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712.

How consistent are the evolutionary trajectories of sex chromosomes shortly after they form? Insights into the evolution of recombination, differentiation, and degeneration can be provided by comparing closely related species with homologous sex chromosomes. The sex chromosomes of the threespine stickleback (Gasterosteus aculeatus) and its sister species, the Japan Sea stickleback (G. nipponicus), have been well characterized. Read More

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Adipokines, Weight Gain and Metabolic and Inflammatory Markers after Antiretroviral Therapy Initiation: ACTG A5260s.

Clin Infect Dis 2021 Jun 12. Epub 2021 Jun 12.

Case Western Reserve University, Cleveland, Ohio, USA.

Background: The adipokines leptin and adiponectin, produced primarily by adipose tissue, have diverse endocrine and immunologic effects, and circulating levels reflect adipocyte lipid content, local inflammation, and tissue composition. We assessed relationships between changes in regional fat depots, leptin and adiponectin levels, and metabolic and inflammatory markers over 96 weeks in the ACTG A5260s metabolic substudy of the A5257 randomized trial of tenofovir disoproxil fumarate-emtricitabine plus atazanavir-ritonavir, darunavir-ritonavir, or raltegravir among treatment-naïve persons with HIV (PWH).

Methods: Fat depots were measured using dual-energy absorptiometry and abdominal CT imaging at treatment initiation and 96 weeks later. Read More

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Immune correlates of therapy outcomes in women with cervical cancer treated with chemoradiotherapy: A systematic review.

Cancer Med 2021 Jun 12. Epub 2021 Jun 12.

Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Immune markers have been correlated with prognosis in a variety of solid tumors, including cervical cancer.

Objective: To review the literature on hematologic and immune markers and their association with recurrence and survival among patients with cervical cancer treated with chemoradiation.

Evidence Review: This systematic review was conducted in accordance with PRISMA guidelines via searches of Ovid MEDLINE, Ovid Embase, and the Cochrane Library using keywords regarding cervical cancer, immune markers, and HIV. Read More

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Suppression of lncRNA HOXA11-AS/miR-124 Axis Inhibits Glioma Progression.

Cell Biochem Biophys 2021 Jun 11. Epub 2021 Jun 11.

Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Our aim was to clarify the regulations of lncRNA HOXA11-AS (HOXA11-AS) played on the progression of glioma as well as to investigate the mechanisms by which HOXA11-AS modulated development of glioma. This study confirmed the regulations of miR-124 and HOXA11-AS on the progression of glioma. Here, HOXA11-AS was overexpressed and miR-124 was underexpressed in glioma. Read More

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Effects of stereopsis on vection, presence and cybersickness in head-mounted display (HMD) virtual reality.

Sci Rep 2021 Jun 11;11(1):12373. Epub 2021 Jun 11.

School of Optometry and Vision Science, University of New South Wales (UNSW Sydney), Kensington, Australia.

Stereopsis provides critical information for the spatial visual perception of object form and motion. We used virtual reality as a tool to understand the role of global stereopsis in the visual perception of self-motion and spatial presence using virtual environments experienced through head-mounted displays (HMDs). Participants viewed radially expanding optic flow simulating different speeds of self-motion in depth, which generated the illusion of self-motion in depth (i. Read More

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Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.

Cell Death Dis 2021 Jun 11;12(6):606. Epub 2021 Jun 11.

Division of Trauma and Surgical Intensive Care Unit, Research Institute of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, Jiangsu, P. R. China.

Increased neutrophil extracellular traps (NETs) formation has been found to be associated with intestinal inflammation, and it has been reported that NETs may drive the progression of gut dysregulation in sepsis. However, the biological function and regulation of NETs in sepsis-induced intestinal barrier dysfunction are not yet fully understood. First, we found that both circulating biomarkers of NETs and local NETs infiltration in the intestine were significantly increased and had positive correlations with markers of enterocyte injury in abdominal sepsis patients. Read More

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Ritonavir concentrations in hair predict virologic outcomes in HIV-infected adolescents with virologic failure on atazanavir/ritonavir-based second-line treatment.

J Acquir Immune Defic Syndr 2021 Jun 8. Epub 2021 Jun 8.

Department of Clinical Pharmacology, University of Zimbabwe; Department of Paediatrics, University of Zimbabwe; Department of Community Medicine, University of Zimbabwe; Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco; Department of Medicine, Division of Infectious Diseases, Stanford University and Department of Medicine, Division of Pulmonary and Critical Care, University of California San Francisco.

Background: Sub-optimal adherence to antiretroviral therapy (ART) is responsible for most virologic failure among adolescents with HIV. Methods for objectively measuring adherence to ART are limited. This study assessed the association between ritonavir concentrations in hair, self-reported adherence and modified directly administered antiretroviral therapy on virologic outcomes among HIV-infected adolescents who were virologically failing second-line ART in Harare, Zimbabwe. Read More

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Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis.

J Pharmacol Sci 2021 Aug 1;146(4):216-225. Epub 2021 May 1.

Department of Pediatrics, Shanghai 9th People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200011, PR China. Electronic address:

We aim to explore the effects of emodin and its mechanisms on renal fibrosis (RF). We firstly modeled adriamycin-induced rat RF with unilateral nephrectomy. In vivo and in vitro pharmacological experiments were performed in this study. Read More

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Inhibition of the Ras/ERK1/2 pathway contributes to the protective effect of ginsenoside Re against intimal hyperplasia.

Food Funct 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Neointimal hyperplasia is the major cause of carotid stenosis after vascular injury, which restricts the long-term efficacy of endovascular treatment and endarterectomy in preventing stenosis. Ginsenoside Re (Re) is a major active ingredient of ginseng having multifaceted pharmacological effects on the cardiovascular system, and is a potential treatment for restenosis. In this study, we demonstrated that Re treatment significantly inhibited vascular injury-induced neointimal thickening, reduced the intimal area and intima/media (I/M) ratio, increased the lumen area, and inhibited pro-inflammatory cytokines. Read More

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Adjuvant endocrine therapy for premenopausal women with breast cancer: Patient adherence and physician prescribing practices in Mexico.

Breast 2021 Jun 1;59:8-15. Epub 2021 Jun 1.

Departamento de Tumores Mamarios e Investigacion, Instituto Nacional de Cancerologia, San Fernando 22, Belisario Dominguez Secc 16, Tlalpan, Mexico City, 14080, Mexico.

Background: In resource-constrained settings, data regarding breast cancer patients' adherence to endocrine therapy (ET) and physicians' prescribing practices is limited. This study aims to decrease this knowledge gap in a real-world clinical practice.

Methods: Premenopausal women with stage 0-III hormone-sensitive breast cancer and receiving adjuvant ET during the past 1-5 years were identified in three Mexican referral centers. Read More

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Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo.

Eur J Med Chem 2021 May 30;222:113562. Epub 2021 May 30.

Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, 1206, Geneva, Switzerland; School of Biomedicine, Far Eastern Federal University, 690922, Vladivostok, Russia. Electronic address:

Triple-negative breast cancer (TNBC) is a cancer subtype critically dependent upon excessive activation of Wnt pathway. The anti-mycobacterial drug clofazimine is an efficient inhibitor of canonical Wnt signaling in TNBC, reducing tumor cell proliferation in vitro and in animal models. These properties make clofazimine a candidate to become first targeted therapy against TNBC. Read More

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Medial olivary complex reflex in term newborns with hyperbilirubinemia.

Int J Pediatr Otorhinolaryngol 2021 May 21;147:110777. Epub 2021 May 21.

Dept. of Otolaryngology, Faculty of Medicine, Baskent University, Ankara, Turkey.

Objective: This study aimed to compare the integrity of the efferent auditory pathways of newborns that had high hyperbilirubinemia levels and required treatment due to these and healthy newborns.

Methods: Term-born (37 weeks or later) infants that were brought to the Newborn Polyclinic of the Başkent University Hospital were included in the study. The study included a total of 84 infants including healthy newborns (n = 42) and those that had jaundice and were receiving phototherapy (n = 42). Read More

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Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b.

J Sport Health Sci 2021 Jun 8. Epub 2021 Jun 8.

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China; Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China. Electronic address:

Background: Exercise is beneficial for muscle atrophy. Peroxisome proliferator-activated receptor gamma (PPARγ) and microRNA-29b (miR-29b) have been reported to be responsible for angiotensin Ⅱ (AngⅡ)-induced muscle atrophy. However, it is unclear whether exercise can protect AngⅡ-induced muscle atrophy by targeting PPARγ/miR-29b. Read More

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The Novel FAT4 Activator Jujuboside A Suppresses NSCLC Tumorigenesis by Activating HIPPO Signaling and Inhibiting YAP Nuclear Translocation.

Pharmacol Res 2021 Jun 8:105723. Epub 2021 Jun 8.

Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China; State Key Laboratory of Quality Research in Chinese Medicine/ Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China. Electronic address:

FAT atypical cadherin 4 (FAT4) has been identified as a tumor suppressor in lung cancers. However, no agent for lung cancer treatment targeting FAT4 has been used in the clinic. Jujuboside A (JUA) is a major active compound in Semen Ziziphi Spinosae. Read More

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A tailored telehealth group tobacco cessation treatment program for people with HIV: Study protocol for a randomized controlled trial.

Contemp Clin Trials 2021 Jun 8:106475. Epub 2021 Jun 8.

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, United States of America. Electronic address:

Background: Smoking-related illnesses are the leading cause of death among people with HIV (PWH). Yet, there are few effective evidence-based interventions that help PWH quit smoking. The group-based program Positively Smoke Free is a biobehavioral cessation intervention for PWH with a growing evidence base. Read More

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Neuroendocrine regulation of pubertal suppression in the naked mole-rat: what we know and what comes next.

Mol Cell Endocrinol 2021 Jun 8:111360. Epub 2021 Jun 8.

Department of Cell and Systems Biology, University of Toronto; Department of Psychology, University of Toronto Mississauga; Department of Ecology and Evolutionary Biology, University of Toronto.

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Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress.

Eur J Pharmacol 2021 Jun 8:174247. Epub 2021 Jun 8.

Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar; Biomedical and Pharmaceutical Research Unit (BPRU), QU Health, Qatar University, P.O. Box 2713, Doha, Qatar; Office of Vice President for Research and Graduate Studies, Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address:

Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to endothelial dysfunction, a hallmark of cardiovascular diseases, in close interplay with oxidative stress. Recently, Sestrin2 (SESN2) emerged as a novel stress-inducible protein protecting cells from oxidative stress. We investigated here, for the first time, the impact of SESN2 suppression on oxidative stress and cell survival in human endothelial cells subjected to pharmacologically (thapsigargin)-induced ER stress and studied the underlying cellular pathways. Read More

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Tim-4 cavity-resident macrophages impair anti-tumor CD8 T cell immunity.

Cancer Cell 2021 May 29. Epub 2021 May 29.

Departments of Surgery and Pathology, Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI, USA.

Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer; however, the majority of patients do not respond to ICB therapy. We show that metastatic disease in the pleural and peritoneal cavities is associated with poor clinical outcomes after ICB therapy. Cavity-resident macrophages express high levels of Tim-4, a receptor for phosphatidylserine (PS), and this is associated with reduced numbers of CD8 T cells with tumor-reactive features in pleural effusions and peritoneal ascites from patients with cancer. Read More

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Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis and ERK activation.

FEBS Open Bio 2021 Jun 11. Epub 2021 Jun 11.

Department of Emergency, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

ATP-sensitive potassium channels (KATPs) have protective effects in ischemia-reperfusion-induced injuries and can be activated by levosimendan. This study investigated the effects of levosimendan on renal injury, inflammation, apoptosis and survival in a rat model of acute kidney injury (AKI) following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Rats underwent a 5-minute asphyxia-based CA and resuscitation. Read More

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Impact of the apelin/APJ axis in the pathogenesis of Parkinson's disease with therapeutic potential.

J Neurosci Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

The pathogenesis of Parkinson's disease (PD) remains elusive. There is still no available disease-modifying strategy against PD, whose management is mainly symptomatic. A growing amount of preclinical evidence shows that a complex interplay between autophagy dysregulation, mitochondrial impairment, endoplasmic reticulum stress, oxidative stress, and excessive neuroinflammation underlies PD pathogenesis. Read More

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Reaching UNAIDS 95-95-95 targets worldwide: predicted benefits and treatment costs with generic manufacture.

AIDS 2021 Jun 9. Epub 2021 Jun 9.

Burnet Institute, 85 Commercial Road, Melbourne, 3004 VIC, Australia Accident and Emergency Medicine, Homerton Row, Clapton, London, E9 6SR, UK Department of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, UK.

Background: UNAIDS aims for HIV testing, treatment and viral suppression rates to be 95%-95%-95% by 2025. Patented drug prices remain a barrier to HIV treatment. Generic alternatives are being produced and exported from countries without patent barriers at a fraction of the cost. Read More

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