Chem Biol Interact 2020 Jan 24;315:108874. Epub 2019 Oct 24.
Department of Anatomy, Chonbuk National University Medical School, Jeonju, 54907, Republic of Korea; Institute for Medical Sciences, Chonbuk National University, Jeonju, 54907, Republic of Korea; Research Institute of Clinical Medicine of Chonbuk National University, Jeonju, 54907, Republic of Korea; Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea. Electronic address:
Allergic rhinitis (AR) is a type I hypersensitivity immune response and is a common chronic allergic respiratory disorder characterized by one or more nasal symptoms. Despite many studies on AR therapy, the drugs of treatment for AR remain limited in effect. In the present study, we aimed to elucidate the effects of saikosaponin A (SSA) on nasal inflammation, T helper (Th)2 and Th17 cytokines, retinoic acid-related orphan nuclear receptor (ROR)-γt, signal transducer and activator of transcription (STAT)3, and nuclear factor (NF)-κB signalings in ovalbumin (OVA)-induced AR mice model. Read More