27 results match your criteria suppressing sneeze

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Higenamine alleviates allergic rhinitis by activating AKT1 and suppressing the EGFR/JAK2/c-JUN signaling.

Phytomedicine 2021 Jun 20;86:153565. Epub 2021 Apr 20.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Guangzhou Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou 510515, China; Guangdong Provincial Engineering Laboratory of Chinese Medicine Preparation Technology, Guangzhou 510515, China. Electronic address:

Background: Allergic rhinitis (AR) is an inflammatory, immunoglobulin E (IgE)-mediated disease characterized by the typical symptoms of sneezing, rhinorrhea, nasal itching, and congestion. Higenamine (HG) is a plant-based alkaloid, possesses a wide range of activities, including vascular and tracheal relaxation, antioxidative, antiapoptotic, anti-inflammatory, and immunomodulatory activities. So far, the effect and the underlying mechanism of HG on AR have not been studied. Read More

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miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses.

Mol Med Rep 2021 01 12;23(1). Epub 2020 Nov 12.

Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

The present study aimed to investigate whether microRNA (miR)‑31 exerted therapeutic potential in allergic rhinitis (AR) and to explore its underlying mechanism. Firstly, the expression levels of miR‑31 were detected by reverse transcription‑quantitative PCR in the nasal mucosa of patients and mice. Subsequently, an ovalbumin (OVA)‑induced animal model of AR was constructed. Read More

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January 2021

A Rapid Advice Guideline for the Prevention of Novel Coronavirus Through Nutritional Intervention.

Curr Nutr Rep 2020 09;9(3):119-128

Department of Nutrition Biology, School of Interdisciplinary and Applied Life Sciences, Central University of Haryana, Mahendragarh, Haryana, 123031, India.

Purpose Of Review: An unexpected and sudden outbreak of a novel infection known as a coronavirus (COVID-19) has imposed important problems to global well-being and economy. Based upon current researches, this virus is spreading from one human to another through respiratory droplets, i.e. Read More

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September 2020

Saikosaponin A ameliorates nasal inflammation by suppressing IL-6/ROR-γt/STAT3/IL-17/NF-κB pathway in OVA-induced allergic rhinitis.

Chem Biol Interact 2020 Jan 24;315:108874. Epub 2019 Oct 24.

Department of Anatomy, Chonbuk National University Medical School, Jeonju, 54907, Republic of Korea; Institute for Medical Sciences, Chonbuk National University, Jeonju, 54907, Republic of Korea; Research Institute of Clinical Medicine of Chonbuk National University, Jeonju, 54907, Republic of Korea; Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea. Electronic address:

Allergic rhinitis (AR) is a type I hypersensitivity immune response and is a common chronic allergic respiratory disorder characterized by one or more nasal symptoms. Despite many studies on AR therapy, the drugs of treatment for AR remain limited in effect. In the present study, we aimed to elucidate the effects of saikosaponin A (SSA) on nasal inflammation, T helper (Th)2 and Th17 cytokines, retinoic acid-related orphan nuclear receptor (ROR)-γt, signal transducer and activator of transcription (STAT)3, and nuclear factor (NF)-κB signalings in ovalbumin (OVA)-induced AR mice model. Read More

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January 2020

Comparative Study between the Efficacy of Fentanyl, Antihistamines, and Dexmedetomidine in Suppressing Photic Sneeze Reflex during Peribulbar Block.

Anesth Essays Res 2019 Jan-Mar;13(1):40-43

Department of Anesthesia, Fayoum University, Faiyum, Egypt.

Background: The photic sneeze reflex (autosomal dominant) is a condition that causes sneezing in response to numerous stimuli, such as looking at bright lights or periocular (surrounding the eyeball) injection. Unexpected or sudden sneezing during injection can be a dangerous side effect in periocular injection, in which abrupt head movement may cause globe injury.

Aims: We intended to evaluate the efficacy of adding fentanyl, dexmedetomidine, and antihistamines on the incidence of the sneeze reflex associated with propofol sedation during periocular local anesthesia injections. Read More

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Therapeutic effect of topical administration of red onion extract in a murine model of allergic rhinitis.

Sci Rep 2019 02 27;9(1):2883. Epub 2019 Feb 27.

Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

The aim of this study was to evaluate the effect of topical administration of onion (Allium cepa) extract on nasal cavity for treatment of allergic rhinitis (AR). BALB/c mice were sensitized by intraperitoneal injection of ovalbumin (OVA) and challenged with intranasal instillation of OVA with or without onion extracts for five times a week on 3 consecutive weeks. Allergic symptom score according to frequencies of sneezing, serum total and OVA specific immunoglobulin E (IgE) level, cytokine levels of nasal mucosa and eosinophilic infiltration were analyzed. Read More

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February 2019

The protective role of Piper nigrum fruit extract in an ovalbumin-induced allergic rhinitis by targeting of NFκBp65 and STAT3 signalings.

Biomed Pharmacother 2019 Jan 26;109:1915-1923. Epub 2018 Nov 26.

Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea; Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 54896, Republic of Korea. Electronic address:

Piper nigrum L. is commonly used as a traditional medicine and food in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. Read More

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January 2019

Effect of Royal Jelly and Brazilian Green Propolis on the Signaling for Histamine H Receptor and Interleukin-9 Gene Expressions Responsible for the Pathogenesis of the Allergic Rhinitis.

Biol Pharm Bull 2018 ;41(9):1440-1447

Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School.

The significant correlation between nasal symptom scores and level of histamine H receptor (H1R) mRNA in nasal mucosa was observed in patients with pollinosis, suggesting that H1R gene is an allergic disease sensitive gene. We demonstrated that H1R and interleukin (IL)-9 gene are the allergic rhinitis (AR)-sensitive genes and protein kinase Cδ (PKCδ) signaling and nuclear factor of activated T-cells (NFAT) signaling are involved in their expressions, respectively. Honey bee products have been used to treat allergic diseases. Read More

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November 2018

Effects of 1,25-dihydroxyvitamin D3 in an ovalbumin-induced allergic rhinitis model.

Int Immunopharmacol 2017 Jun 13;47:182-189. Epub 2017 Apr 13.

Department of Otorhinolaryngology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.

IL-17-producing Th17 cells play an important role in allergic airway diseases, but their local expression and regulation in allergic rhinitis (AR) is not well understood. This study investigated the effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)D) on T-bet expression, Th1 cells, Th2 cells, Th17 cells and IL-33-positive epithelial cells in AR. C57BL/6 mice were intranasally sensitized and challenged with ovalbumin (OVA), and 1,25-(OH)D was intraperitoneally injected into AR mice. Read More

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Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress.

J Inflamm (Lond) 2017 13;14. Epub 2017 Jan 13.

Department of Otolaryngology, Tongji Hospital, Tongji University, 389 Xincun road, Putuo District, Shanghai, 200065 China.

Background: It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute to elevating oxidative stress. Hydrogen, emerging as a novel antioxidant, has been proven effective in selectively reducing ROS in animals models of oxidative damage. We herein aim to verify protective effects of hydrogen on eosinophils cells in guinea pigs models of AR. Read More

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January 2017

[Analysis on Influencing Factors of Acupoint Injection of Drugs for Improving Allergic Rhinitis in Rats].

Zhen Ci Yan Jiu 2016 Jun;41(3):220-4

Clinical Medical College of Guizhou Medical University, Guiyang 550004, China.

Objective: To observe the therapeutic effect of acupoint injection of mixture solution of lidocaine, dexa-methasone (DX) and transfer factor on symptoms and serum histamine contents in allergic rhinitis (AR) rats, so as to differentiate the role of acupoint stimulation or drug factor influencing the therapeutic effect.

Methods: SD rats were randomized into normal (=8), model, non-acupoint-drug injection, acupoint-drug injection and acupoint-saline injection groups (=11 in each group). The AR model was established by intraperitoneal injection of suspension of ovalbumin (0. Read More

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Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats.

J Pharmacol Sci 2016 Apr 11;130(4):212-8. Epub 2016 Feb 11.

Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto, Tokushima 770-8503, Japan.

Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of nasal symptoms. Here, we show that antihistamine suppressed upregulation of histidine decarboxylase (HDC) mRNA expression in patients with pollinosis, and its expression level was correlated with that of H1R mRNA. Read More

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Computer simulations of pressure and velocity fields in a human upper airway during sneezing.

Comput Biol Med 2016 Apr 2;71:115-27. Epub 2016 Feb 2.

Aeronautical & Mechanical Engineering Department, Clarkson University, Potsdam, NY, USA.

In this paper, the airflow field including the velocity, pressure and turbulence intensity distributions during sneezing of a female subject was simulated using a computational fluid dynamics model of realistic upper airways including both oral and nasal cavities. The effects of variation of reaction of the subject during sneezing were also investigated. That is, the impacts of holding the nose or closing the mouth during sneezing on the pressure and velocity distributions were studied. Read More

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Intranasal exposure to monoclonal antibody Fab fragments to Japanese cedar pollen Cry j1 suppresses Japanese cedar pollen-induced allergic rhinitis.

Br J Pharmacol 2016 05 6;173(10):1629-38. Epub 2016 Apr 6.

Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Japan.

Background And Purpose: Fab fragments (Fabs) of antibodies have the ability to bind to specific allergens but lack the Fc portion that exerts effector functions via binding to receptors including FcεR1 on mast cells. In the present study, we investigated whether intranasal administration of the effector function-lacking Fabs of a monoclonal antibody IgG1 (mAb, P1-8) to the major allergen Cry j1 of Japanese cedar pollen (JCP) suppressed JCP-induced allergic rhinitis in mice.

Experimental Approach: Balb/c mice sensitized with JCP on days 0 and 14 were challenged intranasally with the pollen on days 28, 29, 30 and 35. Read More

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Role of adrenocorticotropic hormone in the modulation of pollinosis induced by pollen antigens.

Neuroimmunomodulation 2015 10;22(4):256-62. Epub 2014 Dec 10.

Department of Physiology, Osaka City University Medical School, Suzuka, Japan.

Background: A mild restraint stressor suppressed an increase in the levels of Th2-dependent cytokines and IgE, thereby reducing the symptoms of pollinosis. In the present study, to clarify the mechanism of action of adrenocorticotropic hormone (ACTH) in improving the symptoms of pollinosis, we studied the effects of ACTH on the plasma level of histamine, mast cell number in nasal-associated lymphoid tissue (NALT) and the T cell differentiation in splenocytes.

Methods: The role of ACTH in the development of pollen antigen-induced pollinosis was studied in mice. Read More

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Ca2+ -activated K+ channel-3.1 blocker TRAM-34 alleviates murine allergic rhinitis.

Int Immunopharmacol 2014 Dec;23(2):642-8

The precise pathogenesis of allergic rhinitis (AR) remains unclear and AR is less easily cured. Recent evidence has suggested that calcium-activated K+ channel-3.1(KCa3. Read More

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December 2014

Short-term beneficial effect of aspirin in patient with chronic rhinosinusitis and tolerant to acetylsalicylic acid.

Iran J Allergy Asthma Immunol 2013 Aug 28;12(4):400-3. Epub 2013 Aug 28.

Department of Immunulogy and Allergology, GATA Haydarpasa Training Hospital, Istanbul, Turkey.

It is well known that desensitization treatment with aspirin can significantly improve symptoms and quality of life in patient with aspirin-exacerbated respiratory disease. However, its mechanism has not been clearly understood yet. In this case report, 41-year-old male patient was referred to our allergy and immunology department with complaints of chronic rhinosinusitis including postnasal discharge, sneezing, facial pain/pressure, waking up tired, nasal obstruction, smell loss for a long time. Read More

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Naloxone blocks suppression of cough by codeine in anesthetized rabbits.

Adv Exp Med Biol 2013 ;756:65-71

Department of Medical Biophysics, Comenius University in Bratislava, Martin, Slovakia.

Opioid receptors which are involved in cough generation are abundantly expressed in the brainstem. Codeine is a potent μ-opioid receptor agonist. In the present study we examined the effects of naloxone, a μ-opioid receptor antagonist, on mechanically-induced tracheobronchial cough and on the cough suppressing effect of codeine in six pentobarbitone anesthetized spontaneously breathing rabbits. Read More

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December 2012

The assessment of the optimal duration of early intervention with montelukast in the treatment of Japanese cedar pollinosis symptoms induced in an artificial exposure chamber.

J Drug Assess 2012 9;1(1):40-7. Epub 2012 Oct 9.

Department of Otolaryngology, Nippon Medical School, TokyoJapan.

Objective: The study objective was to investigate the prophylactic efficacy of montelukast (MLK) 10 mg in suppressing seasonal allergic rhinitis (SAR) symptoms induced by Japanese cedar (JC) pollen and to determine how many days before exposure to JC in the artificial exposure chamber (OHIO chamber) would be optimal to start administration.

Methods: This was a single-institution, double-blind, randomized placebo-controlled four-group parallel inter-group comparison study. Adult volunteers with JC pollinosis were divided into four groups: an MLK 7-day administration group (n = 27), an MLK 3-day administration group (n = 27), an MLK 1-day administration group (n = 26), and a placebo group (n = 26). Read More

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Preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H₁ receptor mRNA in the nasal mucosa of patients with pollinosis.

Methods Find Exp Clin Pharmacol 2010 Dec;32(10):745-8

Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.

Administration of antihistamines 2-4 weeks before the pollen season showed a greater inhibitory effect on nasal allergy symptoms in patients with seasonal allergic rhinitis. However, the mechanism of slow-onset effects of preseasonal treatment with antihistamines remains unclear. Here, we investigated the effect of preseasonal prophylactic treatment with antihistamines on nasal symptoms and the expression of histamine H₁ receptor (H1R) mRNA of the nasal mucosa in patients with cedar pollen pollinosis. Read More

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December 2010

Efficacy of fentanyl or alfentanil in suppressing reflex sneezing after propofol sedation and periocular injection.

Ophthalmic Plast Reconstr Surg 2008 Nov-Dec;24(6):465-7

Department of Ophthalmology, University of California, Irvine, California 92697, USA.

Purpose: A sneeze reflex may occur after propofol sedation and during periocular injections. Unexpected movement from sneezing can result in needle injury to the globe or optic nerve, or hematoma. We investigate the efficacy of concomitant fentanyl or alfentanil in reducing sneezing following propofol and during periocular injections. Read More

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Airborne infectious disease and the suppression of pulmonary bioaerosols.

Drug Discov Today 2006 Jan;11(1-2):51-7

Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

The current understanding of airborne pathogen spread in relation to the new methods of suppressing exhaled bioaerosols using safe surface-active materials, such as isotonic saline, is reviewed here. We discuss the physics of bioaerosol generation in the lungs, what is currently known about the relationship between expired bioaerosols and airborne infectious disease and current methods of airborne infectious disease containment. We conclude by reviewing recent experiments that suggest the delivery of isotonic saline can significantly diminish exhaled aerosol--generated from airway lining fluid in the course of natural breathing. Read More

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January 2006

Evaluation of a bedtime dose of a combination antihistamine/analgesic/decongestant product on antigen challenge the next morning.

Laryngoscope 1992 Mar;102(3):330-4

Department of Medicine (Division of Clinical Immunology), Johns Hopkins University School of Medicine, Baltimore, Md.

The effects of CAAD (diphenhydramine hydrochloride, 50 mg; pseudoephedrine hydrochloride, 60 mg; acetaminophen, 1 g in 10% ethanol) were evaluated in a double-blind, three-way, placebo-controlled, cross-over study on 18 volunteers with allergic rhinitis. The number of sneezes following nasal challenge with antigen was significantly reduced after a bed-time dose of CAAD (P less than .005) and a single dose of diphenhydramine (P less than . Read More

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In vivo and in vitro effects of antihistamines on mast cell mediator release: a potentially important property in the treatment of allergic disease.

Ann Allergy 1989 Nov;63(5):465-9

Department of Medicine, Division of Clinical Immunology, Hopkins University School of Medicine, Baltimore, Maryland.

A nasal antigen challenge model of allergic individuals was used to evaluate whether antihistamines could inhibit human mast cell and basophil mediator release in vivo. In placebo-controlled trials, topically applied azatadine base, a tricyclic antihistamine with in vitro antirelease action, effectively reduced symptoms and mediator levels in nasal lavage fluids after antigen challenge, suggesting mast cell inhibition. Both terfenadine and cetirizine, systemically administered antihistamines, were clinically effective in reducing sneezing and changes in vascular permeability. Read More

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November 1989

Medical management of noninfectious rhinitis.

Am J Hosp Pharm 1980 Nov;37(11):1496-1504

Noninfectious rhinitis and the clinical pharmacology of drugs used in its treatment, including specific treatment recommendations, are reviewed. Characterized by hyperreactivity of the nasal mucosa to a variety of stimuli, noninfectious rhinitis can be classified either as seasonal or perennial allergic rhinitis (when antigens can be identified) or as vasomotor or nonallergic rhinitis (when antigens are not identifiable). However, noninfectious rhinitis is probably better viewed as a continuum between these extremes rather than as definitive categories. Read More

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November 1980

Suppression of seasonal allergic rhinitis symptoms with daily hydroxyzine.

J Allergy Clin Immunol 1979 Feb;63(2):129-33

The effectiveness of hydroxyzine in the suppression of allergic rhinitis symptoms was evaluated using a double-blind, parallel study design during the 1977 ragweed season. Forty-three subjects with positive ragweed skin tests and a history of an exacerbation of symptoms during August and September of the previous two years were randomly assigned to receive either hydroxyzine or placebo. Subjects scored the severity and duration of symptoms in a daily diary and adverse effects were evaluated from a structured interview at two-week intervals. Read More

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February 1979
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