171,781 results match your criteria suppressed cell


ethanol crude extract from sequential maceration induces lipid accumulation and inflammatory suppression in RAW264.7 macrophages.

Food Funct 2021 Sep 27. Epub 2021 Sep 27.

Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

(AP), an edible mushroom, is continuously being studied due to the medicinal properties. In this study, AP crude extracts from three sequential extraction, starting from hexane (APH), ethanol (APE) and water (APW), were examined for their anti-inflammatory activity and lipid accumulation property in macrophages. APE treatment was found to increase lipid droplet accumulation in both RAW264. Read More

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September 2021

Arsenic (III) induces oxidative stress and inflammation in the gills of common carp, which is ameliorated by zinc (II).

J Inorg Biochem 2021 Sep 20;225:111617. Epub 2021 Sep 20.

College of wildlife and protected area, Northeast Forestry University, Harbin 150040, Heilongjiang, PR China. Electronic address:

Arsenic (As) is widely present in the environment in form of arsenite (As) and arsenate (As). Oxidative stress and inflammation are believed to be the dominant mechanisms of As toxicity in vivo and in vitro. The aim of this study was to investigate whether zinc (Zn) alleviates exogenous gill toxicity in carp induced by As and to gain insight into the underlying mechanisms. Read More

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September 2021

Mechanistic toxicity assessment of fine particulate matter emitted from fuel combustion via pathway-based approaches in human cells.

Sci Total Environ 2021 Sep 10;806(Pt 1):150214. Epub 2021 Sep 10.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China; Fudan Tyndall Center, Department of Environmental Science & Engineering, Fudan University, Shanghai 200438, China.

Fuel exhaust particulate matter (FEPM) is an important source of air pollution worldwide. However, the comparative and mechanistic toxicity of FEPMs emitted from combustion of different fuels is still not fully understood. This study employed pathway-based approaches via human cells to evaluate mechanistic toxicity of FEPMs. Read More

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September 2021

DL-3-n-butylphthalide suppressed autophagy and promoted angiogenesis in rats with vascular dementia by activating the Shh/Ptch1 signaling pathway.

Neurosci Lett 2021 Sep 24:136266. Epub 2021 Sep 24.

Department of Neurology, Hebei General Hospital, Shijiazhuang, China. Electronic address:

DL-3-n-butylphthalide (NBP) has neuroprotective effect on chronic cerebral hypoperfusion animals. Here, we explored the role and underlying mechanism of NBP on autophagy and angiogenesis in rats with vascular dementia (VD). Adult male Sprague-Dawley (SD) rats were subjected to permanent bilateral occlusion of the common carotid arteries (2VO) to establish VD model. Read More

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September 2021

EZH2 inhibitor enhances the STING agonist-induced antitumor immunity in melanoma.

J Invest Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing 100142, China. Electronic address:

STING agonists are a new class of drugs for cancer immunotherapy that activate both innate and adaptive antitumor immunity. Recently, multiple clinical trials of STING agonists have been conducted in hematological malignancies and solid tumors. However, STING is commonly suppressed in melanoma via mechanisms that remain unclear. Read More

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September 2021

Selective autophagic receptor NbNBR1 prevents NbRFP1-mediated UPS-dependent degradation of βC1 to promote geminivirus infection.

PLoS Pathog 2021 Sep 27;17(9):e1009956. Epub 2021 Sep 27.

State Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou, Zhejiang, China.

Autophagy is an evolutionarily conserved, lysosomal/vacuolar degradation mechanism that targets cell organelles and macromolecules. Autophagy and autophagy-related genes have been studied for their antiviral and pro-viral roles in virus-infected plants. Here, we demonstrate the pro-viral role of a selective autophagic receptor NbNBR1 in geminivirus-infected Nicotiana benthamiana plants. Read More

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September 2021

mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation.

RNA Biol 2021 Sep 27:1-11. Epub 2021 Sep 27.

College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.

5-Methylcytosine (mC) is a type of RNA modification that exists in tRNAs and rRNAs and was recently found in mRNA. Although mRNA mC modification has been reported to regulate diverse biological process, its function in adipogenesis remains unknown. Here, we demonstrated that knockdown of NOL1/NOP2/Sun domain family member 2 (NSUN2), a mC methyltransferase, increased lipid accumulation of 3T3-L1 preadipocytes through accelerating cell cycle progression during mitotic clonal expansion (MCE) at the early stage of adipogenesis. Read More

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September 2021

Propofol Suppresses Cell Proliferation in Gastric Cancer Cells through NRF2-mediated Polyol Pathway.

Clin Exp Pharmacol Physiol 2021 Sep 27. Epub 2021 Sep 27.

Department of Anesthesia, Zhuhai Center for Maternal and Child Health Care, Zhuhai, 519000, China.

Propofol, a widely used short-acting intravenous sedative agent, is gradually gained attention due to the tumor-suppressing role and non-anesthetic effect. dysfunction of metabolic reprogramming has been recognized as a well-documented factor for tumor progression. The aim of this study is to explore the effect of propofol on polyol pathway in gastric cancer cells. Read More

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September 2021

Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms.

Eur Heart J 2021 Sep 27. Epub 2021 Sep 27.

Program of Kidney and Cardiovascular Diseases, the Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan 2 Rd, Guangzhou 510080, China.

Aims: Our previous study demonstrated that Ca2+ influx through the Orai1 store-operated Ca2+ channel in macrophages contributes to foam cell formation and atherosclerosis via the calcineurin-ASK1 pathway, not the classical calcineurin-nuclear factor of activated T-cell (NFAT) pathway. Moreover, up-regulation of NFATc3 in macrophages inhibits foam cell formation, suggesting that macrophage NFATc3 is a negative regulator of atherogenesis. Hence, this study investigated the precise role of macrophage NFATc3 in atherogenesis. Read More

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September 2021

Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy.

Drug Deliv 2021 Dec;28(1):2033-2043

Department of Liver Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.

Triptolide (TPL) is a diterpenoid triepoxide with broad antitumor efficacy, while lack of mechanism of action, severe systemic toxicity, and poor water solubility of TPL limited its usage. To unveil the mechanism of action and improve the pharmaceutical properties of TPL, here we explored the molecular mechanism of TPL and then fabricated TPL-loaded membrane protein-chimeric liposomes ([email protected]) and tested its anticancer efficacy against hepatocellular carcinoma (HCC). CCK8 assay, colony formation assay, EdU assay, and flow cytometry were used to examine the activity of TPL. Read More

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December 2021

Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL).

Bioengineered 2021 Dec;12(1):7314-7324

Department of Neonatology, Affiliated Longhua People's Hospital, Southern Medical University (Longhua People's Hospital), Shenzhen, China.

The G protein-coupled receptor-17 (GPR17) plays an important role in regulating the differentiation of oligodendrocytes and remyelination, which is a key negative regulator of oligodendrocyte differentiation. The present study aimed to investigate the function of GPR17 in the white matter of periventricular leukomalacia (PVL) neonatal rats. The PVL model was established in 2-day old neonatal rats by intracerebral injection of LPS (1 mg/kg). Read More

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December 2021

Integrated Analysis of DNA methylation and transcriptome profile to identify key features of age-related macular degeneration.

Bioengineered 2021 Dec;12(1):7061-7078

Aier School of Ophthalmology, Central South University, Changsha, China.

Age-related macular degeneration (AMD) is a common vision-threatening disease. The current study sought to integrate DNA methylation with transcriptome profile to explore key features in AMD. Gene expression data were obtained from the Gene Expression Omnibus (GEO, accession ID: GSE135092) and DNA methylation data were obtained from the ArrayExpress repository (E-MTAB-7183). Read More

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December 2021

SHP2 inhibition attenuates osteoarthritis by maintaining homeostasis of cartilage metabolism via the DOK1/UPP1/uridine cascade.

Arthritis Rheumatol 2021 Sep 27. Epub 2021 Sep 27.

State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Life Sciences, Nanjing University, 163 Xianlin Avenue, 210023, Jiangsu, China.

Objective: Protein tyrosine kinases (PTKs) regulate osteoarthritis (OA) progression by activating a series of signal transduction pathways. However, the roles of protein tyrosine phosphatases (PTPs) in OA remain obscure.

Methods: The expression of 107 PTP genes in human OA cartilage was analyzed based on a single-cell sequencing dataset. Read More

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September 2021

Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stress.

FASEB J 2021 Oct;35(10):e21883

Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.

Organism scale mechanical forces elicit cellular scale changes through coordinated regulation of multiple signaling pathways. The mechanisms by which cells integrate signaling to generate a unified biological response remains a major question in mechanobiology. For example, the mechanosensitive response of bone and other tissues requires coordinated signaling by the transforming growth factor beta (TGFβ) and Wnt pathways through mechanisms that are not well-defined. Read More

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October 2021

A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress.

EMBO J 2021 Sep 27:e108439. Epub 2021 Sep 27.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

Upon replication stress, budding yeast checkpoint kinase Mec1 triggers the downregulation of transcription, thereby reducing the level of RNA polymerase (RNAP) on chromatin to facilitate replication fork progression. Here, we identify a hydroxyurea-induced phosphorylation site on Mec1, Mec1-S1991, that contributes to the eviction of RNAPII and RNAPIII during replication stress. The expression of the non-phosphorylatable mec1-S1991A mutant reduces replication fork progression genome-wide and compromises survival on hydroxyurea. Read More

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September 2021

Overexpression of ICAT Inhibits the Progression of Colorectal Cancer by Binding with β-Catenin in the Cytoplasm.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211041253

26469Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Inhibitor of β-catenin and T-cell factor (ICAT) was first found as a polypeptide that blocks β-catenin-TCF interaction. Abundant evidence has shown that ICAT has different functions in diverse cancers' progression. Nevertheless, the roles it plays in colorectal cancer (CRC) have not been described. Read More

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September 2021

Pyroglutamate Aminopeptidase I Promotes Hepatocellular Carcinoma via IL-6/STAT3 Activation as Revealed by a Specific Biosensor.

Anal Chem 2021 Sep 27. Epub 2021 Sep 27.

Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China.

As a global health challenge, hepatocellular carcinoma (HCC) is strongly associated with chronic inflammation. Targeting inflammation, particularly inflammatory factors, is regarded as an important strategy for HCC diagnosis and treatment. Pyroglutamic aminopeptidase I (PGP-I), a common exopeptidase, was recently identified as a novel inflammatory cytokine in cells. Read More

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September 2021

Mitochondrion-Anchored Photosensitizer with Near Infrared-I Aggregation-Induced Emission for Near Infrared-II Two-Photon Photodynamic Therapy.

Adv Healthc Mater 2021 Sep 26:e2101056. Epub 2021 Sep 26.

National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China.

Two-photon photodynamic therapy (2P-PDT) that employs photosensitizers (PSs) with 2P absorption is particularly intriguing in cancer treatment, in that 2P excitation enables precise spatial localization and deep tissue penetration. Here, a donor-π-acceptor PS (named TPBPy) with near infrared (NIR) aggregation-induced emission (AIE) is designed and synthesized for imaging-guided 2P-PDT. The maximal photoluminescence (PL) peak of TPBPy is as high as 720 nm when it is encapsulated in liposomes. Read More

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September 2021

Regulatory role and mechanisms of myeloid TLR4 in anti-GBM glomerulonephritis.

Cell Mol Life Sci 2021 Sep 27. Epub 2021 Sep 27.

Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, People's Republic of China.

Myeloid cells and TLR4 play a critical role in acute kidney injury. This study investigated the regulatory role and mechanisms of myeloid TLR4 in experimental anti-glomerular basement membrane (GBM) glomerulonephritis (GN). Anti-GBM GN was induced in tlr4 and tlr4 mice by intravenous injection of the sheep anti-mouse GBM antibody. Read More

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September 2021

Polarized M2 macrophages induced by mechanical stretching modulate bone regeneration of the craniofacial suture for midfacial hypoplasia treatment.

Cell Tissue Res 2021 Sep 27. Epub 2021 Sep 27.

Department of Plastic Surgery, Peking University Third Hospital, Beijing, 100191, China.

The underlying mechanism of the trans-sutural distraction osteogenesis (TSDO) technique as an effective treatment that improves the symptoms of midfacial hypoplasia syndromes is not clearly understood. Increasing findings in the orthopedics field indicate that macrophages are mechanically sensitive and their phenotypes can respond to mechanical cues. However, how macrophages respond to mechanical stretching and consequently influence osteoblast differentiation of suture-derived stem cells (SuSCs) remains unclear, particularly during the TSDO process. Read More

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September 2021

Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition.

Front Mol Biosci 2021 10;8:720370. Epub 2021 Sep 10.

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.

Despite considerable efforts to improve treatment modalities for cholangiocarcinoma, a common form of malignant tumor, its long-term survival rate remains poor. Hydroxychloroquine (HCQ) is a 4-aminoquinoline derivative antimalarial drug that has antimalarial and autophagy inhibition effects and exhibits comprehensive therapeutic effects on various cancers. In this study, we aimed to explore the anticancer potential and the underlying molecular mechanism of HCQ in cholangiocarcinoma treatment and . Read More

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September 2021

Platelet-Rich Plasma Induces Autophagy and Promotes Regeneration in Human Dental Pulp Cells.

Front Bioeng Biotechnol 2021 8;9:659742. Epub 2021 Sep 8.

Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Regenerative endodontic procedures using autologous platelet-rich plasma (PRP) can improve the biologic outcome of treatment. However, its mechanism of action on improving pulp regeneration is not fully elucidated. Autophagy was recently shown to be related to tissue repair and osteogenesis. Read More

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September 2021

Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism Activating SP1/Caveolin-1 Signaling.

Front Oncol 2021 8;11:745584. Epub 2021 Sep 8.

Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Breast cancer remains the most common malignancy and the leading causality of cancer-associated mortality among women worldwide. With proven efficacy, has been extensively applied in breast cancer treatment in Traditional Chinese Medicine (TCM) for thousands of years. However, the bioactive compounds of accounting for its anti-breast cancer activity and the underlying biological mechanisms remain to be uncovered. Read More

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September 2021

SLC25A21 Suppresses Cell Growth in Bladder Cancer an Oxidative Stress-Mediated Mechanism.

Front Oncol 2021 9;11:682710. Epub 2021 Sep 9.

Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Bladder cancer (BCa) is a commonly diagnosed malignancy worldwide that has poor survival depending on its intrinsic biologic aggressiveness and a peculiar radio- and chemoresistance features. Gaining a better understanding of tumorigenesis and developing new diagnosis and treatment strategies for BCa is important for improving BCa clinical outcome. SLC25 family member 21 (SLC25A21), a carrier transporting C5-C7 oxodicarboxylates, has been reported to contribute to oxoadipate acidemia. Read More

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September 2021

Combined Scutellarin and CHNO Imperils the Survival of Glioma: Partly Associated With the Repression of PSEN1/PI3K-AKT Signaling Axis.

Front Oncol 2021 9;11:663262. Epub 2021 Sep 9.

Institute of Neurological Disease, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.

Glioma, the most common intracranial tumor, harbors great harm. Since the treatment for it has reached the bottleneck stage, the development of new drugs becomes a trend. Therefore, we focus on the effect of scutellarin (SCU) and its combination with CHNO (abbreviated as ) on glioma and its possible mechanism in this study. Read More

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September 2021

Sodium-glucose cotransporter 2 inhibitor canagliflozin attenuates lung cancer cell proliferation in vitro.

Diabetol Int 2021 Oct 16;12(4):389-398. Epub 2021 Feb 16.

Department of General Thoracic, Breast and Pediatric Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180 Japan.

Cancer is a major cause of death in patients with type 2 diabetes mellitus (T2DM) and lung cancer is one of the most prevalent cancers in patients with T2DM. In the present study, we examined the anti-cancer effect of the Sodium-glucose cotransporter 2 (SGLT2) inhibitor, canagliflozin, using a lung cancer model. In lung cancer tissues from non-T2DM human subjects, SGLT2 was detected by immunohistochemistry. Read More

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October 2021

A Comprehensive Review of Trichosporon spp.: An Invasive and Emerging Fungus.

Cureus 2021 Aug 21;13(8):e17345. Epub 2021 Aug 21.

Clinical Microbiology, Government Medical College & Hospital, Chandigarh, Chandigarh, IND.

species are basidiomycetous yeast-like organisms found ubiquitous in nature. They are increasingly been recognized as opportunistic pathogens capable of causing life-threatening invasive diseases (trichosporonosis), especially in immuno-suppressed patients and rarely in immuno-competent patients too. Earlier multiple members of the genus were clubbed together as but after the advent of molecular techniques, more than 50 different subspecies and around 16 different strains causing human diseases are reported. Read More

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Protease Inhibitor-Dependent Inhibition of Light-Induced Stomatal Opening.

Front Plant Sci 2021 10;12:735328. Epub 2021 Sep 10.

Graduate School of Science, Nagoya University, Nagoya, Japan.

Stomata in the epidermis of plants play essential roles in the regulation of photosynthesis and transpiration. Stomata open in response to blue light (BL) by phosphorylation-dependent activation of the plasma membrane (PM) H-ATPase in guard cells. Under water stress, the plant hormone abscisic acid (ABA) promotes stomatal closure the ABA-signaling pathway to reduce water loss. Read More

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September 2021

The Interplay Among HIV, LINE-1, and the Interferon Signaling System.

Front Immunol 2021 9;12:732775. Epub 2021 Sep 9.

Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, China.

Human immunodeficiency viruses (HIVs) are retroviruses that replicate effectively in human CD4 cells and cause the development of acquired immune deficiency syndrome (AIDS). On the other hand, type 1 long interspersed elements (LINE-1s or L1s) are the only active retroelements that can replicate autonomously in human cells. They, along with other active yet nonautonomous retroelements, have been associated with autoimmune diseases. Read More

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September 2021

Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NF-κB/NLRP3 Pathway.

Front Immunol 2021 10;12:719574. Epub 2021 Sep 10.

Henan Key Laboratory of Digestive Organ Transplantation, Open and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou Key Laboratory of Hepatobiliary and Pancreatic Diseases and Organ Transplantation, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Oridonin (Ori), the main bioactive ingredient of the natural anti-inflammatory herb , could be a covalent inhibitor of the NLRP3 inflammasome. Solid organ transplantation provides a life-saving optional therapy for patients with end-stage organ dysfunction. The long-term survival of solid organ transplantation remains restricted because of the possibility of rejection and the toxicity, infection, cardiovascular disease, and malignancy related to immunosuppressive (IS) drugs. Read More

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September 2021