4,298 results match your criteria supportive culture

How organizational culture influences holistic review: a qualitative multiple case study.

Adv Health Sci Educ Theory Pract 2021 Jun 12. Epub 2021 Jun 12.

Edson College of Nursing and Health Innovation, Arizona State University, Downtown Phoenix Campus, Phoenix, AZ, USA.

Studies primarily involving single health professions programs suggest that holistic review in admissions can increase underrepresented minority (URM) representation among admitted students. However, data showing little improvement in the overall proportion of URMs in many health professions, despite widespread use of holistic review, suggest that relatively few programs using holistic review admit substantial proportions of underrepresented minorities. Therefore, more research is needed to understand factors that facilitate holistic review practices that successfully promote diverse student enrollment. Read More

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Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis.

Nat Commun 2021 06 10;12(1):3516. Epub 2021 Jun 10.

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

Profiling studies have revealed considerable phenotypic heterogeneity in cancer-associated fibroblasts (CAFs) present within the tumour microenvironment, however, functional characterisation of different CAF subsets is hampered by the lack of specific markers defining these populations. Here we show that genetic deletion of the Endo180 (MRC2) receptor, predominantly expressed by a population of matrix-remodelling CAFs, profoundly limits tumour growth and metastasis; effects that can be recapitulated in 3D co-culture assays. This impairment results from a CAF-intrinsic contractility defect and reduced CAF viability, which coupled with the lack of phenotype in the normal mouse, demonstrates that upregulated Endo180 expression by a specific, potentially targetable CAF subset is required to generate a supportive tumour microenvironment. Read More

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Effect of low tongue pressure on nutritional status and improvement of swallowing function in sarcopenic dysphagia.

Nutrition 2021 Apr 28;90:111295. Epub 2021 Apr 28.

Department of Health Sciences, Faculty of Human Culture and Science, Prefectural University of Hiroshima, Hiroshima, Japan.

Objectives: This study aimed to evaluate the effect of low tongue pressure on the improvement of swallowing function in people with sarcopenic dysphagia and ongoing dysphagia or physical rehabilitation. In addition, we investigated whether sarcopenic dysphagia at admission was associated with severity of malnutrition.

Methods: This was a prospective cohort study of 146 people with sarcopenic dysphagia (mean age 84. Read More

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Adoptive cell therapy using tumor-infiltrating lymphocytes for melanoma refractory to immune-checkpoint inhibitors.

Cancer Sci 2021 Jun 7. Epub 2021 Jun 7.

Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

To evaluate the feasibility of adoptive cell therapy (ACT) using ex vivo-expanded tumor-infiltrating lymphocytes (TILs) in Japanese patients with melanoma who failed immune-checkpoint inhibitor therapy, an open-label, single arm, pilot study was conducted. We investigated the immunological and genetic factors of the pretreatment tumor and expanded TILs that may be associated with the clinical response. The treatment protocol comprised preparation of TIL culture, lympho-depleting non-myeloablative preconditioning with cyclophosphamide and fludarabine, TIL infusion, and intravenous administration of low-dose IL-2. Read More

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Reversal of 'the dying' diagnosis.

BMJ Case Rep 2021 Jun 7;14(6). Epub 2021 Jun 7.

Macmillan Palliative Care Unit, Northern General Hospital, Sheffield, UK.

A 75-year-old woman was admitted with sepsis and treated with broad-spectrum antibiotics until examination of her lower limbs noted necrotising wounds. Surgical intervention was advised by the plastic surgeons; however, she was deemed unsuitable for intensive care. She underwent incision and drainage of the necrotic area and biopsies were taken. Read More

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WNT5A from the fetal liver vascular niche supports human fetal liver hematopoiesis.

Stem Cell Res Ther 2021 Jun 5;12(1):321. Epub 2021 Jun 5.

Department of Bioengineering, University of Washington, Seattle, WA, USA.

The human fetal liver is a critical organ for prenatal hematopoiesis, the study of which offers insights into niche signals that regulate the fates of hematopoietic stem and progenitor cells (HSPCs) during fetal development. Here, we demonstrate that human fetal liver endothelium uniquely supports the maturation and expansion of multilineage HSPCs. Specifically, co-culture of fetal liver-derived immature CD43CD45 hematopoietic cells with human fetal liver endothelial cells (ECs) led to a profound increase in the numbers of phenotypic CD45CD34 HSPCs and multilineage colony-forming progenitors generated in vitro, when compared to co-culture with ECs derived from other organs. Read More

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Cultural competency and sensitivity in the curriculum for palliative care professionals: a survey in Switzerland.

BMC Med Educ 2021 Jun 4;21(1):318. Epub 2021 Jun 4.

Liaison Psychiatry Service, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.

Background: Cultural and linguistic diversity in patients and their relatives represents a challenge for clinical practice in palliative care around the world. Cross-cultural training for palliative care professionals is still scarce, and research can help determine and support the implementation of appropriate training. In Switzerland, health policies address diversity and equity issues, and there is a need for educational research on cross-cultural training in palliative care. Read More

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The Compliance of End-of-life Care Preferences Among Older Adults and Its Facilitators and Barriers: A Scoping Review.

J Am Med Dir Assoc 2021 Jun 1. Epub 2021 Jun 1.

School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Objectives: To explore the compliance of end-of-life (EOL) care preferences, and the facilitators and barriers of promoting quality of EOL care among older adults.

Design: A scoping review was used to identify key themes in the compliance of EOL care preferences among older adults.

Setting And Participants: Studies published between 2009 and 2020 were identified from the Medline and Cochrane libraries. Read More

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Understanding Children's Independent Mobility Through the Lens of Universal Design: A Case of Delhi, India.

Stud Health Technol Inform 2021 Jun;282:361-373

Department of Architecture & Planning, Indian Institute of Technology Roorkee, India.

Children's independent mobility (CIM) is associated with improved physical activity and social competence among children. Despite such benefits, there is a worldwide decline in overall CIM levels, owing to the multi-factors of the insufficient supportive built environment, traffic and negative parental perception. This paper attempts to make a unique case of relooking children's everyday mobility experiences by adopting a universal design (UD) approach. Read More

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The Investigation of Physical Design, Executives' Attitude and Policy Towards Service Efficiency Based on Universal Design Principles; A Case Study of Naresuan University Hospital.

Stud Health Technol Inform 2021 Jun;282:273-287

Faculty of Medicine, Naresuan University, THAILAND.

Public hospitals should be designed to clover as wider inclusivity levels as possible forproviding access for all. Unfortunately, and for a variety of reasons, a quality service is not always provided. When evaluation of the service quality in healthcare organizations is carried out, it is mostly conducted in terms of medical service quality, whilst the physical layout, functionality and facilitating devices are not given as much scrutiny. Read More

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Cross-cultural validation and psychometric testing of the supportive supervisory scale in Spanish.

Int J Older People Nurs 2021 Jun 3:e12381. Epub 2021 Jun 3.

Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada.

Background: Supervisory effectiveness in long-term care facilities has been identified a key factor in staff satisfaction and quality of care. Determining its utility in Spanish speaking countries will assist with understanding different cultural and health service contexts.

Objectives: To develop and psychometrically test the Supervisory Support Scale in Spanish. Read More

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Promoting healthy foods among urban school children in Bangladesh: a qualitative inquiry of the challenges and opportunities.

BMC Public Health 2021 Jun 1;21(1):1029. Epub 2021 Jun 1.

Universal Health Coverage, Health Systems and Population Studies Division (HSPSD), International Centre for Diarrhoeal Disease Research, Bangladesh, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh.

Background: In Bangladesh overweight and obesity among urban school children are on the rise. Urban school children tend to consume foods dense in calories and few fruits and vegetables which is associated with overweight and obesity. The current study explored the barriers and opportunities for promoting healthy diets among school children from the perspective of teachers and parents in Dhaka, Bangladesh. Read More

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A Virus-Like Particle-Based Vaccine Candidate against the Tick-Borne Powassan Virus Induces Neutralizing Antibodies in a Mouse Model.

Pathogens 2021 May 31;10(6). Epub 2021 May 31.

American Type Culture Collection (ATCC®), ATCC Federal Solutions, 10801 University Boulevard, Manassas, VA 20110, USA.

Powassan virus (POWV) is a tick-borne flavivirus circulating in North America and the Russian Far East that can cause severe neuroinvasive diseases, including encephalitis, meningitis, and meningoencephalitis. The reported neuroinvasive case fatality is about 10%, and approximately 50% of the survivors from the neuroinfection exhibit long-lasting or permanent neurological sequelae. Currently, treatment of POWV infection is supportive, and no FDA-approved vaccines or specific therapeutics are available. Read More

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Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice.

Biomolecules 2021 May 29;11(6). Epub 2021 May 29.

Section of Experimental Virology, Institute of Medical Microbiology, Center for Molecular Biomedicine (CMB), Jena University Hospital, Hans-Knoell-Str. 2, D-07745 Jena, Germany.

Influenza virus (IV) infections are considered to cause severe diseases of the respiratory tract. Beyond mild symptoms, the infection can lead to respiratory distress syndrome and multiple organ failure. Occurrence of resistant seasonal and pandemic strains against the currently licensed antiviral medications points to the urgent need for new and amply available anti-influenza drugs. Read More

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The Organizational Atmosphere in Israeli Hospital during COVID-19: Concerns, Perceptions, and Burnout.

Int J Environ Res Public Health 2021 May 22;18(11). Epub 2021 May 22.

Department of Public Health, Ashkelon Academic College, Ashkelon 78211, Israel.

The COVID-19 crisis poses challenges to healthcare systems and requires micro- and macro-organizational adaptations. This study examined the organizational atmosphere in Israeli hospitals by evaluating workers' perceptions and concerns about the COVID-19 crisis and its management. At the end of the pandemic's first wave in Israel, 547 healthcare workers responded to an online survey, which inquired about COVID-19 concerns at the individual and family level, perceptions at the national and organizational level, perceptions of the way the crisis was managed, self-assessment of coping with the crisis and burnout, and demographics. Read More

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Status and consolidated list of threatened medicinal plants of India.

Genet Resour Crop Evol 2021 May 25:1-29. Epub 2021 May 25.

Tissue Culture and Cryopreservation Unit, ICAR-National Bureau of Plant Genetic Resources (NBPGR), Pusa Campus, New Delhi, 110012 India.

A wide array of medicinal plants in India, primarily used by locals for health care, have found wide acceptance and adoption globally (either directly or processed) due to distinct advantages of good results, low or no side-effects and ease of access to general public. Indigenous and traditional systems of medicine in practice since historical times have shown potential (direct or indirect as immune-boosters) against many dreaded ailments including the recent global pandemic of COVID-19. With prediction of sixth mass extinction, there is worldwide concern as majority of these plants, collected from natural stands, are also facing threat of extinction. Read More

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Nurse Managers' Perception of Governance among Korean Nurses.

Sujin Choi

J Nurs Manag 2021 May 30. Epub 2021 May 30.

College of Nursing, Woosuk University.

Aim: This study aims to ascertain nurse managers' perception of nurses' governance and explore their perception of facilitating and hindering factors of shared governance.

Background: Shared governance has been introduced in nursing as a plan to improve nursing service quality. There is limited understanding about how governance is implemented. Read More

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β-estradiol promotes the growth of primary human fetal spermatogonial stem cells via the induction of stem cell factor in Sertoli cells.

J Assist Reprod Genet 2021 May 28. Epub 2021 May 28.

Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, 410078, China.

Background: Mammalian spermatogenesis is responsible for male fertility and is supported by the self-renewal and differentiation of spermatogonial stem cells (SSCs). Sertoli cells provide a supportive microenvironment for SSCs, in part by the production of stem cell factor (SCF), which is a potent regulator of spermatogonia proliferation and survival.

Methods: We investigated the novel role of β-estradiol in modulating the proliferation and apoptosis of fetal SSCs via the regulation of SCF secretion in Sertoli cells isolated from human fetal testes. Read More

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5-hydroxymethyl-2-furaldehyde impairs Candida albicans - Staphylococcus epidermidis interaction in co-culture by suppressing crucial supportive virulence traits.

Microb Pathog 2021 May 25;158:104990. Epub 2021 May 25.

Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, 630 003, Tamil Nadu, India. Electronic address:

Polymicrobial biofilms involving fungal-bacterial interactions are stated to modulate host immune response and exhibit enhanced antibiotic resistance. In this milieu, clinically important opportunistic pathogens Candida albicans and Staphylococcus epidermidis associate synergistically and instigate implant and blood stream infections. Impediment of virulence traits that support successive pathogenic lifestyle and inter-kingdom interactions without altering the microbial growth represents an attractive alternate strategy. Read More

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Culture, cognisance, capacity and capability: The interrelationship of individual and organisational factors in developing a research hospital.

J Clin Nurs 2021 May 27. Epub 2021 May 27.

Centre for Outcomes and Experience Research in Children's Health, Illness and Disability (ORCHID) Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Aim: To share our experience of implementing a programme of interventions aimed at building research capacity and capability of nurses and allied health professionals in a specialist children's hospital.

Background: Clinicians at the forefront of care are well positioned to lead on research to improve outcomes and experiences of patients but some professional groups continue to be underrepresented. Inequities persist alongside robust national infrastructures to support Clinical Academic Careers for non-medical health professionals, further highlighting the need to address local infrastructure and leadership to successfully build research capacity. Read More

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A novel form of anti-angiogenic molecular antibody drug induces apoptosis in myeloma cells after cultivation upon endothelial feeder cells.

Leuk Res 2021 May 15;108:106617. Epub 2021 May 15.

Department of Medical Biochemistry, Faculty of Medicine, Çukurova University, Adana, Turkey. Electronic address:

The present study aimed to investigate the ability of a novel form of the anti-angiogenic molecular antibody drug to induce Myeloma cell death after cultivation upon endothelial feeder cells. Bevacizumab-loaded chitosan (BCS) nanoparticles (NPs) were prepared by the ionic gelation method. Human U266 cell line and human umbilical vein endothelial cells were co-cultured for 72 h and treated with BCS nanoparticles (10μM) to study their impact on inhibition of cell growth and induction of apoptosis. Read More

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Disabled in academia: to be or not to be, that is the question.

Trends Neurosci 2021 May 11. Epub 2021 May 11.

Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.

The authors explore the real-life issue of diversity disclosure within academia. The breadth of disability and discrimination is framed within the context of high demands and competitiveness. While some institutions are supportive, the culture of ableism, stigmatization, and the disabling barriers make disclosure of disability a complex and difficult decision. Read More

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Validity and reliability of the Amharic version of supportive care needs survey - short form 34 among cancer patients in Ethiopia.

BMC Health Serv Res 2021 May 21;21(1):484. Epub 2021 May 21.

School of Public Health, Department of Preventive Medicine, Addis Ababa University, Addis Ababa, Ethiopia.

Objectives: Supportive care needs survey short form has a total of 34 items that have 5 domains that measure the unmet needs of cancer patients. It is important to validate this tool since there are differences in culture, geographic areas, and clinical care service which influence patients' needs. Therefore, this study aimed to assess the construct validity and reliability of the tool. Read More

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Early top-down modulation in visual word form processing: Evidence from an intracranial SEEG study.

J Neurosci 2021 May 14. Epub 2021 May 14.

State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China

Visual word recognition, at a minimum, involves the processing of word form and lexical information. Opinions diverge on the spatiotemporal distribution of and interaction between the two types of information. Feedforward theory argues that they are processed sequentially, while interactive theory advocates that lexical information is processed fast and modulates early word form processing. Read More

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Consumer Views on Using Digital Data for COVID-19 Control in the United States.

JAMA Netw Open 2021 05 3;4(5):e2110918. Epub 2021 May 3.

Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia.

Importance: Curbing COVID-19 transmission is currently the greatest global public health challenge. Consumer digital tools used to collect data, such as the Apple-Google digital contact tracing program, offer opportunities to reduce COVID-19 transmission but introduce privacy concerns.

Objective: To assess uses of consumer digital information for COVID-19 control that US adults find acceptable and the factors associated with higher or lower approval of use of this information. Read More

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Pharmacy Faculty Burnout: Cause for Concern that Requires Our Support and Use of Best Evidence.

Innov Pharm 2020 31;11(3). Epub 2020 Jul 31.

Southeast Missouri State University.

Recent attention has been afforded to the concept of burnout and other quality of worklife issues among pharmacy faculty, underscoring the importance of organizational culture, citizenship, collegiality, and support. Support comes from the larger academic institution, the college/school, and individual colleagues. Evidence points to reassurance of worth, guidance, and positive affirmation as being among the most salient factors in mitigating burnout of faculty, who are caught in the midst of increasing demands and higher administrative burdens. Read More

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Integrated knowledge translation to advance noncommunicable disease policy and practice in South Africa: application of the Exploration, Preparation, Implementation, and Sustainment (EPIS) framework.

Health Res Policy Syst 2021 May 17;19(1):82. Epub 2021 May 17.

Chronic Disease Initiative for Africa, University of Cape Town, Cape Town, South Africa.

Background: In response to the "know-do" gap, several initiatives have been implemented to enhance evidence-informed decision-making (EIDM). These include individual training, organizational culture change management, and legislative changes. The importance of relationships and stakeholder engagement in EIDM has led to an evolution of models and approaches including integrated knowledge translation (IKT). Read More

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SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System.

Stem Cell Rev Rep 2021 May 12. Epub 2021 May 12.

Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, 3000, Belgium.

Astrocytes, the main supportive cell type of the brain, show functional impairments upon ageing and in a broad spectrum of neurological disorders. Limited access to human astroglia for pre-clinical studies has been a major bottleneck delaying our understanding of their role in brain health and disease. We demonstrate here that functionally mature human astrocytes can be generated by SOX9 overexpression for 6 days in pluripotent stem cell (PSC)-derived neural progenitor cells. Read More

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: An uncommon cause of liver abscess.

IDCases 2021 16;24:e01125. Epub 2021 Apr 16.

Department of General Medicine, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India.

We report an uncommon case of pyogenic liver abscess due to in an apparently immune-competent individual, the timely recognition of which could avoid a potentially fatal course of infection in the patient. A 45-year-old man, with history of moderate alcohol intake since the last 10 years, was admitted with intense right-sided upper abdominal pain and right-sided chest pain of 10-days duration. Culture of the ultrasound-guided liver aspirate sample yielded a pure growth of identified by the VITEK-2™ automated microbial identification system. Read More

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