213,880 results match your criteria support recognition


The limited effect of neural stimulation on visual attention and social cognition in individuals with schizophrenia.

Neuropsychologia 2021 May 4:107880. Epub 2021 May 4.

School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX; Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX.

Background: Research demonstrates a relationship between faulty visual attention and poorer social cognition in schizophrenia. One potential explanatory model suggests abnormal neuromodulation in specific neural networks may result in reduced attention to socially important cues, leading to poorer understanding of another's emotional state or intentions.

Objective: The current study experimentally manipulated neural networks using tDCS to examine this potential causal mechanism. Read More

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Conjugates of Human Serum Butyrylcholinesterase and Nerve Agents are Behaviorally Safe in Rhesus Macaques.

Chem Biol Interact 2021 May 4:109499. Epub 2021 May 4.

US Army War College, Carlisle, PA 17013, USA.

Exogenously administered human serum butyrylcholinesterase (Hu BChE) affords protection by binding to organophosphorus (OP) nerve agents and pesticides in circulation. The resulting Hu BChE-OP conjugate undergoes 'aging' and the conjugate circulates until cleared from the body. Thus, we evaluated the effects of Hu BChE-OP conjugates on the general health and operant behavior of macaques. Read More

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Emerging Wearable Interfaces and Algorithms for Hand Gesture Recognition: A Survey.

IEEE Rev Biomed Eng 2021 May 7;PP. Epub 2021 May 7.

Hands are vital in a wide range of fundamental daily activities, and neurological diseases that impede hand function can significantly affect quality of life. Wearable hand gesture interfaces hold promise to restore and assist hand function and to enhance human-human and human-computer communication. The purpose of this review is to synthesize current novel sensing interfaces and algorithms for hand gesture recognition, and the scope of applications covers rehabilitation, prosthesis control, sign language recognition, and human-computer interaction. Read More

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Barriers to pre-emptive kidney transplantation in New Zealand children.

J Paediatr Child Health 2021 May 7. Epub 2021 May 7.

Paediatric Nephrology Department, Starship Children's Hospital, Auckland, New Zealand.

Aim: Pre-emptive kidney transplantation (PKT) is generally considered the optimal treatment for kidney failure as it minimises dialysis-associated morbidity and mortality and is associated with improved allograft survival. This study aimed to determine rates of paediatric PKT in New Zealand, identify barriers to PKT and consider potential interventions to influence future rates of pre-emptive transplantation.

Methods: Children commencing kidney replacement therapy between 2005 and 2017 in New Zealand were included. Read More

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Occupational stressors in oncology nurses: A qualitative descriptive study.

J Clin Nurs 2021 May 6. Epub 2021 May 6.

Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Aim And Objectives: The present study aims at exploring oncology nurses' perceptions regarding work-related stressors.

Background: Oncology nurses work in an environment with a high degree of stress, which can negatively affect their health. There is limited research on work-related stressors from the oncology nurses' perspective. Read More

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Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues.

Proc Natl Acad Sci U S A 2021 May;118(21)

Whitehead Institute for Biomedical Research, Cambridge, MA 02142;

Prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and recurrence of PCR-positive tests have been widely reported in patients after recovery from COVID-19, but some of these patients do not appear to shed infectious virus. We investigated the possibility that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the DNA of human cells in culture and that transcription of the integrated sequences might account for some of the positive PCR tests seen in patients. In support of this hypothesis, we found that DNA copies of SARS-CoV-2 sequences can be integrated into the genome of infected human cells. Read More

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Maternal temperament and character: associations to child behavior at the age of 3 years.

Child Adolesc Psychiatry Ment Health 2021 May 6;15(1):23. Epub 2021 May 6.

Division of Children's and Women's Health, Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85, Linköping, Sweden.

Background: The influence of maternal temperament on child behavior, and whether maternal temperament impact boys and girls differently is not thoroughly studied. The aim was to investigate the impact of maternal temperament and character on child externalizing and internalizing problems at age 3.

Methods: A birth-cohort of 1723 mothers and their children were followed from birth to age 3. Read More

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Time to say good-bye? Homeopathy, skeptics and thoughts on how to proceed.

J Complement Integr Med 2021 May 6. Epub 2021 May 6.

homöopathie-pannek, Basel, Switzerland.

Background: Although homeopathy is frequently used by many health professionals, there are ongoing debates concerning its effectiveness. Currently no unifying explanation how homeopathy works exists. Homeopaths are frequently challenged by skeptics, and in public opinion, the swan song for homeopathy is frequently sung. Read More

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Crystal structures of NAD-linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP-linked homologs.

Arch Biochem Biophys 2021 May 3:108898. Epub 2021 May 3.

Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases and Key Laboratory of Biomedicine in Gene Diseases and Health of Anhui Higher Education Institutes, No.1 Beijing East Road, College of Life Sciences, Anhui Normal University, Wuhu, Anhui, 241000, China. Electronic address:

NAD-linked isocitrate dehydrogenases (NAD-IDHs) catalyze the oxidative decarboxylation of isocitrate into α-ketoglutarate. Previously, we identified a novel phylogenetic clade including NAD-IDHs from several algae in the type II subfamily, represented by homodimeric NAD-IDH from Ostreococcus tauri (OtIDH). However, due to its lack of a crystalline structure, the molecular mechanisms of the ligand binding and catalysis of OtIDH are little known. Read More

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Reflections from the forgotten frontline: 'The reality for children and staff in residential care' during COVID-19.

Health Soc Care Community 2021 May 6. Epub 2021 May 6.

Manchester Metropolitan University, Manchester, UK.

Currently, 78,150 children are in care in England, with 11% of the most vulnerable living in 2,460 residential homes due to multitype traumas. These children require safe and secure trauma-informed therapeutic care. However, the children's residential care workforce delivering this vital care is an unrepresented, under-researched and largely unsupported professional group. Read More

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Forming new habits in the face of chronic cancer-related fatigue: An interpretative phenomenological study.

Support Care Cancer 2021 May 6. Epub 2021 May 6.

Scientific Research Department, Centre for Psycho-Oncology, Helen Dowling Institute, Professor Bronkhorstlaan 20, 3723 MB, Bilthoven, the Netherlands.

Purpose: The growing group of patients who suffer from chronic cancer-related fatigue (CCRF) after cancer have helpful and less helpful ways of responding to this long-lasting and disruptive problem. This qualitative study aimed to gain insight in essential elements of how patients respond to CCRF, with a focus on helpful responses to facilitate adaptation.

Methods: We conducted semi-structured interviews with a purposive sample of 25 participants who experienced severe CCRF for at least 3 months. Read More

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Support Vector Machine Weather Prediction Technology Based on the Improved Quantum Optimization Algorithm.

Comput Intell Neurosci 2021 13;2021:6653659. Epub 2021 Apr 13.

College of Computer and Information Science, Chongqing Normal University, Chongqing, China.

Emotion recognition is a research hotspot in the field of artificial intelligence. If the human-computer interaction system can sense human emotion and express emotion, it will make the interaction between the robot and human more natural. In this paper, a multimodal emotion recognition model based on many-objective optimization algorithm is proposed for the first time. Read More

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Temporal patterns of organ dysfunction after severe trauma.

Crit Care 2021 05 5;25(1):165. Epub 2021 May 5.

Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, 171 76, Stockholm, Sweden.

Background: Understanding temporal patterns of organ dysfunction (OD) may aid early recognition of complications after trauma and assist timing and modality of treatment strategies. Our aim was to analyse and characterise temporal patterns of OD in intensive care unit-admitted trauma patients.

Methods: We used group-based trajectory modelling to identify temporal trajectories of OD after trauma. Read More

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Privacy versus Convenience: A Historical Perspective, Analysis of Risks, and an Informatics Call to Action.

Appl Clin Inform 2021 Mar 5;12(2):274-284. Epub 2021 May 5.

Penn State Health Holy Spirit Medical Center, Information Services, Geisinger Commonwealth School of Medicine, Camp Hill, Pennsylvania, United States.

Background:  The pace of technological change dwarfs the pace of social and policy change. This mismatch allows for individual harm from lack of recognition of changes in societal context. The value of privacy has not kept pace with changes in technology over time; individuals seem to discount how loss of privacy can lead to directed personal harm. Read More

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Experiences of fathers regarding the diagnosis of their child with autism spectrum disorder: A narrative review of the international research.

J Clin Nurs 2021 May 5. Epub 2021 May 5.

School of Nursing and Midwifery, University of Dublin, Trinity College, Dublin, Ireland.

Aim And Objectives: The aim of this systematic review was to identify the views and experiences of fathers regarding their child's Autism Spectrum Disorder diagnosis.

Background: The diagnosis of a child's Autism Spectrum Disorder may be a stressful experience, creating uncertainty for parents. There has been a limited research focus on the views and experiences of fathers in relation to the diagnosis of Autism Spectrum Disorder of their child. Read More

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Trauma Prehospital Hypothermia Prevention and Treatment: An Observational Study.

J Trauma Nurs 2021 May-Jun 01;28(3):194-202

Abel Salazar Institute of Biomedical Sciences (Mr Mota) and CINTESIS-Center for Health Technology and Services Research (Dr M. R. Santos), University of Porto, Porto, Portugal; Superior Health School of Viseu, Viseu, Portugal (Mr Mota and Dr Cunha); UICISA: E/ESEnfC-Cluster at the Health School of Polytechnic Institute of Viseu, Viseu, Portugal (Mr Mota and Dr Cunha); Hospital Nossa Senhora da Assunção, Local Health Unit of Guarda, Seia, Portugal (Mr Mota); Nursing School of Porto, Porto, Portugal (Dr M. R. Santos); Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal (Dr E. J. F. Santos); Health Sciences Research Unit: Nursing, Nursing School of Coimbra, Coimbra. Portugal (Dr E. J. F. Santos); Polytechnic Institute of Viseu, Viseu, Portugal (Drs Henriques and Matos); Centre for Mathematics of the University of Coimbra (CMUC), Coimbra, Portugal (Dr Henriques); and Research Centre in Digital Services (CISeD), Viseu, Portugal (Dr Matos).

Background: Hypothermia in trauma patients causes increased morbidity and mortality. Swift recognition and treatment are important to prevent any further heat loss. In addition, patient discomfort from cold decreases satisfaction with care. Read More

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Osteochondral Lesions of the Distal Tibial Plafond: A Systematic Review of Lesion Locations and Treatment Outcomes.

Orthop J Sports Med 2021 Apr 15;9(4):2325967121997120. Epub 2021 Apr 15.

Division of Sports Medicine, Department of Orthopaedic Surgery, Duke Sport Science Institute, Duke University, Durham, North Carolina, USA.

Background: Osteochondral lesions of the tibial plafond (OLTPs) remain less common than osteochondral lesions of the talus (OLTs), but recognition of the condition has increased.

Purpose: To systematically evaluate the literature on lesion locations and treatment outcomes of OLTPs, whether in isolation or in combination with OLTs.

Study Design: Systematic review; Level of evidence, 4. Read More

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Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements.

Nat Commun 2021 05 4;12(1):2502. Epub 2021 May 4.

Institute of Applied Physics, TU Wien, Vienna, Austria.

Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their magnitude, spread, and temporal behavior are still poorly defined. We here report a FRET-based sensor equipped either with a TCR-reactive single chain antibody fragment or peptide-loaded MHC, the physiological TCR-ligand. The sensor was tethered to planar glass-supported lipid bilayers (SLBs) and informed most directly on the magnitude and kinetics of TCR-imposed forces at the single molecule level. Read More

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Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes.

Science 2021 May 4. Epub 2021 May 4.

Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.

The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following SARS-CoV-2 infection are unknown. Proteomic deconvolution of the IgG repertoire to the spike glycoprotein in convalescent subjects revealed that the response is directed predominantly (>80%) against epitopes residing outside the receptor-binding domain (RBD). In one subject, just four IgG lineages accounted for 93. Read More

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The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral / Transcripts.

mBio 2021 05 4;12(3). Epub 2021 May 4.

Viral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany

Interferon-stimulated gene products (ISGs) play a crucial role in early infection control. The ISG zinc finger CCCH-type antiviral protein 1 (ZAP/ZC3HAV1) antagonizes several RNA viruses by binding to CG-rich RNA sequences, whereas its effect on DNA viruses is less well understood. Here, we decipher the role of ZAP in the context of human cytomegalovirus (HCMV) infection, a β-herpesvirus that is associated with high morbidity in immunosuppressed individuals and newborns. Read More

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Performance of seven different paediatric early warning scores to predict critical care admission in febrile children presenting to the emergency department: a retrospective cohort study.

BMJ Open 2021 May 4;11(5):e044091. Epub 2021 May 4.

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK

Objective: Paediatric Early Warning Scores (PEWS) are widely used in the UK, but the heterogeneity across tools and the limited data on their predictive performance represent obstacles to improving best practice. The standardisation of practice through the proposed National PEWS will rely on robust validation. Therefore, we compared the performance of the National PEWS with six other PEWS currently used in NHS hospitals, for their ability to predict critical care (CC) admission in febrile children attending the emergency department (ED). Read More

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Living labs for patient engagement and knowledge exchange: an exploratory sequential mixed methods study to develop a living lab in paediatric rehabilitation.

BMJ Open 2021 May 4;11(5):e041530. Epub 2021 May 4.

College of Nursing, University of Manitoba, Winnipeg, Manitoba, Canada.

Introduction: Despite recognition of the importance of patient engagement in research and knowledge translation, systematic approaches to engagement and co-ideation remain limited. Living labs are collaborative knowledge sharing systems that use multimethod, user-centred approaches that hold potential to catalyse these aims. However, their use in healthcare is limited, and no living lab has been developed in paediatric rehabilitation. Read More

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Prevention and management of major complications in percutaneous endoscopic gastrostomy.

BMJ Open Gastroenterol 2021 May;8(1)

AZ Nikolaas, Nutrition Support Team, Sint-Niklaas, Oost-Vlaanderen, Belgium.

Background: Percutaneousendoscopic gastrostomy is a commonly used endoscopic technique where a tube isplaced through the abdominal wall mainly to administer fluids, drugs and/orenteral nutrition. Several placement techniques are described in the literaturewith the 'pull' technique (Ponsky-Gardener) as the most popular one.Independent of the method used, placement includes a 'blind' perforation of thestomach through a small acute surgical abdominal wound. Read More

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Survey analysis to determine the impact of evidence informed practice education upon East Asian medicine faculty clinical instruction and students' skills, knowledge, attitudes and behaviors within a master's degree program.

BMC Med Educ 2021 May 4;21(1):256. Epub 2021 May 4.

University of Minnesota, Minneapolis, MN, 55455, USA.

Background: Between 2013 and 2018 Pacific College of Health and Science (formerly Pacific College of Oriental Medicine) trained faculty and developed curriculum in evidence informed practice (EIP), with support from a grant from the National Institutes of Health (NIH). A three-credit (45 h) Foundations of EIP course, and online EIP learning modules (developed as part of a previous NIH R25 award), were used for faculty and student training. In addition, EIP was incorporated into 73% of the East Asian medicine degree program. Read More

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ER Stress, UPR Activation and the Inflammatory Response to Viral Infection.

Authors:
Mara Cirone

Viruses 2021 04 29;13(5). Epub 2021 Apr 29.

Department of Experimental Medicine, La Sapienza University of Rome, Viale Regina Elena 324, 00185 Rome, Italy.

The response to invading pathogens such as viruses is orchestrated by pattern recognition receptor (PRR) and unfolded protein response (UPR) signaling, which intersects and converges in the activation of proinflammatory pathways and the release of cytokines and chemokines that harness the immune system in the attempt to clear microbial infection. Despite this protective intent, the inflammatory response, particularly during viral infection, may be too intense or last for too long, whereby it becomes the cause of organ or systemic diseases itself. This suggests that a better understanding of the mechanisms that regulate this complex process is needed in order to achieve better control of the side effects that inflammation may cause while potentiating its protective role. Read More

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Radiomics and Artificial Intelligence Analysis with Textural Metrics Extracted by Contrast-Enhanced Mammography in the Breast Lesions Classification.

Diagnostics (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Radiology Division, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Naples, Italy.

The aim of the study was to estimate the diagnostic accuracy of textural features extracted by dual-energy contrast-enhanced mammography (CEM) images, by carrying out univariate and multivariate statistical analyses including artificial intelligence approaches. In total, 80 patients with known breast lesion were enrolled in this prospective study according to regulations issued by the local Institutional Review Board. All patients underwent dual-energy CEM examination in both craniocaudally (CC) and double acquisition of mediolateral oblique (MLO) projections (early and late). Read More

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Midwives' views on alcohol guidelines: A qualitative study of barriers and facilitators to implementation in UK antenatal care.

Sex Reprod Healthc 2021 Apr 28;29:100628. Epub 2021 Apr 28.

Institute of Clinical Applied Health Research, Faculty of Health Sciences, University of Hull, Hull HU6 7RX, United Kingdom.

Objective: Midwives play an important role in health promotion and prevention of alcohol-related harm, but previous research has suggested that although most midwives report advising on abstinence, evidence exist that women are informed that "some" alcohol is not harmful. The aim of this qualitative study was to explore midwives' views on implementation of the 2016 Chief Medical Officers' alcohol guidelines in antenatal care in the UK.

Methods: Focus groups and individual interviews with 22 midwives working in maternity and educational settings in the UK were conducted either in person or over telephone. Read More

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Gender and the experiences of living with mesothelioma: A thematic analysis.

Eur J Oncol Nurs 2021 Apr 28;52:101966. Epub 2021 Apr 28.

Division of Nursing and Midwifery, Health Sciences School, University of Sheffield, Sheffield, United Kingdom.

Purpose: Mesothelioma is a terminal cancer caused by exposure to asbestos. As a cancer with a higher rate in men than women, women's experiences of living with mesothelioma are often underexplored. Furthermore, men's experiences are often taken for granted and therefore have remained underexplored. Read More

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MHC reflects fine-scale habitat structure in white-tailed eagles Haliaeetus albicilla.

J Hered 2021 May 4. Epub 2021 May 4.

Eagle Conservation Committee, Niepodległości 53/55, 10-044 Olsztyn, Poland.

The Major Histocompatibility Complex (MHC) genes code for key immune receptors responsible for recognition of intra- and extra-cellular pathogens (MHC class I and class II, respectively). It was hypothesized that MHC polymorphism can be maintained via fluctuating selection resulting from between-habitat variation in pathogen regimes. We examined associations between MHC class I and class II genes and habitat structure in an apex avian predator, the white-tailed eagle Haliaeetus albicilla. Read More

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Identifying trends over time in food affordability: the Illawarra Healthy Food Basket survey, 2011-2019.

Health Promot J Austr 2021 May 3. Epub 2021 May 3.

School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Australia.

Objective: To determine the affordability of a healthy food basket (HFB) for welfare recipients and average income earners in 2019, and to compare trends from 2011.

Methods: Fifty-seven food items prices were collected from fifteen stores across five suburbs representing low, medium and high socioeconomic status. Costs were compared to average weekly income and welfare payments to assess the baskets' affordability for a family of four and five. Read More

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