3,877 results match your criteria support longstanding

Co-developing and implementing a community nursing simulated learning resource for undergraduate nursing students.

Nurse Educ Pract 2021 Sep 11;56:103192. Epub 2021 Sep 11.

School of Healthcare Sciences, Cardiff University, EastGate House, 35-43 Newport Road, Cardiff CF24 OAB, United Kingdom. Electronic address:

Policy agendas across the developed world privilege systems transformation, notably shifting the balance of service provision from hospital to community settings. Primary and community health services have pivotal roles in the United Kingdom's longstanding policy ambition of healthcare services transformation, and it is imperative that undergraduate nursing students comprehend community settings as valuable learning environments, places of care and community nurses' roles therein. However, limited community placement learning opportunities means nursing students may be inadequately prepared to work in community settings at the point of initial registration. Read More

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September 2021

Treatment of adults with Eisenmenger syndrome-state of the art in the 21st century: a short overview.

Cardiovasc Diagn Ther 2021 Aug;11(4):1190-1199

Toronto Adult Congenital Heart Disease Program, Division of Cardiology, Peter Munk Cardiac Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada.

Eisenmenger syndrome (ES) develops in association with unrepaired, non-restrictive cardiac shunt lesions at the atrial, ventricular or arterial level over time. In developed countries, cardiac defects are being operated on in a timely manner, before pulmonary vascular disease develops. However, with rising immigration from underserved countries, we increasingly see patients with shunt lesions, that are not amenable for repair as pulmonary vascular disease has already established. Read More

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Reminder through mobile messaging application improves outpatient attendance and medication adherence among patients with depression: An open-label randomised controlled trial.

Med J Malaysia 2021 Sep;76(5):617-623

University of Malaya, Faculty of Medicine, Department of Psychological Medicine, Kuala Lumpur, Malaysia.

Introduction: Non-attendance and medication adherence are longstanding concerns in psychiatric outpatient settings. This study aimed to determine effectiveness of reminders using mobile messaging applications (messaging apps) in improving outpatient attendance and medication adherence among patients with depression.

Methods: This was a parallel, open-label randomised controlled trial with participants recruited from psychiatric outpatient services of a teaching hospital in Kuala Lumpur and a secondary hospital in Melaka. Read More

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September 2021

Homelessness during COVID-19: challenges, responses, and lessons learned from homeless service providers in Tippecanoe County, Indiana.

BMC Public Health 2021 09 10;21(1):1657. Epub 2021 Sep 10.

Department of Public Health, College of Health and Human Sciences, Purdue University, West Lafayette, Indiana, USA.

Background: The COVID-19 pandemic laid bare some of the United States' most devastating health and social inequities faced by people experiencing homelessness. Homeless populations experience disproportionate rates of underlying health conditions, stigma and marginalization that often disenfranchise them from health and social services, and living conditions that potentiate the risk of COVID-19 transmission and adverse outcomes.

Methods: Guided by the socio-ecological model, this community-based participatory research study examined the impacts of the COVID-19 public health crisis on people experiencing homelessness in Tippecanoe County, Indiana, and the ways in which homeless service providers prepared for, experienced, and responded to the pandemic. Read More

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September 2021

Immigration and screening programs for hemoglobinopathies in Italy, Spain and Turkey.

Acta Biomed 2021 09 2;92(4):e2021410. Epub 2021 Sep 2.

Quisisana Hospital, Ferrara.

Sickle cell disease (SCD) and thalassemias are the most common monogenic diseases in the world. The number of migrants and refugees in Europe and Turkey, in the past decade, has increased dramatically due to war, violence or prosecutions in their homeland. Prevention and management of haemoglobin disorders is well established and managed in countries where these conditions were traditionally endemic or in countries that have a longstanding tradition of receiving migrants. Read More

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September 2021

Restorative Neurostimulation for Chronic Mechanical Low Back Pain: Results from a Prospective Multi-centre Longitudinal Cohort.

Pain Ther 2021 Sep 3. Epub 2021 Sep 3.

Department of Pain Medicine, The James Cook University Hospital, Middlesbrough, UK.

Introduction: Low back pain impacts most people throughout the course of their lives and contributes significantly to the global burden of disease. In some patients, symptoms resolve with little intervention, while others are amenable to surgical intervention, some cases are intractable to current care paradigms. Restorative neurostimulation is an emerging therapy for chronic mechanical low back pain. Read More

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September 2021

Symbols Are Special: An fMRI Adaptation Study of Symbolic, Nonsymbolic, and Non-Numerical Magnitude Processing in the Human Brain.

Cereb Cortex Commun 2021 23;2(3):tgab048. Epub 2021 Jul 23.

Numerical Cognition Laboratory, Department of Psychology & Brain and Mind Institute, University of Western Ontario, London, ON N6A 3K7, Canada.

How are different formats of magnitudes represented in the human brain? We used functional magnetic resonance imaging adaptation to isolate representations of symbols, quantities, and physical size in 45 adults. Results indicate that the neural correlates supporting the passive processing of number symbols are largely dissociable from those supporting quantities and physical size, anatomically and representationally. Anatomically, passive processing of quantities and size correlate with activation in the right intraparietal sulcus, whereas symbolic number processing, compared with quantity processing, correlates with activation in the left inferior parietal lobule. Read More

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The Improvement of Air Quality and Associated Mortality during the COVID-19 Lockdown in One Megacity of China: An Empirical Strategy.

Int J Environ Res Public Health 2021 08 18;18(16). Epub 2021 Aug 18.

Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, 38 Xueyuan Road, Haidian District, Beijing 100191, China.

Although the lockdown policy implemented during the COVID-19 pandemic indeed improved the air quality and reduced the related health risks, the real effects of the lockdown and its resulting health risks remain unclear considering the effects of unobserved confounders and the longstanding efforts of the government regarding air pollution. We compared air pollution between the lockdown period and the period before the lockdown using a difference-in-differences (DID) model and estimated the mortality burden caused by the number of deaths related to air pollution changes. The NO and CO concentrations during the lockdown period (17 days) declined by 8. Read More

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Myelin densities in retinotopically defined dorsal visual areas of the macaque.

Brain Struct Funct 2021 Aug 21. Epub 2021 Aug 21.

Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, 3000, Leuven, Belgium.

The visuotopic organization of dorsal visual cortex rostral to area V2 in primates has been a longstanding source of controversy. Using sub-millimeter phase-encoded retinotopic fMRI mapping, we recently provided evidence for a surprisingly similar visuotopic organization in dorsal visual cortex of macaques compared to previously published maps in New world monkeys (Zhu and Vanduffel, Proc Natl Acad Sci USA 116:2306-2311, 2019). Although individual quadrant representations could be robustly delineated in that study, their grouping into hemifield representations remains a major challenge. Read More

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The role and value of science in shark conservation advocacy.

Sci Rep 2021 Aug 17;11(1):16626. Epub 2021 Aug 17.

Earth to Oceans Group, Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.

Many species of sharks are threatened with extinction, and there has been a longstanding debate in scientific and environmental circles over the most effective and appropriate strategy to conserve and protect them. Should we allow for sustainable fisheries exploitation of species which can withstand fishing pressure, or ban all fisheries for sharks and trade in shark products? In the developing world, exploitation of fisheries resources can be essential to food security and poverty alleviation, and global management efforts are typically focused on sustainably maximizing economic benefits. This approach aligns with traditional fisheries management and the perspectives of most surveyed scientific researchers who study sharks. Read More

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The baculum affects paternity success of first but not second males in house mouse sperm competition.

BMC Ecol Evol 2021 08 12;21(1):159. Epub 2021 Aug 12.

School of Biological Sciences, Norwich Research Park, University of East Anglia, Norwich, NR4 7TJ, UK.

The vast variation observed in genital morphology is a longstanding puzzle in evolutionary biology. Studies showing that the morphology of the mammalian baculum (penis bone) can covary with a male's paternity success indicate a potential impact of baculum morphology on male fitness, likely through influencing sperm competition outcomes. We therefore measured the size (measurements of length and width) and shape (geometric morphometric measurements) of the bacula of male house mice used in previously published sperm competition experiments, in which two males mated successively with the same female in staged matings. Read More

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COVID-19 vaccinations among Black Asian and Minority Ethnic (BAME) groups: Learning the lessons from influenza.

Int J Clin Pract 2021 Oct 11;75(10):e14641. Epub 2021 Aug 11.

Institute of Global Health Innovation, Imperial College London, London, UK.

Background: The COVID-19 vaccination roll-out continues to grow at significant pace around the world. There is, however, growing concern regarding vaccine hesitancy amongst Black, Asian and Minority Ethnic (BAME) populations. Such inequalities have the potential for exposing, an already at-risk population, further. Read More

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October 2021

Chronic kidney disease linked to SARS-CoV-2 infection: a case report.

BMC Nephrol 2021 08 10;22(1):278. Epub 2021 Aug 10.

Department of Pathology, University Hospital of Dijon, F-21000, Dijon, France.

Background: The recent COVID-19 pandemic has raised concerns about patient diagnosis and follow-up of chronically ill patients. Patients suffering from chronic illnesses, concomitantly infected by SARS-CoV-2, globally tend to have a worse prognosis and poor outcomes. Renal tropism and acute kidney injury following SARS-CoV-2 infection has recently been described in the literature, with elevated mortality rates. Read More

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Illuminating subcortical GABAergic and glutamatergic circuits for reward and aversion.

Neuropharmacology 2021 Aug 8;198:108725. Epub 2021 Aug 8.

Center for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, 98195, Seattle, WA, USA. Electronic address:

Reinforcement, reward, and aversion are fundamental processes for guiding appropriate behaviors. Longstanding theories have pointed to dopaminergic neurons of the ventral tegmental area (VTA) and the limbic systems' descending pathways as crucial systems for modulating these behaviors. The application of optogenetic techniques in neurotransmitter- and projection-specific circuits has supported and enhanced many preexisting theories but has also revealed many unexpected results. Read More

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Developing and evaluating online COVID-centric advance care planning training and information resources for nursing staff and family members in nursing homes: the necessary discussions study protocol.

BMC Geriatr 2021 08 9;21(1):456. Epub 2021 Aug 9.

School of Nursing and Midwifery, Centre for Evidence and Social Innovation, Queen's University Belfast, Belfast, UK.

Background: Nursing home residents are typically older adults with high levels of chronic illness and impairment. As such, they are particularly susceptible to severe complications and mortality from COVID-19. Since all nursing home residents are at increased risk, nursing home care staff need to know what residents would want to happen should they become infected with COVID-19. Read More

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UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae.

Nat Commun 2021 08 6;12(1):4769. Epub 2021 Aug 6.

Morgridge Institute for Research, Madison, WI, USA.

Beyond its role in mitochondrial bioenergetics, Coenzyme Q (CoQ, ubiquinone) serves as a key membrane-embedded antioxidant throughout the cell. However, how CoQ is mobilized from its site of synthesis on the inner mitochondrial membrane to other sites of action remains a longstanding mystery. Here, using a combination of Saccharomyces cerevisiae genetics, biochemical fractionation, and lipid profiling, we identify two highly conserved but poorly characterized mitochondrial proteins, Ypl109c (Cqd1) and Ylr253w (Cqd2), that reciprocally affect this process. Read More

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Improving Patient Outcomes in the Dual Crises of Climate Change and COVID-19: Proceedings of the Third Annual Clinical Climate Change Meeting, January 8, 2021.

J Occup Environ Med 2021 Aug 4. Epub 2021 Aug 4.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY Center for Climate, Health, and the Global Environment, Harvard T.H. Chan School of Public Health, Boston Boston Children's Hospital, Boston, MA WE ACT for Environmental Justice, New York, NY Department of Emergency Medicine, Harvard Medical School, Boston, MA American Lung Association, Chicago, IL Department of Anesthesiology, Yale School of Medicine, New Haven, CT Department of Epidemiology in Environmental Health Sciences, Yale School of Public Health, New Haven, CT Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY Population Health Science & Policy, Institute for Health Equity Research, Icahn School of Medicine at Mount Sinai, New York, NY Diversity Programs, Policy, and Community Affairs, Icahn School of Medicine at Mount Sinai, New York, NY Medical Students for a Sustainable Future New England Journal of Medicine, Waltham, MA New York City Department of Health and Mental Hygiene, Long Island City, NY Departments of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY Mount Sinai Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY.

The tremendous global toll of the COVID-19 pandemic does not fall equally on all populations. Indeed, this crisis has exerted more severe impacts on the most vulnerable communities, spotlighting the continued consequences of longstanding structural, social, and healthcare inequities. This disparity in COVID-19 parallels the unequal health consequences of climate change, whereby underlying inequities perpetuate adverse health outcomes disproportionately among vulnerable populations. Read More

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Uplifting the voices of rural American Indian older adults to improve understanding of physical activity behavior.

Transl Behav Med 2021 Sep;11(9):1655-1664

Center for Behavioral Health Research and Services, University of Alaska Anchorage, AK, USA.

American Indian (AI) older adults experience pronounced health disparities and demonstrate one of the lowest levels of physical activity (PA) among racial and ethnic groups. Nearly half of AI older adults live in rural areas, indicating distinct challenges to participation in PA. Research to identify factors influencing PA in this population is missing from the literature, yet is critical to informing culturally relevant PA intervention development and implementation. Read More

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September 2021

Optimizing Healthcare Through Digital Health and Wellness Solutions to Meet the Needs of Patients With Chronic Disease During the COVID-19 Era.

Front Public Health 2021 12;9:667654. Epub 2021 Jul 12.

American Heart Association, Center for Health Technology and Innovation, New York, NY, United States.

The COVID-19 pandemic exposed and exacerbated longstanding inefficiencies and deficiencies in chronic disease management and treatment in the United States, such as a fragmented healthcare experience and system, narrowly focused services, limited resources beyond office visits, expensive yet low quality care, and poor access to comprehensive prevention and non-pharmacological resources. It is feared that the addition of COVID-19 survivors to the pool of chronic disease patients will burden an already precarious healthcare system struggling to meet the needs of chronic disease patients. Digital health and telemedicine solutions, which exploded during the pandemic, may address many inefficiencies and deficiencies in chronic disease management, such as increasing access to care. Read More

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Genome-wide SNPs clarify a complex radiation and support recognition of an additional cat species.

Mol Biol Evol 2021 Jul 28. Epub 2021 Jul 28.

PUCRS, Escola de Ciências da Saúde e da Vida, Laboratório de Biologia Genômica e Molecular, Porto Alegre, RS, Brazil.

Phylogenetic reconstruction and species delimitation are often challenging in the case of recent evolutionary radiations, especially when post-speciation gene flow is present. Leopardus is a Neotropical cat genus that has a long history of recalcitrant taxonomic problems, along with both ancient and current episodes of interspecies admixture. Here we employ genome-wide SNP data from all presently recognized Leopardus species, including several individuals from the tigrina complex (representing L. Read More

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Chloroquine Cardiotoxicity Leading to Cardiogenic Shock.

JACC Case Rep 2020 Dec 25;2(15):2381-2386. Epub 2020 Nov 25.

Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

A patient with a history of heart block and longstanding chloroquine use presented in cardiogenic shock refractory to medical therapy and mechanical circulatory support. Autopsy supported antimalarial-induced cardiomyopathy (AMIC). Progression of AMIC may be halted with early recognition and cessation of antimalarial therapy, highlighting importance of screening and timely diagnosis. Read More

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December 2020

Single-trial modeling separates multiple overlapping prediction errors during reward processing in human EEG.

Commun Biol 2021 07 23;4(1):910. Epub 2021 Jul 23.

Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.

Learning signals during reinforcement learning and cognitive control rely on valenced reward prediction errors (RPEs) and non-valenced salience prediction errors (PEs) driven by surprise magnitude. A core debate in reward learning focuses on whether valenced and non-valenced PEs can be isolated in the human electroencephalogram (EEG). We combine behavioral modeling and single-trial EEG regression to disentangle sequential PEs in an interval timing task dissociating outcome valence, magnitude, and probability. Read More

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Making the move to a learning healthcare system: has the pandemic brought us one step closer?

Aust Health Rev 2021 Jul 22. Epub 2021 Jul 22.

The notion of a learning healthcare system (LHS) is gaining traction to advance the objectives of high-quality patient-centred care. Within such a system, real-world data analysis, clinical research and health service research are core activities of the health system. To support the transition to an LHS, the Australian Government is implementing the National Clinical Trials Governance Framework, which extends health service accreditation standards to the conduct of clinical trials. Read More

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Among respiratory symptoms, wheeze associates most strongly with impaired lung function in adults with asthma: a long-term prospective cohort study.

BMJ Open Respir Res 2021 Jul;8(1)

Department of Public Health and Clinical Medicine, Section of Sustainable Health, The OLIN Unit, Umeå University, Umeå, Sweden.

Background: Asthma is a common disease and a major public health concern. Respiratory symptoms are related to its prognosis, which in turn associates with lung function. Still this association on a long-term basis is not entirely understood. Read More

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The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development.

Elife 2021 07 19;10. Epub 2021 Jul 19.

CoMPLEX, University College London, London, United Kingdom.

Selection against deleterious mitochondrial mutations is facilitated by germline processes, lowering the risk of genetic diseases. How selection works is disputed: experimental data are conflicting and previous modeling work has not clarified the issues; here, we develop computational and evolutionary models that compare the outcome of selection at the level of individuals, cells and mitochondria. Using realistic mutation rates and germline development parameters from mouse and humans, the evolutionary model predicts the observed prevalence of mitochondrial mutations and diseases in human populations. Read More

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Niche partitioning facilitates coexistence of closely related honey bee gut bacteria.

Elife 2021 07 19;10. Epub 2021 Jul 19.

Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.

Ecological processes underlying bacterial coexistence in the gut are not well understood. Here, we disentangled the effect of the host and the diet on the coexistence of four closely related species colonizing the honey bee gut. We serially passaged the four species through gnotobiotic bees and in liquid cultures in the presence of either pollen (bee diet) or simple sugars. Read More

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New but for whom? Discourses of innovation in precision agriculture.

Agric Human Values 2021 Jul 14:1-19. Epub 2021 Jul 14.

Department of Geography, Environment and Geomatics, University of Guelph, 50 Stone Road East, Guelph, ON N1G2W1 Canada.

We describe how the set of tools, practices, and social relations known as "precision agriculture" is defined, promoted, and debated. To do so, we perform a critical discourse analysis of popular and trade press websites. Promoters of precision agriculture champion how big data analytics, automated equipment, and decision-support software will optimize yields in the face of narrow margins and public concern about farming's environmental impacts. Read More

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"We used to get food from the garden." Understanding changing practices of local food production and consumption in small island states.

Soc Sci Med 2021 09 8;284:114214. Epub 2021 Jul 8.

European Centre for Environment and Human Health, University of Exeter Medical School, Truro, UK; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Many Small Island Developing States (SIDS) lead global rates in obesity and non-communicable chronic diseases (NCDs). Drivers for this are complex and include lack of food sovereignty, evidenced by an increasing reliance on cheap nutrient-poor food imports and a focus on export orientated cash crop production for much local agriculture. To better inform SIDS' policy goals of improving nutrition through increased local food production, we explored in two SIDS current practices of food production and consumption. Read More

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September 2021

Public Support for Policies to Increase Housing Stability During the COVID-19 Pandemic.

Am J Prev Med 2021 Jun 24. Epub 2021 Jun 24.

Department of Mental Health, Johns Hopkins School of Public Health, Johns Hopkins University, Baltimore, Maryland.

Introduction: The COVID-19 pandemic has exacerbated longstanding housing precarity. This study measures the public support for policies designed to increase housing stability and gauges whether support levels are associated with views about the role of evictions in COVID-19 transmission and the existence of racial inequities in the housing market.

Methods: A cross-sectional survey with a representative sample of U. Read More

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Maximizing metal utilization by coupling cross-linked PtRu multi-atom on an atomically dispersed ZnFeNC support.

Dalton Trans 2021 Aug;50(30):10354-10358

The state Key Laboratory of Power Transmission Equipment & System Security and New Technology, Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China.

Minimizing noble-metal (NM) usage by exposing all metal atoms on surfaces for catalysis has been a longstanding goal in the development of highly efficient NM catalysts. Here, we realized the full utilization of Pt and Ru atoms by anchoring the cross-linked PtRu multi-atom on the surface of atomically dispersed Zn, Fe and N tri-doped carbon nanomaterials through Pt-N and Ru-N bonds. This supported bimetallic PtRu multi-atom catalyst has extremely high atom efficiency and shows excellent stability and high activity towards the methanol oxidation reaction (MOR). Read More

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