69,726 results match your criteria supplementation study


A fed-batch feeding with succinic acid strategy for astaxanthin and lipid hyper-production in Haematococcus pluviualis.

Bioresour Technol 2021 Jul 26;340:125648. Epub 2021 Jul 26.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address:

Effects of succinic acid (SA) in fed-batch feeding mode on astaxanthin and lipids biopoduction of Haematococcus pluvialis against abiotic stresses were explored. By comparison with the control, the initial addition of SA on day 0 increased the production of astaxanthin by 71.61%. Read More

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Effect of lycopene supplementation to bovine oocytes exposed to heat shock during in vitro maturation.

Theriogenology 2021 Jul 24;173:48-55. Epub 2021 Jul 24.

Department of Reproduction, Obstetrics, and Herd Health, Ghent University, 9820, Merelbeke, Belgium; Department of Veterinary Sciences, Gamete Research Center, Veterinary Physiology and Biochemistry, University of Antwerp, Wilrijk, Belgium. Electronic address:

We investigated the effect of the antioxidant lycopene supplemented into the in vitro maturation medium (TCM-199 with 20 ng/mL epidermal growth factor and 50 mg/mL gentamycin) in a heat shock (HS) model to mimic in vivo heat stress conditions. Bovine cumulus-oocyte complexes were supplemented with 0.2 μM lycopene (or not supplemented; control) under HS (40. Read More

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Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study.

J Steroid Biochem Mol Biol 2021 Jul 28:105958. Epub 2021 Jul 28.

Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France.

Background: The objective of this extension phase of the quasi-experimental GERIA-COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19.

Methods: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000IU per month, or 80,000IU or 100,000IU or 200,000IU every 2-3 months), or daily supplementation with 800IU. Read More

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Oral administration of silver nanoparticles-adorned starch as a growth promotor in poultry: Immunological and histopathological study.

Int J Biol Macromol 2021 Jul 28. Epub 2021 Jul 28.

Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, 22758 Edfina, Egypt. Electronic address:

Silver nanoparticles (AgNPs) have recently emerged as promising growth promoters and immune-lifting agents in the poultry industry. This study investigated the potential impact of AgNP supplementation in the drinking water (DW) of broiler chickens during the fattening period. AgNPs were produced through chemical reduction using starch as a reducing and stabilizing agent. Read More

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Challenging patient phenotypes in the management of anemia of chronic kidney disease.

Int J Clin Pract 2021 Jul 31:e14681. Epub 2021 Jul 31.

Department of Medicine, Division of Nephrology, NYU School of Medicine, New York, NY, USA.

Background: Chronic kidney disease (CKD) is often complicated by anemia, which is associated with disease progression and increased hospital visits, decreased quality of life, and increased mortality.

Methods: A comprehensive literature search of English language peer-reviewed articles in PubMed/MedLine published between 1998 and 2020 related to the treatment of anemia of CKD was conducted. The United States Renal Database System and Dialysis Outcomes and Practice Patterns Study (DOPPS) data reports, the Centers for Disease Control and Prevention and the US Food and Drug Administration websites, and published congress abstracts in 2020 were surveyed for relevant information. Read More

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Reduced infiltration of T-regulatory cells in tumours from mice fed daily with gamma-tocotrienol supplementation.

Clin Exp Immunol 2021 Jul 31. Epub 2021 Jul 31.

Pathology Division, School of Medicine, International Medical University, Kuala Lumpur, Malaysia.

Gamma-tocotrienol (γT3) is an analogue of vitamin E with beneficial effects on the immune system, including immune-modulatory properties. This study reports the immune-modulatory effects of daily supplementation of γT3 on host T-helper (Th) and T-regulatory (Treg) populations in a syngeneic mouse model of breast cancer. Female BALB/c mice were fed with either γT3 or vehicle (soy oil) for 2-weeks via oral gavage before they were inoculated with syngeneic 4T1 mouse mammary cancer cells (4T1 cells). Read More

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Increased α-tocopherol metabolism in horses with equine neuroaxonal dystrophy.

J Vet Intern Med 2021 Jul 31. Epub 2021 Jul 31.

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

Background: Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is an inherited neurodegenerative disorder associated with a vitamin E deficiency within the first year of life. Vitamin E consists of 8 isoforms metabolized by the CYP4F2 enzyme. No antemortem diagnostic test currently exists for eNAD/EDM. Read More

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Curcumin for the Treatment of Prostate Diseases: A Systematic Review of Controlled Clinical Trials.

Adv Exp Med Biol 2021 ;1291:345-362

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Prostate cancer is one of the significant causes of morbidity and mortality worldwide. Benign prostatic hyperplasia is another condition of the prostate which, like prostate cancer, is more common among ageing men and is linked to inflammation. In this study, a systematic review was undertaken to estimate the effect of turmeric or curcumin supplementation on prostate diseases. Read More

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January 2021

A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.

Adv Exp Med Biol 2021 ;1291:295-326

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Gastrointestinal (GI) diseases are highly prevalent worldwide, with considerable morbidity and mortality. Curcumin has been used for many years as a plant-derived product for the management of various conditions such as abdominal pain and poor digestion. This systematic review was undertaken with the aim of investigating the effect of curcumin or turmeric supplementation on GI diseases. Read More

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January 2021

Effect of Curcumin on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review of Randomized Clinical Trials.

Adv Exp Med Biol 2021 ;1291:139-149

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition, which carries considerable morbidity and mortality. There is growing evidence that curcumin could modulate glucose homeostasis and improve vascular risk in patients with T2DM. The aim of this systematic review was to study the effect of curcumin on glycemic indices in patients with diabetes. Read More

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January 2021

Impact of probiotics supplement on the gut microbiota in neonates with antibiotic exposure: an open-label single-center randomized parallel controlled study.

World J Pediatr 2021 Jul 31. Epub 2021 Jul 31.

Department of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai, China.

Background: Antibiotics, a common strategy used for neonatal infection, show consistent effect on the gut microbiota of neonates. Supplementation with probiotics has become increasingly popular in mitigating the loss of the gut microbiota. However, no clear consensus recommending the use of probiotics in the infection of neonates currently exists. Read More

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Optimal Control Strategies and Sensitivity Analysis of an HIV/AIDS-Resistant Model with Behavior Change.

Acta Biotheor 2021 Jul 30. Epub 2021 Jul 30.

School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Durban, South Africa.

Despite several research on HIV/AIDS, it is still incumbent to investigate more effective control measures to mitigate its infection level. Therefore, we introduce an HIV/AIDS-resistant model with behavior change and study its basic properties. In order to determine the most sensitive parameters that are responsible for disease transmission with respect to the basic reproduction number and those responsible for disease prevalence with respect to the endemic equilibrium, the sensitivity analysis was established and it was confirmed that the influx rate of people into the infected population and total abstinence from all risk practices and endemic areas are some of the most sensitive parameters for disease spread and disease eradication, respectively. Read More

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Risk factors for hyperglycemia in extremely low birth weight infants during the first 14 days.

Pediatr Neonatol 2021 Jul 17. Epub 2021 Jul 17.

Division of Neonatology, Saitama Children's Medical Center, Saitama-City, Saitama, Japan.

Background: There are limited data regarding the risk factors for hyperglycemia in extremely low birth weight infants (ELBWIs). The aim of this observational study was to investigate the incidence of hyperglycemia among ELBWIs during the first 14 days of life and identify independent risk factors for hyperglycemia development.

Methods: We retrospectively evaluated 55 ELBWIs (32 male infants) between January 2015 and March 2020. Read More

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Impact of vitamin D deficiency on COVID-19.

Clin Nutr ESPEN 2021 Aug 29;44:372-378. Epub 2021 May 29.

Queensland University of Technology, School of Exercise & Nutrition Sciences, Brisbane, Queensland, Australia; Department of Physiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. Electronic address:

Background & Aims: COVID-19 has emerged as a global pandemic affecting millions of people. Vitamin D deficiency is one of the risk factors for increased susceptibility to COVID-19. This study aimed to examine the correlation between the prevalence of vitamin D deficiency and COVID-19 infection and mortality rates among the adult population in European and Asian continents. Read More

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Bioelectrical spectroscopy impedance phase angle is not associated with nutritional status in a stable cohort of paediatric inflammatory bowel disease patients.

Clin Nutr ESPEN 2021 Aug 23;44:276-281. Epub 2021 Jun 23.

Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK. Electronic address:

Background & Aims: Nutritional assessment in paediatric inflammatory bowel disease (IBD) is key to supporting growth whilst minimising adiposity. Bedside assessment using bioelectrical impedance spectroscopy (BIS) has previous identified patients with declining cellular and nutritional health. We aimed to assess BIS measures in stable paediatric IBD patient. Read More

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No additional effects of ursolic acid supplementation associated with combined exercise program on metabolic syndrome of postmenopausal women: A double-blind, randomized, placebo-controlled trial.

Clin Nutr ESPEN 2021 Aug 19;44:143-149. Epub 2021 Jun 19.

Post-Graduate Program in Human Movement Sciences, Methodist University of Piracicaba (UNIMEP), Piracicaba, SP, Brazil. Electronic address:

Background & Aims: Ursolic acid (UA) supplementation may have therapeutic effects on metabolic syndrome (MetS). Therefore, this study aimed to investigate the effects of UA supplementation associated with a combined exercise program on MetS components in postmenopausal women.

Methods: Twenty-six women (61 ± 7 years) were randomized into two groups: UA (n = 13) and placebo (PLA, n = 13). Read More

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Antioxidant and anti-inflammatory response to curcumin supplementation in hemodialysis patients: A randomized, double-blind, placebo-controlled clinical trial.

Clin Nutr ESPEN 2021 Aug 24;44:136-142. Epub 2021 Jun 24.

Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil.

Background And Objectives: Hemodialysis (HD) patients are vulnerable to malnutrition and cardiovascular complications due to many factors, including oxidative stress and inflammation. Curcumin supplementation is associated with attenuation of proinflammatory cytokines and increased activity of antioxidant enzymes, but its effects in HD patients are unknown. This study aimed to evaluate the effect of curcumin supplementation on oxidative stress and inflammation in HD patients. Read More

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Effect of omega-3 supplementation on fatty liver and visceral adiposity indices in diabetic patients with non-alcoholic fatty liver disease: A randomized controlled trial.

Clin Nutr ESPEN 2021 Aug 3;44:130-135. Epub 2021 Jul 3.

Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease is closely linked to type 2 diabetes mellitus (T2DM). Omega-3 supplementation has been proposed as a strategy to manage T2DM and NAFLD. The present study aimed to investigate the effect of omega-3 supplementation on fatty liver index, lipid accumulation product and visceral adiposity index in diabetic patients with NAFLD. Read More

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Effects of omega-3 supplementation on body weight and body fat mass: A systematic review.

Clin Nutr ESPEN 2021 Aug 19;44:122-129. Epub 2021 May 19.

Post Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.

Background: Omega-3 is a supplement that promotes several health benefits. The evidence on omega-3 in weight loss or body fat mass is inconclusive. This study aimed to review the literature on studies that evaluated the effect of omega-3 supplementation and changes in weight and/or body fat mass in humans. Read More

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Randomized double blind clinical trial evaluating the Ellagic acid effects on insulin resistance, oxidative stress and sex hormones levels in women with polycystic ovarian syndrome.

J Ovarian Res 2021 Jul 31;14(1):100. Epub 2021 Jul 31.

Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

Objective: The design of this study was due to the report of the antioxidant properties of Ellagic acid (EA) for its evaluation on the Insulin resistance (IR), oxidative stress and sex hormones levels in women with polycystic ovarian syndrome (PCOS).

Methods: In this randomized, double-blind, placebo-controlled clinical trial, 60 patients were recruited. Patients were randomly allocated consumed a capsule containing 200 mg of EA per day (n = 30) or placebo (n = 30) for 8 weeks. Read More

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Human Platelet Lysate as an Alternative to Autologous Serum for Human Chondrocyte Clinical Use.

Cartilage 2021 Jul 30:19476035211035433. Epub 2021 Jul 30.

Service of Orthopaedic Surgery and Traumatology, Lausanne University Hospital, University of Lausanne, Switzerland.

Objective: A pivotal aspect of cartilage tissue engineering resides in cell culture medium supplementation, in view of maximizing cell proliferation and preserving cellular functionality. Autologous human serum (aHS) is commonly used as an inducive supplement for safe human articular chondrocyte (HAC) proliferation prior to clinical implantation. However, practical clinical use of aHS is hindered by constraining manufacturing requirements and quality assurance-driven downstream processing. Read More

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Effect of key regulators in augmenting transcriptional expression of Transglutaminase in Streptomyces mobaraensis.

Bioresour Technol 2021 Jul 22;340:125627. Epub 2021 Jul 22.

Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry, Indian Institute of Technology Delhi, New Delhi 110016, India. Electronic address:

Transglutaminase forms isopeptide bonds in proteins which are helpful in various industrial applications. However, low productivity and high cost are the major bottlenecks for industrial Transglutaminase production. The present study describes the regulatory mechanism of microbial Transglutaminase (MTGase) biosynthesis from Streptomyces mobaraensis and the effect of key regulators to maximize production. Read More

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Polymeric nanoparticle mediated inhibition of miR-21 with enhanced miR-124 expression for combinatorial glioblastoma therapy.

Biomaterials 2021 Jul 20;276:121036. Epub 2021 Jul 20.

Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan, 475004, China; Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences & School of Pharmacy, Henan University, Kaifeng, Henan, 475004, China; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia. Electronic address:

Glioblastoma (GBM) is the most common and fatal form of malignant brain tumor. Despite intensive effort, there is still no effective GBM treatment. Therefore, novel and more effective GBM therapeutic approaches are highly desired. Read More

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Evaluation of the influence of diet supplementation with conjugated linoleic acid isomers on elemental composition in the cardio-oncological nutritional programming rat' model.

J Trace Elem Med Biol 2021 Jul 7;68:126816. Epub 2021 Jul 7.

The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.

Background: The 'developmental origin of health and disease' (DOHaD) hypothesis assumes that due to the action of some stimuli during fetal life the long-term physiological changes occurs and may affects the risk of various diseases. The main aim of this study was to assess impact of supplementation of maternal' and early postnatal diet with conjugated linoleic acids (CLA) isomers on selected elements content in hearts of their female offspring with chemically induced breast cancer.

Methods: Elemental composition was determined by quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS). Read More

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Chronic cereulide exposure causes intestinal inflammation and gut microbiota dysbiosis in mice.

Environ Pollut 2021 Jul 19;288:117814. Epub 2021 Jul 19.

Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong, 510642, PR China; Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, Guangdong, 510642, PR China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, 510642, PR China. Electronic address:

Known as a cause of food poisoning, Bacillus cereus (B. cereus) is widespread in nature. Cereulide, the heat-stable and acid-resistant emetic toxin which is produced by some B. Read More

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Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial.

Eur J Nutr 2021 Jul 30. Epub 2021 Jul 30.

Molecular Gastroenterology Research Group, Department of Oncology & Metabolism, The Medical School, The University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK.

Purpose: Several small trials suggest a benefit of vitamin D supplementation in irritable bowel syndrome (IBS). The generalisability of these reports is limited by their design and scale. This study aimed to assess whether vitamin D supplementation improved IBS symptoms in a UK community setting. Read More

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The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial.

Biomed Pharmacother 2021 Jul 10;141:111915. Epub 2021 Jul 10.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Background: Based on a comprehensive search, we realized that the findings of the available literature are contradictory, and also limited data are available on Middle Eastern populations in terms of probiotic supplementation during the pregnancy. Therefore, the current double-blind, randomized, placebo-controlled clinical trial was carried out to investigate the effects of probiotic supplementation during pregnancy on the risk of gestational diabetes mellitus and also other maternal and neonatal outcomes.

Materials And Methods: The pregnant women were randomized to either received probiotic supplement (n = 271) or placebo (n = 271) from the first half of the second trimester (14 weeks of pregnancy) up to 24 weeks when pregnant women routinely evaluated regarding the GDM. Read More

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Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats.

Biomed Pharmacother 2021 Jul 10;141:111908. Epub 2021 Jul 10.

Department of Pharmaceutical Sciences, North South University Bangladesh, Bangladesh. Electronic address:

The present investigation was an attempt to evaluate the hypoglycemic, lipid-lowering, antioxidant and hepatoprotective effects of cumin (Cuminum cyminum family: Apiaceae) supplementation in high fat (HF) diet fed rats. Male Wistar rats were divided into four groups, such as control, control+ cumin, HF and HF+ cumin. Oral glucose tolerance test, plasma lipids, oxidative stress parameters, antioxidant enzymes activities, and liver dysfunction marker enzyme activities were evaluated. Read More

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Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia.

Mol Cell Biochem 2021 Jul 29. Epub 2021 Jul 29.

Faculty of Medical Sciences, Department of Internal Medicine, University of Kragujevac, Kragujevac, Serbia.

The aim of our study was to investigate the effects of one-month consumption of polyphenol-rich standardized Aronia melanocarpa extract (SAE) on redox status in anemic hemodialysis patients. The study included 30 patients (Hb < 110 g/l, hemodialysis or hemodiafiltration > 3 months; > 3 times week). Patients were treated with commercially available SAE in a dose of 30 ml/day, for 30 days. Read More

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The effectiveness of the 13-valent pneumococcal conjugate vaccine against hypoxic pneumonia in children in Lao People's Democratic Republic: An observational hospital-based test-negative study.

Lancet Reg Health West Pac 2020 Sep 6;2:100014. Epub 2020 Sep 6.

Centre for International Child Health, Department of Paediatrics (WHO Collaborating Centre for Child and Neonatal Health Research and Training), The University of Melbourne, Melbourne, Victoria, Australia.

Background: Pneumococcal pneumonia is a leading cause of childhood mortality. Pneumococcal conjugate vaccines (PCVs) have been shown to reduce hypoxic pneumonia in children. However, there are no studies from Asia examining the effectiveness of PCVs on hypoxic pneumonia. Read More

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September 2020