Invest Radiol 2021 Mar 19. Epub 2021 Mar 19.
From the Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health Berlin Institute of Health Department of Veterinary Medicine, Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Freie Universität Berlin, Berlin, Germany Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT Institute of Inorganic and Analytical Chemistry, Westfälische Wilhelms-Universität Münster, Münster, Germany Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel King's College London, School of Biomedical Engineering and Imaging Sciences, United Kingdom, St Thomas' Hospital British Heart Foundation Centre of Research Excellence, King's College London, London, United Kingdom Department of Radiology, TU München, München, Germany.
Objectives: Macrophages accumulating in the periablational rim play a pivotal role in initiating and sustaining the perifocal inflammatory reaction, which has been shown to be at least 1 of the mechanisms responsible for the systemic pro-oncogenic effects of focal hepatic radiofrequency ablation (RFA). Herein, we tested the hypothesis to use superparamagnetic iron oxide nanoparticle (SPION)-enhanced magnetic resonance imaging (MRI) for noninvasive quantification of iron-loaded macrophages in the periablational rim of VX2 tumor-bearing rabbits.
Materials And Methods: Twelve VX2 tumor-bearing rabbits underwent MRI immediately after and up to 3 weeks after focal hepatic RFA. Read More