29,165 results match your criteria superoxide production


Polyethylene glycol acute and sub-lethal toxicity in neotropical Physalaemus cuvieri tadpoles (Anura, Leptodactylidae).

Environ Pollut 2021 Apr 4;283:117054. Epub 2021 Apr 4.

Biological Research Laboratory, Goiano Federal Institute - Urutaí Campus, Urutaí, GO, Brazil; Post-Graduation Program in Biotechnology and Biodiversity, Federal University of Goiás, Goiânia, GO, Brazil; Graduate Program in Conservation of Cerrado Natural Resources, Goiano Federal Institute, Urutaí, GO, Brazil; Post-Graduation Program in Ecology and Natural Resources Conservation, Uberlândia, MG, Brazil. Electronic address:

Although many polymers are known by their toxicity, we know nothing about the impact of polyethylene glycol (PEG) on anurofauna. Its presence in different products and disposal in aquatic environments turn assessments about its impact on amphibians an urgent matter. Accordingly, we tested the hypothesis that short-time exposure (72 h) of tadpoles belonging to the species Physalaemus cuvieri (Anura, Leptodactylidae) to PEG induces oxidative stress and neurotoxicity on them. Read More

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Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells.

Mol Neurobiol 2021 Apr 13. Epub 2021 Apr 13.

Brain Research Laboratory, Department of Emergency Medicine, Emory University School of Medicine, Whitehead Biomedical Research Building, Room 655A, Atlanta, GA, 30322, USA.

A substantial literature supports the notion that cancer is a metabolic disease. Mitochondria are sexually dimorphic, and progesterone (P4) plays a key regulatory role in mitochondrial functions. We investigated the effect of P4 on mitochondrial functions in three human glioblastoma multiforme (GBM) cell lines. Read More

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Assessment of changes in the liver of pregnant female rats and their fetuses following monosodium glutamate administration.

Environ Sci Pollut Res Int 2021 Apr 13. Epub 2021 Apr 13.

Zoology Department, Faculty of Sciences, Suez University, Ismailia, Egypt.

Monosodium glutamate (MSG) is a common flavor enhancer and stabilizer for ready-made or packaged foods. This research investigated the impact of MSG on the maternal and fetal liver. The present study was carried out on sixteen mature female Albino rats and eight male rats of reproductive age. Read More

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Trichoderma-mediated rice straw compost promotes plant growth and imparts stress tolerance.

Environ Sci Pollut Res Int 2021 Apr 12. Epub 2021 Apr 12.

Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India.

Rice straw burning is causing huge economic losses and environmental hazards. Microbial mediated ex situ composting could be a viable solution which would not only reduce the straw burning but also will enrich nutrition to the soil. Strains of Trichoderma isolated from tree bark were tested to decompose rice straw efficiently, and the Trichoderma-mediated rice straw compost was used subsequently to improve rice growth. Read More

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Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Pharmacology, School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China.

Arsenic trioxide (ATO)‑induced hepatotoxicity limits the therapeutic effect of acute myelogenous leukemia treatment. Magnesium isoglycyrrhizinate (MgIG) is a natural compound extracted from licorice and a hepatoprotective drug used in liver injury. It exhibits anti‑oxidant, anti‑inflammatory and anti‑apoptotic properties. Read More

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Halotolerant bacteria mitigate the effects of salinity stress on soybean growth by regulating secondary metabolites and molecular responses.

BMC Plant Biol 2021 Apr 12;21(1):176. Epub 2021 Apr 12.

School of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea.

Background: Salinity is a major threat to the agriculture industry due to the negative impact of salinity stress on crop productivity. In the present study, we isolated rhizobacteria and evaluated their capacities to promote crop growth under salt stress conditions.

Results: We isolated rhizospheric bacteria from sand dune flora of Pohang beach, Korea, and screened them for plant growth-promoting (PGP) traits. Read More

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Apigenin alleviates methotrexate-induced liver and kidney injury in mice.

Hum Exp Toxicol 2021 Apr 12:9603271211009964. Epub 2021 Apr 12.

Animal Experiments Production and Experimental Research Laboratory, Faculty of Veterinary Medicine, 175651Burdur Mehmet Akif Ersoy University, Burdur, Turkey.

Methotrexate (MTX) is a drug used in the treatment of various types of cancer and inflammatory diseases, but its clinical use has been restricted due to its toxicity. Apigenin (API) is an effective flavonoid with antioxidant and anti-inflammatory properties. The aim of this study was to determine the protective effect of API against MTX-induced liver and kidney toxicity. Read More

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A comparison of the production of antimicrobial peptides and proteins by Galleria mellonella larvae in response to infection with two Pseudomonas aeruginosa strains differing in the profile of secreted proteases.

J Insect Physiol 2021 Apr 9:104239. Epub 2021 Apr 9.

Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19 St., 20-033 Lublin, Poland.

The work presents identification of antimicrobial peptides and proteins (AMPs) in the hemolymph of Galleria mellonella larvae infected with two Pseudomonas aeruginosa strains (ATCC 27853 and PA18), differing in the profile of secreted proteases. The insects were immunized with bacteria cultivated in rich (LB) and minimal (M9) media, which resulted in appearance of a similar broad set of AMPs in the hemolymph. Among them, 13 peptides and proteins were identified, i. Read More

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Novel Magnetic FeO/α-FeOOH Nanocomposites and Their Enhanced Mechanism for Tetracycline Hydrochloride Removal in the Visible Photo-Fenton Process.

ACS Omega 2021 Apr 26;6(13):9095-9103. Epub 2021 Mar 26.

Anhui Province Key Laboratory of Metallurgical Emission Reduction, Anhui University of Technology, Maanshan 243002, Anhui, P. R. China.

Magnetic FeO/α-FeOOH heterojunction nanocomposites (denoted as Fe-NCs) have been synthesized by a fast one-pot hydrothermal method. The obtained Fe-NCs contain rich micropores with a high surface area of 135.15 m/g. Read More

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Assessing of growth, antioxidant enzymes, and phytohormone regulation in under cadmium stress.

Food Sci Nutr 2021 Apr 31;9(4):2021-2031. Epub 2021 Jan 31.

RME-Laboratory of Resources, Materials and Ecosystems Faculty of Sciences of Bizerte University of Carthage Bizerte Tunisia.

One of the major problems worldwide is soil pollution by trace metal elements, which limits plant productivity and threatens human health. In this work, we have studied the effect of different concentrations of cadmium on plants, evaluating different physiological and biochemical parameters: hormone signaling, metabolite concentration (malondialdehyde and hydrogen peroxide) and, in addition, the antioxidant enzyme activities of catalase and superoxide dismutase were evaluated. The production of biomass decreased under the Cd-stress. Read More

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Efficacy of short-synthetic antifungal peptides on pathogenic Aspergillus flavus.

Pestic Biochem Physiol 2021 May 27;174:104810. Epub 2021 Feb 27.

Department of Biochemistry, University College of Science, Osmania University, Hyderabad 500007, Telangana State, India. Electronic address:

The efficacies of three short synthetic antifungal peptides were tested for their inhibitory action on pathogenic fungi, Aspergillus flavus. The sequences of the short synthetic peptides are PPD1- FRLHF, 66-10-FRLKFH, 77-3- FRLKFHF, respectively. These test peptides inhibited fungal growth and showed a membranolytic activity. Read More

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Tebuconazole induced cytotoxic and genotoxic effects in HCT116 cells through ROS generation.

Pestic Biochem Physiol 2021 May 11;174:104797. Epub 2021 Feb 11.

University of Monastir, Faculty of Dental Medicine, Laboratory for Research on Biologically Compatible Compounds, LR01SE17, Avicenne Street, 5000 Monastir, Tunisia; Higher Institute of Biotechnology, University of Monastir, Taher Haddad Street, 5000, Monastie, Tunisia. Electronic address:

Tebuconazole (TEB) is a common triazole fungicide that has been widely used for the control of plant pathogenic fungi, suggesting that mammal exposure occurs regularly. Several studies demonstrated that TEB exposure has been linked to a variety of toxic effects, including neurotoxicity, immunotoxicity, reprotoxicity and carcinogenicity. However, there is a few available data regarding the molecular mechanism involved in TEB-induced toxicity. Read More

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Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation.

Redox Biol 2020 Dec 18;41:101834. Epub 2020 Dec 18.

National University Cancer Institute, National University Health System, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, NUS, Singapore; Integrative Science and Engineering Programme, NUS Graduate School, NUS, Singapore; Faculté de Medicine, University of Paris, Paris, France. Electronic address:

Apart from its physiological role in inflammation and immunity, the nuclear factor-kappa B (NF-κB) protein complex has been implicated in tumorigenesis and its progression. Here, we provide evidence that a pro-oxidant milieu is an upstream effector of oncogenic NF-κB signaling. Through pharmacological or genetic inhibition of SOD1, we show that elevated intracellular superoxide (O) mediates sustained IKK phosphorylation, and induces downstream degradation of IκBα, leading to the nuclear localization and transcriptional activation of NF-κB. Read More

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December 2020

Evaluating the mitochondrial activity and inflammatory state of dimethyl sulfoxide differentiated PLB-985 cells.

Mol Immunol 2021 Apr 7;135:1-11. Epub 2021 Apr 7.

Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada; New Brunswick Center for Precision Medicine, Moncton, NB, Canada. Electronic address:

Neutrophils play a key role in the innate immunity with their ability to generate and release inflammatory mediators that promote the inflammatory response and consequently restore the hemostasis. As active participants in several steps of the normal inflammatory response, neutrophils are also involved in chronic inflammatory diseases such as asthma, atherosclerosis, and arthritis. Given their dual role in the modulation of inflammation, regulating the inflammatory response of neutrophils has been suggested as an important therapeutic approach by numerous researchers. Read More

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Extracellular superoxide dismutase prevents skin aging by promoting collagen production via activation of AMPK and Nrf2/HO-1 cascades.

J Invest Dermatol 2021 Apr 6. Epub 2021 Apr 6.

Laboratory of Dermato-Immunology, College of Medicine, The Catholic University of Korea, 06591, Seoul, Republic of Korea. Electronic address:

With aging, the skin becomes thin and drastically losses collagen. Extracellular (EC) Superoxide dismutase (SOD), also known as SOD3 is the major SOD in the extracellular matrix of the tissues, and is well known to maintain the redox homeostasis and matrix components of such tissues. However, the role of EC-SOD in aging-associated reductions of skin thickness and collagen production is not well studied. Read More

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Antioxidant, Cytotoxicity and Cytoprotective Potential of Extracts of and Berries.

J Pharmacopuncture 2021 Mar;24(1):24-31

Department of Biological Sciences and Biotechnology, Faculty of Sciences, Botswana International University of Science and Technology, Palapye, Botswana.

Objectives: Accumulation of cellular reactive oxygen species (ROS) leads to oxidative stress. Increased production of ROS, such as superoxide anion, or a deficiency in their clearance by antioxidant defences, mediates cellular pathology. fruits are a source of bioactive compounds and have notable antioxidant activity. Read More

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Response of the critically endangered Przewalski's gazelle (Procapra przewalskii) to selenium deprived environment.

J Proteomics 2021 Apr 5:104218. Epub 2021 Apr 5.

School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.

Selenium (Se) is an essential mineral nutrient for animals. Se deprivation can lead to many disorders and even death. This study investigated the response of Przewalski's gazelle (P. Read More

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Hesperidin alleviates bupivacaine anesthesia-induced neurotoxicity in SH-SY5Y cells by regulating apoptosis and oxidative damage.

J Biochem Mol Toxicol 2021 Apr 8:e22787. Epub 2021 Apr 8.

Anesthesiology Department, Shanxi People's Hospital, Taiyuan, China.

Local anesthetic with bupivacaine (BV) administration may cause severe neurotoxicity and neurological complications in developing neurons. Any substances that can mitigate the toxic effects of BV are of great importance in surgical procedures and pain management. The present study attempted to investigate if hesperidin (HN) could inhibit or prevent BV-induced neurotoxicity in SH-SY5Y cells. Read More

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