13,037 results match your criteria summarized key


Degradation of toxic agrochemicals and pharmaceutical pollutants: Effective and alternative approaches toward photocatalysis.

Environ Pollut 2022 Jan 12:118844. Epub 2022 Jan 12.

Department of Biotechnology, Rajalakshmi Engineering College, Chennai, 602105, India.

Emerging concern regarding the remediation of environmental pollution has expanded tremendously in recent years. Pharmaceutical industries and agricultural sectors release an enormous amount of residues containing toxic pollutants at trace levels which poses a serious impact on the environment and human health. To cope with the effect of hazardous and toxic contaminants, numerous methodologies have been developed for the treatment of effluents released from the agrochemical and pharmaceutical industries. Read More

View Article and Full-Text PDF
January 2022

Activation-induced cell death in CAR-T cell therapy.

Hum Cell 2022 Jan 15. Epub 2022 Jan 15.

School of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China.

Engineered T cells expressing chimeric antigen receptors (CARs) with tumor specificity have shown remarkable therapeutic effects on hematologic malignancies. However, CAR-T cells are less effective on solid tumors mainly due to the weak persistence of CAR-T cells, which might be caused by T cell death. Significant activation-induced cell death (AICD) of CAR-T cells was triggered by repeated antigen stimulation. Read More

View Article and Full-Text PDF
January 2022

Perovskite Quantum Dots in Solar Cells.

Adv Sci (Weinh) 2022 Jan 14:e2104577. Epub 2022 Jan 14.

Dalian National Laboratory for Clean Energy, iChEM, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China.

Perovskite quantum dots (PQDs) have captured a host of researchers' attention due to their unique properties, which have been introduced to lots of optoelectronics areas, such as light-emitting diodes, lasers, photodetectors, and solar cells. Herein, the authors aim at reviewing the achievements of PQDs applied to solar cells in recent years. The engineering concerning surface ligands, additives, and hybrid composition for PQDSCs is outlined first, followed by analyzing the reasons of undesired performance of PQDSCs. Read More

View Article and Full-Text PDF
January 2022

Understanding the key factors determining rural domestic waste treatment behavior in China: a meta-analysis.

Environ Sci Pollut Res Int 2022 Jan 15. Epub 2022 Jan 15.

College of Economics and Management, Northwest A&F University, Xianyang, 712100, Yangling, China.

The growing interest of policy-makers, environmental stakeholders, and academics in rural domestic waste treatment has made it a recent focus of research in the field of rural human settlements. Many studies have been conducted to understand the related factors; however, their results are inconsistent. Therefore, different from previous studies, the study systematically analyzed and summarized empirical studies on rural domestic waste treatment and explored the key factors that fostered and impeded it. Read More

View Article and Full-Text PDF
January 2022

Zebrafish Xenotransplantation Models for Studying Gene Function and Drug Treatment in Hepatocellular Carcinoma.

J Gastrointest Cancer 2022 Jan 15. Epub 2022 Jan 15.

Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey.

Introduction: Zebrafish is a promising model organism for human disease including hepatocellular cancer (HCC). Recently, zebrafish has emerged also as a host for xenograft studies of liver cancer cell lines and patient derived tumors of HCC. Zebrafish embryos enable drug screening and gene function studies of xenografted cells via ease of microinjection and visualization of tumor growth and metastasis. Read More

View Article and Full-Text PDF
January 2022

A review on characterizing the metabolite property of anammox sludge by spectroscopy.

Sci Total Environ 2022 Jan 11:153065. Epub 2022 Jan 11.

School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China. Electronic address:

As one of the most promising autotrophic biological nitrogen removal technology, anaerobic ammonia oxidation (anammox) has gained intense attention for the past decades and several full-scale facilities have been implemented worldwide. However, anammox bacteria are easily affected by disturbed external environmental factors, which commonly leads to the fluctuations in reactor performance. The response of anammox sludge to external stress results in changes in components and structural characteristics of intracellular and extracellular polymer substances. Read More

View Article and Full-Text PDF
January 2022

A Systematic Review of Health Technology Assessments of Chimeric Antigen Receptor T-Cell Therapies in Young Compared With Older Patients.

Value Health 2022 Jan 28;25(1):47-58. Epub 2021 Aug 28.

Centre for Health Economics Research and Evaluation, University of Technology Sydney, Sydney, Australia.

Objectives: The objective of this review was to identify sources of variability in cost-effectiveness analyses of chimeric antigen receptor T-cell (CAR-T) therapies, tisagenlecleucel and axicabtagene ciloleucel, evaluated by health technology assessment (HTA) agencies, focusing on young compared with older patients.

Methods: HTA evaluations in pediatric acute lymphoblastic leukemia (ALL) and adult diffuse large B-cell lymphoma (DLBCL) were included from Australia, Canada, England, Norway, and the United States. Key clinical evidence, economic approach, and outcomes (costs, quality-adjusted life-years [QALYs] and incremental cost-effectiveness ratios) were summarized. Read More

View Article and Full-Text PDF
January 2022

Study on the Mechanism of Compound Kidney-Invigorating Granule for Osteoporosis based on Network Pharmacology and Experimental Verification.

Evid Based Complement Alternat Med 2022 4;2022:6453501. Epub 2022 Jan 4.

The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China.

Background: This study used a combination of network pharmacology and experimental confirmation to clarify the mechanism of the compound kidney-invigorating granule (CKG) in treating osteoporosis (OP).

Methods: The main bioactive compounds and corresponding targets of CKG were collected and screened via the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Yet another Traditional Chinese Medicine (YaTCM), and UniProt databases. Disease targets of OP were summarized in GeneCards and the Comparative Toxicogenomics Database (CTD). Read More

View Article and Full-Text PDF
January 2022

Expression of Prostate Specific Membrane Antigen (PSMA) in Breast Cancer.

Geburtshilfe Frauenheilkd 2022 Jan 10;82(1):50-58. Epub 2022 Jan 10.

Klinik für Frauenheilkunde, Universitätsklinikum Freiburg, Freiburg, Germany.

Prostate specific membrane antigen (PSMA) is a promising protein for breast cancer patients. It has not only been detected in prostate cancer but is also expressed by tumor cells and the endothelial cells of tumor vessels in breast cancer patients. PSMA plays a role in tumor progression and tumor angiogenesis. Read More

View Article and Full-Text PDF
January 2022

Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms.

Phytother Res 2022 Jan 13. Epub 2022 Jan 13.

Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular-related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. Read More

View Article and Full-Text PDF
January 2022

Neuroimaging Prediction of Hemorrhagic Transformation for Acute Ischemic Stroke.

Cerebrovasc Dis 2022 Jan 13:1-11. Epub 2022 Jan 13.

Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.

Background: Hemorrhagic transformation (HT) is a common complication of acute ischemic stroke, often resulting from reperfusion therapy. Early prediction of HT can enable stroke neurologists to undertake measures to avoid clinical deterioration and make optimal treatment strategies. Moreover, the trend of extending the time window for reperfusion therapy (both for intravenous thrombolysis and endovascular treatment) further requires more precise detection of HT tendency. Read More

View Article and Full-Text PDF
January 2022

Advanced detection and sensing strategies of Pseudomonas aeruginosa and quorum sensing biomarkers: A review.

Talanta 2022 Jan 7;240:123210. Epub 2022 Jan 7.

The Affiliated Hospital of Medical School, Ningbo University, Ningbo, Zhejiang Province, 315211, People's Republic of China; Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang Province, 315211, People's Republic of China. Electronic address:

Pseudomonas aeruginosa (P. aeruginosa), a ubiquitous opportunistic pathogen, can frequently cause chronic obstructive pulmonary disease, cystic fibrosis and chronic wounds, and potentially lead to severe morbidity and mortality. Timely and adequate treatment of nosocomial infection in clinic depends on rapid detection and accurate identification of P. Read More

View Article and Full-Text PDF
January 2022

Genus Lonicera: New drug discovery from traditional usage to modern chemical and pharmacological research.

Phytomedicine 2021 Dec 20;96:153889. Epub 2021 Dec 20.

Center Lab of Longhua Branch and Department of Infectious Disease, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong 518020, China; Department of Pathology (Longhua Branch), Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong 518020, China; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Medicine School of Shenzhen University, Shenzhen, Guangdong 518037, China. Electronic address:

Background: Lonicera Linn. belonging to the family Caprifoliaceae, the largest genus in the plant family, includes about more than 200 species, which are mainly distributed in northern Africa, North America, Europe and Asia. Some species of this genus have been usually used in traditional Chinese medicine as well as functional foods, cosmetics and other applications, such as L. Read More

View Article and Full-Text PDF
December 2021

A novel strategy by integrating chemical profiling, molecular networking, chemical isolation, and activity evaluation to target isolation of potential anti-ACE2 candidates in Forsythiae Fructus.

Phytomedicine 2021 Dec 12;96:153888. Epub 2021 Dec 12.

Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.

Background: Traditional Chinese medicine (TCM) is regarded as a large database containing hundreds to thousands of chemical constituents that can be further developed as clinical drugs, such as artemisinin in Artemisia annua. However, effectively exploring novel candidates is still a challenge faced by researchers.

Purpose: In this work, an integrated strategy combining chemical profiling, molecular networking, chemical isolation, and activity evaluation (CMCA strategy) was proposed and applied to systematically characterize and screen novel candidates, and Forsythiae fructus (FF) was used as an example. Read More

View Article and Full-Text PDF
December 2021

Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment.

Biotechnol Adv 2022 Jan 10:107902. Epub 2022 Jan 10.

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China; Key Laboratory of Meat Processing of Sichuan, Chengdu University, Chengdu 610106, China. Electronic address:

Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized libraries, presenting high affinity and specificity toward targets with similar to antibodies. Recently, aptamers have demonstrated their outstanding application potential ranging from biosensors, bioimaging, and therapeutics due to various advantages including low immunogenicity, ease of large-scale synthesis, low batch-to-batch variation, easily chemical modification, and programmability. However, the current overall success rate of aptamer is far from being satisfactory, and still needs to overwhelm the major obstacle in affinity, specificity, and stability for practical application. Read More

View Article and Full-Text PDF
January 2022

Lessons learned from terror attacks: thematic priorities and development since 2001-results from a systematic review.

Eur J Trauma Emerg Surg 2022 Jan 13. Epub 2022 Jan 13.

Subsection Emergency and Disaster Relief Medicine, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Oberduerrbacherstrasse 6, 97080, Wuerzburg, Germany.

Purpose: The threat of national and international terrorism remains high. Preparation is the key requirement for the resilience of hospitals and out-of-hospital rescue forces. The scientific evidence for defining medical and tactical strategies often feeds on the analysis of real incidents and the lessons learned derived from them. Read More

View Article and Full-Text PDF
January 2022

Novel Insights Into the Multifaceted Functions of RNA n-Methyladenosine Modification in Degenerative Musculoskeletal Diseases.

Front Cell Dev Biol 2021 27;9:766020. Epub 2021 Dec 27.

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.

N-methyladenosine (mA) is an important modification of eukaryotic mRNA. Since the first discovery of the corresponding demethylase and the subsequent identification of mA as a dynamic modification, the function and mechanism of mA in mammalian gene regulation have been extensively investigated. "Writer", "eraser" and "reader" proteins are key proteins involved in the dynamic regulation of mA modifications, through the anchoring, removal, and interpretation of mA modifications, respectively. Read More

View Article and Full-Text PDF
December 2021

Supramolecular Adhesive Hydrogels for Tissue Engineering Applications.

Chem Rev 2022 Jan 13. Epub 2022 Jan 13.

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ or tissue, with the aim to restore the dysfunctional tissues and enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue engineering applications owing to their favorable attributes such as tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, and particularly attractive self-adhesiveness. In this review, the key design principles and various supramolecular strategies to construct adhesive hydrogels are comprehensively summarized. Read More

View Article and Full-Text PDF
January 2022

Mapping Techniques for the Design of Lithium-Sulfur Batteries.

Small 2022 Jan 13:e2106657. Epub 2022 Jan 13.

State Key Laboratory of Electronic Thin Film and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, 610054, China.

Mapping technique has been the powerful tool for the design of next-generation energy storage devices. Unlike the traditional ion-insertion based lithium batteries, the Li-S battery is based on the complex conversion reactions, which require more cooperation from mapping techniques to elucidate the underlying mechanism. Therefore, in this review, the representative works of mapping techniques for Li-S batteries are summarized, and categorized into the studies of lithium metal anode and sulfur cathode, with sub-sections based on shared characterization mechanisms. Read More

View Article and Full-Text PDF
January 2022

Neutrophils as potential therapeutic targets in hepatocellular carcinoma.

Nat Rev Gastroenterol Hepatol 2022 Jan 12. Epub 2022 Jan 12.

Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

The success of atezolizumab plus bevacizumab treatment contributed to a shift in systemic therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer immunotherapeutic agents. Thus far, the principal focus of cancer immunotherapy has been on interrupting immune checkpoints that suppress antitumour lymphocytes. As well as lymphocytes, the HCC environment includes numerous other immune cell types, among which neutrophils are emerging as an important contributor to the pathogenesis of HCC. Read More

View Article and Full-Text PDF
January 2022

Sequentially calibrating a Bayesian microsimulation model to incorporate new information and assumptions.

BMC Med Inform Decis Mak 2022 Jan 12;22(1):12. Epub 2022 Jan 12.

Argonne National Laboratory, Building 221, 9700 South Cass Avenue, Argonne, IL, 60439, USA.

Background: Microsimulation models are mathematical models that simulate event histories for individual members of a population. They are useful for policy decisions because they simulate a large number of individuals from an idealized population, with features that change over time, and the resulting event histories can be summarized to describe key population-level outcomes. Model calibration is the process of incorporating evidence into the model. Read More

View Article and Full-Text PDF
January 2022

Current advances in the anti-inflammatory effects and mechanisms of natural polysaccharides.

Crit Rev Food Sci Nutr 2022 Jan 12:1-21. Epub 2022 Jan 12.

College of Light Industry and Food Sciences, Zhongkai University of Agriculture and Engineering, Guangzhou, China.

Inflammatory bowel disease (IBD) is a chronic, multifactorial and inflammatory disease occurring in the colon tract. Bioactive polysaccharides from natural resources have attracted extensive attention due to their safety, accessibility and good bioactivities. In recent years, a variety of natural bioactive polysaccharides have been proven to possess anti-inflammatory effects on treating acute colitis. Read More

View Article and Full-Text PDF
January 2022

New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer.

Cancer Commun (Lond) 2022 Jan 12. Epub 2022 Jan 12.

Ministry of Education Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou, Guangdong, 510632, P. R. China.

With the development of proteomics and epigenetics, a large number of RNA-binding proteins (RBPs) have been discovered in recent years, and the interaction between long non-coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in-depth research on the lncRNA-RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA-RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. Read More

View Article and Full-Text PDF
January 2022

The interaction between gut microbiome and anti-tumor drug therapy.

Am J Cancer Res 2021 15;11(12):5812-5832. Epub 2021 Dec 15.

Department of Pharmacology, School of Pharmacy, China Medical University Shenyang 110122, P. R. China.

A large number of symbiotic gut microbiome exists in the human gastrointestinal micro-ecosystem. The daily diet, lifestyle, and body constitution influence the type and quantity of gut microbiome in the body. Increasing evidence demonstrates that the gut microbiome can affect tumor development and progress. Read More

View Article and Full-Text PDF
December 2021

Generation of Leydig-like cells: approaches, characterization, and challenges.

Asian J Androl 2022 Jan 11. Epub 2022 Jan 11.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou 510632, China.

Testosterone production by Leydig cells (LCs) plays a crucial role in male reproduction. The functional degeneration of LCs can cause testosterone deficiency, ultimately resulting in primary male hypogonadism. Transplantation of exogenous LCs with the ability to produce testosterone in response to the regulation of the hypothalamus-pituitary-gonad axis could be a promising alternative option to treat male primary hypogonadism. Read More

View Article and Full-Text PDF
January 2022

Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development-Current State-of-the-Art and Future Perspectives.

Pharmacol Rev 2022 Jan;74(1):141-206

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (S.Y., A.M.K., L.P., Y.Z., J.X.S., S.K.G., R.Z.S., C.M.S., V.M.L.); Department of Drug Metabolism and Pharmacokinetics (DMPK), Merck KGaA, Darmstadt, Germany (L.P.); Department of Health Technology, Technical University of Denmark, Lyngby, Denmark (S.D.C., J.U.L.); Synthetic Physiology Laboratory, Department of Civil Engineering and Architecture, University of Pavia, Pavia, Italy (F.S.P.); Division of Micro- and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden (Z.S.); and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.)

The number of successful drug development projects has been stagnant for decades despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target identification and poor translatability of preclinical models have been identified as major causes of failure. To improve predictions of clinical efficacy and safety, interest has shifted to three-dimensional culture methods in which human cells can retain many physiologically and functionally relevant phenotypes for extended periods of time. Read More

View Article and Full-Text PDF
January 2022

Phytoremediation of potentially toxic elements (PTEs) contaminated soils using alfalfa (Medicago sativa L.): A comprehensive review.

Chemosphere 2022 Jan 8;293:133577. Epub 2022 Jan 8.

College of Chemistry, Chemical Engineering and Environment, Minnan Normal University, Zhangzhou, 363000, China; College of Natural Resources and Environment, Northwest A&F University, Yangling, 712100, China; State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Institute of Soil and Water Conservation CAS and MWR, Yangling, 712100, China; CAS Center for Excellence in Quaternary Science and Global Change, Xi'an, 710061, China. Electronic address:

Soil contamination with potentially toxic elements (PTEs) is an increasing environmental problem, posing serious threats to the living organisms. Phytoremediation is a sustainable and highly accepted technology for remediation of PTE-contaminated soils. Alfalfa has been widely adopted for the phytoremediation of PTE-contaminated soils due to its large biomass productivity, high PTE tolerance, and strong capacity to take up PTEs. Read More

View Article and Full-Text PDF
January 2022

Toxic effects, mechanisms, and ecological impacts of harmful algal blooms in China.

Harmful Algae 2022 Jan 4;111:102148. Epub 2021 Dec 4.

Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, Shandong Province, 266071, China. Electronic address:

Over the last 30 years, harmful algal blooms (HABs) have occurred frequently in the coastal waters of China, resulting in financial losses of over 5.9 billion yuan (about 0.87 billion US dollars) due to massive fish and shellfish mortalities and negative impacts on tourism. Read More

View Article and Full-Text PDF
January 2022

Electrocardiographic findings over time and their prognostic value in patients with COVID-19.

Ann Palliat Med 2021 Dec;10(12):12280-12290

Sichuan Province Public Health Clinical Medical Center, Chengdu, China.

Background: The objective of this study was to carry out a retrospective analysis of the progression of electrocardiographic (ECG) findings over time, based on biomarkers for myocardial injuries in patients with coronavirus disease 2019 (COVID-19). Also, the ECG observations were assessed for possible prognostic use.

Methods: Diagnostic criteria provided by the Coronavirus Pneumonia Diagnosis and Treatment Program of the Chinese National Health Commission were used. Read More

View Article and Full-Text PDF
December 2021

A narrative review of multimodal imaging of white matter lesions in type-2 diabetes mellitus.

Ann Palliat Med 2021 Dec;10(12):12867-12876

Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, China; Heilongjiang Key Laboratory of Ischemic Stroke Prevention and Treatment, Mudanjiang, China.

Objective: To discuss the relevant studies about the structural and functional changes of the brain in patients with type-2 DM (T2DM) and white matter lesion (WML) in recent years, and to summarize them.

Background: T2DM is a common metabolic disease with increasing prevalence worldwide. This disease is closely related to central nervous system and vascular disease, and is considered a risk factor for white matter lesions in the brain. Read More

View Article and Full-Text PDF
December 2021