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Optimizing the Frame Duration for Data-Driven Rigid Motion Estimation in Brain PET Imaging.

Med Phys 2021 Apr 20. Epub 2021 Apr 20.

Department of Radiology, University of Wisconsin, Madison, WI, USA.

Purpose: Data-driven rigid motion estimation for PET brain imaging is usually performed using data frames sampled at low temporal resolution to reduce the overall computation time and to provide adequate signal-to-noise ratio in the frames. In recent work it has been demonstrated that list-mode reconstructions of ultra-short frames are sufficient for motion estimation and can be performed very quickly. In this work we take the approach of using image-based registration of reconstructions of very short frames for data-driven motion estimation, and optimize a number of reconstruction and registration parameters (frame duration, MLEM iterations, image pixel size, post-smoothing filter, reference image creation, and registration metric) to ensure accurate registrations while maximizing temporal resolution and minimizing total computation time. Read More

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Strain Tensor Imaging: Cardiac-induced brain tissue deformation in humans quantified with high-field MRI.

Neuroimage 2021 Apr 17:118078. Epub 2021 Apr 17.

Radiology, University Medical Center Utrecht, The Netherlands.

The cardiac cycle induces blood volume pulsations in the cerebral microvasculature that cause subtle deformation of the surrounding tissue. These tissue deformations are highly relevant as a potential source of information on the brain's microvasculature as well as of tissue condition. Besides, cyclic brain tissue deformations may be a driving force in clearance of brain waste products. Read More

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Impulsive Communication With Full and Partial Information for Adaptive Tracking Consensus of Uncertain Second-Order Multiagent Systems.

IEEE Trans Cybern 2021 Apr 20;PP. Epub 2021 Apr 20.

The uncertainty of dynamics is often unavoidable in practical applications especially for networked control systems while energy cost reduction is a perpetual issue for engineering. With this motivation, this article considers the adaptive tracking consensus problem of uncertain second-order multiagent systems via impulsive communication. The tracking consensus is achieved by designing proper adaptive control schemes with neural networks. Read More

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Rapid identification of genetic variation of ectomycorrhizal fungi by amplification of ribosomal RNA genes.

New Phytol 1992 Oct;122(2):289-298

Laboratoire de Microbiologie Forestière, Centre de Recherches Forestières de Nancy, Institut National de la Recherche Agronomique, Champenoux 54280, France.

There is a clear requirement to develop sensitive methods for detecting denned isolates of ectomycorrhizal fungi within the complex microbial communities of natural ecosystems and reforestation sites. We present a method that permits the rapid identification of an ectomycorrhizal isolate using enzymatic amplification (polymerase chain reaction) of DNA extracted either from pure cultures or ectomycorrhizas. A set of oligonucleotide primers capable of amplifying full-length nuclear 17S and 25S ribosomal RNA genes, together with the ribosomal internal transcribed spacer and intergenic spacer, have been designed and could be used for amplifying target sequences from a wide range of ectomycorrhizal genera. Read More

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October 1992

Reconstruction of the weight-bearing heel with nonsensate reverse sural artery flaps.

Injury 2021 Apr 7. Epub 2021 Apr 7.

Department of Orthopaedic Surgery, Korea University Anam Hospital, Seoul, South Korea. Electronic address:

Background: The reverse sural artery flap (RSAF) is widely used to reconstruct foot and ankle defects. Although it is commonly used in a nonsensate type, there has been controversy as to whether it provides sufficient stability and durability when applied to weight-bearing heels. The aim of this study was to evaluate patient outcomes after weight-bearing heel coverage using a nonsensate RSAF. Read More

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A scoping review on the influencing factors and development process of professional identity among nursing students and nurses.

J Prof Nurs 2021 Mar-Apr;37(2):391-398. Epub 2020 May 6.

Kiang Wu Hospital, 85-87 Estr. de Coelho do Amaral, Macau, China.

Background: Professional identity (PI) is culturally shaped. It is associated with a sufficient and stable workforce of professionals. China has a relatively low ratio of nursing professionals to its population. Read More

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Optogenetic-based Localization of Talin to the Plasma Membrane Promotes Activation of β3 Integrins.

J Biol Chem 2021 Apr 15:100675. Epub 2021 Apr 15.

Department of Medicine, University of California, San Diego, La Jolla, CA, 92093. Electronic address:

Interaction of talin with the cytoplasmic tails of integrin β triggers integrin activation, leading to an increase of integrin affinity/avidity for extracellular ligands. In talin knockout mice, loss of talin interaction with platelet integrin αIIbβ3 causes a severe hemostatic defect, and loss of talin interaction with endothelial cell integrin αVβ3 affects angiogenesis. In normal cells, talin is auto-inhibited and localized in the cytoplasm. Read More

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The clinical effects of cerebral near-infrared spectroscopy monitoring (NIRS) versus no monitoring: a protocol for a systematic review with meta-analysis and trial sequential analysis.

Syst Rev 2021 Apr 16;10(1):111. Epub 2021 Apr 16.

Department of Neonatology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Background: Multiple clinical conditions are associated with cerebral hypoxia/ischaemia and thereby an increased risk of hypoxic-ischaemic brain injury. Cerebral near-infrared spectroscopy monitoring (NIRS) is a tool to monitor brain oxygenation and perfusion, and the clinical uptake of NIRS has expanded over recent years. Specifically, NIRS is used in the neonatal, paediatric, and adult perioperative and intensive care settings. Read More

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The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects.

ACS Pharmacol Transl Sci 2021 Apr 10;4(2):568-572. Epub 2020 Dec 10.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.

Classic psychedelics produce altered states of consciousness that individuals often interpret as meaningful experiences. Across a number of human studies, when the participant-rated intensity of the overall drug effects are statistically controlled for, certain subjective effects predict therapeutic and other desirable outcomes. Underlying neurobiological mechanisms are likely necessary but not sufficient to confer full and enduring beneficial effects. Read More

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Vertical Transmission of SARS-CoV-2: A Systematic Review.

Rev Bras Ginecol Obstet 2021 Mar 15;43(3):207-215. Epub 2021 Apr 15.

SEMEAR Fertilidade, Ribeirão Preto, São Paulo, SP, Brazil.

Objective:  The evaluation of the available evidence on vertical transmission by severe acute respiratory syndrome coronavirus 2 (SARS-CoV)-2.

Data Sources:  An electronic search was performed on June 13, 2020 on the Embase, PubMed and Scopus databases using the following search terms: ( OR OR OR OR OR ) AND ( OR OR ).

Selection Of Studies:  The electronic search resulted in a total of 2,073 records. Read More

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Event-triggered fuzzy filtering for nonlinear networked systems with dynamic quantization and stochastic cyber attacks.

ISA Trans 2021 Mar 31. Epub 2021 Mar 31.

School of Information Science and Engineering, Wuhan University of Science and Technology, Wuhan 430081, China. Electronic address:

In this article, the H filtering issue is considered for discrete-time nonlinear networked systems subject to event-triggered communication scheme, dynamic quantization, and stochastic cyber attacks. The considered nonlinear networked system is described by the Takagi-Sugeno (T-S) fuzzy model. The event-triggered policy and the dynamic quantizer will be considered to realize the effective use of the restricted network bandwidth resources. Read More

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Assessing cerebral arterial pulse wave velocity using 4D flow MRI.

J Cereb Blood Flow Metab 2021 Apr 14:271678X211008744. Epub 2021 Apr 14.

Department of Radiation Sciences, Umeå University, Umeå, Sweden.

Intracranial arterial stiffening is a potential early marker of emerging cerebrovascular dysfunction and could be mechanistically involved in disease processes detrimental to brain function via several pathways. A prominent consequence of arterial wall stiffening is the increased velocity at which the systolic pressure pulse wave propagates through the vasculature. Previous non-invasive measurements of the pulse wave propagation have been performed on the aorta or extracranial arteries with results linking increased pulse wave velocity to brain pathology. Read More

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A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer.

Gut 2021 Apr 12. Epub 2021 Apr 12.

Institute of Cancer Research, Departmet of Medicine I, Medical University of Vienna, Wien, Austria

Objective: Molecular taxonomy of tumours is the foundation of personalised medicine and is becoming of paramount importance for therapeutic purposes. Four transcriptomics-based classification systems of pancreatic ductal adenocarcinoma (PDAC) exist, which consistently identified a subtype of highly aggressive PDACs with basal-like features, including ΔNp63 expression and loss of the epithelial master regulator GATA6. We investigated the precise molecular events driving PDAC progression and the emergence of the basal programme. Read More

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Measurement Properties of the Full and Brief Version of the Work Rehabilitation Questionnaire in Persons with Physical Disabilities.

J Occup Rehabil 2021 Apr 12. Epub 2021 Apr 12.

Department of Rehabilitation Medicine, Center for Rehabilitation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Purpose The Work Rehabilitation Questionnaire (WORQ) is a self-report vocational rehabilitation assessment. A comprehensive (WORQ-FULL) and a brief version (WORQ-BRIEF) are available. The purpose of this study was to investigate measurement properties of both versions in persons with physical disabilities. Read More

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Human Herpesviruses 6A and 6B in Reproductive Diseases.

Front Immunol 2021 25;12:648945. Epub 2021 Mar 25.

Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Human herpesviruses 6A (HHV-6A) and human herpesvirus 6B (HHV-6B)-collectively, HHV-6A/B-are recently-discovered but ancient human viruses. The vast majority of people acquire one or both viruses, typically very early in life, producing an ineradicable lifelong infection. The viruses have been linked to several neurological, pulmonary and hematological diseases. Read More

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The acetabular roof reinforcement plate for the treatment of displaced acetabular fractures in the elderly: results in 59 patients.

Arch Orthop Trauma Surg 2021 Apr 11. Epub 2021 Apr 11.

Department of Orthopaedics and Traumatology, Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, 5020, Salzburg, Austria.

Introduction: Open reduction and internal fixation is considered the gold standard of treatment for displaced acetabular fractures in younger patients. For elderly patients with osteoporotic bone quality, however, primary total hip arthroplasty (THA) with the advantage of immediate postoperative mobilization might be an option. The purpose of this study was to evaluate the clinical and radiological outcomes of surgical treatment of displaced osteoporotic acetabular fractures using the acetabular roof reinforcement plate (ARRP) combined with THA. Read More

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Capacity and site readiness for hypertension control program implementation in the Federal Capital Territory of Nigeria: a cross-sectional study.

BMC Health Serv Res 2021 Apr 9;21(1):322. Epub 2021 Apr 9.

Cardiovascular Research Unit, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.

Background: Nigeria faces an increase in the burden of non-communicable diseases (NCDs), including cardiovascular diseases (CVDs), leading to an estimated 29% of all deaths in the country. Nigeria has an estimated hypertension prevalence ranging from 25 to 40% of her adult population. Despite this high burden, awareness (14-30%), treatment (< 20%), and control (9%) rates of hypertension are low in Nigeria. Read More

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Combined Complex Skin Repair in Patient With Extensive Burns: A Case Report.

J Burn Care Res 2021 Apr 9. Epub 2021 Apr 9.

Department of Medical Cosmetology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous, China.

Auto-skin grafting is the current treatment of choice for extensive burns. Nevertheless, the lack of donor sites for skin grafting remains one of the greatest limiting factors for the treatment of extensively burned patients. We present the case of a 53-year-old male patient with deep and full thickness burns on 91% of the total body surface area. Read More

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Factors affecting the infection of sweet cherry fruit by .

Plant Dis 2021 Apr 9. Epub 2021 Apr 9.

Washington State University, Plant Pathology, 24106 N Bunn Road, Prosser, Washington, United States, 99350;

Powdery mildew caused by is the most important fungal disease of sweet cherries in the Pacific Northwest of the United States. In this study, several factors related to disease epidemiology were evaluated. The experiments were conducted to investigate flower susceptibility to infection by in planta and in vitro inoculation. Read More

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Innovative alignment of sprinting prostheses for persons with transfemoral amputation: Exploratory study on a gold medal Paralympic athlete.

Prosthet Orthot Int 2021 Feb;45(1):46-53

1Applied Research, INAIL Prosthetic Center, Vigorso di Budrio, Italy 2Department of Industrial Engineering, Università di Padova, Padova, Italy 3Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan 4National Institute of Fitness and Sports in Kanoya, Kagoshima, Japan 5Law Course, Department of Law, Nihon Bunka University, Tokyo, Japan.

Background: Recommendations for the alignment of the socket and foot in the sprinting prosthesis of athletes with transfemoral amputation are either based on walking biomechanics or lack public scientific evidence.

Objectives: To explore the biomechanical changes and the sensations of a gold medal Paralympic sprinter, while running with three bench alignments: a conventional reference (A0), an innovative alignment based on the biomechanics of elite able-bodied sprinters (A2), and an intermediate alignment (A1).

Study Design: Single subject with repeated measures. Read More

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February 2021

A Scoping Review of Approaches for Measuring "Interdependent" Collaborative Performances.

Med Educ 2021 Apr 7. Epub 2021 Apr 7.

University of Western Ontario, Department of Medicine, 200 Elizabeth Street, Eaton South 1-565 Suite 225, 100 Collip Circle (MOG, London, Ontario, N6G 4X8, Canada.

Introduction: Individual assessment disregards the team aspect of clinical work. Team assessment collapses the individual into the group. Neither is sufficient for medical education, where measures need to attend to the individual while also accounting for interactions with others. Read More

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Self-Shielding for the ZAP-X®: Revised Characterization and Evaluation.

Cureus 2021 Mar 2;13(3):e13660. Epub 2021 Mar 2.

Radiation Oncology, Stanford University Medical Center, Stanford, USA.

The ZAP-X® is a newly designed, self-contained, and first-of-its-kind self-shielded therapeutic radiation therapy device dedicated to brain and head and neck stereotactic radiosurgery (SRS). By using an S-band linear accelerator (linac) and employing integrated minimal but sufficient shielding, the ZAP-X does not typically require a radiation bunker. At the same time, the self-shielded features of the ZAP-X are designed for more consistency of radiation protection, reducing the risk to radiation workers and others potentially exposed from a poorly designed or constructed radiotherapy vault. Read More

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The socioeconomic burden of antibiotic resistance in conflict-affected settings and refugee hosting countries: a systematic scoping review.

Confl Health 2021 Apr 6;15(1):21. Epub 2021 Apr 6.

Conflict Medicine Program, Global Health Institute, American University of Beirut, Beirut, Lebanon.

Background: Antibiotic resistance (ABR) is a major global threat. Armed and protracted conflicts act as multipliers of infection and ABR, thus leading to increased healthcare and societal costs. We aimed to understand and describe the socioeconomic burden of ABR in conflict-affected settings and refugee hosting countries by conducting a systematic scoping review. Read More

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Point-of-care detection of lactate in cerebrospinal fluid.

Intensive Care Med Exp 2021 Apr 6;9(1):18. Epub 2021 Apr 6.

Clinic for Anesthesiology, University Medical Center Goettingen, Robert Koch-Strasse 40, 37075, Goettingen, Germany.

Purpose: Measurements of cerebrospinal fluid (CSF) lactate can aid in detecting infections of the central nervous system and surrounding structures. Neurosurgical patients with temporary lumbar or ventricular CSF drainage harbor an increased risk for developing infections of the central nervous system, which require immediate therapeutic responses. Since blood gas analyzers enable rapid blood-lactate measurements, we were interested in finding out if we can reliably measure CSF-lactate by this point-of-care technique. Read More

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Quantum reactive scattering calculations for the cold and ultracold Li + LiNa → Li + Na reaction.

Authors:
Brian K Kendrick

J Chem Phys 2021 Mar;154(12):124303

Theoretical Division (T-1, MS B221), Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

A first-principles based quantum dynamics study of the Li + LiNa(v = 0, j = 0) → Li(v, j') + Na reaction is reported for collision energies spanning the ultracold (1 nK) to cold (1 K) regimes. A full-dimensional ab initio potential energy surface for the ground electronic state of LiNa is utilized that includes an accurate treatment of the long-range interactions. The Li + LiNa reaction is barrierless and exoergic and exhibits a deep attractive potential well that supports complex formation. Read More

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Physiological Basis of Extracorporeal Membrane Oxygenation and Extracorporeal Carbon Dioxide Removal in Respiratory Failure.

Membranes (Basel) 2021 Mar 22;11(3). Epub 2021 Mar 22.

Department of Adult Critical Care, Guy's and St. Thomas' NHS Foundation Trust, King's Health Partners, London SE1 7EH, UK.

Extracorporeal life support (ECLS) for severe respiratory failure has seen an exponential growth in recent years. Extracorporeal membrane oxygenation (ECMO) and extracorporeal CO removal (ECCOR) represent two modalities that can provide full or partial support of the native lung function, when mechanical ventilation is either unable to achieve sufficient gas exchange to meet metabolic demands, or when its intensity is considered injurious. While the use of ECMO has defined indications in clinical practice, ECCOR remains a promising technique, whose safety and efficacy are still being investigated. Read More

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High ROS Production by Celecoxib and Enhanced Sensitivity for Death Ligand-Induced Apoptosis in Cutaneous SCC Cell Lines.

Int J Mol Sci 2021 Mar 31;22(7). Epub 2021 Mar 31.

Department of Dermatology, Venerology and Allergology, Skin Cancer Center, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.

Incidence of cutaneous squamous cell carcinoma (cSCC) and actinic keratosis has increased worldwide, and non-steroidal anti-inflammatory drugs as celecoxib are considered for treatment. We show here strong anti-proliferative effects of celecoxib in four cSCC cell lines, while apoptosis and cell viability largely remained unaffected. Impeded apoptosis was overcome in combinations with agonistic CD95 antibody or TNF-related apoptosis-inducing ligand (TRAIL), resulting in up to 60% apoptosis and almost complete loss of cell viability. Read More

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Ultrafiltration Process in Disinfection and Advanced Treatment of Tertiary Treated Wastewater.

Membranes (Basel) 2021 Mar 20;11(3). Epub 2021 Mar 20.

Department of Water and Wastewater Technology, Faculty of Civil and Environmental Engineering, Gdansk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, Poland.

The paper presents the results of research on the use of ultrafiltration, using membranes of 200 and 400 kDa separation, for disinfection of municipal treated wastewater. The research was conducted on a fractional technical scale using real municipal treated wastewater from two large wastewater treatment plants treating most of the wastewater over the one-million polycentric Gdańsk agglomeration (1.2 million inhabitants). Read More

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A Two-Phase Stochastic Dynamic Model for COVID-19 Mid-Term Policy Recommendations in Greece: A Pathway towards Mass Vaccination.

Int J Environ Res Public Health 2021 03 3;18(5). Epub 2021 Mar 3.

Department of Statistics and Insurance Science, University of Piraeus, 18534 Piraeus, Greece.

From 7 November 2020, Greece adopted a second nationwide lockdown policy to mitigate the transmission of SARS-CoV-2 (the first took place from 23 March to 4 May 2020), just as the second wave of COVID-19 was advancing, as did other European countries. To secure the full benefits of mass vaccination, which started in early January 2021, it is of utmost importance to complement it with mid-term non-pharmaceutical interventions (NPIs). The objective was to minimize human losses and to limit social and economic costs. Read More

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