Appl Microbiol Biotechnol 2011 Nov 9;92(3):479-97. Epub 2011 Sep 9.
Department Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.
DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher eukaryotes, making it an attractive target for antibacterials. The fluoroquinolones are examples of very successful gyrase-targeted drugs, but the rise in bacterial resistance to these agents means that we not only need to seek new compounds, but also new modes of inhibition of this enzyme. Read More